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Review

Role of curcumin in regulating p53 in breast cancer: an overview of the mechanism of action

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Pages 207-217 | Published online: 29 Nov 2018

References

  • ParkerSLTongTBoldenSWingoPACancer statistics, 1997CA Cancer J Clin19974715278996076
  • SiegelRLMillerKDJemalACancer statistics, 2015CA Cancer J Clin201565152925559415
  • StefanCWill a global fund for cancer be the answer?Nat Rev Clin Oncol201815419519629335653
  • DesantisCELinCCMariottoABCancer treatment and survivorship statistics, 2014CA Cancer J Clin201464425227124890451
  • SiegelRLMillerKDJemalACancer statistics, 2016CA Cancer J Clin201666173026742998
  • DesantisCEBreast Cancer Statistics, 2017, racial disparity in mortality by state2017676439448
  • TalibWHConsumption of garlic and lemon aqueous extracts combination reduces tumor burden by angiogenesis inhibition, apoptosis induction, and immune system modulationNutrition201743–448997
  • TalibWHRegressions of breast carcinoma syngraft following treatment with piperine in combination with thymoquinoneSci Pharm20178532711
  • BordoloiDKunnumakkaraABThe Potential of Curcumin: A Multi-targeting Agent in Cancer Cell ChemosensitizationBhartiACAggarwalBBRole of Nutraceuticals in Chemoresistance to Cancer 2AmsterdamElsevier Inc20183160
  • KimSAnSSRole of p53 isoforms and aggregations in cancerMedicine20169526e399327368003
  • ParralesAIwakumaTTargeting Oncogenic Mutant p53 for Cancer TherapyFront Oncol20155Suppl 128826732534
  • BeusterienKGrinspanJKuchukIUse of conjoint analysis to assess breast cancer patient preferences for chemotherapy side effectsOncologist201419212713424473225
  • DiesendruckYBenharINovel immune check point inhibiting antibodies in cancer therapy-Opportunities and challengesDrug Resist Updat201730394728363334
  • MennaPSalvatorelliEMinottiGPerspective Cardiotoxicity of Antitumor DrugsChem Res Toxicol200821597898918376852
  • EscalanteJMcQuadeRMStojanovskaVNurgaliKImpact of chemotherapy on gastrointestinal functions and the enteric nervous systemMaturitas2017105232928545907
  • VieleCSOverview of chemotherapy-induced diarrheaSemin Oncol Nurs2003194 Suppl 325
  • KueblerJPWieandHSO’ConnellMJOxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage II and III colon cancer: results from NSABP C-07J Clin Oncol200725162198220417470851
  • CaoXNieXXiongSRenal protective effect of polysulfide in cisplatin-induced nephrotoxicityRedox Biol20181551352129413963
  • OunRMoussaYWheateNThe side effects of platinum-based chemotherapy drugs: a review for chemistsDalton Trans201847196645665329632935
  • VinayDSRyanEPPawelecGImmune evasion in cancer: Mechanistic basis and therapeutic strategiesSemin Cancer Biol201535SupplS185S19825818339
  • DavisJNMedberyCSharmaSStereotactic body radiotherapy for centrally located early-stage non-small cell lung cancer or lung metastases from the RSSearch® patient registryRadiat Oncol201510111325975848
  • FalahRRTalibWHShbailatSJCombination of metformin and curcumin targets breast cancer in mice by angiogenesis inhibition, immune system modulation and induction of p53 independent apoptosisTher Adv Med Oncol20179423525228491145
  • ZriaDAAOsensteinBASRZsahinMAOHRadiation-induced side effects with or without systemic therapies: prime time for prediction of individual radiosensitivityInt J Radiat Oncol Biol Phys20087151293129418640495
  • NarvaezCDoemerCIdelCRadiotherapy related skin toxicity (RAREST-01): Mepitel® film versus standard care in patients with locally advanced head-and-neck cancerBMC Cancer20181811629291726
  • SchnurJBOuelletteSCDilorenzoTAGreenSMontgomeryGHA qualitative analysis of acute skin toxicity among breast cancer radiotherapy patientsPsychooncology201120326026820238306
  • SchultheissTELeeWRHuntMAHanlonALPeterRSHanksGELate GI and GU complications in the treatment of prostate cancerInt J Radiat Oncol Biol Phys19973713119054871
  • DearnaleyDPKhooVSNormanARComparison of radiation side-effects of conformal and conventional radiotherapy in prostate cancer: a randomised trialLancet199935391492672729929018
