References
- AnguloPObesity and nonalcoholic fatty liver diseaseNutr Rev2007656 Pt 25763
- LazoMClarkJMThe epidemiology of nonalcoholic fatty liver disease: a global perspectiveSemin Liver Dis200828433935018956290
- WilliamsCDStengelJAsikeMIPrevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective studyGastroenterology2011140112413120858492
- NakamutaMKohjimaMMorizonoSEvaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver diseaseInt J Mol Med200516463163516142397
- MachadoMMarques-VidalPCortez-PintoHHepatic histology in obese patients undergoing bariatric surgeryJ Hepatol200645460060616899321
- WieckowskaAPapouchadoBGLiZLopezRZeinNNFeldsteinAEIncreased hepatic and circulating interleukin-6 levels in human nonalcoholic steatohepatitisAm J Gastroenterol200810361372137918510618
- EkstedtMFranzénLEMathiesenULLong-Term Follow-up of Patients with NAFLD and Elevated Liver EnzymesHepatology200644486587317006923
- FarrellGCLarterCZNonalcoholic fatty liver disease: from steatosis to cirrhosisHepatology2006432 Suppl 1S99S11216447287
- DowmanJKTomlinsonJWNewsomePNSystematic review: the diagnosis and staging of non-alcoholic fatty liver disease and non-alcoholic steatohepatitisAliment Pharmacol Ther201133552554021198708
- MarchesiniGBugianesiEForlaniGNonalcoholic fatty liver, steatohepatitis, and the metabolic syndromeHepatology200337491792312668987
- AdamsLAWatersORKnuimanMWElliottRROlynykJKNAFLD as a risk factor for the development of diabetes and the metabolic syndrome: an eleven-year follow-up studyAm J Gastroenterol2009104486186719293782
- AdamsLAFeldsteinAENon-invasive diagnosis of nonalcoholic fatty liver and nonalcoholic steatohepatitisJ Dig Dis2011121101621091933
- YanEDurazoFTongMHongKNonalcoholic fatty liver disease: pathogenesis, identification, progression, and managementNutr Rev2007658 Pt 137638417867371
- SorbiDBoyntonJLindorKDThe ratio of aspartate aminotransferase to alanine aminotransferase: potential value in differentiating nonalcoholic steatohepatitis from alcoholic liver diseaseAm J Gastroenterol19999441018102210201476
- AdamsLAAnguloPLindorKDNonalcoholic fatty liver diseaseCMAJ2005172789990515795412
- FestiDSchiumeriniRMarziLReview article: the diagnosis of non-alcoholic fatty liver disease – availability and accuracy of non-invasive methodsAliment Pharmacol Ther201337439240023278163
- FedericoATrappoliereMLoguercioCTreatment of patients with non-alcoholic fatty liver disease: current views and perspectivesDig Liver Dis2006381178980116750661
- PacificoLCelestreMAnaniaCPaolantonioPChiesaCLaghiAMRI and ultrasound for hepatic fat quantification: relationships to clinical and metabolic characteristics of pediatric nonalcoholic fatty liver diseaseActa Paediatr200796454254717306008
- LewisJRMohantySRNonalcoholic fatty liver disease: a review and updateDig Dis Sci201055356057820101463
- YilmazYUlukayaEDolarEA “biomarker biopsy” for the diagnosis of NASH: promises from CK-18 fragmentsObes Surg2008181115071508 author reply 1509–151018679759
- SchwengerKJAllardJPClinical approaches to non-alcoholic fatty liver diseaseWorld J Gastroenterol20142071712172324587650
- McCarthyEMRinellaMEThe role of diet and nutrient composition in nonalcoholic fatty liver diseaseJ Acad Nutr Diet2012112340140922717200
- PromratKKleinerDENiemeierHMRandomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitisHepatology201051112112919827166
- St GeorgeABaumanAJohnstonAFarrellGCheyTGeorgeJEffect of a lifestyle intervention in patients with abnormal liver enzymes and metabolic risk factorsJ Gastroenterol Hepatol200924339940719067776
- HaukelandJWKonopskiZEggesbøHBMetformin in patients with non-alcoholic fatty liver disease: a randomized, controlled trialScand J Gastroenterol200944785386019811343
- OhMKWinnJPoordadFReview article: diagnosis and treatment of non-alcoholic fatty liver diseaseAliment Pharmacol Ther200828550352218532991
- Van WagnerLBRinellaMEThe role of insulin-sensitizing agents in the treatment of nonalcoholic steatohepatitisTherap Adv Gastroenterol201144249263
- LutchmanGModiAKleinerDEThe effects of discontinuing pioglitazone in patients with nonalcoholic steatohepatitisHepatology200746242442917559148
- AithalGPThomasJAKayePVRandomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitisGastroenterology200813541176118418718471
- MaroniLGuastiLCastiglioniLLipid targets during statin treatment in dyslipidemic patients affected by nonalcoholic fatty liver diseaseAm J Med Sci2011342538338721629037
- EkstedtMFranzénLEMathiesenULHolmqvistMBodemarGKechagiasSStatins in non-alcoholic fatty liver disease and chronically elevated liver enzymes: a histopathological follow-up studyJ Hepatol200747113514117400325
- TandraSVuppalanchiRUse of statins in patients with liver diseaseCurr Treat Options Cardiovasc Med200911427227819627660
- ChalasaniNYounossiZLavineJEThe diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological AssociationHepatology20125562005202322488764
- MussoGGambinoRCassaderMRecent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD)Prog Lipid Res200948112618824034
- PettaSMuratoreCCraxìANon-alcoholic fatty liver disease pathogenesis: the present and the futureDig Liver Dis200941961562519223251
- UtzschneiderKMKahnSEReview: the role of insulin resistance in nonalcoholic fatty liver diseaseJ Clin Endocrinol Metab200691124753476116968800
- HotamisligilGSInflammation and metabolic disordersNature2006444712186086717167474
- SavageDBSempleRKRecent insights into fatty liver, metabolic dyslipidaemia and their links to insulin resistanceCurr Opin Lipidol201021432933620581678
- PosticCGirardJContribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered miceJ Clin Invest2008118382983818317565
- LewisGFCarpentierAAdeliKGiaccaADisordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetesEndocr Rev200223220122911943743
- TilgHMoschenAREvolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesisHepatology20105251836184621038418
- KoliwadSKStreeperRSMonettiMDGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammationJ Clin Invest2010120375676720124729
- YamaguchiKYangLMcCallSInhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitisHepatology20074561366137417476695
- AmaroAFabbriniEKarsMDissociation between intrahepatic triglyceride content and insulin resistance in familial hypobetalipoproteinemiaGastroenterology2010139114915320303351
- FeldsteinAEWerneburgNWCanbayAFree fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathwayHepatology200440118519415239102
- MaríMCaballeroFColellAMitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitisCell Metab20064318519816950136
- CheungOSanyalAJAbnormalities of lipid metabolism in nonalcoholic fatty liver diseaseSemin Liver Dis200828435135918956291
- MalhiHGoresGJMolecular mechanisms of lipotoxicity in nonalcoholic fatty liver diseaseSemin Liver Dis200828436036918956292
- ArnerPHuman fat cell lipolysis: biochemistry, regulation and clinical roleBest Pract Res Clin Endocrinol Metab200519447148216311212
- DelarueJMagnanCFree fatty acids and insulin resistanceCurr Opin Clin Nutr Metab Care200710214214817285001
- BerkPDRegulatable fatty acid transport mechanisms are central to the pathophysiology of obesity, fatty liver, and metabolic syndromeHepatology20084851362137618972439
- MartinGNemotoMGelmanLThe human fatty acid transport protein-1 (SLC27A1; FATP-1) cDNA and gene: organization, chromosomal localization, and expressionGenomics200066329630410873384
- GeFZhouSHuCLobdellHBerkPDInsulin- and leptin-regulated fatty acid uptake plays a key causal role in hepatic steatosis in mice with intact leptin signaling but not in ob/ob or db/db miceAm J Physiol Gastrointest Liver Physiol20102994G855G86620595619
- ZhouSLStumpDSorrentinoDPotterBJBerkPDAdipocyte differentiation of 3T3-L1 cells involves augmented expression of a 43-kDa plasma membrane fatty acid-binding proteinJ Biol Chem19922672014456144611629231
- ZhouSLStumpDKiangCLIsolaLMBerkPDMitochondrial aspartate aminotransferase expressed on the surface of 3T3-L1 adipocytes mediates saturable fatty acid uptakeProc Soc Exp Biol Med199520832632707878064
- TrigattiBLAndersonRGGerberGEIdentification of caveolin-1 as a fatty acid binding proteinBiochem Biophys Res Commun19992551343910082651
