1,935
Views
67
CrossRef citations to date
0
Altmetric
Review

Dermal fillers in aesthetics: an overview of adverse events and treatment approaches

&
Pages 295-316 | Published online: 12 Dec 2013

References

  • American Society for Aesthetic Plastic SurgeryCosmetic surgery national data bank statistics 2012 Available from: http://www.surgery.org/sites/default/fles/ASAPS-2011-Stats.pdfAccessed September 13, 2013
  • RzanyBHiltonSPragerWExpert guideline on the use of porcine collagen in aesthetic medicineJ Dtsch Dermatol Ges20108321021720030742
  • GoldbergDJLegal ramifications of off-label filler useDermatol Ther200619318919316784518
  • GlogauRGKaneMAEffect of injection techniques on the rate of local adverse events in patients implanted with nonanimal hyaluronic acid gel dermal fillersDermatol Surg200834Suppl 1S105S10918547173
  • ZielkeHWölberLWiestLRzanyBRisk profiles of different injectable fillers: results from the Injectable Filler Safety Study (IFS Study)Dermatol Surg200834332633518177399
  • NarinsRSBrandtFSLorencZPMaasCSMonheitGDSmithSRTwelve-month persistency of a novel ribose-cross-linked collagen dermal fillerDermatol Surg200834Suppl 1S31S3918547179
  • BassLSSmithSBussoMMcClarenMCalcium hydroxylapatite (Radiesse) for treatment of nasolabial folds: long-term safety and efficacy resultsAesthet Surg J201030223523820442101
  • FitzgeraldRVleggaarDFacial volume restoration of the aging face with poly-l-lactic acidDermatol Ther201124122721276155
  • HilinskiJMCohenSRSoft tissue augmentation with ArteFillFacial Plast Surg200925211411919415579
  • PalluaNWolterTPA 5-year assessment of safety and aesthetic results after facial soft-tissue augmentation with polyacrylamide hydrogel (Aquamid): a prospective multicenter study of 251 patientsPlast Reconstr Surg201012561797180420517105
  • GladstoneHBCohenJLAdverse effects when injecting facial fillersSemin Cutan Med Surg2007261343917349561
  • ShahNSLazarusMCBugdodelRThe effects of topical vitamin K on bruising after laser treatmentJ Am Acad Dermatol200247224124412140470
  • BaileySHCohenJLKenkelJMEtiology, prevention, and treatment of dermal filler complicationsAesthet Surg J201131111012121239678
  • ZeichnerJACohenJLUse of blunt tipped cannulas for soft tissue fillersJ Drugs Dermatol2012111707222206080
  • Van DykeSHaysGPCagliaAECagliaMSevere Acute Local Reactions to a Hyaluronic Acid-derived Dermal FillerJ Clin Aesthet Dermatol201035323520725567
  • GeislerDShumerSElsonMLDelayed hypersensitivity reaction to Restylane®Cosmetic Dermatol20072012784786
  • ArronSTNeuhausIMPersistent delayed-type hypersensitivity reaction to injectable non-animal-stabilized hyaluronic acidJ Cosmet Dermatol20076316717117760694
  • CassutoDMarangoniODe SantisGChristensenLAdvanced laser techniques for filler-induced complicationsDermatol Surg200935Suppl 21689169519807765
  • FuntDKAvoiding malar edema during midface/cheek augmentation with dermal fillersJ Clin Aesthet Dermatol2011412323622191006
  • GriepentrogGJLucarelliMJBurkatCNLemkeBNRoseJGPeriorbital edema following hyaluronic acid gel injection: a retrospective reviewAm J Cosmetic Surg2011284251254
  • PessaJEGarzaJRThe malar septum: the anatomic basis of malar mounds and malar edemaAesthet Surg J1997171111719327681
  • CohenJLBhatiaACThe role of topical vitamin K oxide gel in the resolution of postprocedural purpuraJ Drugs Dermatol20098111020102419894369
  • TaylorSCBurgessCMCallenderVDSafety of nonanimal stabilized hyaluronic acid dermal fillers in patients with skin of color: a randomized, evaluator-blinded comparative trialDermatol Surg200935Suppl 21653166019807760
  • HeathCRTaylorSCFillers in the skin of color populationJ Drugs Dermatol201110549449821533295
  • PavicicTEfficacy and tolerability of a new monophasic, double-crosslinked hyaluronic acid filler for correction of deep lines and wrinklesJ Drugs Dermatol201110213413921283917
