119
Views
30
CrossRef citations to date
0
Altmetric
Review

Asimadoline and its potential for the treatment of diarrhea-predominant irritable bowel syndrome: a review

&
Pages 1-10 | Published online: 12 Jan 2012

References

  • EverhartJERenaultPFIrritable bowel syndrome in office-based practices in the United StatesGastroenterology1991100499810052001837
  • RussoMWGaynesBNDrossmanDAA national survey of practice patterns of gastroenterologists with comparison to the past two decadesJ Clin Gastroenterol199229433934310599638
  • MayerEAClinical practice. Irritable bowel syndromeN Engl J Med2008358161692169918420501
  • WatsonMELaceyLKongSAlosetron improves quality of life in women with diarrhea-predominant irritable bowel syndromeAm J Gastroenterol200196245545911232690
  • WellsNEHahnBAWhorwellPJClinical economics review: irritable bowel syndromeAliment Pharmacol Ther1997116101910309663824
  • WhiteheadWEBurnettCKCookEWIIITaubEImpact of irritable bowel syndrome on quality of lifeDig Dis Sci19964111224822538943980
  • CorneyRHStantonRPhysical symptom severity, psychological and social dysfunction in a series of outpatients with irritable bowel syndromeJ Psychosom Res19903454834912231481
  • HahnBAYanSStrasselsSImpact of irritable bowel syndrome on quality of life and resource use in the United States and United KingdomDigestion199960177819892803
  • AndrewsEBEatonSCHollisKAPrevalence and demographics of irritable bowel syndrome: results from a large web-based surveyAliment Pharmacol Ther2005221093594216268967
  • PatelRPPetittaAFogelAPetersonEZarowitzBJThe economic impact of irritable bowel syndrome in a managed care settingJ Clin Gastroenterol2002351142012080220
  • LevyRLVon KorffMWhiteheadWECosts of care for irritable bowel syndrome in a health maintenance organizationAm J Gastroenterol200196113122312911721759
  • SandlerRSEpidemiology of irritable bowel syndrome in the United StatesGastroenterology19909924094152365191
  • DrossmanDALiZAndruzziEU.S. householder survey of functional gastrointestinal disorders. Prevalence, sociodemography, and health impactDig Dis Sci1993389156915808359066
  • HunginAPWhorwellPJTackJMearinFThe prevalence patterns and impact of irritable bowel syndrome: an international survey of 40,000 subjectsAliment Pharmacol Ther200317564365012641512
  • LongstrethGFThompsonWGCheyWDHoughtonLAMearinFSpillerRCFunctional bowel disordersDrossmanDACorazziariEDelvauxMRome III: The Functional Gastrointestinal DisordersMcLean, VADegnon Associates Inc2006
  • MangelAWNorthcuttARReview article: the safety and efficacy of alosetron, a 5-HT3 receptor antagonist, in female irritable bowel syndrome patientsAliment Pharmacol Ther199913Suppl 2778210429745
  • CamilleriMCheyWYMayerEAA randomized controlled clinical trial of the serotonin type 3 receptor antagonist alosetron in women with diarrhea-predominant irritable bowel syndromeArch Int Med2001161141733174011485506
  • PimentelMLemboACheyWDfor TARGET Study GroupRifaximin therapy for patients with irritable bowel syndrome without constipationN Eng J Med201136412232
  • PimentelMLemboACheyWDfor TARGET Study GroupRifaximin therapy for patients with irritable bowel syndrome without constipationN Eng J Med20113641 Supplementary Appendix
  • TackJMüller-LissnerSBytzerPA randomised controlled trial assessing the efficacy and safety of repeated tegaserod therapy in women with irritable bowel syndrome with constipationGut200554121707171316020489
  • Müller-LissnerSAFumagalliIBardhanKDTegaserod, a 5-HT(4) receptor partial agonist, relieves symptoms in irritable bowel syndrome patients with abdominal pain, bloating and constipationAliment Pharmacol Ther200115101655166611564007
  • DrossmanDACheyWDJohansonJFClinical trial: lubiprostone in patients with constipation-associated irritable bowel syndrome – results of two randomized, placebo-controlled studiesAliment Pharmacol Ther200929332934119006537
  • JohnstonJMKurtzCBMacdougallJELinaclotide improves abdominal pain and bowel habits in a phase IIb study of patients with irritable bowel syndrome with constipationGastroenterology201013961877188620801122
