Unveiling a Shared Precursor Condition for Acne Keloidalis Nuchae and Primary Cicatricial Alopecias

References

• Dinehart SM, Herzberg AJ, Kerns BJ, Pollack SV. Acne keloidalis: a review. J Dermatol Surg Oncol. 1989;15(6):642–647. doi:10.1111/j.1524-4725.1989.tb03603.x
   PubMedGoogle Scholar
• Herzberg AJ, Dinehart SM, Kerns BJ, Pollack SV. Acne keloidalis. Transverse microscopy, immunohistochemistry, and electron microscopy. Am J Dermatopathol. 1990;12(2):109–121. doi:10.1097/00000372-199004000-00001
   PubMed Web of Science ®Google Scholar
• Ogunbiyi A. Acne keloidalis nuchae: prevalence, impact, and management challenges. Clin Cosmet Investig Dermatol. 2016;9:483–489. doi:10.2147/CCID.S99225
   PubMed Web of Science ®Google Scholar
• Umar S, Lee DJ, Lullo JJ. A retrospective cohort study and clinical classification system of acne keloidalis nuchae. J Clin Aesthet Dermatol. 2021;14(4):E61–E67.
   PubMedGoogle Scholar
• Dinehart SM, Tanner L, Mallory SB, Herzberg AJ. Acne keloidalis in women. Cutis. 1989;44(3):250–252.
   PubMed Web of Science ®Google Scholar
• Sperling LC, Homoky C, Pratt L, Sau P. Acne keloidalis is a form of primary scarring alopecia. Arch Dermatol. 2000;136(4):479. doi:10.1001/archderm.136.4.479
   PubMedGoogle Scholar
• Cosman B, Wolff M. Acne keloidalis. Plast Reconstr Surg. 1972;50(1):25–30. doi:10.1097/00006534-197207000-00004
   PubMed Web of Science ®Google Scholar
• Halder RM. Pseudofolliculitis barbae and related disorders. Dermatol Clin. 1988;6(3):407–412. doi:10.1016/S0733-8635(18)30652-1
   PubMed Web of Science ®Google Scholar
• Mikiel D, Polańska A, Żaba R, Adamski Z, Dańczak-Pazdrowska A. Usefulness of high-frequency ultrasonography in the assessment of alopecia areata - comparison of ultrasound images with trichoscopic images. Postepy Dermatol Alergol. 2022;39:132–140. doi:10.5114/ada.2020.102641
   PubMed Web of Science ®Google Scholar
• Sahu VK, Datta A, Sarkar T, Gayen T, Chatterjee G. Role of trichoscopy in evaluation of alopecia areata: a study in a tertiary care referral centre in the Eastern India. Indian J Dermatol. 2022;67(2):127–132. doi:10.4103/ijd.ijd_577_21
   PubMed Web of Science ®Google Scholar
• Karnik P, Tekeste Z, McCormick TS, et al. Hair follicle stem cell-specific PPARgamma deletion causes scarring alopecia. J Invest Dermatol. 2009;129(5):1243–1257. doi:10.1038/jid.2008.369
   PubMed Web of Science ®Google Scholar
• Olsen EA, Bergfeld WF, Cotsarelis G, et al; Workshop on cicatricial alopecia. Summary of North American Hair Research Society (NAHRS)-sponsored workshop on cicatricial alopecia, Duke University Medical Center, 2001. J Am Acad Dermatol. 2003;48(1):103–110. doi:10.1067/mjd.2003.68
   PubMedGoogle Scholar
• East-Innis ADC, Stylianou K, Paolino A, Ho JD. Acne keloidalis nuchae: risk factors and associated disorders - a retrospective study. Int J Dermatol. 2017;56:828–832. doi:10.1111/ijd.13678
   PubMed Web of Science ®Google Scholar
• Doche I, Coelho EQ, Quaresma MV, da Matta Rivitti-Machado MC. Acne keloidalis nuchae and folliculitis decalvans: same process affecting the follicle or coexisting diseases? A retrospective study. Int J Dermatol. 2019;58(10):e200–e203. doi:10.1111/ijd.14565
   PubMed Web of Science ®Google Scholar