  • HirschRJNarurkarVCarruthersJManagement of injected hyaluronic acid induced Tyndall effectsLasers Surg Med200638320220416485276
  • Douse-DeanTJacobCIFast and easy treatment for reduction of the Tyndall effect secondary to cosmetic use of hyaluronic acidJ Drugs Dermatol20087328128318380210
  • RoussoJJPitmanMJEnterococcus faecalis complicating dermal filler injection: a case of virulent facial abscessesDermatol Surg201036101638164121053422
  • SclafaniAPFagienSTreatment of injectable soft tissue filler complicationsDermatol Surg200935Suppl 21672168019807763
  • VoigtsRDevoreDPGrazerJMDispersion of calcium hydroxylapatite accumulations in the skin: animal studies and clinical practicesDermatol Surg201036Suppl s1798803
  • VrcekIMMaloufPGillilandGDA novel solution for superficially placed calcium hydroxylapatite (Radiesse) in the inferior eyelidOrbit201231643143222731869
  • ReddyKKBrauerJAAnolikRCalcium hydroxylapatite nodule resolution after fractional carbon dioxide laser therapyArch Dermatol2012148563463622351789
  • HeinzBCLadhoffUKahlChRzanyBvon MallekDSurvey of incidents associated with injectable dermal fillers reported to the German Medical Devices Vigilance SystemBundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz2008517787792 German18560778
  • ChristensenLHHost tissue interaction, fate, and risks of degradable and nondegradable gel fillersDermatol Surg200935Suppl 21612161919807755
  • MonheitGDRohrichRJThe nature of long-term fillers and the risk of complicationsDermatol Surg200935Suppl 21598160419807753
  • NarinsRSColemanWPGlogauRGRecommendations and treatment options for nodules and other filler complicationsDermatol Surg200935Suppl 21667167119807762
  • DayanSHArkinsJPBrindiseRSoft tissue fillers and biofilmsFacial Plast Surg2011271232821246453
  • BjarnsholtTTolker-NielsenTGivskovMJanssenMChristensenLHDetection of bacteria by fluorescence in situ hybridization in culture-negative soft tissue filler lesionsDermatol Surg200935Suppl 21620162419709133
  • GrippaudoFRPacilioMDi GirolamoMDierckxRASignoreARadiolabelled white blood cell scintigraphy in the work-up of dermal filler complicationsEur J Nucl Med Mol Imaging201340341842523208702
  • Alijotas-ReigJFernández-FiguerasMTPuigLLate-onset inflammatory adverse reactions related to soft tissue filler injectionsClin Rev Allergy Immunol20134519710823361999
  • LemperleGGauthier-HazanNWoltersMEisemann-KleinMZimmermannUDuffyDMForeign body granulomas after all injectable dermal fillers: part 1. Possible causesPlast Reconstr Surg200912361842186319483587
  • LemperleGGauthier-HazanNForeign body granulomas after all injectable dermal fillers: part 2. Treatment optionsPlast Reconstr Surg200912361864187319483588
  • Alijotas-ReigJGarcia-GimenezVMiró-MurFVilardell-TarrésMDelayed immune-mediated adverse effects of polyalkylimide dermal fillers: clinical findings and long-term follow-upArch Dermatol2008144563764218490590
  • Chrastil-LaTowskyBWesleyNOMacGregorJLKaminerMSArndtKADelayed inflammatory reaction to bio-alcamid polyacrylamide gel used for soft-tissue augmentationArch Dermatol2009145111309131219917963
  • SachdevMAnantheswarYAshokBHameedSPaiSAFacial granulomas secondary to injection of semi-permanent cosmetic dermal filler containing acrylic hydrogel particlesJ Cutan Aesthet Surg20103316216621430829
  • DescampsVLandryJFrancèsCMarinhoERatziuVChosidowOFacial cosmetic filler injections as possible target for systemic sarcoidosis in patients treated with interferon for chronic hepatitis C: two casesDermatology (Basel)20082171818418446029
  • DammakATailléCMarinhoECrestaniBCrickxBDescampsVGranulomatous foreign-body reaction with facial dermal fillers after omalizumab treatment for severe persistent allergic asthma: a case reportBr J Dermatol201216661375137622233356
