Promelanogenic Effects by an Annurca Apple-Based Natural Formulation in Human Primary Melanocytes

References

• Slominski A, Tobin DJ, Shibahara S, Wortsman J. Melanin pigmentation in mammalian skin and its hormonal regulation. Physiol Rev. 2004;84(4):1155–1228.
   PubMed Web of Science ®Google Scholar
• Solano F. Melanins: skin pigments and much more – types, structural models, biological functions, and formation routes. New Journal of Science. 2014;2014:1–28. doi:10.1155/2014/498276
   Google Scholar
• Maranduca MA, Branisteanu D, Serban DN, et al. Synthesis and physiological implications of melanic pigments. Oncol Lett. 2019;17(5):4183–4187. doi:10.3892/ol.2019.10071
   PubMed Web of Science ®Google Scholar
• Schlessinger DI, Anoruo M, Schlessinger J. Biochemistry, Melanin. Treasure Island (FL): StatPearls Publishing; 2020.
   Google Scholar
• Watt AAR, Bothmab JP, Meredith P. The supramolecular structure of melanin. Soft Matter. 2009;5:3754–3760. doi:10.1039/b902507c
   Web of Science ®Google Scholar
• Panzella L, Ebato A, Napolitano A, Koike K. The late stages of melanogenesis: exploring the chemical facets and the application opportunities. Int J Mol Sci. 2018;19(6):1753. doi:10.3390/ijms19061753
   Web of Science ®Google Scholar
• Ortonne JP. Photoprotective properties of skin melanin. Br J Dermatol. 2002;146(61):7–10. doi:10.1046/j.1365-2133.146.s61.3.x
   Web of Science ®Google Scholar
• Simon JD, Peles DN. The red and the black. Acc Chem Res. 2010;43(11):1452–1460. doi:10.1021/ar100079y
   PubMed Web of Science ®Google Scholar
• Cichorek M, Wachulska M, Stasiewicz A, Tymińska A. Skin melanocytes: biology and development. Postepy Dermatol Alergol. 2013;30(1):30–41. doi:10.5114/pdia.2013.33376
   PubMed Web of Science ®Google Scholar
• D’Alba L, Shawkey MD. Melanosomes: biogenesis, properties, and evolution of an ancient organelle. Physiol Rev. 2019;99(1):1–19. doi:10.1152/physrev.00059.2017
   Web of Science ®Google Scholar
• Seiberg M. Keratinocyte-melanocyte interactions during melanosome transfer. Pigment Cell Res. 2001;14(4):236–242. doi:10.1034/j.1600-0749.2001.140402.x
   PubMedGoogle Scholar
• Schallreuter KU, Kothari S, Chavan B, Spencer JD. Regulation of melanogenesis–controversies and new concepts. Exp Dermatol. 2008;17(5):395–404. doi:10.1111/j.1600-0625.2007.00675.x
   Web of Science ®Google Scholar
• Pavan WJ, Sturm RA. The genetics of human skin and hair pigmentation. Annu Rev Genomics Hum Genet. 2019;20(1):41–72. doi:10.1146/annurev-genom-083118-015230
   PubMed Web of Science ®Google Scholar
• D’Mello SA, Finlay GJ, Baguley BC, Askarian-Amiri ME. Signaling pathways in melanogenesis. Int J Mol Sci. 2016;17(7):1144. doi:10.3390/ijms17071144
   PubMed Web of Science ®Google Scholar
• Serre C, Busuttil V, Botto JM. Intrinsic and extrinsic regulation of human skin melanogenesis and pigmentation. Int J Cosmet Sci. 2018;40(4):328–347. doi:10.1111/ics.12466
   PubMed Web of Science ®Google Scholar
• Slominski A. Neuroendocrine activity of the melanocyte. Exp Dermatol. 2009;18(9):760–763. doi:10.1111/j.1600-0625.2009.00892.x
   Web of Science ®Google Scholar
• Yuan XH, Jin ZH. Paracrine regulation of melanogenesis. Br J Dermatol. 2018;178(3):632–639. doi:10.1111/bjd.15651
   PubMed Web of Science ®Google Scholar
• Rzepka Z, Buszman E, Beberok A, Wrześniok D. From tyrosine to melanin: signaling pathways and factors regulating melanogenesis. Postepy Hig Med Dosw. 2016;70:695–708. doi:10.5604/17322693.1208033
   Web of Science ®Google Scholar
• Zaidi KU, Ali SA, Ali AS, Thawani V. Natural melanogenesis stimulator a potential tool for the treatment of hypopigmentation disease. Int J Mol Biol. 2017;2(1):37‒40.
