Acne Comorbidities

References

• Younis S, Shamim S, Nisar K, et al. Association of TNF-alpha polymorphisms (−857, −863 and −1031), TNF-alpha serum level and lipid profile with acne vulgaris. Saudi J Biol Sci. 2021;28(11):6615–6620. doi:10.1016/j.sjbs.2021.07.042
   PubMed Web of Science ®Google Scholar
• Cerman AA, Aktas E, Altunay IK, et al. Dietary glycemic factors, insulin resistance, and adiponectin levels in acne vulgaris. J Am Acad Dermatol. 2016;75(1):155–162. doi:10.1016/j.jaad.2016.02.1220
   PubMed Web of Science ®Google Scholar
• Zhou J. Association between acne and abnormal glucose and lipid metabolism. Hunan Univ Tradit Chin Med. 2021;26:45.
   Google Scholar
• Elsaie ML, Aly DG. The immunogenetics of acne. Adv Exp Med Biol. 2022;1367:137–154.
   PubMedGoogle Scholar
• Chen X, Min S, Chen C, et al. Influence of RETN, IL-1, and IL-6 gene polymorphisms on the risk of acne vulgaris in the Chinese population. J Cosmet Dermatol. 2022. doi:10.1111/jocd.14911
   Web of Science ®Google Scholar
• Rathwa N, Patel R, Palit SP, et al. Genetic variants of resistin and its plasma levels: association with obesity and dyslipidemia related to type 2 diabetes susceptibility. Genomics. 2019;111(4):980–985. doi:10.1016/j.ygeno.2018.06.005
   PubMed Web of Science ®Google Scholar
• Li H. Association Interleukin-6 Gene Polymorphisms with Type 2 Diabetic Retinopathy in Dali Bai Population. Dali University; 2016.
   Google Scholar
• Harun-Or-Roshid M, Ali MB, Mollah M, et al. Statistical meta-analysis to investigate the association between the Interleukin-6 (IL-6) gene polymorphisms and cancer risk. PLoS One. 2021;16(3):e247055. doi:10.1371/journal.pone.0247055
   Web of Science ®Google Scholar
• Akpinar KY. Evaluation of serum insulin-like growth factor-1, insulin, glucose levels in patients with adolescent and post-adolescent acne. J Cosmet Dermatol. 2022;21(3):1292–1296. doi:10.1111/jocd.14327
   PubMed Web of Science ®Google Scholar
• Zhu Y, Peng Z, Lu C. To explore the mechanism of pomegranate peel polyphenol cream on acne sebum metabolism based on IGF-1. Hunan Univ Tradit Chin Med. 2020;15. doi:10.1186/s13020-020-00325-x
   Google Scholar
• Melnik BC. Acne vulgaris: the metabolic syndrome of the pilosebaceous follicle. Clin Dermatol. 2018;36(1):29–40. doi:10.1016/j.clindermatol.2017.09.006
   PubMed Web of Science ®Google Scholar
• Janssen J. Hyperinsulinemia and its pivotal role in aging, obesity, type 2 diabetes, cardiovascular disease and cancer. Int J Mol Sci. 2021;22(15):7797. doi:10.3390/ijms22157797
   PubMed Web of Science ®Google Scholar
• Clatici VG, Voicu C, Voaides C, et al. Diseases of civilization - cancer, diabetes, obesity and acne - the implication of milk, IGF-1 and mTORC1. Maedica. 2018;13(4):273–281. doi:10.26574/maedica.2018.13.4.273
   PubMedGoogle Scholar
• Shuhui W, Mingfang Z, Xi Z, et al. Effect of milk on sebaceous gland spots and IGF-1/SREBP-1/ACC-1 signaling pathway in golden hamsters. Chin J Dermatol. 2022;55(03):238–242.
   Google Scholar
• Melnik BC, John SM, Plewig G. Acne: risk indicator for increased body mass index and insulin resistance. Acta Derm Venereol. 2013;93(6):644–649. doi:10.2340/00015555-1677
   PubMed Web of Science ®Google Scholar
• Nickles MA, Sharma D, Tsoukas MM, et al. Acne and insulin resistance: a systematic review and meta-analysis. J Am Acad Dermatol. 2022;87(3):687–688. doi:10.1016/j.jaad.2021.12.033
   PubMed Web of Science ®Google Scholar
• Alan S, Cenesizoglu E. Effects of hyperandrogenism and high body mass index on acne severity in women. Saudi Med J. 2014;35(8):886–889.
