179
Views
2
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Metformin Inhibits HaCaT Cell Proliferation Under Hyperlipidemia Through Reducing Reactive Oxygen Species via FOXO3 Activation

, , , , , , & show all
Pages 1403-1413 | Received 02 Apr 2022, Accepted 11 Jul 2022, Published online: 22 Jul 2022

References

  • Korman NJ. Management of psoriasis as a systemic disease: what is the evidence? Br J Dermatol. 2020;182(4):840–848. doi:10.1111/bjd.18245
  • Ogawa E, Sato Y, Minagawa A, Okuyama R. Pathogenesis of psoriasis and development of treatment. J Dermatol. 2018;45(3):264–272. doi:10.1111/1346-8138.14139
  • Rendon A, Schakel K. Psoriasis pathogenesis and treatment. Int J Mol Sci. 2019;20(6). doi:10.3390/ijms20061475
  • Choi MR, Kim HD, Cho S, et al. Anoctamin1 induces hyperproliferation of HaCaT keratinocytes and triggers imiquimod-induced psoriasis-like skin injury in mice. Int J Mol Sci. 2021;22(13):7145.
  • Campione E, Cosio T, Lanna C, et al. Predictive role of vitamin A serum concentration in psoriatic patients treated with IL-17 inhibitors to prevent skin and systemic fungal infections. J Pharmacol Sci. 2020;144(1):52–56. doi:10.1016/j.jphs.2020.06.003
  • Gisondi P, Fostini AC, Fossa I, Girolomoni G, Targher G. Psoriasis and the metabolic syndrome. Clin Dermatol. 2018;36(1):21–28. doi:10.1016/j.clindermatol.2017.09.005
  • Gisondi P, Tessari G, Conti A, et al. Prevalence of metabolic syndrome in patients with psoriasis: a hospital-based case-control study. Br J Dermatol. 2007;157(1):68–73. doi:10.1111/j.1365-2133.2007.07986.x
  • Fatima F, Das A, Kumar P, Datta D. Skin and metabolic syndrome: an evidence based comprehensive review. Indian J Dermatol. 2021;66(3):302–307. doi:10.4103/ijd.IJD_728_20
  • Mazzilli S, Lanna C, Chiaramonte C, et al. Real life experience of apremilast in psoriasis and arthritis psoriatic patients: preliminary results on metabolic biomarkers. J Dermatol. 2020;47(6):578–582. doi:10.1111/1346-8138.15293
  • Raychaudhuri SK, Chatterjee S, Nguyen C, Kaur M, Jialal I, Raychaudhuri SP. Increased prevalence of the metabolic syndrome in patients with psoriatic arthritis. Metab Syndr Relat Disord. 2010;8(4):331–334. doi:10.1089/met.2009.0124
  • Miao C, Li J, Li Y, Zhang X. Obesity and dyslipidemia in patients with psoriasis: a case-control study. Medicine. 2019;98(31):e16323. doi:10.1097/MD.0000000000016323
  • Pietrzak A, Chabros P, Grywalska E, et al. Serum lipid metabolism in psoriasis and psoriatic arthritis - an update. Arch Med Sci. 2019;15(2):369–375. doi:10.5114/aoms.2018.74021
  • Fan Z, Wang L, Jiang H, Lin Y, Wang Z. Platelet dysfunction and its role in the pathogenesis of psoriasis. Dermatology. 2021;237(1):56–65. doi:10.1159/000505536
  • Cannavo SP, Riso G, Casciaro M, Di Salvo E, Gangemi S. Oxidative stress involvement in psoriasis: a systematic review. Free Radic Res. 2019;53(8):829–840. doi:10.1080/10715762.2019.1648800
  • Ko W, Kim N, Lee H, et al. Anti-inflammatory effects of compounds from cudrania tricuspidata in HaCaT human keratinocytes. Int J Mol Sci. 2021;22(14):7472. doi:10.3390/ijms22147472