   Google Scholar
• Niu C, Aisa HA. Upregulation of melanogenesis and tyrosinase activity: potential agents for vitiligo. Molecules. 2017;22(8):1303. doi:10.3390/molecules22081303
   PubMed Web of Science ®Google Scholar
• Niu C, Yin L, Nie LF, et al. Synthesis and bioactivity of novel isoxazole chalcone derivatives on tyrosinase and melanin synthesis in murine B16 cells for the treatment of vitiligo. Bioorg Med Chem. 2016;24(21):5440–5448. doi:10.1016/j.bmc.2016.08.066
   PubMed Web of Science ®Google Scholar
• Chisvert A, Benedé JL, Salvador A. Chapter 6 - tanning and whitening agents in cosmetics: regulatory aspects and analytical methods. In: Salvador A, Chisvert A, editors. Analysis of Cosmetic Products. 2nd ed. Elsevier; 2018:107–121.
   Google Scholar
• Ali SA, Naaz I, Zaidi KU, Ali AS. Recent updates in melanocyte function: the use of promising bioactive compounds for the treatment of hypopigmentary disorders. Mini Rev Med Chem. 2017;17(9):785–798. doi:10.2174/1389557516666161223153953
   PubMed Web of Science ®Google Scholar
• Boo YC. Emerging strategies to protect the skin from ultraviolet rays using plant-derived materials. Antioxidants. 2020;9(7):637. doi:10.3390/antiox9070637
   Web of Science ®Google Scholar
• Piccolo M, Ferraro MG, Maione F, et al. Induction of hair keratins expression by an annurca apple-based nutraceutical formulation in human follicular cells. Nutrients. 2019;11(12):3041. doi:10.3390/nu11123041
   Web of Science ®Google Scholar
• Tenore GC, Caruso D, Buonomo G, et al. Annurca apple nutraceutical formulation enhances keratin expression in a human model of skin and promotes hair growth and tropism in a randomized clinical trial. J Med Food. 2018;21(1):90–103. doi:10.1089/jmf.2017.0016
   Web of Science ®Google Scholar
• Tenore GC, Caruso D, Buonomo G, et al. A healthy balance of plasma cholesterol by a novel annurca apple-based nutraceutical formulation: results of a randomized trial. J Med Food. 2017;20(3):288–300. doi:10.1089/jmf.2016.0152
   Web of Science ®Google Scholar
• Tenore GC, Caruso D, Buonomo G, et al. Lactofermented annurca apple puree as a functional food indicated for the control of plasma lipid and oxidative amine levels: results from a randomised clinical trial. Nutrients. 2019;11(1):122. doi:10.3390/nu11010122
   PubMed Web of Science ®Google Scholar
• Yamauchi K, Mitsunaga T. Methylquercetins stimulate melanin biosynthesis in a three-dimensional skin model. J Nat Med. 2018;72(2):563–569. doi:10.1007/s11418-018-1175-0
   Web of Science ®Google Scholar
• Takekoshi S, Nagata H, Kitatani K. Flavonoids enhance melanogenesis in human melanoma cells. Tokai J Exp Clin Med. 2014;39(3):116–121.
   PubMedGoogle Scholar
• Piccolo M, Misso G, Ferraro MG, et al. Exploring cellular uptake, accumulation and mechanism of action of a cationic Ru-based nanosystem in human preclinical models of breast cancer. Sci Rep. 2019;9(1):7006. doi:10.1038/s41598-019-43411-3
   PubMed Web of Science ®Google Scholar
• Iovine B, Nino M, Irace C, Bevilacqua MA, Monfrecola G. Ultraviolet B and A irradiation induces fibromodulin expression in human fibroblasts in vitro. Biochimie. 2009;91(3):364–372. doi:10.1016/j.biochi.2008.10.017
   Web of Science ®Google Scholar
• Song X, Mosby N, Yang J, Xu A, Abdel-Malek Z, Kadekaro AL. alpha-MSH activates immediate defense responses to UV-induced oxidative stress in human melanocytes. Pigment Cell Melanoma Res. 2009;22(6):809–818. doi:10.1111/j.1755-148X.2009.00615.x
   Web of Science ®Google Scholar
• Hosoi J, Abe E, Suda T, Kuroki T. Regulation of melanin synthesis of B16 mouse melanoma cells by 1 alpha, 25-dihydroxyvitamin D3 and retinoic acid. Cancer Res. 1985;45(4):1474–1478.
