The Associations of Androgen-Related Genes CYP21A2 and CYP19A1 with Severe Acne Vulgaris in Patients from Southwest China

References

• Tan JK, Bhate K. A global perspective on the epidemiology of acne. Br J Dermatol. 2015;172 (Suppl 1):3–12. doi:10.1111/bjd.13462
   PubMed Web of Science ®Google Scholar
• Tan JK. Psychosocial impact of acne vulgaris: evaluating the evidence. Skin Therapy Lett. 2004;9 (7):1–3, 9.
   PubMedGoogle Scholar
• Tian LM, Xie H-F, Yang T, et al. Association study of tumor necrosis factor receptor type 2 M196R and toll-like receptor 2 Arg753Gln polymorphisms with acne vulgaris in a Chinese Han ethnic group. Dermatology. 2010;221 (3):276–284. doi:10.1159/000319851
   PubMed Web of Science ®Google Scholar
• Bhate K, Williams HC. Epidemiology of acne vulgaris. Br J Dermatol. 2013;168 (3):474–485. doi:10.1111/bjd.12149
   PubMed Web of Science ®Google Scholar
• He L, Yang Z, Yu H, et al. The relationship between CYP17-34T/C polymorphism and acne in Chinese subjects revealed by sequencing. Dermatology. 2006;212 (4):338–342. doi:10.1159/000092284
   Web of Science ®Google Scholar
• Keshari S, Kumar M, Balasubramaniam A, Chang TW, Tong Y, Huang CM. Prospects of acne vaccines targeting secreted virulence factors of Cutibacterium acnes. Expert Rev Vaccines. 2019;18 (5):433–437. doi:10.1080/14760584.2019.1593830
   PubMed Web of Science ®Google Scholar
• Kuiri-Hänninen T, Haanpää M, Turpeinen U, et al. Transient postnatal secretion of androgen hormones is associated with acne and sebaceous gland hypertrophy in early infancy. J Clin Endocrinol Metab. 2013;98 (1):199–206. doi:10.1210/jc.2012-2680
   Web of Science ®Google Scholar
• Paraskevaidis A, Drakoulis N, Roots I, et al. Polymorphisms in the human cytochrome P-450 1A1 Gene (CYP1A1) as a factor for developing acne. Dermatology. 1998;196 (1):171–175. doi:10.1159/000017855
   PubMed Web of Science ®Google Scholar
• Pang Y, He CD, Liu Y, et al. Combination of short CAG and GGN repeats in the androgen receptor gene is associated with acne risk in North East China. J Eur Acad Dermatol Venereol. 2008;22 (12):1445–1451. doi:10.1111/j.1468-3083.2008.02891.x
   Web of Science ®Google Scholar
• Ostlere LS, Rumsby G, Holownia P, et al. Carrier status for steroid 21-hydroxylase deficiency is only one factor in the variable phenotype of acne. Clin Endocrinol. 1998;48 (2):209–215. doi:10.1046/j.1365-2265.1998.3811205.x
   Web of Science ®Google Scholar
• Travis RC, Schumacher F, Hirschhorn JN, et al. CYP19A1 genetic variation in relation to prostate cancer risk and circulating sex hormone concentrations in men from the breast and prostate cancer cohort consortium. Cancer Epidemiol Biomarkers Prev. 2009;18 (10):2734–2744. doi:10.1158/1055-9965.EPI-09-0496
   Web of Science ®Google Scholar
• Lazaros L, Xita N, Hatzi E, et al. CYP19 gene variants affect the assisted reproduction outcome of women with polycystic ovary syndrome. Gynecol Endocrinol. 2013;29 (5):478–482. doi:10.3109/09513590.2013.774359
   PubMed Web of Science ®Google Scholar
• Wang H, Li Q, Wang T, et al. A common polymorphism in the human aromatase gene alters the risk for polycystic ovary syndrome and modifies aromatase activity in vitro. Mol Hum Reprod. 2011;17 (6):386–391. doi:10.1093/molehr/gar007
   Web of Science ®Google Scholar
• Onsory K, Sobti RC, Al-Badran AI, et al. Hormone receptor-related gene polymorphisms and prostate cancer risk in North Indian population. Mol Cell Biochem. 2008;314 (1–2):25–35. doi:10.1007/s11010-008-9761-1
   Web of Science ®Google Scholar
• Yip L, Zaloumis S, Irwin D, et al. Gene-wide association study between the aromatase gene (CYP19A1) and female pattern hair loss. Br J Dermatol. 2009;161 (2):289–294. doi:10.1111/j.1365-2133.2009.09186.x
   PubMed Web of Science ®Google Scholar
• Ramalhinho AC, Fonseca-Moutinho JA, Breitenfeld Granadeiro LA. Positive association of polymorphisms in estrogen biosynthesis gene, CYP19A1, and metabolism, GST, in breast cancer susceptibility. DNA Cell Biol. 2012;31 (6):1100–1106. doi:10.1089/dna.2011.1538
