Honey and Chamomile Activate Keratinocyte Antioxidative Responses via the KEAP1/NRF2 System

Tatsuya Ogawa1 Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan

Yosuke Ishitsuka1 Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, JapanCorrespondence[email protected]

https://orcid.org/0000-0002-1733-5427

Yoshiyuki Nakamura1 Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan

Naoko Okiyama1 Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan

https://orcid.org/0000-0002-5398-0773

Rei Watanabe1 Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan;2 Department of Dermatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

Yasuhiro Fujisawa1 Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan

https://orcid.org/0000-0003-3010-8496

Manabu Fujimoto1 Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan;2 Department of Dermatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

https://orcid.org/0000-0002-3062-4872

show all

References

Ishitsuka Y, Roop DR. Loricrin: past, present, and future. Int J Mol Sci. 2020;21(7):2271. doi:10.3390/ijms21072271
Web of Science ®Google Scholar
Yamamoto M, Kensler TW, Motohashi H. The KEAP1-NRF2 system: a thiol-based sensor-effector apparatus for maintaining redox homeostasis. Physiol Rev. 2018;98(3):1169–1203. doi:10.1152/physrev.00023.201729717933
PubMed Web of Science ®Google Scholar
Huebner AJ, Dai D, Morasso M, et al. Amniotic fluid activates the nrf2/keap1 pathway to repair an epidermal barrier defect in utero. Dev Cell. 2012;23(6):1238–1246. doi:10.1016/j.devcel.2012.11.00223237955
PubMed Web of Science ®Google Scholar
Ishitsuka Y, Huebner AJ, Rice RH, et al. Lce1 family members are Nrf2-target genes that are induced to compensate for the loss of loricrin. J Invest Dermatol. 2016;136(8):1656–1663. doi:10.1016/j.jid.2016.04.02227167730
PubMed Web of Science ®Google Scholar
Ranneh Y, Akim AM, Hamid HA, Khazaai H, Fadel A, Mahmoud AM. Stingless bee honey protects against lipopolysaccharide induced-chronic subclinical systemic inflammation and oxidative stress by modulating Nrf2, NF-kappaB and p38 MAPK. Nutr Metab (Lond). 2019;16:15. doi:10.1186/s12986-019-0341-z30858869
PubMed Web of Science ®Google Scholar
Bhaskaran N, Srivastava JK, Shukla S, Gupta S. Chamomile confers protection against hydrogen peroxide-induced toxicity through activation of Nrf2-mediated defense response. Phytother Res. 2013;27(1):118–125. doi:10.1002/ptr.470122511316
PubMed Web of Science ®Google Scholar
Ogawa T, Ishitsuka Y, Nakamura Y, et al. NRF2 augments epidermal antioxidant defenses and promotes atopy. J Immunol. 2020;205(4):907–914. doi:10.4049/jimmunol.200027432690656
PubMed Web of Science ®Google Scholar

Honey and Chamomile Activate Keratinocyte Antioxidative Responses via the KEAP1/NRF2 System

References

Information for

Open access

Opportunities

Help and information

Your download is now in progress and you may close this window

Login or register to access this feature

Honey and Chamomile Activate Keratinocyte Antioxidative Responses via the KEAP1/NRF2 System

References

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date