  • WiestLGStolzWSchroederJAElectron microscopic documentation of late changes in permanent fillers and clinical management of granulomas in affected patientsDermatol Surg200935Suppl 21681168819807764
  • BrodyHJUse of hyaluronidase in the treatment of granulomatous hyaluronic acid reactions or unwanted hyaluronic acid misplacementDermatol Surg2005318 Pt 189389716042932
  • KwonSGHongJWRohTSKimYSRahDKKimSSIschemic oculomotor nerve palsy and skin necrosis caused by vascular embolization after hyaluronic Acid filler injection: a case reportAnn Plast Surg201371433333423203244
  • PeterSMennelSRetinal branch artery occlusion following injection of hyaluronic acid (Restylane)Clin Experiment Ophthalmol200634436336416764658
  • KimYJKimSSSongWKLeeSYYoonJSOcular ischemia with hypotony after injection of hyaluronic acid gelOphthal Plast Reconstr Surg2011276e152e155
  • GrunebaumLDBogdan AllemannIDayanSMandySBaumannLThe risk of alar necrosis associated with dermal filler injectionDermatol Surg200935Suppl 21635164019807758
  • SchanzSSchippertWUlmerARassnerGFierlbeckGArterial embolization caused by injection of hyaluronic acid (Restylane)Br J Dermatol2002146592892912000405
  • ColemanSRAvoidance of arterial occlusion from injection of soft tissue fillersAesthet Surg J200222655555719332014
  • FeinendegenDLBaumgartnerRWVuadensPAutologous fat injection for soft tissue augmentation in the face: a safe procedure?Aesthetic Plast Surg19982231631679618180
  • EgidoJAArroyoRMarcosAJiménez-AlfaroIMiddle cerebral artery embolism and unilateral visual loss after autologous fat injection into the glabellar areaStroke19932446156168465374
  • LeeDHYangHNKimJCShynKHSudden unilateral visual loss and brain infarction after autologous fat injection into nasolabial grooveBr J Ophthalmol19968011102610278976738
  • ThaunatOThalerFLoiratPDecroixJPBoulinACerebral fat embolism induced by facial fat injectionPlast Reconstr Surg200411372235223615253237
  • YoonSSChangDIChungKCAcute fatal stroke immediately following autologous fat injection into the faceNeurology20036181151115214581689
  • SilvaMTCuriALBlindness and total ophthalmoplegia after aesthetic polymethylmethacrylate injection: case reportArq Neuropsiquiatr2004623B87387415476086
  • DayanSHArkinsJPMathisonCCManagement of impending necrosis associated with soft tissue filler injectionsJ Drugs Dermatol20111091007101222052269
  • HirschRJCohenJLCarruthersJDSuccessful management of an unusual presentation of impending necrosis following a hyaluronic acid injection embolus and a proposed algorithm for management with hyaluronidaseDermatol Surg200733335736017338697
  • BachmannFErdmannRHartmannVWiestLRzanyBThe spectrum of adverse reactions after treatment with injectable fillers in the glabellar region: results from the Injectable Filler Safety StudyDermatol Surg200935Suppl 21629163419807757
  • GeorgescuDJonesYMcCannJDAndersonRLSkin necrosis after calcium hydroxylapatite injection into the glabellar and nasolabial foldsOphthal Plast Reconstr Surg2009256498499
  • KassirRKolluruAKassirMExtensive necrosis after injection of hyaluronic acid filler: case report and review of the literatureJ Cosmet Dermatol201110322423121896135
  • GlaichASCohenJLGoldbergLHInjection necrosis of the glabella: protocol for prevention and treatment after use of dermal fillersDermatol Surg200632227628116442055
  • BurtBNakraTIsaacsDKGoldbergRAAlar necrosis after facial injection of hyaluronic AcidPlast Reconstr Surg20101255199e200e
  • KleydmanKCohenJLMarmurENitroglycerin: a review of its use in the treatment of vascular occlusion after soft tissue augmentationDermatol Surg201238121889189723205544
  • LoweNJMaxwellCAPatnaikRAdverse reactions to dermal fillers: reviewDermatol Surg20053111 Pt 21616162516416647