• Doche I, Hordinsky MK, Valente NS, et al. Evidence for lymphocytic inflammation in non-lesional scalp of folliculitis decalvans: an observational study of 25 patients. J Eur Acad Dermatol Venereol. 2022;36(2):e109–e111. doi:10.1111/jdv.17649
   PubMed Web of Science ®Google Scholar
• Yip L, Barrett TH, Harries MJ. Folliculitis decalvans and lichen planopilaris phenotypic spectrum: a case series of biphasic clinical presentation and theories on pathogenesis. Clin Exp Dermatol. 2020;45(1):63–72. doi:10.1111/ced.13989
   PubMed Web of Science ®Google Scholar
• Egger A, Stojadinovic O, Miteva M. Folliculitis decalvans and lichen planopilaris phenotypic spectrum-a series of 7 new cases with focus on histopathology. Am J Dermatopathol. 2020;42(3):173–177. doi:10.1097/DAD.0000000000001595
   PubMed Web of Science ®Google Scholar
• Powell JJ, Dawber RP, Gatter K. Folliculitis decalvans including tufted folliculitis: clinical, histological and therapeutic findings. Br J Dermatol. 1999;140:328–333. doi:10.1046/j.1365-2133.1999.02675.x
   PubMed Web of Science ®Google Scholar
• Ceruti JM, Leirós GJ, Balañá ME. Androgens and androgen receptor action in skin and hair follicles. Mol Cell Endocrinol. 2018;465:122–133.
   PubMed Web of Science ®Google Scholar
• Pindado-Ortega C, Saceda-Corralo D, Moreno-Arrones ÓM, et al. Effectiveness of dutasteride in a large series of patients with frontal fibrosing alopecia in real clinical practice. J Am Acad Dermatol. 2021;84:1285–1294. doi:10.1016/j.jaad.2020.09.093
   PubMed Web of Science ®Google Scholar
• Vañó-Galván S, Saceda-Corralo D, Alonso-Castro L, Urech M, Espada J. Antiandrogenic drugs, a therapeutic option for frontal fibrosing alopecia patients. J Am Acad Dermatol. 2016;74(4):e77. Erratum in: J Am Acad Dermatol 2018;78:431. doi:10.1016/j.jaad.2015.11.047
   PubMed Web of Science ®Google Scholar
• Chew AL, Bashir SJ, Wain EM, Fenton DA, Stefanato CM. Expanding the spectrum of frontal fibrosing alopecia: a unifying concept. J Am Acad Dermatol. 2010;63(4):653–660. doi:10.1016/j.jaad.2009.09.020
   PubMed Web of Science ®Google Scholar
• Senatore S, Maglie R, Maio V, Montefusco F, Antiga E. Folliculitis decalvans with exclusive beard involvement. Indian J Dermatol Venereol Leprol. 2021;87:569–571. doi:10.25259/IJDVL_694_20
   PubMed Web of Science ®Google Scholar
• Turegano MM, Sperling LC. Lichenoid folliculitis: a unifying concept. J Cutan Pathol. 2017;44(7):647–654. doi:10.1111/cup.12938
   PubMed Web of Science ®Google Scholar
• Doche I, Romiti R, Hordinsky MK, Valente NS. ”Normal-appearing” scalp areas are also affected in lichen planopilaris and frontal fibrosing alopecia: an observational histopathologic study of 40 patients. Exp Dermatol. 2020;29:278–281. doi:10.1111/exd.13834
   PubMed Web of Science ®Google Scholar
• Porriño-Bustamante ML, Pinedo-Moraleda FJ, Fernández-Flores Á, Montero-Vílchez T, Fernández-Pugnaire MA, Arias-Santiago S. Frontal fibrosing alopecia: a histopathological comparison of the frontal hairline with normal-appearing scalp. J Clin Med. 2022;11(14):4121. doi:10.3390/jcm11144121
   PubMed Web of Science ®Google Scholar
• Felix K, De Souza B, Portilla N, et al. Dermatoscopic evaluation of central centrifugal cicatricial alopecia beyond the vertex scalp. JAMA Dermatol. 2020;156(8):916–918. doi:10.1001/jamadermatol.2020.1287
