Effect of Chemotherapy on the Gut Microbiome of Breast Cancer Patients During the First Year of Treatment

References

• Ley RE. Obesity and the human microbiome. Curr Opin Gastroenterol. 2010;26(1):5–11. doi:10.1097/MOG.0b013e328333d751
   PubMed Web of Science ®Google Scholar
• Tilg H, Kaser A. Gut microbiome, obesity, and metabolic dysfunction. J Clin Invest. 2011;121:2126–2132. doi:10.1172/JCI58109
   PubMed Web of Science ®Google Scholar
• Tremaroli V, Kovatcheva-Datchary P, Backhed F. A role for the gut microbiota in energy harvesting? Gut. 2010;59:1589–1590. doi:10.1136/gut.2010.223594
   PubMed Web of Science ®Google Scholar
• Goedert JJ, Jones G, Hua X, et al. Investigation of the association between the fecal microbiota and breast cancer in postmenopausal women: a population-based case-control pilot study. J Natl Cancer Inst. 2015;2:107.
   Google Scholar
• Bobin-Dubigeon C, Luu HT, Leuillet S, et al. Faecal microbiota composition varies between patients with breast cancer and healthy women: a comparative case-control study. Nutrients. 2021;13(8):2705. doi:10.3390/nu13082705
   PubMed Web of Science ®Google Scholar
• Byrd DA, Vogtmann E, Wu Z, et al. Associations of fecal microbial profiles with breast cancer and nonmalignant breast disease in the Ghana Breast Health Study. Int J Cancer. 2021;148:2712–2723. doi:10.1002/ijc.33473
   PubMed Web of Science ®Google Scholar
• Hou MF, Ou-Yang F, Li CL, et al. Comprehensive profiles and diagnostic value of menopausal-specific gut microbiota in premenopausal breast cancer. Exp Mol Med. 2021;53:1636–1646. doi:10.1038/s12276-021-00686-9
   PubMed Web of Science ®Google Scholar
• Aarnoutse R, Hillege LE, Ziemons J, et al. Intestinal microbiota in postmenopausal breast cancer patients and controls. Cancers. 2021;13(24):6200. doi:10.3390/cancers13246200
   PubMed Web of Science ®Google Scholar
• He C, Liu Y, Ye S, et al. Changes of intestinal microflora of breast cancer in premenopausal women. Eur J Clin Microbiol Infect Dis. 2021;40(3):503–513. doi:10.1007/s10096-020-04036-x
   PubMed Web of Science ®Google Scholar
• Zhu J, Liao M, Yao Z, et al. Breast cancer in postmenopausal women is associated with an altered gut metagenome. Microbiome. 2018;6:136. doi:10.1186/s40168-018-0515-3
   PubMed Web of Science ®Google Scholar
• Alexander JL, Wilson ID, Teare J, et al. Gut microbiota modulation of chemotherapy efficacy and toxicity. Nat Rev Gastroenterol Hepatol. 2017;14(6):356–365. doi:10.1038/nrgastro.2017.20
   PubMed Web of Science ®Google Scholar
• Miko E, Kovacs T, Sebo E, et al. Microbiome-microbial metabolome-cancer cell interactions in breast cancer-familiar, but unexplored. Cells. 2019;8:293. doi:10.3390/cells8040293
   PubMed Web of Science ®Google Scholar
• Sampsell K, Hao D, Reimer RA. The gut microbiota: a potential gateway to improved health outcomes in breast cancer treatment and survivorship. Int J Mol Sci. 2020;21(23):9239. doi:10.3390/ijms21239239
   PubMed Web of Science ®Google Scholar
• Viaud S, Saccheri F, Mignot G, et al. The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science. 2013;342(6161):971–976. doi:10.1126/science.1240537
   PubMed Web of Science ®Google Scholar