  • Sreedhar A, Aguilera-Aguirre L, Singh KK. Mitochondria in skin health, aging, and disease. Cell Death Dis. 2020;11(6):444. doi:10.1038/s41419-020-2649-z
  • Campione E, Mazzilli S, Di Prete M, et al. The role of Glutathione-S transferase in psoriasis and associated comorbidities and the effect of dimethyl fumarate in this pathway. Front Med. 2022;9:760852. doi:10.3389/fmed.2022.760852
  • Bai H, Zhang W, Qin XJ, et al. Hydrogen peroxide modulates the proliferation/quiescence switch in the liver during embryonic development and posthepatectomy regeneration. Antioxid Redox Signal. 2015;22(11):921–937. doi:10.1089/ars.2014.5960
  • Liu C, Liao JZ, Li PY. Traditional Chinese herbal extracts inducing autophagy as a novel approach in therapy of nonalcoholic fatty liver disease. World J Gastroenterol. 2017;23(11):1964–1973. doi:10.3748/wjg.v23.i11.1964
  • Kim HR, Kim JC, Kang SY, Kim HO, Park CW, Chung BY. Rapamycin alleviates 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Induced aggravated dermatitis in mice with imiquimod-induced psoriasis-like dermatitis by inducing autophagy. Int J Mol Sci. 2021;22(8):3968.
  • Caputo V, Strafella C, Termine A, et al. Overview of the molecular determinants contributing to the expression of Psoriasis And Psoriatic Arthritis phenotypes. J Cell Mol Med. 2020;24(23):13554–13563. doi:10.1111/jcmm.15742
  • Morris BJ, Willcox DC, Donlon TA, Willcox BJ. FOXO3: a major gene for human Longevity–A Mini-Review. Gerontology. 2015;61(6):515–525. doi:10.1159/000375235
  • Tsitsipatis D, Klotz LO, Steinbrenner H. Multifaceted functions of the forkhead box transcription factors FoxO1 and FoxO3 in skin. Biochim Biophys Acta Gen Subj. 2017;1861(5 Pt A):1057–1064. doi:10.1016/j.bbagen.2017.02.027
  • Lin F. Molecular regulation and function of FoxO3 in chronic kidney disease. Curr Opin Nephrol Hypertens. 2020;29(4):439–445. doi:10.1097/MNH.0000000000000616
  • Shen Z, Zhou H, Li A, et al. Metformin inhibits hepatocellular carcinoma development by inducing apoptosis and pyroptosis through regulating FOXO3. Aging. 2021;13(18):22120–22133. doi:10.18632/aging.203464
  • Hartwig J, Loebel M, Steiner S, et al. Metformin attenuates ROS via FOXO3 activation in immune cells. Front Immunol. 2021;12:581799. doi:10.3389/fimmu.2021.581799
  • Wu CY, Shieh JJ, Shen JL, Liu YY, Chang YT, Chen YJ. Association between antidiabetic drugs and psoriasis risk in diabetic patients: results from a nationwide nested case-control study in Taiwan. J Am Acad Dermatol. 2015;72(1):123–130. doi:10.1016/j.jaad.2014.08.042
  • Chang JE, Choi MS. A molecular perspective on the potential benefits of metformin for the treatment of inflammatory skin disorders. Int J Mol Sci. 2020;21(23):8960. doi:10.3390/ijms21238960
  • Gao Y, Zhang W, Zeng LQ, et al. Exercise and dietary intervention ameliorate high-fat diet-induced NAFLD and liver aging by inducing lipophagy. Redox Biol. 2020;36:101635. doi:10.1016/j.redox.2020.101635
  • Proenca CC, Stoehr N, Bernhard M, et al. Atg4b-dependent autophagic flux alleviates Huntington’s disease progression. PLoS One. 2013;8(7):e68357. doi:10.1371/journal.pone.0068357