   PubMed Web of Science ®Google Scholar
• Mirmirani P, Willey A, Headington JT, Stenn K, McCalmont TH, Price VH. Primary cicatricial alopecia: histopathologic findings do not distinguish clinical variants. J Am Acad Dermatol. 2005;52(4):637–643. doi:10.1016/j.jaad.2004.07.069
   PubMed Web of Science ®Google Scholar
• Wang EHC, Monga I, Sallee BN, et al. Primary cicatricial alopecias are characterized by dysregulation of shared gene expression pathways. PNAS Nexus. 2022;1(3):c111. doi:10.1093/pnasnexus/pgac111
   Google Scholar
• Saceda-Corralo D, Desai K, Pindado-Ortega C, Moreno-Arrones OM, Vañó-Galván S, Miteva M. Histological evidence for epidermal and dermal atrophy of the alopecic band in treatment-naïve patients with frontal fibrosing alopecia. J Eur Acad Dermatol Venereol. 2021;35:e47–e49. doi:10.1111/jdv.16792
   PubMed Web of Science ®Google Scholar
• Pindado‐Ortega C, Perna C, Saceda‐Corralo D, Fernández‐Nieto D, Jaén‐Olasolo P, Vañó‐Galván S. Frontal fibrosing alopecia: histopathological, immunohistochemical and hormonal study of clinically unaffected scalp areas. J Eur Acad Dermatol Venereol. 2020;34(2):e84–e85. doi:10.1111/jdv.15977
   PubMed Web of Science ®Google Scholar
• Sperling LLC, Skelton CHG, Smith CKJ, Sau CP, Friedman K. Follicular degeneration syndrome in men. Arch Dermatol. 1994;130:763–769. doi:10.1001/archderm.1994.01690060093012
   PubMedGoogle Scholar
• Jordan CS, Chapman C, Kolivras A, Roberts JL, Thompson NB, Thompson CT. Clinicopathologic and immunophenotypic characterization of lichen planopilaris and central centrifugal cicatricial alopecia: a comparative study of 51 cases. J Cutan Pathol. 2020;47(2):128–134. doi:10.1111/cup.13592
   PubMed Web of Science ®Google Scholar
• Conti P, Caraffa A, Mastrangelo F, et al. Critical role of inflammatory mast cell in fibrosis: potential therapeutic effect of IL −37. Cell Prolif. 2018;51(5):e12475. doi:10.1111/cpr.12475
   PubMed Web of Science ®Google Scholar
• Strattan E, Palaniyandi S, Kumari R, et al. Mast cells are mediators of fibrosis and effector cell recruitment in dermal chronic graft-vs.-host disease. Front Immunol. 2019;10:2470. doi:10.3389/fimmu.2019.02470
   PubMed Web of Science ®Google Scholar
• Dlova NC, Jordaan FH, Sarig O, Sprecher E. Autosomal dominant inheritance of central centrifugal cicatricial alopecia in black South Africans. J Am Acad Dermatol. 2014;70(4):679–82.e1. doi:10.1016/j.jaad.2013.11.035
   PubMed Web of Science ®Google Scholar
• Ranasinghe GC, Piliang MP, Bergfeld WF. Prevalence of hormonal and endocrine dysfunction in patients with lichen planopilaris (LPP): a retrospective data analysis of 168 patients. J Am Acad Dermatol. 2017;76(2):314–320. doi:10.1016/j.jaad.2016.05.038
   PubMed Web of Science ®Google Scholar
• Jerjen R, Pinczewski J, Sinclair R, Bhoyrul B. Clinicopathological characteristics and treatment outcomes of fibrosing alopecia in a pattern distribution: a retrospective cohort study. J Eur Acad Dermatol Venereol. 2021;35(12):2440–2447. doi:10.1111/jdv.17604
   PubMed Web of Science ®Google Scholar