• Aarnoutse R, Ziemons J, Hillege LE, et al. Changes in intestinal microbiota in postmenopausal oestrogen receptor-positive breast cancer patients treated with (neo)adjuvant chemotherapy. NPJ Breast Cancer. 2022;8(1):89. doi:10.1038/s41523-022-00455-5
   PubMed Web of Science ®Google Scholar
• Terrisse S, Derosa L, Iebba V, et al. Intestinal microbiota influences clinical outcome and side effects of early breast cancer treatment. Cell Death Differ. 2021;28(9):2778–2796. doi:10.1038/s41418-021-00784-1
   PubMed Web of Science ®Google Scholar
• Di Modica M, Gargari G, Regondi V, et al. Gut Microbiota Condition the Therapeutic Efficacy of Trastuzumab in HER2-Positive Breast Cancer. Cancer Res. 2021;81:2195–2206. doi:10.1158/0008-5472.CAN-20-1659
   PubMed Web of Science ®Google Scholar
• Jonat W, Pritchard KI, Sainsbury R, et al. Trends in endocrine therapy and chemotherapy for early breast cancer: a focus on the premenopausal patient. J Cancer Res Clin Oncol. 2006;132(5):275–286. doi:10.1007/s00432-006-0082-z
   PubMed Web of Science ®Google Scholar
• Kogawa T, Fujii T, Fouad TM, et al. Impact of change in body mass index during neoadjuvant chemotherapy and survival among breast cancer subtypes. Breast Cancer Res Treat. 2018;171:501–511. doi:10.1007/s10549-018-4853-4
   PubMed Web of Science ®Google Scholar
• Schvartsman G, Gutierrez-Barrera AM, Song J, et al. Association between weight gain during adjuvant chemotherapy for early-stage breast cancer and survival outcomes. Cancer Med. 2017;6(11):2515–2522. doi:10.1002/cam4.1207
   PubMed Web of Science ®Google Scholar
• van den Berg MM, Winkels RM, de Kruif JT, et al. Weight change during chemotherapy in breast cancer patients: a meta-analysis. BMC Cancer. 2017;17:259. doi:10.1186/s12885-017-3242-4
   PubMed Web of Science ®Google Scholar
• Wu AH, Tseng C, Vigen C, et al. Gut microbiome associations with breast cancer risk factors and tumor characteristics: a pilot study. Breast Cancer Res Treat. 2020;182:451–463. doi:10.1007/s10549-020-05702-6
   PubMed Web of Science ®Google Scholar
• Lin D, Peters BA, Friedlander C, et al. Association of dietary fibre intake and gut microbiota in adults. Br J Nutr. 2018;120:1014–1022. doi:10.1017/S0007114518002465
   PubMed Web of Science ®Google Scholar
• Shively CA, Register TC, Appt SE, et al. Consumption of mediterranean versus western diet leads to distinct mammary gland microbiome populations. Cell Rep. 2018;25:47–56 e3. doi:10.1016/j.celrep.2018.08.078
   PubMed Web of Science ®Google Scholar
• Sze MA, Schloss PD. Looking for a Signal in the Noise: revisiting Obesity and the Microbiome. mBio. 2016;7. doi:10.1128/mBio.01018-16
   PubMed Web of Science ®Google Scholar
• Guan X, Ma F, Sun X, et al. Gut Microbiota Profiling in Patients With HER2-Negative Metastatic Breast Cancer Receiving Metronomic Chemotherapy of Capecitabine Compared to Those Under Conventional Dosage. Front Oncol. 2020;10:902. doi:10.3389/fonc.2020.00902
   PubMed Web of Science ®Google Scholar
• Montassier E, Gastinne T, Vangay P, et al. Chemotherapy-driven dysbiosis in the intestinal microbiome. Aliment Pharmacol Ther. 2015;42:515–528. doi:10.1111/apt.13302
   PubMed Web of Science ®Google Scholar
• Flores R, Shi J, Gail MH, et al. Assessment of the human faecal microbiota: II. Reproducibility and associations of 16S rRNA pyrosequences. Eur J Clin Invest. 2012;42(8):855–863. doi:10.1111/j.1365-2362.2012.02659.x