   PubMed Web of Science ®Google Scholar
• Alshammrie FF, Alshammari R, Alharbi RM, et al. Epidemiology of acne vulgaris and its association with lifestyle among adolescents and young adults in Hail, Kingdom of Saudi Arabia: a Community-Based Study. Cureus. 2020;12(7):e9277. doi:10.7759/cureus.9277
   PubMed Web of Science ®Google Scholar
• Hirt PA, Castillo DE, Yosipovitch G, et al. Skin changes in the obese patient. J Am Acad Dermatol. 2019;81(5):1037–1057. doi:10.1016/j.jaad.2018.12.070
   PubMed Web of Science ®Google Scholar
• Cong TX, Hao D, Wen X, et al. From pathogenesis of acne vulgaris to anti-acne agents. Arch Dermatol Res. 2019;311(5):337–349. doi:10.1007/s00403-019-01908-x
   PubMed Web of Science ®Google Scholar
• Cheng Z, Xiong X, Wu F, et al. Network pharmacology research indicates that Wu-Mei-Wan treats obesity by inhibiting Th17 cell differentiation and alleviating metabolic inflammation. Comb Chem High Throughput Screen. 2022;25. doi:10.2174/1386207325666220221121919
   Google Scholar
• Zhang LJ, Guerrero-Juarez CF, Chen SX, et al. Diet-induced obesity promotes infection by impairment of the innate antimicrobial defense function of dermal adipocyte progenitors. Sci Transl Med. 2021;13(577):eabb5280. doi:10.1126/scitranslmed.abb5280
   PubMed Web of Science ®Google Scholar
• Chang D, Xing Q, Su Y, et al. The conserved non-coding sequences CNS6 and CNS9 control cytokine-induced rorc transcription during T helper 17 cell differentiation. Immunity. 2020;53(3):614–626. doi:10.1016/j.immuni.2020.07.012
   PubMed Web of Science ®Google Scholar
• Lu WEI, Zhang J-G, Ming-fang Z. Research progress of Th17 in the pathogenesis of acne. J Clin Dermatol. 2021;50(02):122–124.
   Google Scholar
• Guixian W, Wenming Z, Zhenjun S. Association of single nucleotide polymorphism of TNF-α gene G308A with obesity and metabolic disorder in children. Chin J Endocrinol Metab. 2021;37(10):924–929.
   Google Scholar
• Abulnaja KO. Changes in the hormone and lipid profile of obese adolescent Saudi females with acne vulgaris. Braz J Med Biol Res. 2009;42(6):501–505. doi:10.1590/S0100-879X2009000600005
   PubMed Web of Science ®Google Scholar
• Bakry OA, El SR, El FS, et al. Role of hormones and blood lipids in the pathogenesis of acne vulgaris in non-obese, non-hirsute females. Indian Dermatol Online J. 2014;5(Suppl 1):S9–S16. doi:10.4103/2229-5178.144506
   PubMedGoogle Scholar
• Shrestha S. Correlation of hormonal profile and lipid levels with female adult acne in a tertiary care center of Nepal. J Nepal Health Res Counc. 2018;16(2):222–227. doi:10.33314/jnhrc.v16i2.1178
   PubMedGoogle Scholar
• Da CM, Batista AL, Macedo MS, et al. Study of lipid profile in adult women with acne. Clin Cosmet Investig Dermatol. 2015;8:449–454. doi:10.2147/CCID.S83248
   PubMedGoogle Scholar
• Sobhan M, Seif RM, Amerifar M. Correlation between lipid profile and acne vulgaris. Clin Cosmet Investig Dermatol. 2020;13:67–71. doi:10.2147/CCID.S230617
   PubMed Web of Science ®Google Scholar
• Mastrototaro L, Roden M. Insulin resistance and insulin sensitizing agents. Metabolism. 2021;125:154892. doi:10.1016/j.metabol.2021.154892
   PubMed Web of Science ®Google Scholar
• Aktas KE, Saltik ZA, Unay DO. Evaluation of serum FoxO1, mTORC1, IGF-1, IGFBP-3 levels, and metabolic syndrome components in patients with acne vulgaris: a prospective case-control study. Dermatol Ther. 2020;33(6):e13887. doi:10.1111/dth.13887
   PubMed Web of Science ®Google Scholar
• Unluhizarci K, Karaca Z, Kelestimur F. Role of insulin and insulin resistance in androgen excess disorders. World J Diabetes. 2021;12(5):616–629. doi:10.4239/wjd.v12.i5.616
   PubMed Web of Science ®Google Scholar
• Zinati-Saeed S, Shakiba E, Rahimi Z, et al. The insulin-like growth factor-1 (G>A) and 5,10-methylenetetrahydrofolate reductase (C677T) gene variants and the serum levels of insulin-like growth factor-1, insulin, and homeostasis model assessment in patients with acne vulgaris. Iran J Pathol. 2020;15(1):23–29. doi:10.30699/ijp.2019.105695.2098
   PubMedGoogle Scholar
• Yiqiu W, Man L, Jia Y. Research progress in the relationship between chronic inflammation and insulin resistance. J Clin Pathol Res. 2019;39(03):640–645.