• Lobato-Berezo A, March-Rodríguez A, Deza G, Bertolín-Colilla M, Pujol RM. Frontal fibrosing alopecia after antiandrogen hormonal therapy in a male patient. J Eur Acad Dermatol Venereol. 2018;32(7):e291–e292. doi:10.1111/jdv.14825
   PubMed Web of Science ®Google Scholar
• Panchaprateep R, Ruxrungtham P, Chancheewa B, Asawanonda P. Clinical characteristics, trichoscopy, histopathology and treatment outcomes of frontal fibrosing alopecia in an Asian population: a retro-prospective cohort study. J Dermatol. 2020;47(11):1301–1311. doi:10.1111/1346-8138.15517
   PubMed Web of Science ®Google Scholar
• Peters EM, Liotiri S, Bodo E, et al. Probing the effects of stress mediators on the human hair follicle: substance P holds central position. Am J Pathol. 2007;171(6):1872–1886. doi:10.2353/ajpath.2007.061206
   PubMed Web of Science ®Google Scholar
• George AO, Akanji AO, Nduka EU, Olasode JB, Odusan O. Clinical, biochemical and morphologic features of acne keloidalis in a black population. Int J Dermatol. 1993;32(10):714–716. doi:10.1111/j.1365-4362.1993.tb02739.x
   PubMed Web of Science ®Google Scholar
• Azurdia RM, Graham RM, Weismann K, Guerin DM, Parslew R. Acne keloidalis in Caucasian patients on cyclosporin following organ transplantation. Br J Dermatol. 2000;143(2):465–466. doi:10.1046/j.1365-2133.2000.03694.x
   PubMed Web of Science ®Google Scholar
• Carnero L, Silvestre JF, Guijarro J, Albares MP, Botella R. Nuchal acne keloidalis associated with cyclosporin. Br J Dermatol. 2001;144(2):4290430. doi:10.1046/j.1365-2133.2001.04049.x
   Web of Science ®Google Scholar
• Grunwald MH, Ben‐Dor D, Livni E, Halevy S. Acne keloidalis‐like lesions on the scalp associated with antiepileptic drugs. Int J Dermatol. 1990;29(8):559–561. doi:10.1111/j.1365-4362.1990.tb03468.x
   PubMed Web of Science ®Google Scholar
• Alahmari L, Almesned R, Alhumidi A, Alkhalifah A. Lichen planopilaris with Koebner phenomenon. JAAD Case Rep. 2018;4(8):848–850. doi:10.1016/j.jdcr.2018.05.009
   PubMedGoogle Scholar
• Yadav S, Kumar R, Sharma A, Saikia UN, Dogra S. Isomorphic phenomenon in discoid lupus erythematosus with review of reported cases. Rheumatol Int. 2013;33(6):1651–1652. doi:10.1007/s00296-011-2289-9
   PubMed Web of Science ®Google Scholar
• Constantinou A, Polak-Witka K, Tomazou M, et al. Dysbiosis and enhanced beta-defensin production in hair follicles of patients with lichen planopilaris and frontal fibrosing alopecia. Biomedicines. 2021;9(3):266. doi:10.3390/biomedicines9030266
   PubMed Web of Science ®Google Scholar
• Yang CC, Khanna T, Sallee B, Christiano AM, Bordone LA. Tofacitinib for the treatment of lichen planopilaris: a case series. Dermatol Ther. 2018;31(6):e12656. doi:10.1111/dth.12656
   PubMed Web of Science ®Google Scholar
• Imanishi H, Ansell DM, Chéret J, et al. Epithelial-to-mesenchymal stem cell transition in a human organ: lessons from lichen planopilaris. J Invest Dermatol. 2018;138(3):511–519. doi:10.1016/j.jid.2017.09.047
   PubMed Web of Science ®Google Scholar
• Kennedy Crispin M, Ko JM, Craiglow BG, et al. Safety and efficacy of the JAK inhibitor tofacitinib citrate in patients with alopecia areata. JCI Insight. 2016;1(15):e89776. doi:10.1172/jci.insight.89776
   PubMed Web of Science ®Google Scholar