- DoegeHStahlAProtein-mediated fatty acid uptake: novel insights from in vivo modelsPhysiology (Bethesda)20062125926816868315
- DoegeHBaillieRAOrtegonAMTargeted deletion of FATP5 reveals multiple functions in liver metabolism: alterations in hepatic lipid homeostasisGastroenterology200613041245125816618416
- AuingerAValentiLPfeufferMA promoter polymorphism in the liver-specific fatty acid transport protein 5 is associated with features of the metabolic syndrome and steatosisHorm Metab Res2010421285484920945272
- FernándezMAAlborCIngelmo-TorresMCaveolin-1 is essential for liver regenerationScience200631357931628163216973879
- MastrodonatoMCalamitaGRossiRAltered distribution of caveolin-1 in early liver steatosisEur J Clin Invest201141664265121250982
- Miquilena-ColinaMELima-CabelloESánchez-CamposSHepatic fatty acid translocase CD36 upregulation is associated with insulin resistance, hyperinsulinaemia and increased steatosis in non-alcoholic steatohepatitis and chronic hepatitis CGut201160101394140221270117
- InoueMOhtakeTMotomuraWIncreased expression of PPARgamma in high fat diet-induced liver steatosis in miceBiochem Biophys Res Commun2005336121522216125673
- BuquéXMartínezMJCanoAA subset of dysregulated metabolic and survival genes is associated with severity of hepatic steatosis in obese Zucker ratsJ Lipid Res201051350051319783528
- DegracePMoindrotBMohamedIUpregulation of liver VLDL receptor and FAT/CD36 expression in LDLR−/− apoB100/100 mice fed trans-10, cis-12 conjugated linoleic acidJ Lipid Res200647122647265516957181
- ZhouJFebbraioMWadaTHepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosisGastroenterology2008134255656718242221
- GrecoDKotronenAWesterbackaJGene expression in human NAFLDAm J Physiol Gastrointest Liver Physiol20082945G1281G128718388185
- BechmannLPGieselerRKSowaJ-PApoptosis is associated with CD36/fatty acid translocase upregulation in non-alcoholic steatohepatitisLiver Int201030685085920408954
- FuruhashiMHotamisligilGSFatty acid-binding proteins: role in metabolic diseases and potential as drug targetsNat Rev Drug Discov20087648950318511927
- KarakasSEAlmarioRUKimKSerum fatty acid binding protein 4, free fatty acids, and metabolic risk markersMetabolism20095871002100719394980
- ZimmermanAWVeerkampJHNew insights into the structure and function of fatty acid-binding proteinsCell Mol Life Sci20025971096111612222958
- ChmurzyńskaAThe multigene family of fatty acid-binding proteins (FABPs): function, structure and polymorphismJ Appl Genet2006471394816424607
- KrusinováEPelikánováTFatty acid binding proteins in adipose tissue: a promising link between metabolic syndrome and atherosclerosis?Diabetes Res Clin Pract200882Suppl 2S127S13418977052
- TaskinenMRAdielsMWesterbackaJDual metabolic defects are required to produce hypertriglyceridemia in obese subjectsArterioscler Thromb Vasc Biol20113192144215021778423
- WesterbackaJKolakMKiviluotoTGenes involved in fatty acid partitioning and binding, lipolysis, monocyte/macrophage recruitment, and inflammation are overexpressed in the human fatty liver of insulin-resistant subjectsDiabetes200756112759276517704301
- FalconADoegeHFluittAFATP2 is a hepatic fatty acid transporter and peroxisomal very long-chain acyl-CoA synthetaseAm J Physiol Endocrinol Metab20102993E384E39320530735
- DoegeHGrimmDFalconASilencing of hepatic fatty acid transporter protein 5 in vivo reverses diet-induced non-alcoholic fatty liver disease and improves hyperglycemiaJ Biol Chem200828332221862219218524776
- NieBParkHMKazantzisMSpecific bile acids inhibit hepatic fatty acid uptake in miceHepatology20125641300131022531947
- OkamuraMInagakiTTanakaTSakaiJRole of histone methylation and demethylation in adipogenesis and obesityOrganogenesis201061243220592862
- SanyalAJChalasaniNKowdleyKVPioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitisN Engl J Med2010362181675168520427778
- FabbriniESullivanSKleinSObesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implicationsHepatology201051267968920041406
- BechmannLPHannivoortRAGerkenGHotamisligilGSTraunerMCanbayAThe interaction of hepatic lipid and glucose metabolism in liver diseasesJ Hepatol201256495296422173168
- KawanoYCohenDEMechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver diseaseJ Gastroenterol201348443444123397118
- FuchsMNon-alcoholic fatty liver disease: the bile acid-activated farnesoid x receptor as an emerging treatment targetJ Lipids2012201293439622187656
- FerréPFoufelleFHepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1cDiabetes Obes Metab201012Suppl 2839221029304
- MitsuyoshiHYasuiKHaranoYAnalysis of hepatic genes involved in the metabolism of fatty acids and iron in nonalcoholic fatty liver diseaseHepatol Res200939436637319054139
- KohjimaMHiguchiNKatoMSREBP-1c, regulated by the insulin and AMPK signaling pathways, plays a role in nonalcoholic fatty liver diseaseInt J Mol Med200821450751118360697
- BaranowskiMBiological role of liver X receptorsJ Physiol Pharmacol200859Suppl 7315519258656
- FauldsMHZhaoCDahlman-WrightKMolecular biology and functional genomics of liver X receptors (LXR) in relationship to metabolic diseasesCurr Opin Pharmacol201010669269720829110
- LiangGYangJHortonJDHammerREGoldsteinJLBrownMSDiminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1cJ Biol Chem2002277119520952811782483
- PeetDJTurleySDMaWCholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alphaCell19989356937049630215
- RepaJJLiangGOuJRegulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbetaGenes Dev200014222819283011090130
- SchultzJRTuHLukARole of LXRs in control of lipogenesisGenes Dev200014222831283811090131
- HiguchiNKatoMShundoYLiver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver diseaseHepatol Res200838111122112918684130
- Lima-CabelloEGarcia-MediavillaMVMiquilena-ColinaMEEnhanced expression of pro-inflammatory mediators and liver X-receptor-regulated lipogenic genes in non-alcoholic fatty liver disease and hepatitis CClin Sci (Lond)2011120623925020929443
- HortonJDGoldsteinJLBrownMSCritical review SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liverJ Clin Invest200210991125113111994399
- ShimomuraIShimanoHHortonJDGoldsteinJLBrownMSDifferential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cellsJ Clin Invest19979958388459062340
- ShimomuraIBashmakovYIkemotoSHortonJDBrownMSGoldsteinJLInsulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetesProc Natl Acad Sci U S A19999624136561366110570128
- ForetzMPacotCDugailIADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucoseMol Cell Biol19991953760376810207099
- Azzout-MarnicheDBécardDGuichardCInsulin effects on sterol regulatory-element-binding protein-1c (SREBP-1c) transcriptional activity in rat hepatocytesBiochem J2000350Pt 238939310947952
- OsborneTFSterol regulatory element-binding proteins (SREBPs): key regulators of nutritional homeostasis and insulin actionJ Biol Chem200027542323793238210934219
- ChakravartyKLeahyPBecardDSterol regulatory element-binding protein-1c mimics the negative effect of insulin on phosphoenolpyruvate carboxykinase (GTP) gene transcriptionJ Biol Chem200127637348163482311443121
- ShimanoHSterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genesProg Lipid Res200140643945211591434
- HortonJDBashmakovYShimomuraIShimanoHRegulation of sterol regulatory element binding proteins in livers of fasted and refed miceProc Natl Acad Sci U S A19989511598759929600904
- KimJBSarrafPWrightMNutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1J Clin Invest19981011199421459
- NagayaTTanakaNSuzukiTDown-regulation of SREBP-1c is associated with the development of burned-out NASHJ Hepatol201053472473120655124
- DenechaudPDDentinRGirardJPosticCRole of ChREBP in hepatic steatosis and insulin resistanceFEBS Lett20085821687317716660
- FoufelleFFerréPNew perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1cBiochem J2002366Pt 237739112061893
- DentinRPégorierJPBenhamedFHepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expressionJ Biol Chem200427919203142032614985368
- IshiiSIizukaKMillerBCUyedaKCarbohydrate response element binding protein directly promotes lipogenic enzyme gene transcriptionProc Natl Acad Sci U S A200410144155971560215496471
- MaLTsatsosNGTowleHCDirect role of ChREBP.Mlx in regulating hepatic glucose-responsive genesJ Biol Chem200528012120191202715664996