   Google Scholar
• Jieya Y, Wenzhong X, Xiuzu S. Metabolic syndrome and skin diseases. Chin J Dermatol. 2021;54(07):642–645.
   Google Scholar
• Colafella K, Denton KM. Sex-specific differences in hypertension and associated cardiovascular disease. Nat Rev Nephrol. 2018;14(3):185–201. doi:10.1038/nrneph.2017.189
   PubMed Web of Science ®Google Scholar
• Ziemens B, Wallaschofski H, Volzke H, et al. Positive association between testosterone, blood pressure, and hypertension in women: longitudinal findings from the Study of Health in Pomerania. J Hypertens. 2013;31(6):1106–1113. doi:10.1097/HJH.0b013e3283603eb1
   PubMed Web of Science ®Google Scholar
• Matsuda K, Ruff A, Morinelli TA, et al. Testosterone increases thromboxane A2 receptor density and responsiveness in rat aortas and platelets. Am J Physiol. 1994;267(3 Pt 2):H887–H893. doi:10.1152/ajpheart.1994.267.3.H887
   PubMed Web of Science ®Google Scholar
• McCrohon JA, Jessup W, Handelsman DJ, et al. Androgen exposure increases human monocyte adhesion to vascular endothelium and endothelial cell expression of vascular cell adhesion molecule-1. Circulation. 1999;99(17):2317–2322. doi:10.1161/01.CIR.99.17.2317
   PubMed Web of Science ®Google Scholar
• Nagpal M, De D, Handa S, et al. Insulin resistance and metabolic syndrome in young men with acne. JAMA Dermatol. 2016;152(4):399–404. doi:10.1001/jamadermatol.2015.4499
   PubMed Web of Science ®Google Scholar
• Serrano NC, Guio E, Becerra-Bayona SM, et al. C-reactive protein, interleukin-6 and pre-eclampsia: large-scale evidence from the GenPE case-control study. Scand J Clin Lab Invest. 2020;80(5):381–387. doi:10.1080/00365513.2020.1747110
   PubMed Web of Science ®Google Scholar
• Morawiec E, Cholewa K, Zenderowski M, et al. The expression profile of genes encoding tumor necrosis factor-alpha, interleukin-6 and their receptor in benign adrenal tumors. J Physiol Pharmacol. 2020;71(4). doi:10.26402/jpp.2020.4.11
   PubMed Web of Science ®Google Scholar
• Gao H, Bigalke J, Jiang E, et al. TNFalpha triggers an augmented inflammatory response in brain neurons from dahl salt-sensitive rats compared with normal sprague dawley rats. Cell Mol Neurobiol. 2022;42(6):1787–1800. doi:10.1007/s10571-021-01056-9
   PubMed Web of Science ®Google Scholar
• Shaohong S, Lin Z, Junfeng Z. Total glucosides of paeony has effect on TNF-α/P38MAPK/NF-κB/RBP4 signaling pathways in rats with atherosclerosis and its regulating effect on IL-17, IL-27 and IL-33 in serum. New Chin Med. 2019;51(07):18–21.
   Google Scholar
• Na L, Yan Z, Ying J. Correlation between NF – κB /RBP4 signaling pathway and changes of inflammatory factors in patients with hypertension. J Clin Exp Med. 2021;20(24):2592–2595.
   Google Scholar
• Du-fang M, Lu C, Ping J, et al. Activation of α7 nAChR attenuates diet-induced obesity-associated hypertension in rats by suppressing chronic inflammation. Chin J Pathophysiol. 2021;37(12):2131–2138.
   Google Scholar
• McCullough D, Webb R, Enright KJ, et al. How the love of muscle can break a heart: impact of anabolic androgenic steroids on skeletal muscle hypertrophy, metabolic and cardiovascular health. Rev Endocr Metab Disord. 2021;22(2):389–405. doi:10.1007/s11154-020-09616-y
   PubMed Web of Science ®Google Scholar
• Reynoso-Villalpando GL, Sevillano-Collantes C, Valle Y, et al. ApoB/ApoA1 ratio and non-HDL-cholesterol/HDL-cholesterol ratio are associated to metabolic syndrome in patients with type 2 diabetes mellitus subjects and to ischemic cardiomyopathy in diabetic women. Endocrinol Diabetes Nutr. 2019;66(8):502–511. doi:10.1016/j.endinu.2019.03.019
   Web of Science ®Google Scholar
• Bodde MC, Hermans M, Jukema JW, et al. Apolipoproteins A1, B, and apoB/apoA1 ratio are associated with first ST-segment elevation myocardial infarction but not with recurrent events during long-term follow-up. Clin Res Cardiol. 2019;108(5):520–538.
   PubMed Web of Science ®Google Scholar
• Qian-qian Y, Yi-juan C, Xiao-nan Y, et al. Effect of obesity and high free androgen index on the increase of apolipoprotein B/A1 ratio in PCOS patients of different ages. J Reprod Med. 2021;30(09):1212–1216.
