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Clinical, Cosmetic and Investigational Dermatology Volume 13, 2020 - Issue
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Original Research

Neuronal Precursor Cell Expressed Developmentally Down Regulated 4 (NEDD4) Gene Polymorphism Contributes to Keloid Development in Egyptian Population

Azza G A Farag1 Dermatology, Andrology and STDs Department, Faculty of Medicine, Menoufia University, Shibin El Kom, EgyptCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-0333-5506View further author information
ORCID Icon,
Hesham N Khaled1 Dermatology, Andrology and STDs Department, Faculty of Medicine, Menoufia University, Shibin El Kom, EgyptView further author information
,
Mostafa A Hammam1 Dermatology, Andrology and STDs Department, Faculty of Medicine, Menoufia University, Shibin El Kom, EgyptView further author information
,
Mustafa Elsayed Elshaib2 Faculty of Medicine, Menoufia University, Shibin El Kom, EgyptORCID Iconhttps://orcid.org/0000-0001-8701-3143View further author information
ORCID Icon,
Nermin Reda Tayel3 Department of Molecular Diagnostics and Therapeutics, Genetic Engineering Biotechnology Research Institute, Sadat City, EgyptView further author information
,
Sahar Elsoudy Ibrahim Hommos4 Dermatology Department, Elsherouk General Hospital, Cairo, EgyptORCID Iconhttps://orcid.org/0000-0002-5926-1091View further author information
ORCID Icon &
Eman Masoud Abd El Gayed5 Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Menoufia University, Shibin El Kom, EgyptORCID Iconhttps://orcid.org/0000-0002-0884-5820View further author information
ORCID Icon show all
Pages 649-656 | Published online: 26 Aug 2020

References

  • Halim AS, Emami A, Salahshourifar I, Kannan TP. Keloid scarring: understanding the genetic basis, advances, and prospects. Arch Plast Surg. 2012;39(3):184. doi:10.5999/aps.2012.39.3.18422783524
  • Lu W, Zheng X, Yao X, Zhang L. Clinical and epidemiological analysis of keloids in Chinese patients. Arch Dermatol Res. 2015;307(2):109–114. doi:10.1007/s00403-014-1507-125266787
  • O’Sullivan ST, O’Shaughnessy M, O’Connor TP. Aetiology and management of hypertrophic scars and keloids. Ann R Coll Surg Engl. 1996;78(3 pt 1):168–175.8779496
  • Limandjaja GC, van den Broek LJ, Waaijman T, et al. Increased epidermal thickness and abnormal epidermal differentiation in keloid scars. Br J Dermatol. 2017;176(1):116–126. doi:10.1111/bjd.1484427377288
  • Jiao H, Zhang T, Fan J, Xiao R. The superficial dermis may initiate keloid formation: histological analysis of the keloid dermis at different depths. Front Physiol. 2017;8. doi:10.3389/fphys.2017.00885.
  • Rossiello L, D’Andrea F, Grella R, et al. Differential expression of cyclooxygenases in hypertrophic scar and keloid tissues. Wound Repair Regen. 2009;17(5):750–757. doi:10.1111/j.1524-475X.2009.00530.x19769727
  • Nakashima M, Chung S, Takahashi A, et al. A genome-wide association study identifies four susceptibility loci for keloid in the Japanese population. Nat Genet. 2010;42(9):768–771. doi:10.1038/ng.64520711176
  • Marneros AG, Norris JE, Watanabe S, Reichenberger E. Clinical genetics of familial keloid. Arch Dermatol. 2001;137(11):1429–1434.11708945
  • Boase NA, Kumar S. NEDD4: the founding member of a family of ubiquitin-protein ligases. Gene. 2015;557(2):113–122. doi:10.1016/j.gene.2014.12.02025527121
  • Cao XR, Lill NL, Boase N, et al. Nedd4 controls animal growth by regulating IGF-1 signaling. Sci Signal. 2008;1(38):ra5. doi:10.1126/scisignal.116094018812566
  • Chung S, Nakashima M, Zembutsu H, Nakamura Y. Possible involvement of NEDD4 in keloid formation; its critical role in fibroblast proliferation and collagen production. Proc Jpn Acad Ser B. 2011;87(8):563–573. doi:10.2183/pjab.87.56321986318
  • Marneros AG. A role for the E3 ubiquitin ligase NEDD4 in keloid pathogenesis. J Investig Dermatol. 2019;139(2):279–280. doi:10.1016/j.jid.2018.09.00730471838
  • Yang Y, Liang Y, Ma X, Su Y, Zhang X. Genetic susceptibility to keloid scarring in Chinese Han population: NEDD4 gene single nucleotide polymorphism. Int J Clin Exp Med. 2017;10(2):4042–4048.
  • Zhu Z, Wu B, Li P, et al. Association study confirmed susceptibility loci with keloid in the Chinese Han Population. PLoS One. 2013;8(5).
  • Ogawa R, Watanabe A, Than Naing B, et al. Associations between keloid severity and single-nucleotide polymorphisms: importance of rs8032158 as a biomarker of keloid severity. J Invest Dermatol. 2014;134(7):2041–2043. doi:10.1038/jid.2014.7124496234
  • Fujita M, Yamamoto Y, Jiang JJ, et al. NEDD4 is involved in inflammation development during keloid formation. J Investig Dermatol. 2019;139(2):333–341. doi:10.1016/j.jid.2018.07.04430273597
  • Kendrick M. Why being “overweight” means you live longer: the way scientists twist the facts. Independent. 2015;15:32.
  • Fearmonti R, Bond J, Erdmann D, et al. A review of scar scales and scar measuring devices. Eplasty. 2010;10.
  • Baryza MJ, Baryza GA. The Vancouver scar scale: an administration tool and its interrater reliability. J Burn Care Rehabil. 1995;16(5):535–538. doi:10.1097/00004630-199509000-000138537427
  • Shih B, Bayat A. Genetics of keloid scarring. Arch Dermatol Res. 2010;302(5):319–339. doi:10.1007/s00403-009-1014-y20130896
  • Zhao Y, Liu S, Xie J, et al. NEDD4 single nucleotide polymorphism rs2271289 is associated with keloids in Chinese Han population. Am J Transl Res. 2016;8(2):544–555.27158346
  • Atsumi T, Singh R, Sabharwal L, et al. Inflammation amplifier, a new paradigm in cancer biology. Cancer Res. 2014;74(1):8–14. doi:10.1158/0008-5472.CAN-13-232224362915
  • Meng J, Jiang JJ, Atsumi T, et al. Breakpoint cluster region–mediated inflammation is dependent on Casein Kinase II. J Immunol. 2016;197(8):3111–3119. doi:10.4049/jimmunol.160108227630163
  • Ogura H, Arima Y, Kamimura D, Murakami M. The gateway theory: how regional neural activation creates a gateway for immune cells via an inflammation amplifier. Biomed J. 2013;36(6).

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