  • American College of Gastroenterology Task Force on Irritable Bowel SyndromeBrandtLJCheyWDFoxx-OrensteinAEAn evidence- based position statement on the management of irritable bowel syndromeAm J Gastroenterol2009104Suppl 1S1S3519521341
  • WalshSLStrainECAbreuMEBigelowGEEnadoline, a selective kappa opioid agonist: comparison with butorphanol and hydromorphone in humansPsychopharmacology (Berl)2001157215116211594439
  • BarberABartoszykGDBenderHMA pharmacological profile of the novel, peripherally-selective kappa-opioid receptor agonist, EMD 61753Br J Pharmacol19941134131713277889287
  • SuXJoshiSKKardosSGebhartGFSodium channel blocking actions of the kappa-opioid receptor agonist U50,488 contribute to its visceral antinociceptive effectsJ Neurophysiol20028731271127911877501
  • JoshiSKLambKBielefeldtKGebhartGFArylacetamide kappa-opioid receptor agonists produce a tonic- and use-dependent block of tetrodotoxin-sensitive and -resistant sodium currents in colon sensory neuronsJ Pharmacol Exp Ther2003307136737212954815
  • JonkerJWWagenaarEvan DeemterLRole of blood-brain barrier P-glycoprotein in limiting brain accumulation and sedative side-effects of asimadoline, a peripherally acting analgesic drugBr J Pharmacol19991271435010369454
  • BarberAGottschlichRNovel developments with selective, nonpeptidic kappa-opioid receptor agonistsExpert Opin Investig Drugs199761013511368
  • BenderHMDasenbrockJBrain concentrations of asimadoline in mice: the influence of coadministration of various P-glycoprotein substratesInt J Clin Pharmacol Ther199836276799520149
  • SlizgiGRLudensJHStudies on the nature and mechanism of the diuretic activity of the opioid analgesic ethylketocyclazocineJ Pharmacol Exp Ther198222035855916121047
  • RimoyGHBhaskarNKWrightDMRubinPCMechanism of diuretic action of spiradoline (U-62066E) – a kappa-opioid receptor agonist in the humanBr J Clin Pharmacol19913256116151659438
  • BrooksDPGiardinaGGellaiMOpiate receptors within the blood-brain barrier mediate kappa agonist-induced water diuresisJ Pharmacol Exp Ther199326611641718392549
  • AshtonNBalmentRJBlackburnTPKappa-opioid-receptor agonists modulate the renal excretion of water and electrolytes in anaesthetized ratsBr J Pharmacol19909911811852158834
  • KramerHJUhlWLadstetterBBäckerAInfluence of asimadoline, a new kappa-opioid receptor agonist, on tubular water absorption and vasopressin secretion in manBr J Clin Pharmacol200050322723510971307
  • JordanBDeviLAMolecular mechanisms of opioid receptor signal transductionBr J Anaesth199881112199771268
  • NorthRAOpioid receptor types and membrane ion channelsTrends Neurosci19869114117
  • HerzAPeripheral opioid analgesia – facts and mechanismsProg Brain Res1996110951049000718
  • DiopLRivièrePJPascaudXJunienJLPeripheral kappa-opioid receptors mediate the antinociceptive effect of fedotozine (correction of fetodozine) on the duodenal pain reflex in ratEur J Pharmacol1994271165717698213
  • HaradaYNishiokaKKitahataLMNakataniKCollinsJGContrasting actions of intrathecal U50, 488H, morphine, or [D-Pen2, D-Pen5] enkephalin or intravenous U50, 488H on the visceromotor response to colorectal distension in the ratAnesthesiology19958323363437631956
  • DanzebrinkRMGreenSAGebhartGFSpinal mu and delta, but not kappa, opioid-receptor agonists attenuate responses to noxious colorectal distension in the ratPain199563139478577489
  • SenguptaJNSuXGebhartGFKappa, but not mu or delta, opioids attenuate responses to distention of afferent fibers innervating the rat colonGastroenterology199611149689808831591
  • SuXSenguptaJNGebhartGFEffects of kappa-opioid receptor-selective agonists on responses of pelvic nerve afferents to noxious colorectal distensionJ Neurophysiol1997782100310129307130
  • DelvauxMBeckAJacobJEffect of asimadoline, a kappa opioid agonist, on pain induced by colonic distension in patients with irritable bowel syndromeAliment Pharmacol Ther200420223724615233705
  • RivièrePJPeripheral kappa-opioid agonists for visceral painBr J Pharmacol200414181331133415051626
  • SenguptaJNSniderASuXGebhartGFEffects of kappa opioids in the inflamed rat colonPain1999792–317518510068163