- ChaJYRepaJJThe liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXRJ Biol Chem2007282174375117107947
- UlvenSMDalenKTGustafssonJANebbHILXR is crucial in lipid metabolismProstaglandins Leukot Essent Fatty Acids2005731596315913974
- ChenGLiangGOuJGoldsteinJLBrownMSCentral role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liverProc Natl Acad Sci U S A200410131112451125015266058
- JosephSBLaffitteBPatelPHDirect and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptorsJ Biol Chem200227713110191102511790787
- ZhangYYinLHillgartnerFBSREBP-1 integrates the actions of thyroid hormone, insulin, cAMP, and medium-chain fatty acids on ACCalpha transcription in hepatocytesJ Lipid Res200344235636812576518
- ChuKMiyazakiMManWCNtambiJMStearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activationMol Cell Biol200626186786679816943421
- MitroNMakPAVargasLThe nuclear receptor LXR is a glucose sensorNature2007445712421922317187055
- ArdenCPetrieJLTudhopeSJElevated glucose represses liver glucokinase and induces its regulatory protein to safeguard hepatic phosphate homeostasisDiabetes201160123110312022013014
- MaLRobinsonLNTowleHCChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liverJ Biol Chem200628139287212873016885160
- de la IglesiaNMukhtarMSeoaneJGuinovartJJAgiusLThe role of the regulatory protein of glucokinase in the glucose sensory mechanism of the hepatocyteJ Biol Chem200027514105971060310744755
- IizukaKBruickRKLiangGHortonJDUyedaKDeficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysisProc Natl Acad Sci U S A2004101197281728615118080
- IizukaKMillerBUyedaKDeficiency of carbohydrate-activated transcription factor ChREBP prevents obesity and improves plasma glucose control in leptin-deficient (ob/ob) miceAm J Physiol Endocrinol Metab20062912E358E36416705063
- DentinRBenhamedFHainaultILiver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob miceDiabetes20065582159217016873678
- IizukaKTakedaJHorikawaYHepatic overexpression of dominant negative Mlx improves metabolic profile in diabetes-prone C57BL/6J miceBiochem Biophys Res Commun2009379249950419121288
- BenhamedFDenechaudPLemoineMThe lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humansJ Clin Invest201212262176219422546860
- BrownMSGoldsteinJLSelective versus total insulin resistance: a pathogenic paradoxCell Metab200872959618249166
- FormanBMGoodeEChenJIdentification of a nuclear receptor that is activated by farnesol metabolitesCell19958156876937774010
- LuTTMakishimaMRepaJJMolecular basis for feedback regulation of bile acid synthesis by nuclear receptorsMol Cell20006350751511030331
- ZhangYKast-WoelbernHREdwardsPANatural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activationJ Biol Chem2003278110411012393883
- DownesMVerdeciaMARoeckerAJA chemical, genetic, and structural analysis of the nuclear bile acid receptor FXRMol Cell20031141079109212718892
- ThomasCPellicciariRPruzanskiMAuwerxJSchoonjansKTargeting bile-acid signalling for metabolic diseasesNat Rev Drug Discov20087867869318670431
- KokTHulzebosCVWoltersHEnterohepatic circulation of bile salts in farnesoid X receptor-deficient mice: efficient intestinal bile salt absorption in the absence of ileal bile acid-binding proteinJ Biol Chem200327843419304193712917447
- SinalCJTohkinMMiyataMWardJMLambertGGonzalezFJTargeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasisCell2000102673174411030617
- WatanabeMHoutenSMWangLBile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1cJ Clin Invest2004113101408141815146238
- MaKSahaPKChanLMooreDDFarnesoid X receptor is essential for normal glucose homeostasisJ Clin Invest200611641102110916557297
- ZhangYLeeFYBarreraGActivation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic miceProc Natl Acad Sci U S A200610341006101116410358
- YangZXShenWSunHEffects of nuclear receptor FXR on the regulation of liver lipid metabolism in patients with non-alcoholic fatty liver diseaseHepatol Int20104474174821286345
- TeodoroJSRoloAPPalmeiraCMHepatic FXR: key regulator of whole-body energy metabolismTrends Endocrinol Metab2011221145846621862343