  • RepulloDDiazMHolbrechtsSUnusual presentation of a hepatocellular carcinoma as a potential late side effect of radiotherapy in a patient treated for Wilms tumor in childhoodWorld J Surg Oncol20181611529291744
  • KovalicJJThomasPRMBeckwithJBFeusnerTJHNorkoolPAHepatocellular Carcinoma as Second Malignant Neoplasms in Successfully Treated Wilms’ Tumor PatientsCancer19916723423441845942
  • TalibWHMahasnehAMCombination of Ononis hirta and Bifidobacterium longum decreases syngeneic mouse mammary tumor burden and enhances immune responseJ Cancer Res Ther20128341723174725
  • TalibWHMahasnehAMAntimicrobial, cytotoxicity and phytochemical screening of Jordanian plants used in traditional medicineMolecules20101531811182420336015
  • FarnsworthNRAkereleOBingelASSoejartoDDGuoZMedicinal plants in therapyBull World Health Organ19856369659813879679
  • AslamMSAhmadMSMamatASA review on phytochemical constituents and pharmacological activities of Clinacanthus nutansInt J Pharm Pharm Sci2015723033
  • KhanHRaufAMedicinal plants: economic perspective and recent developmentsWorld Appl Sci J20143119251929
  • HarveyAStrategies for discovering drugs from previously unexplored natural productsDrug Discov Today20005729430010856912
  • VerpoorteRPharmacognosy in the New Millennium: Leadfinding and BiotechnologyJ Pharm Pharmacol20005225326210757412
  • KingstonDGModern natural products drug discovery and its relevance to biodiversity conservationJ Nat Prod201174349651121138324
  • TalibWHAnticancer and antimicrobial potential of plant-derived natural productsRasooliIPhytochemicals - bioactivities and impact on healthRijekaInTech2011141160
  • NewmanDJCraggGMNatural products as sources of new drugs over the 30 years from 1981 to 2010J Nat Prod201275331133522316239
  • EidSYEl-ReadiMZFataniSHMohamed Nour EldinEEWinkMNatural products modulate the multifactorial multidrug resistance of cancerPharmacol Pharm20150603146176
  • ShishodiaSSethiGAggarwalBBCurcumin: getting back to the rootsAnn N Y Acad Sci20051056120621716387689
  • HatcherHPlanalpRChoJTortiFMTortiSVCurcumin: from ancient medicine to current clinical trialsCell Mol Life Sci200865111631165218324353
  • NelsonKMDahlinJLBissonJGrahamJPauliGFWaltersMAThe essential medicinal chemistry of curcuminJ Med Chem20176051620163728074653
  • AwasthiMSinghSPandeyVPDwivediUCurcumin: Structure-activity relationship towards its role as a versatile multi-targeted therapeuticsMini Rev Org Chem2017144311322
  • KhalidEBAymanEERahmanHAbdelkarimGNajdaANatural products against cancer angiogenesisTumour Biol20163711145131453627651162
  • AnandPSundaramCJhuraniSKunnumakkaraABAggarwalBBCurcumin and cancer: an “old-age” disease with an “age-old” solutionCancer Lett2008267113316418462866
  • FerriCWestKOteroKKimYHEffectiveness of curcumin for treating cancer during chemotherapyAltern Complement Ther20182411318
  • SagarSMYanceDWongRKNatural health products that inhibit angiogenesis: a potential source for investigational new agents to treat cancer-Part 1Curr Oncol2006131142617576437
  • BahmaniMShirzadHShahinfardNSheivandiLRafieian-KopaeiMCancer Phytotherapy: Recent Views on the Role of Antioxidant and Angiogenesis ActivitiesJ Evid Based Complement Altern Med2017222299309
  • BiYHZhangLHChenSJLingQZChenSAntitumor mechanisms of curcumae rhizoma based on network pharmacologyEvid Based Complement Alternat Med2018201819
  • YangJWangCZhangZCurcumin inhibits the survival and metastasis of prostate cancer cells via the Notch-1 signaling pathwayAPMIS2017125213414028120490
  • LiYDominaALimGChangTZhangTEvaluation of curcumin, a natural product in turmeric, on Burkitt lymphoma and acute myeloid leukemia cancer stem cell markersFuture Oncol201814232353236030139269
  • SuPYangYWangGChenXJuYCurcumin attenuates resistance to irinotecan via induction of apoptosis of cancer stem cells in chemoresistant colon cancer cellsInt J Oncol20185331343135329956726
  • LiXWangXXieCSonic hedgehog and Wnt/β-catenin pathways mediate curcumin inhibition of breast cancer stem cellsAnticancer Drugs201829320821529356693