   Google Scholar
• Liao YH, Xia N, Zhou SF, et al. Interleukin-17A contributes to myocardial ischemia/reperfusion injury by regulating cardiomyocyte apoptosis and neutrophil infiltration. J Am Coll Cardiol. 2012;59(4):420–429. doi:10.1016/j.jacc.2011.10.863
   PubMed Web of Science ®Google Scholar
• Xing Y, Deng W, Tang Q. Role of toll-like receptor in cardiovascular diseases. Adv Cardiovascu Dis. 2021;42(08):711–715.
   Google Scholar
• Ding G, Cheng L, Qin Q, et al. PPARdelta modulates lipopolysaccharide-induced TNFalpha inflammation signaling in cultured cardiomyocytes. J Mol Cell Cardiol. 2006;40(6):821–828. doi:10.1016/j.yjmcc.2006.03.422
   PubMed Web of Science ®Google Scholar
• Han M. Role of Targeted Inhibition of NF-Κbsignaling Pathway in Myocardial Ischemia-Reperfusion Injury in Aged Mice. Xinjiang Medical University; 2020.
   Google Scholar
• Biagi LG, Sanudo A, Bagatin E. Severe acne and metabolic syndrome: a possible correlation. Dermatology. 2019;235(6):456–462. doi:10.1159/000501986
   PubMed Web of Science ®Google Scholar
• Yu-xi A, Lin C. Acne vulgaris and metabolic syndrome. J Pract Dermatol. 2020;13(06):359–362.
   Google Scholar
• Inoue T, Miki Y, Kakuo S, et al. Expression of steroidogenic enzymes in human sebaceous glands. J Endocrinol. 2014;222(3):301–312. doi:10.1530/JOE-14-0323
   PubMed Web of Science ®Google Scholar
• Monfrecola G, Lembo S, Caiazzo G, et al. Mechanistic target of rapamycin (mTOR) expression is increased in acne patients’ skin. Exp Dermatol. 2016;25(2):153–155. doi:10.1111/exd.12885
   PubMed Web of Science ®Google Scholar
• Melnik BC. Acne vulgaris: an inflammasomopathy of the sebaceous follicle induced by deviated FoxO1/mTORC1 signalling. Br J Dermatol. 2016;174(6):1186–1188. doi:10.1111/bjd.14564
   PubMed Web of Science ®Google Scholar
• Howell JJ, Hellberg K, Turner M, et al. Metformin inhibits hepatic mTORC1 signaling via dose-dependent mechanisms involving AMPK and the TSC complex. Cell Metab. 2017;25(2):463–471. doi:10.1016/j.cmet.2016.12.009
   PubMed Web of Science ®Google Scholar
• Robinson S, Kwan Z, Tang MM. Metformin as an adjunct therapy for the treatment of moderate to severe acne vulgaris: a randomized open-labeled study. Dermatol Ther. 2019;32(4):e12953. doi:10.1111/dth.12953
   PubMed Web of Science ®Google Scholar
• Silverberg JI, Silverberg NB. Epidemiology and extracutaneous comorbidities of severe acne in adolescence: a U.S. population-based study. Br J Dermatol. 2014;170(5):1136–1142. doi:10.1111/bjd.12912
   PubMed Web of Science ®Google Scholar
• Misery L, Wolkenstein P, Amici JM, et al. Consequences of acne on stress, fatigue, sleep disorders and sexual activity: a population-based study. Acta Derm Venereol. 2015;95(4):485–488. doi:10.2340/00015555-1998
   PubMed Web of Science ®Google Scholar
• Bar-Tana J. Type 2 diabetes - unmet need, unresolved pathogenesis, mTORC1-centric paradigm. Rev Endocr Metab Disord. 2020;21(4):613–629. doi:10.1007/s11154-020-09545-w
   PubMed Web of Science ®Google Scholar
• Akhaphong B, Baumann DC, Beetch M, et al. Placental mTOR complex 1 regulates fetal programming of obesity and insulin resistance in mice. JCI Insight. 2021;6(13):e149271. doi:10.1172/jci.insight.149271
   PubMed Web of Science ®Google Scholar
• Melnik BC. Lifetime impact of cow’s milk on overactivation of mTORC1: from fetal to childhood overgrowth, acne, diabetes, cancers, and neurodegeneration. Biomolecules. 2021;11(3):404. doi:10.3390/biom11030404
   PubMed Web of Science ®Google Scholar
• Do TH, Ma F, Andrade PR, et al. TREM2 macrophages induced by human lipids drive inflammation in acne lesions. Sci Immunol. 2022;7(73):o2787. doi:10.1126/sciimmunol.abo2787
   Web of Science ®Google Scholar