   PubMed Web of Science ®Google Scholar
• Flores R, Shi J, Gail MH, et al. Association of fecal microbial diversity and taxonomy with selected enzymatic functions. PLoS One. 2012;7:e39745. doi:10.1371/journal.pone.0039745
   PubMed Web of Science ®Google Scholar
• Kuczynski J, Stombaugh J, Walters WA, et al. Using QIIME to analyze 16S rRNA gene sequences from microbial communities. Curr Protoc Bioinformatics. 2011; 1. doi:10.1002/0471250953.bi1007s36
   PubMedGoogle Scholar
• Wang Q, Garrity GM, Tiedje JM, et al. Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. Appl Environ Microbiol. 2007;73:5261–5267. doi:10.1128/AEM.00062-07
   PubMed Web of Science ®Google Scholar
• DeSantis TZ, Hugenholtz P, Larsen N, et al. Greengenes, a chimera-checked 16S rRNA gene database and workbench compatible with ARB. Appl Environ Microbiol. 2006;72:5069–5072. doi:10.1128/AEM.03006-05
   PubMed Web of Science ®Google Scholar
• Liu CM, Aziz M, Kachur S, et al. BactQuant: an enhanced broad-coverage bacterial quantitative real-time PCR assay. BMC Microbiol. 2012;12:56. doi:10.1186/1471-2180-12-56
   PubMed Web of Science ®Google Scholar
• Matsen FA, Kodner RB, Armbrust EV. pplacer: linear time maximum-likelihood and Bayesian phylogenetic placement of sequences onto a fixed reference tree. BMC Bioinform. 2010;11:538. doi:10.1186/1471-2105-11-538
   PubMed Web of Science ®Google Scholar
• Zhang X, Pei YF, Zhang L, et al. Negative binomial mixed models for analyzing longitudinal microbiome data. Front Microbiol. 2018;9:1683. doi:10.3389/fmicb.2018.01683
   PubMed Web of Science ®Google Scholar
• Anderson MJ, Willis TJ. Canonical analysis of principal coordinates: a useful method of constrained ordination for ecology. Ecology. 2003;84(2):511–525. doi:10.1890/0012-9658(2003)084[0511:CAOPCA]2.0.CO;2
   Web of Science ®Google Scholar
• Lozupone C, Knight R. UniFrac: a new phylogenetic method for comparing microbial communities. Appl Environ Microbiol. 2005;71(12):8228–8235. doi:10.1128/AEM.71.12.8228-8235.2005
   PubMed Web of Science ®Google Scholar
• Benjamini YHY. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc. 1995;B:289–300.
   Google Scholar
• Parker BJ, Wearsch PA, Veloo ACM, et al. The genus alistipes: gut bacteria with emerging implications to inflammation, cancer, and mental health. Front Immunol. 2020;11:906. doi:10.3389/fimmu.2020.00906
   PubMed Web of Science ®Google Scholar
• Moschen AR, Gerner RR, Wang J, et al. Lipocalin 2 Protects from Inflammation and Tumorigenesis Associated with Gut Microbiota Alterations. Cell Host Microbe. 2016;19:455–469. doi:10.1016/j.chom.2016.03.007
   PubMed Web of Science ®Google Scholar
• Scorletti E, Afolabi PR, Miles EA, et al. Synbiotics Alter Fecal Microbiomes, But Not Liver Fat or Fibrosis, in a Randomized Trial of Patients With Nonalcoholic Fatty Liver Disease. Gastroenterology. 2020;158:1597–1610 e7. doi:10.1053/j.gastro.2020.01.031
   PubMed Web of Science ®Google Scholar
• Knuesel T, Mohajeri MH. The role of the gut microbiota in the development and progression of major depressive and bipolar disorder. Nutrients. 2021;14. doi:10.3390/nu14010037
   PubMed Web of Science ®Google Scholar
