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Clinical, Cosmetic and Investigational Dermatology Volume 14, 2021 - Issue
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Case Report

Reactive Langerhans Cell Proliferation Mimicking Langerhans Cell Histiocytosis in Association with Sézary Syndrome: A Case Report and Literature Review

Jinjing Zhang1 Department of Hematology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110001, People’s Republic of ChinaView further author information
,
Shiyu Ma1 Department of Hematology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110001, People’s Republic of ChinaView further author information
,
Jinxiang Yu1 Department of Hematology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110001, People’s Republic of ChinaView further author information
,
Song Zheng2 Department of Dermatology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110001, People’s Republic of ChinaView further author information
,
Yuan Miao3 Department of Pathology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110001, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0001-7869-8099View further author information
ORCID Icon,
Pingping Wang1 Department of Hematology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110001, People’s Republic of ChinaView further author information
&
Xiaojing Yan1 Department of Hematology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110001, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-1673-0369View further author information
ORCID Icon show all
Pages 1023-1028 | Published online: 24 Aug 2021

References

  • Whittaker S, Hoppe R, Prince HM. How I treat mycosis fungoides and sezary syndrome. Blood. 2016;127:3142–3153. doi:10.1182/blood-2015-12-611830
  • Christie LJ, Evans AT, Bray SE, et al. Lesions resembling Langerhans cell histiocytosis in association with other lymphoproliferative disorders: a reactive or neoplastic phenomenon? Hum Pathol. 2006;37(1):32–39. doi:10.1016/j.humpath.2005.08.024
  • Ezra N, Van Dyke GS, Binder SW. CD30 positive anaplastic large-cell lymphoma mimicking Langerhans cell histiocytosis. J Cutan Pathol. 2010;37(7):787–792. doi:10.1111/j.1600-0560.2009.01430.x
  • Jokinen CH, Wolgamot GM, Wood BL, Olerud J, Argenyi ZB. Lymphomatoid papulosis with CD1a+ dendritic cell hyperplasia, mimicking Langerhans cell histiocytosis. J Cutan Pathol. 2007;34(7):584–587. doi:10.1111/j.1600-0560.2006.00659.x
  • Vonderheid EC, Bernengo MG, Burg G, et al. Update on erythrodermic cutaneous T-cell lymphoma: report of the International Society for Cutaneous Lymphomas. J Am Acad Dermatol. 2002;46(1):95–106. doi:10.1067/mjd.2002.118538
  • Vega F, Luthra R, Medeiros LJ, et al. Clonal heterogeneity in mycosis fungoides and its relationship to clinical course. Blood. 2002;100(9):3369–3373. doi:10.1182/blood.V100.9.3369
  • Rodriguez-Galindo C, Allen CE. Langerhans cell histiocytosis. Blood. 2020;135(16):1319–1331. doi:10.1182/blood.2019000934
  • Shanmugam V, Craig JW, Hornick JL, Morgan EA, Pinkus GS, Pozdnyakova O. Cyclin D1 is expressed in neoplastic cells of Langerhans cell histiocytosis but not reactive Langerhans cell proliferations. Am J Surg Pathol. 2017;41(10):1390–1396. doi:10.1097/PAS.0000000000000897
  • Chatterjee D, Vishwajeet V, Saikia UN, Radotra B, De D, Bansal D. CyclinD1 is useful to differentiate Langerhans cell histiocytosis from reactive Langerhans cells. Am J Dermatopathol. 2019;41(3):188–192. doi:10.1097/DAD.0000000000001250
  • Hristov AC, Vonderheid EC, Borowitz MJ. Simplified flow cytometric assessment in mycosis fungoides and Sézary syndrome. Am J Clin Pathol. 2011;136(6):944–953. doi:10.1309/AJCP09OTJOYAVZZK
  • Walia R, Yeung CCS. An update on molecular biology of cutaneous T cell lymphoma. Front Oncol. 2019;9:1558. doi:10.3389/fonc.2019.01558
  • Delfau-Larue MH, Laroche L, Wechsler J, et al. Diagnostic value of dominant T-cell clones in peripheral blood in 363 patients presenting consecutively with a clinical suspicion of cutaneous lymphoma. Blood. 2000;96(9):2987–2992. doi:10.1182/blood.V96.9.2987
  • Borcherding N, Voigt AP, Liu V, Link BK, Zhang W, Jabbari A. Single-cell profiling of cutaneous T-cell Lymphoma reveals underlying heterogeneity associated with disease progression. Clin Cancer Res. 2019;25(10):2996–3005. doi:10.1158/1078-0432.CCR-18-3309
  • Buus TB, Willerslev-Olsen A, Fredholm S, et al. Single-cell heterogeneity in Sézary syndrome. Blood Adv. 2018;2(16):2115–2126. doi:10.1182/bloodadvances.2018022608

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