• Harries MJ, Meyer K, Chaudhry I, et al. Lichen planopilaris is characterized by immune privilege collapse of the hair follicle’s epithelial stem cell niche. J Pathol. 2013;231(2):236–247. doi:10.1002/path.4233
   PubMed Web of Science ®Google Scholar
• Liu LY, Craiglow BG, Dai F, King BA. Tofacitinib for the treatment of severe alopecia areata and variants: a study of 90 patients. J Am Acad Dermatol. 2017;76(1):22–28. doi:10.1016/j.jaad.2016.09.007
   PubMed Web of Science ®Google Scholar
• Mackay-Wiggan J, Jabbari A, Nguyen N, et al. Oral ruxolitinib induces hair regrowth in patients with moderate-to-severe alopecia areata. JCI Insight. 2016;1(15):e89790. doi:10.1172/jci.insight.89790
   PubMed Web of Science ®Google Scholar
• Alves de Medeiros AK, Speeckaert R, Desmet E, Van Gele M, De Schepper S, Lambert J. JAK3 as an emerging target for topical treatment of inflammatory skin diseases. PLoS One. 2016;11(10):e0164080. doi:10.1371/journal.pone.0164080
   PubMed Web of Science ®Google Scholar
• Vanden Bossche H, Willemsens G, Janssen PA. Cytochrome-P-450-dependent metabolism of retinoic acid in rat skin microsomes: inhibition by ketoconazole. Skin Pharmacol. 1988;1(3):176–185. doi:10.1159/000210771
   PubMedGoogle Scholar
• Van Wauwe JP, Coene MC, Goossens J, Van Nijen G, Cools W, Lauwers W. Ketoconazole inhibits the in vitro and in vivo metabolism of all-trans-retinoic acid. J Pharmacol Exp Ther. 1988;245:718–722.
   PubMed Web of Science ®Google Scholar
• Mirmirani P, Karnik P. Lichen planopilaris treated with a peroxisome proliferator-activated receptor gamma agonist. Arch Dermatol. 2009;145:1363–1366. doi:10.1001/archdermatol.2009.283
   PubMed Web of Science ®Google Scholar
• Araoye EF, Thomas JAL, Aguh CU. Hair regrowth in 2 patients with recalcitrant central centrifugal cicatricial alopecia after use of topical metformin. JAAD Case Rep. 2020;6(2):106–108. doi:10.1016/j.jdcr.2019.12.008
   PubMedGoogle Scholar
• Umar S, Kan P, Carter MJ, Shitabata P. Treatment-refractory central centrifugal cicatricial alopecia responsive to a novel botanical treatment. Clin Cosmet Investig Dermatol. 2022;15:609–619. doi:10.2147/CCID.S358618
   PubMed Web of Science ®Google Scholar
• Umar S, Kan P, Carter MJ, Shitabata P, Novosilska M. Lichen planopilaris responsive to a novel phytoactive botanical treatment: a case series. Dermatol Ther. 2022;12(7):1697–1710. doi:10.1007/s13555-022-00749-3
   Web of Science ®Google Scholar
• Rambhia PH, Conic RRZ, Murad A, Atanaskova-Mesinkovska N, Piliang M, Bergfeld W. Updates in therapeutics for folliculitis decalvans: a systematic review with evidence-based analysis. J Am Acad Dermatol. 2019;80(3):794–801.e1. doi:10.1016/j.jaad.2018.07.050
   PubMed Web of Science ®Google Scholar
• Nirmal B, Somiah S, Sacchidanand SA, Biligi DS, Palo S. Evaluation of perifollicular inflammation of donor area during hair transplantation in androgenetic alopecia and its comparison with controls. Int J Trichology. 2013;5(2):73–76. doi:10.4103/0974-7753.122963
   PubMedGoogle Scholar
• Sueki H, Stoudemayer T, Kligman AM, Murphy GF. Quantitative and ultrastructural analysis of inflammatory infiltrates in male pattern alopecia. Acta Derm Venereol. 1999;79(5):347–350. doi:10.1080/000155599750010238
   PubMed Web of Science ®Google Scholar