• Heshiki Y, Vazquez-Uribe R, Li J, et al. Predictable modulation of cancer treatment outcomes by the gut microbiota. Microbiome. 2020;8:28. doi:10.1186/s40168-020-00811-2
   PubMed Web of Science ®Google Scholar
• Jin Y, Dong H, Xia L, et al. The Diversity of Gut Microbiome is Associated With Favorable Responses to Anti-Programmed Death 1 Immunotherapy in Chinese Patients With NSCLC. J Thorac Oncol. 2019;14:1378–1389. doi:10.1016/j.jtho.2019.04.007
   PubMed Web of Science ®Google Scholar
• Uzan-Yulzari A, Morr M, Tareef-Nabwani H, et al. The intestinal microbiome, weight, and metabolic changes in women treated by adjuvant chemotherapy for breast and gynecological malignancies. BMC Med. 2020;18:281. doi:10.1186/s12916-020-01751-2
   PubMed Web of Science ®Google Scholar
• Kaakoush NO. Insights into the Role of Erysipelotrichaceae in the Human Host. Front Cell Infect Microbiol. 2015;5:84. doi:10.3389/fcimb.2015.00084
   PubMed Web of Science ®Google Scholar
• Dao MC, Everard A, Aron-Wisnewsky J, et al. Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology. Gut. 2016;65:426–436. doi:10.1136/gutjnl-2014-308778
   PubMed Web of Science ®Google Scholar
• Hills RD, Pontefract BA, Mishcon HR, et al. Gut microbiome: profound implications for diet and disease. Nutrients. 2019;11(7):1613. doi:10.3390/nu11071613
   PubMed Web of Science ®Google Scholar
• Routy B, Le Chatelier E, Derosa L, et al. Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors. Science. 2018;359:91–97. doi:10.1126/science.aan3706
   PubMed Web of Science ®Google Scholar
• Fruge AD, Van der Pol W, Rogers LQ, et al. Fecal Akkermansia muciniphila Is Associated with Body Composition and Microbiota Diversity in Overweight and Obese Women with Breast Cancer Participating in a Presurgical Weight Loss Trial. J Acad Nutr Diet. 2020;120(4):650–659. doi:10.1016/j.jand.2018.08.164
   PubMed Web of Science ®Google Scholar
• Peters BA, Shapiro JA, Church TR, et al. A taxonomic signature of obesity in a large study of American adults. Sci Rep. 2018;8:9749. doi:10.1038/s41598-018-28126-1
   PubMed Web of Science ®Google Scholar
• Luu TH, Michel C, Bard JM, et al. Intestinal Proportion of Blautia sp. is Associated with Clinical Stage and Histoprognostic Grade in Patients with Early-Stage Breast Cancer. Nutr Cancer. 2017;69:267–275. doi:10.1080/01635581.2017.1263750
   PubMed Web of Science ®Google Scholar
• Ramne S, Brunkwall L, Ericson U, et al. Gut microbiota composition in relation to intake of added sugar, sugar-sweetened beverages and artificially sweetened beverages in the Malmo Offspring Study. Eur J Nutr. 2021;60:2087–2097. doi:10.1007/s00394-020-02392-0
   PubMed Web of Science ®Google Scholar
• Galle F, Valeriani F, Cattaruzza MS, et al. Mediterranean Diet, Physical Activity and Gut Microbiome Composition: a Cross-Sectional Study among Healthy Young Italian Adults. Nutrients. 2020;12(7):2164. doi:10.3390/nu12072164
   PubMed Web of Science ®Google Scholar
• Segata N, Izard J, Waldron L, et al. Metagenomic biomarker discovery and explanation. Genome Biol. 2011;12:R60. doi:10.1186/gb-2011-12-6-r60
   PubMed Web of Science ®Google Scholar
• Lin H, Peddada SD. Analysis of compositions of microbiomes with bias correction. Nat Commun. 2020;11:3514. doi:10.1038/s41467-020-17041-7
   PubMed Web of Science ®Google Scholar