  • Shenoy C, Shenoy MM, Rao GK. Dyslipidemia in dermatological disorders. N Am J Med Sci. 2015;7(10):421–428. doi:10.4103/1947-2714.168657
  • Armstrong AW, Read C. Pathophysiology, clinical presentation, and treatment of psoriasis: a review. JAMA. 2020;323(19):1945–1960. doi:10.1001/jama.2020.4006
  • Ba W, Xu Y, Yin G, et al. Metformin inhibits pro-inflammatory responses via targeting nuclear factor-kappaB in HaCaT cells. Cell Biochem Funct. 2019;37(1):4–10. doi:10.1002/cbf.3367
  • Setty AR, Curhan G, Choi HK. Obesity, waist circumference, weight change, and the risk of psoriasis in women: Nurses’ Health Study II. Arch Intern Med. 2007;167(15):1670–1675. doi:10.1001/archinte.167.15.1670
  • Moudgil S, Mahajan R, Narang T, Sachdeva N, Dayal D, Dogra S. Central obesity and dyslipidemia in pediatric patients with psoriasis: an observational study from India. J Am Acad Dermatol. 2021;85(6):1655–1657. doi:10.1016/j.jaad.2020.12.072
  • Gutmark-Little I, Shah KN. Obesity and the metabolic syndrome in pediatric psoriasis. Clin Dermatol. 2015;33(3):305–315. doi:10.1016/j.clindermatol.2014.12.006
  • Rodriguez-Cerdeira C, Cordeiro-Rodriguez M, Carnero-Gregorio M, et al. Biomarkers of inflammation in obesity-psoriatic patients. Mediators Inflamm. 2019;2019:7353420. doi:10.1155/2019/7353420
  • Carrascosa JM, Bonanad C, Dauden E, Botella R, Olveira-Martin A; en nombre del Grupo de Trabajo en Inflamacion Sistemica en P. Psoriasis and nonalcoholic fatty liver disease. Actas Dermosifiliogr. 2017;108(6):506–514. doi:10.1016/j.ad.2016.12.017
  • Checa J, Aran JM. Reactive oxygen species: drivers of physiological and pathological processes. J Inflamm Res. 2020;13:1057–1073. doi:10.2147/JIR.S275595
  • Plenkowska J, Gabig-Ciminska M, Mozolewski P. Oxidative stress as an important contributor to the pathogenesis of psoriasis. Int J Mol Sci. 2020;21(17):6206. doi:10.3390/ijms21176206
  • Kim HR, Lee A, Choi EJ, et al. Reactive oxygen species prevent imiquimod-induced psoriatic dermatitis through enhancing regulatory T cell function. PLoS One. 2014;9(3):e91146. doi:10.1371/journal.pone.0091146
  • Li B, Zhou P, Xu K, et al. Metformin induces cell cycle arrest, apoptosis and autophagy through ROS/JNK signaling pathway in human osteosarcoma. Int J Biol Sci. 2020;16(1):74–84. doi:10.7150/ijbs.33787
  • Yue L, Ailin W, Jinwei Z, et al. PSORI-CM02 ameliorates psoriasis in vivo and in vitro by inducing autophagy via inhibition of the PI3K/Akt/mTOR pathway. Phytomedicine. 2019;64:153054. doi:10.1016/j.phymed.2019.153054
  • Yin H, Wu H, Chen Y, et al. The therapeutic and pathogenic role of autophagy in autoimmune diseases. Front Immunol. 2018;9:1512. doi:10.3389/fimmu.2018.01512
  • Link W. Introduction to FOXO Biology. Methods Mol Biol. 2019;1890:1–9.
  • de Keizer PL, Burgering BM, Dansen TB. Forkhead box o as a sensor, mediator, and regulator of redox signaling. Antioxid Redox Signal. 2011;14(6):1093–1106. doi:10.1089/ars.2010.3403
  • Zhang M, Zhang X. The role of PI3K/AKT/FOXO signaling in psoriasis. Arch Dermatol Res. 2019;311(2):83–91. doi:10.1007/s00403-018-1879-8