   Web of Science ®Google Scholar
• Irace C, Misso G, Capuozzo A, et al. Antiproliferative effects of ruthenium-based nucleolipidic nanoaggregates in human models of breast cancer in vitro: insights into their mode of action. Sci Rep. 2017;7(1):45236. doi:10.1038/srep45236
   Web of Science ®Google Scholar
• Santamaria R, Fiorito F, Irace C, et al. 2,3,7,8-Tetrachlorodibenzo-p-dioxin impairs iron homeostasis by modulating iron-related proteins expression and increasing the labile iron pool in mammalian cells. Biochim Biophys Acta. 2011;1813(5):704–712. doi:10.1016/j.bbamcr.2011.02.003
   Web of Science ®Google Scholar
• Yamaguchi Y, Hearing VJ. Melanocytes and their diseases. Cold Spring Harb Perspect Med. 2014;4(5):a017046. doi:10.1101/cshperspect.a017046
   PubMed Web of Science ®Google Scholar
• Harris J. Vitiligo’s impact is in the eye of the beholder. Nature. 2018;563(7732):S99. doi:10.1038/d41586-018-07435-5
   Google Scholar
• Pillaiyar T, Manickam M, Jung SH. Downregulation of melanogenesis: drug discovery and therapeutic options. Drug Discov Today. 2017;22(2):282–298. doi:10.1016/j.drudis.2016.09.016
   PubMed Web of Science ®Google Scholar
• Boo YC. Up- or downregulation of melanin synthesis using amino acids, peptides, and their analogs. Biomedicines. 2020;8(9):E322. doi:10.3390/biomedicines8090322
   Web of Science ®Google Scholar
• Lajis AFB, Ariff AB. Discovery of new depigmenting compounds and their efficacy to treat hyperpigmentation: evidence from in vitro study. J Cosmet Dermatol. 2019;18(3):703–727. doi:10.1111/jocd.12900
   PubMed Web of Science ®Google Scholar
• Chan CF, Wu CT, Huang WY, et al. Antioxidation and melanogenesis inhibition of various dendrobium tosaense extracts. Molecules. 2018;23(7):1810. doi:10.3390/molecules23071810
   PubMed Web of Science ®Google Scholar
• Nguyen NT, Fisher DE. MITF and UV responses in skin: from pigmentation to addiction. Pigment Cell Melanoma Res. 2019;32(2):224–236. doi:10.1111/pcmr.12726
   Web of Science ®Google Scholar
• Tagashira H, Miyamoto A, Kitamura S, et al. UVB stimulates the expression of endothelin B receptor in human melanocytes via a sequential activation of the p38/MSK1/CREB/MITF pathway which can be interrupted by a French Maritime Pine Bark Extract through a direct inactivation of MSK1. PLoS One. 2015;10(6):e0128678. doi:10.1371/journal.pone.0128678
   Web of Science ®Google Scholar
• Terazawa S, Imokawa G. Signaling cascades activated by UVB in human melanocytes lead to the increased expression of melanocyte receptors, endothelin B Receptor and c-KIT. Photochem Photobiol. 2018;94(3):421–431. doi:10.1111/php.12848
   PubMed Web of Science ®Google Scholar
• Badolati N, Sommella E, Riccio G, et al. Annurca apple polyphenols ignite keratin production in hair follicles by inhibiting the pentose phosphate pathway and amino acid oxidation. Nutrients. 2018;10(10):1406. doi:10.3390/nu10101406
   Web of Science ®Google Scholar
• Takahashi T, Kamiya T, Hasegawa A, Yokoo Y. Procyanidin oligomers selectively and intensively promote proliferation of mouse hair epithelial cells in vitro and activate hair follicle growth in vivo. J Invest Dermatol. 1999;112(3):310–316. doi:10.1046/j.1523-1747.1999.00532.x
   Web of Science ®Google Scholar
• Kanteev M, Goldfeder M, Fishman A. Structure-function correlations in tyrosinases. Protein Sci. 2015;24(9):1360–1369. doi:10.1002/pro.2734
   PubMed Web of Science ®Google Scholar
• Jimbow K, Park JS, Kato F, et al. Assembly, target-signaling and intracellular transport of tyrosinase gene family proteins in the initial stage of melanosome biogenesis. Pigment Cell Res. 2000;13(4):222–229. doi:10.1034/j.1600-0749.2000.130403.x
   Google Scholar
• Gilchrest BA, Eller MS. DNA photodamage stimulates melanogenesis and other photoprotective responses. J Investig Dermatol Symp Proc. 1999;4(1):35–40. doi:10.1038/sj.jidsp.5640178
   Google Scholar
• Nordlund JJ. The melanocyte and the epidermal melanin unit: an expanded concept. Dermatol Clin. 2007;25(3):271–281. doi:10.1016/j.det.2007.04.001
   Web of Science ®Google Scholar