- ModicaSGadaletaRMMoschettaADeciphering the nuclear bile acid receptor FXR paradigmNucl Recept Signal20108e00521383957
- DornCRienerMOKirovskiGExpression of fatty acid synthase in nonalcoholic fatty liver diseaseInt J Clin Exp Pathol20103550551420606731
- KohjimaMEnjojiMHiguchiNRe-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver diseaseInt J Mol Med200720335135817671740
- MorganKUyuniANandgiriGAltered expression of transcription factors and genes regulating lipogenesis in liver and adipose tissue of mice with high fat diet-induced obesity and nonalcoholic fatty liver diseaseEur J Gastroenterol Hepatol200820984385418794597
- ZhangWPatilSChauhanBFoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expressionJ Biol Chem200628115101051011716492665
- QuSAltomonteJPerdomoGAberrant Forkhead box O1 function is associated with impaired hepatic metabolismEndocrinology2006147125641565216997836
- MatsumotoMHanSKitamuraTAcciliDDual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolismJ Clin Invest200611692464247216906224
- ValentiLRamettaRDongiovanniPIncreased expression and activity of the transcription factor FOXO1 in nonalcoholic steatohepatitisDiabetes20085751355136218316359
- SamuelVTChoiCSPhillipsTGTargeting foxo1 in mice using antisense oligonucleotide improves hepatic and peripheral insulin actionDiabetes20065572042205016804074
- NakaeJBiggsWHKitamuraTRegulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1Nat Genet200232224525312219087
- MandardSMüllerMKerstenSPeroxisome proliferator-activated receptor alpha target genesCell Mol Life Sci200461439341614999402
- KerstenSSeydouxJPetersJMGonzalezFJDesvergneBWahliWPeroxisome proliferator-activated receptor alpha mediates the adaptive response to fastingJ Clin Invest1999103111489149810359558
- HaranoYYasuiKToyamaTFenofibrate, a peroxisome proliferator-activated receptor alpha agonist, reduces hepatic steatosis and lipid peroxidation in fatty liver Shionogi mice with hereditary fatty liverLiver Int200626561362016762007
- IpEFarrellGCRobertsonGHallPKirschRLeclercqICentral role of PPARalpha-dependent hepatic lipid turnover in dietary steatohepatitis in miceHepatology200338112313212829994
- ChouCJHaluzikMGregoryCWY14,643, a peroxisome proliferator-activated receptor alpha (PPARalpha) agonist, improves hepatic and muscle steatosis and reverses insulin resistance in lipoatrophic A-ZIP/F-1 miceJ Biol Chem200227727244842448911994294
- HashimotoTCookWSQiCYeldandiAVReddyJKRaoMSDefect in peroxisome proliferator-activated receptor alpha-inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fastingJ Biol Chem200027537289182892810844002
- ReddyJKHashimotoTPeroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: an adaptive metabolic systemAnnu Rev Nutr20012119323011375435
- KashireddyPVRaoMSLack of peroxisome proliferator-activated receptor alpha in mice enhances methionine and choline deficient diet-induced steatohepatitisHepatol Res200430210411015519275
- RaoMSPapreddyKMusunuriSOkonkwoAPrevention/reversal of choline deficiency-induced steatohepatitis by a peroxisome proliferator-activated receptor alpha ligand in ratsIn Vivo200216214515212073774
- IpEFarrellGHallPRobertsonGLeclercqIAdministration of the potent PPARalpha agonist, Wy-14,643, reverses nutritional fibrosis and steatohepatitis in miceHepatology20043951286129615122757
- TailleuxAWoutersKStaelsBRoles of PPARs in NAFLD: potential therapeutic targetsTriglyceride Metab Dis201218215809818
- Vanden BergheWVermeulenLDelerivePDe BosscherKStaelsBHaegemanGA paradigm for gene regulation: inflammation, NF-kappaB and PPARAdv Exp Med Biol200354418119614713228
- DelerivePDe BosscherKBesnardSPeroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-kappa B and AP-1J Biol Chem199927445320483205410542237
- DelerivePGervoisPFruchartJCStaelsBInduction of IkappaBalpha expression as a mechanism contributing to the anti-inflammatory activities of peroxisome proliferator-activated receptor-alpha activatorsJ Biol Chem200027547367033670710980195
- GervoisPVu-DacNKleemannRNegative regulation of human fibrinogen gene expression by peroxisome proliferator-activated receptor alpha agonists via inhibition of CCAAT box/enhancer-binding protein betaJ Biol Chem200127636334713347711418615
