80
Views
2
CrossRef citations to date
0
Altmetric
Key Paper Evaluation

First clinical trial of purified, irradiated malaria sporozoites in humans

Pages 31-33 | Published online: 09 Jan 2014

References

  • Crompton PD, Pierce SK, Miller LH. Advances and challenges in malaria vaccine development. J. Clin. Invest.120, 4168–4178 (2010).
  • Plotkin SA. Vaccines: past, present and future. Nat. Med.11, S5–S11 (2005).
  • Kemp DJ, Coppel RL, Cowman AF, Saint RB, Brown GV, Anders RF. Expression of Plasmodium falciparum blood-stage antigens in Escherichia coli: detection with antibodies from immune humans. Proc. Natl Acad. Sci. USA80, 3787–3791 (1983).
  • Treeck M, Tamborrini M, Daubenberger CA, Gilberger TW, Voss TS. Caught in action: mechanistic insights into antibody-mediated inhibition of Plasmodium merozoite invasion. Trends Parasitol.25, 494–497 (2009).
  • Luke TC, Hoffman SL. Rationale and plans for developing a non-replicating, metabolically active, radiation-attenuated Plasmodium falciparum sporozoite vaccine. J. Exp. Biol.206, 3803–3808 (2003).
  • Chattopadhyay R, Conteh S, Li M, James ER, Epstein JE, Hoffman SL. The effects of radiation on the safety and protective efficacy of an attenuated Plasmodium yoelii sporozoite malaria vaccine. Vaccine27, 3675–3680 (2009).
  • Hoffman SL, Billingsley PF, James E et al. Development of a metabolically active, non-replicating sporozoite vaccine to prevent Plasmodium falciparum malaria. Hum. Vaccin.6, 97–106 (2010).
  • Epstein JE, Tewari K, Lyke KE et al. Live attenuated malaria vaccine designed to protect through hepatic CD8+ T cell immunity. Science334(6055), 475–480 (2011).
  • Mueller AK, Deckert M, Heiss K, Goetz K, Matuschewski K, Schluter D. Genetically attenuated Plasmodium berghei liver stages persist and elicit sterile protection primarily via CD8 T cells. Am. J. Pathol.171, 107–115 (2007).
  • Ballou WR. The development of the RTS,S malaria vaccine candidate: challenges and lessons Parasite Immunol.31, 492–500 (2009).
  • Roestenberg M, McCall M, Hopman J et al. Protection against a malaria challenge by sporozoite inoculation. N. Engl. J. Med.361, 468–477 (2009).
  • Mueller AK, Labaied M, Kappe SH, Matuschewski K. Genetically modified Plasmodium parasites as a protective experimental malaria vaccine. Nature433, 164–167 (2005).
  • Borrmann S, Matuschewski K. Targeting Plasmodium liver stages: better late than never. Trends Mol. Med.17, 527–536 (2011).
  • Friesen J, Silvie O, Putrianti ED, Hafalla JC, Matuschewski K, Borrmann S. Natural immunization against malaria: causal prophylaxis with antibiotics. Sci. Transl. Med.2, 40–49 (2010).
  • Robinson T, Campino SG, Auburn S et al. Drug-resistant genotypes and multi-clonality in Plasmodium falciparum analysed by direct genome sequencing from peripheral blood of malaria patients. PLoS One6, e23204 (2011).
  • Chilengi R. Clinical development of malaria vaccines: should earlier trials be done in malaria endemic countries? Hum. Vaccin.5, 627–636 (2009).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.