  • SunMSuXDingBAdvances in nanotechnology-based delivery systems for curcuminNanomedicine2012771085110022846093
  • AtanasovAGWaltenbergerBPferschy-WenzigEMDiscovery and resupply of pharmacologically active plant-derived natural products: a reviewBiotechnol Adv20153381582161426281720
  • BansalSSGoelMAqilFVadhanamMVGuptaRCAdvanced drug delivery systems of curcumin for cancer chemopreventionCancer Prev Res20114811581171
  • Tabatabaei MirakabadFSAkbarzadehAMilaniMA Comparison between the cytotoxic effects of pure curcumin and curcumin-loaded PLGA-PEG nanoparticles on the MCF-7 human breast cancer cell lineArtif Cells Nanomed Biotechnol201644142343025229832
  • JoergerACFershtARStructural biology of the tumor suppressor p53Annu Rev Biochem200877155758218410249
  • Weinberg RobertAThe biology of cancerJ Chem Inf Model2013531689169923800267
  • TalibWHAl KuryLTParthenolide inhibits tumor-promoting effects of nicotine in lung cancer by inducing P53-dependent apoptosis and inhibiting VEGF expressionBiomed Pharmacother20181071488149530257366
  • MillsKDTumor suppression: putting p53 in contextCell Cycle201312223461346224131920
  • VousdenKHLuXLive or let die: the cell’s response to p53Nat Rev Cancer20022859460412154352
  • SleeEAO’ConnorDJLuXTo die or not to die: how does p53 decide?Oncogene200423162809281815077144
  • VenturaAKirschDGMcLaughlinMERestoration of p53 function leads to tumour regression in vivoNature2007445712866166517251932
  • MitkinNAHookCDSchwartzAMp53-dependent expression of CXCR5 chemokine receptor in MCF-7 breast cancer cellsSci Rep20155933025786345
  • MeekDWMechanisms of switching on p53: a role for covalent modification?Oncogene199918537666767510618706
  • MomandJWuHHDasguptaGMDM2 – master regulator of the p53 tumor suppressor proteinGene20002421–2152910721693
  • WuXBayleJHOlsonDLevineAJThe p53-mdm-2 autoregulatory feedback loopGenes Dev19935311261132
  • TokinoTNakamuraYThe role of p53-target genes in human cancerCrit Rev Oncol Hematol20003311610714958
  • RyanKMPhillipsACVousdenKHRegulation and function of the p53 tumor suppressor proteinCurr Opin Cell Biol200113333233711343904
  • LabuschagneCFZaniFVousdenKHControl of metabolism by p53 - Cancer and beyondBiochim Biophys Acta Rev Cancer201818701324229883595
  • HauptSBergerMGoldbergZHauptYApoptosis – the p53 networkJ Cell Sci2003116Pt 204077408512972501
  • SchulerMGreenDRMechanisms of p53-dependent apoptosisBiochem Soc Trans200129Pt 668468811709054
  • OrenMDecision making by p53: life, death and cancerCell Death Differ200310443144212719720
  • HongBvan den HeuvelAPPrabhuVVZhangSEl-DeiryWSTargeting tumor suppressor p53 for cancer therapy: strategies, challenges and opportunitiesCurr Drug Targets2014151808924387333
  • GohAMCoffillCRLaneDPThe role of mutant p53 in human cancerJ Pathol2011223211612621125670
  • SteghAHTargeting the p53 signaling pathway in cancer therapy – the promises, challenges and perilsExpert Opin Ther Targets2012161678322239435
  • RoblesAIHarrisCCClinical outcomes and correlates of TP53 mutations and cancerCold Spring Harb Perspect Biol200923a001016
  • LevineAJp53, the cellular gatekeeper for growth and divisionCell19978833233319039259
  • BianconiEPiovesanAFacchinFAn estimation of the number of cells in the human bodyAnn Hum Biol201340646347123829164
  • VeeraraghavanJNatarajanMHermanTSAravindanNCurcumin-altered p53-Response Genes Regulate Radiosensitivity in p53 -Mutant Ewings Sarcoma CellsAnticancer Res2010401640074015
  • SongGMaoYBCaiQFYaoLMOuyangGLBaoSDCurcumin induces human HT-29 colon adenocarcinoma cell apoptosis by activating p53 and regulating apoptosis-related protein expressionBraz J Med Biol Res200538121791179816302093
  • XuSYangZFanYCurcumin enhances temsirolimus-induced apoptosis in human renal carcinoma cells through upregulation of YAP/p53Oncol Lett20161264999500628105206
  • WangYYuJCuiRLinJDingXCurcumin in treating breast cancer: a reviewJ Lab Autom201621672373127325106
  • ChoudhuriTPalSAgwarwalMLDasTSaGCurcumin induces apoptosis in human breast cancer cells through p53-dependent Bax inductionFEBS Lett20025121–333434011852106
