1,318
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Antitumor Activity of New Chemical Compounds in Triple Negative Mammary Adenocarcinoma Models

, , , , , , , , , , , , & show all
Article: FSOA442 | Received 06 May 2019, Accepted 20 Nov 2019, Published online: 23 Jan 2020

References

  • BrayF , FerlayJ , SoerjomataramI , SiegelRL , TorreLA , JemalA. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin.68(6), 394–424 (2018).
  • JiaoQ , WuA , ShaoGet al.The latest progress in research on triple negative breast cancer (TNBC): risk factors, possible therapeutic targets and prognostic markers. J. Thorac. Dis.6(9), 1329 (2014).
  • HopkinsAL. Network pharmacology: the next paradigm in drug discovery. Nat. Chem. Biol.4(11), 682–690 (2008).
  • DolleRE. Historical overview of chemical library design. In: Chemical Library Design. Springer, Humana Press3–25 (2011).
  • NicolaouKC. Advancing the drug discovery and development process. Angew. Chem. Int. Ed. Engl.53(35), 9128–9140 (2014).
  • BlumLC , ReymondJ-L. 970 million druglike small molecules for virtual screening in the chemical universe database GDB-13. J. Am. Chem. Soc.131(25), 8732–8733 (2009).
  • ReymondJ-L. The chemical space project. Acc. Chem. Res.48(3), 722–730 (2015).
  • WuD-M , WangY-J , FanS-Het al.High-throughput screening of novel pyruvate dehydrogenase kinases inhibitors and biological evaluation of their in vitro and in vivo antiproliferative activity. Eur. J. Med. Chem.164, 252–262 (2019).
  • CornierPG , DelpiccoloCM , MascaliFCet al.In vitro anticancer activity and SAR studies of triazolyl aminoacyl (peptidyl) penicillins. MedChemComm5(2), 214–218 (2014).
  • RicoM , BaglioniM , BondarenkoMet al.Metformin and propranolol combination prevents cancer progression and metastasis in different breast cancer models. Oncotarget8(2), 2874 (2017).
  • Instituto Nacional del Cáncer. Estadísticas: análisis de la situación del cáncer en Argentina (2018). http://www.msal.gov.ar/inc/index.php/cancer-de-mama
  • FerlayJ , HéryC , AutierP , SankaranarayananR. Global Burden of Breast Cancer. In: Breast Cancer EpidemiologyLiC (Ed.). Springer New York, NY, USA1–19 (2010).
  • HughesJP , ReesS , KalindjianSB , PhilpottKL. Principles of early drug discovery. Br. J. Pharmacol.162(6), 1239–1249 (2011).
  • SugitaY , TakaoK , UesawaY , SakagamiH. Search for new type of anticancer drugs with high tumor specificity and less keratinocyte toxicity. Anticancer Res.37(11), 5919–5924 (2017).
  • ZhangB , FangC , DengD , XiaL. Research progress on common adverse events caused by targeted therapy for colorectal cancer. Oncol. lett.16(1), 27–33 (2018).
  • GuoQ , CaoH , QiXet al.Research progress in reversal of tumor multi-drug resistance via natural products. Anti-Cancer Agents Med. Chem.17(11), 1466–1476 (2017).
  • BoggiánDB , CornierPG , MataEG , BlankVC , CárdenasMG , RoguinLP. A solid-and solution-phase-based library of 2β-methyl substituted penicillin derivatives and their effects on growth inhibition of tumor cell lines. MedChemComm6(4), 619–625 (2015).
  • CornierPG , BoggiánDB , MataEG , DelpiccoloCM. Solid-phase based synthesis of biologically promising triazolyl aminoacyl (peptidyl) penicillins. Tetrahedron Lett.53(6), 632–636 (2012).
  • TesteroS , FisherJ , MobasheryS. β-Lactam antibiotics. In: Burger's Medicinal Chemistry, Drug Discovery and Development. AbrahamDJ, RotellaDP ( Eds). Wiley (2010).
  • BurnettDA. β-Lactam cholesterol absorption inhibitors. Curr. Med. Chem.11(14), 1873–1887 (2004).
  • BanerjeeA , DahiyaM , AnandM , KumarS. Inhibition of proliferation of cervical and leukemic cancer cells by penicillin G. Asian Pac. J. Cancer Prev.14(1), 2127–2130 (2013).
  • TripodiF , DapiaggiF , OrsiniF , PagliarinR , SelloG , CoccettiP. Synthesis and biological evaluation of new 3-amino-2-azetidinone derivatives as anti-colorectal cancer agents. MedChemComm9(5), 843–852 (2018).
  • SunL , VasilevichNI , FuselierJA , HocartSJ , CoyDH. Examination of the 1,4-disubstituted azetidinone ring system as a template for combretastatin A-4 conformationally restricted analogue design. Bioorg. Med. Chem. lett.14(9), 2041–2046 (2004).
  • O’BoyleNM , CarrM , GreeneLMet al.Synthesis and evaluation of azetidinone analogues of combretastatin A-4 as tubulin targeting agents. J. Med. Chem.53(24), 8569–8584 (2010).
  • KumarA , D’SouzaSS , GaonkarS , RaiKL , SalimathBP. Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by a new series of substituted-1, 3, 4-oxadiazole derivatives. Invest. New Drugs26(5), 425–435 (2008).