  • BurtonMBGebhartGFEffects of kappa-opioid receptor agonists on responses to colorectal distension in rats with and without acute colonic inflammationJ Pharmacol Exp Ther199828527077159580617
  • WalkerJSScottCBushKAKirkhamBWEffects of the peripherally selective kappa-opioid asimadoline, on substance P and CGRP mRNA expression in chronic arthritis of the ratNeuropeptides2000343–419320211021980
  • BinderWScottCWalkerJSInvolvement of substance P in the anti-inflammatory effects of the peripherally selective kappa-opioid asimadoline and the NK1 antagonist GR205171Eur J Neurosci19991162065207210336675
  • BergKARowanMPSanchezTARegulation of κ-opioid receptor signaling in peripheral sensory neurons in vitro and in vivoJ Pharmacol Exp Ther20113381929921487072
  • BiJTsaiNPLinYPLohHHWeiLNAxonal mRNA transport and localized translational regulation of kappa-opioid receptor in primary neurons of dorsal root gangliaProc Natl Acad Sci U S A200610352199191992417167054
  • BiJTsaiNPLuHYLohHHWeiLNCopb1-facilitated axonal transport and translation of kappa opioid-receptor mRNAProc Natl Acad Sci U S A200710434138101381517698811
  • TsaiNPBiJLohHHWeiLNNetrin-1 signaling regulates de novo protein synthesis of kappa opioid receptor by facilitating polysomal partition of its mRNAJ Neurosci200626389743974916988045
  • TsaiNPBiJWeiLNThe adaptor Grb7 links netrin-1 signaling to regulation of mRNA translationEMBO J20072661522153117318180
  • Delgado-ArosSChialHJCamilleriMEffects of a kappa-opioid agonist, asimadoline, on satiation and GI motor and sensory functions in humansAm J Physiol Gastrointest Liver Physiol20032844G558G56612631557
  • MangelAWBornsteinJDHammLRClinical trial: asimadoline in the treatment of patients with irritable bowel syndromeAliment Pharmacol Ther200828223924918466359
  • ChamouardPKleinAMartinEAdloffMAngelFRegulatory role of enteric kappa opioid receptors in human colonic motilityLife Sci19935314114911568103909
  • GiulianiSLecciATramontanaMMaggiCARole of kappa opioid receptors in modulating cholinergic twitches in the circular muscle of guinea-pig colonBr J Pharmacol199611959859898922749
  • PoonyachotiSKulkarni-NarlaABrownDRChemical coding of neurons expressing delta- and kappa-opioid receptor and type I vanilloid receptor immunoreactivities in the porcine ileumCell Tissue Res20023071233311810311
  • BagnolDMansourAAkilHWatsonSJCellular localization and distribution of the cloned mu and kappa opioid receptors in rat gastrointestinal tractNeuroscience19978125795919300443
  • SterniniCPatiernoSSelmerISKirchgessnerAThe opioid system in the gastrointestinal tractNeurogastroenterol Motil200416Suppl 231615357847
  • PolOPalacioJRPuigMMThe expression of delta- and kappa-opioid receptor is enhanced during intestinal inflammation in miceJ Pharmacol Exp Ther2003306245546212724348
  • KellowJEPhillipsSFAltered small bowel motility in irritable bowel syndrome is correlated with symptomsGastroenterology1987926188518933569764
  • MarcianiLCoxEFHoadCLPostprandial changes in small bowel water content in healthy subjects and patients with irritable bowel syndromeGastroenterology2010138246947719909743
  • DeiterenACamilleriMBurtonDMcKinzieSRaoAZinsmeisterAREffect of meal ingestion on ileocolonic and colonic transit in health and irritable bowel syndromeDig Dis Sci201055238439119949866
  • CheyWYJinHOLeeMHSunSWLeeKYColonic motility abnormality in patients with irritable bowel syndrome exhibiting abdominal pain and diarrheaAm J Gastroenterol20019651499150611374689
  • BouchouchaMDevroedeGRaynaudJJBonCBejouBBenamouzigRIs the colonic response to food different in IBS in contrast to simple constipation or diarrhea without abdominal pain?Dig Dis Sci201156102947295621479817
  • MangelAWWilliamsVSAsimadoline in the treatment of irritable bowel syndromeExpert Opin Investig Drugs2010191012571264
  • SzarkaLCamilleriMBurtonDEfficacy of on-demand asimadoline, a peripheral k-opioid agonist, in females with irritable bowel syndromeClin Gastroenterol Hepatol20075111268127517900994
  • CamilleriMNovel pharmacology: asimadoline, a kappa-opioid agonist, and visceral sensationNeurogastroenterol Motil200820997197918715494