  • FuHWangCYangDCurcumin regulates proliferation, autophagy, and apoptosis in gastric cancer cells by affecting PI3K and P53 signalingJ Cell Physiol201823364634464228926094
  • RamachandranCExpression profiles of apoptotic genes induced by curcumin in human breast cancer and mammary epithelial cell linesAnticancer Res20052553293330216101141
  • QuanJLiYJinMChenDYinXJinMSuppression of p53-inducible gene 3 is significant for glioblastoma progression and predicts poor patient prognosisTumour Biol2017393101042831769457
  • KatoSHanS-YLiuWUnderstanding the function–structure and function–mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysisProc Natl Acad Sci U S A2003100148424842912826609
  • RafiqSRazaMHYounasMMolecular targets of curcumin and future therapeutic role in leukemiaJ Biosci Med201806043350
  • AggarwalSCurcumin (Diferuloylmethane) Down-Regulates Expression of Cell Proliferation and Antiapoptotic and Metastatic Gene Products through Suppression of IkappaBalpha kinase and Akt ActivationMol Pharmacol20066919520616219905
  • ChiuTSuCCurcumin inhibits proliferation and migration by increasing the Bax to Bcl-2 ratio and decreasing NF-κB p65 expression in breast cancer MDA-MB-231 cellsInt J Mol Med200946947519288022
  • RamachandranCYouWDifferential sensitivity of human mammary epithelial and breast carcinoma cell lines to curcuminBreast Cancer Res Treat199954326927810445426
  • AggarwalBBKumarABhartiACAnticancer potential of curcumin: preclinical and clinical studiesAnticancer Res2003231A36339812680238
  • ReuterSEifesSDicatoMAggarwalBBDiederichMModulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cellsBiochem Pharmacol200876111340135118755156
  • WooJMolecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-X L and IAP, the release of cytochrome c and inhibition of AktCarcinogenesis2003241199120812807727
  • ShehzadALeeJHuhTLLeeYSCurcumin induces apoptosis in human colorectal carcinoma (HCT-15) cells by regulating expression of Prp4 and p53Mol Cells201335652653223686430
  • ChoudhuriTPalSDasTSaGCurcumin Selectively Induces Apoptosis in Deregulated Cyclin D1-expressed Cells at G 2 Phase of Cell Cycle in a p53-dependent MannerJ Biol Chem2005280200592006815738001
  • LiuEWuJCaoWCurcumin induces G2/M cell cycle arrest in a p53-dependent manner and upregulates ING4 expression in human gliomaJ Neurooncol200785326327017594054
  • LopiccoloJBlumenthalGMBernsteinWBDennisPATargeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerationsDrug Resist Updat2008111-2325018166498
  • JinHLianNZhangFActivation of PPARγ/P53 signaling is required for curcumin to induce hepatic stellate cell senescenceCell Death Dis201674e218927077805
  • DasLVinayakMLong term effect of curcumin in restoration of tumour suppressor p53 and phase-II antioxidant enzymes via activation of Nrf2 signalling and modulation of inflammation in prevention of cancerPLoS One2015104e0124000e012402325860911
  • CollinsHMAbdelghanyMKMessmerMDifferential effects of garcinol and curcumin on histone and p53 modifications in tumour cellsBMC Cancer20131313723356739
  • LiWWangYSongYXuLZhaoJFangBA preliminary study of the effect of curcumin on the expression of p53 protein in a human multiple myeloma cell lineOncol Lett2015941719172425789029
  • ZhouBZuoYLiBDeubiquitinase inhibition of 19S regulatory particles by 4-arylidene curcumin analog AC17 causes NF-κB inhibition and p53 reactivation in human lung cancer cellsMol Cancer Ther20131281381139223696216
  • MadanEParkerTMBauerMRThe curcumin analog HO-3867 selectively kills cancer cells by converting mutant p53 protein to transcriptionally active wildtype p53J Biol Chem2018293124262427629382728
  • WangJXieHGaoFZhaoTYangHKangBCurcumin induces apoptosis in p53-null Hep3B cells through a TAp73/DNp73-dependent pathwayTumour Biol20163734203421226490992
  • WatsonJLHillRYaffePBCurcumin causes superoxide anion production and p53-independent apoptosis in human colon cancer cellsCancer Lett201029711820472336
  • BeeversCSLiFLiuLHuangSCurcumin inhibits the mammalian target of rapamycin-mediated signaling pathways in cancer cellsInt J Cancer2006119475776416550606