   PubMed Web of Science ®Google Scholar
• Khvostova EP, Pustylnyak VO, Gulyaeva LF. Genetic polymorphism of estrogen metabolizing enzymes in Siberian women with breast cancer. Genet Test Mol Biomarkers. 2012;16 (3):167–173. doi:10.1089/gtmb.2011.0131
   Web of Science ®Google Scholar
• Lundin E, Wirgin I, Lukanova A, et al. Selected polymorphisms in sex hormone-related genes, circulating sex hormones and risk of endometrial cancer. Cancer Epidemiol. 2012;36 (5):445–452. doi:10.1016/j.canep.2012.04.006
   PubMed Web of Science ®Google Scholar
• Wang HS, Wu HM, Cheng BH, et al. Functional analyses of endometriosis-related polymorphisms in the estrogen synthesis and metabolism-related genes. PLoS One. 2012;7 (11):e47374. doi:10.1371/journal.pone.0047374
   Web of Science ®Google Scholar
• Trabert B, Schwartz SM, Peters U, et al. Genetic variation in the sex hormone metabolic pathway and endometriosis risk: an evaluation of candidate genes. Fertil Steril. 2011;96 (6):1401–1406 e3. doi:10.1016/j.fertnstert.2011.09.004
   Web of Science ®Google Scholar
• Xita N, Chatzikyriakidou A, Stavrou I, et al. The (TTTA) n polymorphism of aromatase (CYP19) gene is associated with age at menarche. Hum Reprod. 2010;25 (12):3129–3133. doi:10.1093/humrep/deq276
   Web of Science ®Google Scholar
• Guo Y, Xiong D-H, Yang T-L, et al. Polymorphisms of estrogen-biosynthesis genes CYP17 and CYP19 may influence age at menarche: a genetic association study in Caucasian females. Hum Mol Genet. 2006;15 (16):2401–2408. doi:10.1093/hmg/ddl155
   Web of Science ®Google Scholar
• Witkowski JA, Parish LC. The assessment of acne: an evaluation of grading and lesion counting in the measurement of acne. Clin Dermatol. 2004;22 (5):394–397. doi:10.1016/j.clindermatol.2004.03.008
   PubMed Web of Science ®Google Scholar
• Tao SQ, Xia R-S, Li F, et al. Efficacy of 3.6% topical ALA-PDT for the treatment of severe acne vulgaris. Eur Rev Med Pharmacol Sci. 2016;20 (2):225–231.
   Web of Science ®Google Scholar
• Barrett JC, Fry B, Maller J, et al. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics. 2005;21 (2):263–265. doi:10.1093/bioinformatics/bth457
   PubMed Web of Science ®Google Scholar
• Gabriel SB, Schaffner SF, Nguyen H, et al. The structure of haplotype blocks in the human genome. Science. 2002;296 (5576):2225–2229. doi:10.1126/science.1069424
   PubMed Web of Science ®Google Scholar
• Grech I, Giatrakou S, Damoraki G, et al. Single nucleotide polymorphisms of toll-like receptor-4 protect against acne conglobata. J Eur Acad Dermatol Venereol. 2012;26 (12):1538–1543. doi:10.1111/j.1468-3083.2011.04338.x
   Web of Science ®Google Scholar
• Al-Shobaili HA, Salem TA, Alzolibani AA, et al. Tumor necrosis factor-α −308 G/A and interleukin 10-1082 A/G gene polymorphisms in patients with acne vulgaris. J Dermatol Sci. 2012;68 (1):52–55. doi:10.1016/j.jdermsci.2012.07.001
   PubMed Web of Science ®Google Scholar
• Karrer-Voegeli S, Rey F, Reymond MJ, Meuwly JY, Gaillard RC, Gomez F. Androgen dependence of hirsutism, acne, and alopecia in women: retrospective analysis of 228 patients investigated for hyperandrogenism. Medicine. 2009;88 (1):32–45. doi:10.1097/md.0b013e3181946a2c
   PubMed Web of Science ®Google Scholar
• Lai JJ, Chang P, Lai KP, Chen L, Chang C. The role of androgen and androgen receptor in skin-related disorders. Arch Dermatol Res. 2012;304 (7):499–510.
   PubMed Web of Science ®Google Scholar
• New MI. An update of congenital adrenal hyperplasia. Ann N Y Acad Sci. 2004;1038:14–43. doi:10.1196/annals.1315.009
   PubMed Web of Science ®Google Scholar
• Caputo V, Fiorella S, Curiale S, et al. Refractory acne and 21-hydroxylase deficiency in a selected group of female patients. Dermatology. 2010;220 (2):121–127. doi:10.1159/000277608
   Web of Science ®Google Scholar