  • AstutiPUtamiDNugrahaniESudjadiSGenistein abrogates G2 arrest induced by curcumin in p53 deficient T47D cellsDaru20122011823226110
  • LiFChenXXuBZhouHCurcumin induces p53-independent necrosis in H1299 cells via a mitochondria-associated pathwayMol Med Rep20151257806781426460892
  • HeZYShiCBWenHLiFLWangBLWangJUpregulation of p53 expression in patients with colorectal cancer by administration of curcuminCancer Invest201129320821321314329
  • TsvetkovPAsherGReissVShaulYSachsLLotemJInhibition of NAD(P)H:quinone oxidoreductase 1 activity and induction of p53 degradation by the natural phenolic compound curcuminProc Natl Acad Sci USA2005102155535554015809436
  • LiontasAYegerHCurcumin and resveratrol induce apoptosis and nuclear translocation and activation of p53 in human neuroblastomaAnticancer Res2004242B98799815161054
  • PanWYangHCaoCAMPK mediates curcumin-induced cell death in CaOV3 ovarian cancer cellsOncol Rep20082061553155919020741
  • ThayyullathilFChathothSHagoAPatelMGaladariSRapid reactive oxygen species (ROS) generation induced by curcumin leads to caspase-dependent and -independent apoptosis in L929 cellsFree Radic Biol Med200845101403141218762247
  • WatsonJLGreenshieldsAHillRCurcumin-induced apoptosis in ovarian carcinoma cells is p53-independent and involves p38 mitogen-activated protein kinase activation and downregulation of Bcl-2 and survivin expression and Akt signalingMol Carcinog2010491132419676105
  • SaGDasTAnti cancer effects of curcumin: cycle of life and deathCell Div200831141418834508
  • BalasubramanyamKVarierRAAltafMCurcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcriptionJ Biol Chem200427949511635117115383533
  • LiuQLooWTSzeSCTongYCurcumin inhibits cell proliferation of MDA-MB-231 and BT-483 breast cancer cells mediated by down-regulation of NFkappaB, cyclinD and MMP-1 transcriptionPhytomedicine2009161091692219524420
  • HallmanKThe effects of turmeric (curcumin) on tumor suppressor protein (p53) and estrogen receptor (ERα) in breast cancer cellsBreast Cancer (Dove Med Press)2017915316128331366
  • SenGSCurcumin Enhances the Efficacy of Chemotherapy by Tailoring p65NF ␬ B-p300 Cross-talk in Favor of p53-p300 in Breast CancerJ Biol Chem2011286422324224722013068
  • ZhouQMWangXFLiuXJZhangHLuYYSuSBCurcumin enhanced antiproliferative effect of mitomycin C in human breast cancer MCF-7 cells in vitro and in vivoActa Pharmacol Sin201132111402141021986579
  • AltenburgJDBieberichAATerryCA synergistic antiproliferation effect of curcumin and docosahexaenoic acid in SK-BR-3 breast cancer cells: unique signaling not explained by the effects of either compound aloneBMC Cancer201111111621194487
  • LiXCurcumin Modulates miR-19/PTEN/AKT/p53 Axis to Suppress Bisphenol A-induced MCF-7 Breast Cancer Cell Proliferation2014281015531560
  • PatelPBThakkarVRPatelJSCellular effect of curcumin and citral combination on breast cancer cells: induction of apoptosis and cell cycle arrestJ Breast Cancer201518322526472972
  • BimonteSBarbieriAPalmaGDissecting the role of curcumin in tumour growth and angiogenesis in mouse model of human breast cancerBiomed Res Int2015201587813425879038
  • AggarwalBBShishodiaSTakadaYCurcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude miceClin Cancer Res200511207490749816243823
  • LvZDLiuXPZhaoWJCurcumin induces apoptosis in breast cancer cells and inhibits tumor growth in vitro and in vivoInt J Clin Exp Pathol2014762818282425031701
  • Faião-floresFMariaDADM-1, sodium 4-[5-(4-hydroxy-3-methoxyphenyl)-3-oxo-penta-1,4-dienyl]-2-methoxy-phenolate: a curcumin analog with a synergic effect in combination with paclitaxel in breast cancer treatmentTumour Biol201233377578522194218
  • SomasundaramSDietary curcumin inhibits chemotherapy-induced apoptosis in models of human breast cancer dietary curcumin inhibits chemotherapy-induced apoptosis in models of humanCancer Res200262133868387512097302
  • PalKLahaDParidaPKAn in vivo study for targeted delivery of curcumin in human triple negative breast carcinoma cells conjugated with folic acidJ Nanosci Nanotechnol20181811429768803