- GervoisPKleemannRPilonAGlobal suppression of IL-6-induced acute phase response gene expression after chronic in vivo treatment with the peroxisome proliferator-activated receptor-alpha activator fenofibrateJ Biol Chem200427916161541616014764586
- HuangYYGusdonAMQuSNonalcoholic fatty liver disease: molecular pathways and therapeutic strategiesLipids Health Dis20131217124209497
- TilgHMoschenARInflammatory mechanisms in the regulation of insulin resistanceMol Med2008143–422223118235842
- TilgHAdipocytokines in nonalcoholic fatty liver disease: key players regulating steatosis, inflammation and fibrosisCurr Pharm Des201016171893189520370678
- MaedaNTakahashiMFunahashiTPPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived proteinDiabetes20015092094209911522676
- WolfAMWolfDRumpoldHEnrichBTilgHAdiponectin induces the anti-inflammatory cytokines IL-10 and IL-1RA in human leukocytesBiochem Biophys Res Commun2004323263063515369797
- TilgHMoschenARAdipocytokines: mediators linking adipose tissue, inflammation and immunityNat Rev Immunol200661077278316998510
- XuAWangYKeshawHXuLYLamKSCooperGJThe fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in miceJ Clin Invest200311219110012840063
- HuiJMHodgeAFarrellGCKenchJGKriketosAGeorgeJBeyond insulin resistance in NASH: TNF-alpha or adiponectin?Hepatology2004401465415239085
- BaranovaAGowderSJSchlauchKGene expression of leptin, resistin, and adiponectin in the white adipose tissue of obese patients with non-alcoholic fatty liver disease and insulin resistanceObes Surg20061691118112516989692
- KaserSMoschenACayonAAdiponectin and its receptors in non-alcoholic steatohepatitisGut200554111712115591515
- MoschenARMolnarCWolfAMEffects of weight loss induced by bariatric surgery on hepatic adipocytokine expressionJ Hepatol200951476577719664840
- MarraFBertolaniCAdipokines in liver diseasesHepatology200950395796919585655
- HotamisligilGSShargillNSSpiegelmanBMAdipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistanceScience1993259509187917678183
- KernPASaghizadehMOngJMBoschRJDeemRSimsoloRBThe expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipaseJ Clin Invest1995955211121197738178
- MoschenARMolnarCGeigerSAnti-inflammatory effects of excessive weight loss: potent suppression of adipose interleukin 6 and tumour necrosis factor alpha expressionGut20105991259126420660075
- LangCHDobrescuCBagbyGJTumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose outputEndocrinology1992130143521727716
- CrespoJCayónAFernández-GilPGene expression of tumor necrosis factor alpha and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patientsHepatology20013461158116311732005
- LesmanaCRAHasanIBudihusodoUDiagnostic value of a group of biochemical markers of liver fibrosis in patients with non-alcoholic steatohepatitisJ Dig Dis200910320120619659788
- ValentiLFracanzaniALDongiovanniPTumor necrosis factor alpha promoter polymorphisms and insulin resistance in nonalcoholic fatty liver diseaseGastroenterology2002122227428011832442
- ZhouYJLiYYNieYQInfluence of polygenetic polymorphisms on the susceptibility to non-alcoholic fatty liver disease of Chinese peopleJ Gastroenterol Hepatol201025477277720492333
- GabayCKushnerIAcute-phase proteins and other systemic responses to inflammationN Engl J Med199934064484549971870
- CressmanDEGreenbaumLEDeAngelisRALiver failure and defective hepatocyte regeneration in interleukin-6-deficient miceScience19962745291137913838910279
- HaukelandJWDamåsJKKonopskiZSystemic inflammation in nonalcoholic fatty liver disease is characterized by elevated levels of CCL2J Hepatol20064461167117416618517
- SennJJKloverPJNowakIASuppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytesJ Biol Chem200327816137401374612560330
- SamalBSunYStearnsGXieCSuggsSMcNieceICloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factorMol Cell Biol1994142143114378289818
- MoschenARGernerRRTilgHPre-B Cell colony enhancing factor/NAMPT/visfatin in inflammation and obesity-related disordersCurr Pharm Des201016171913192020370672
- AllerRde LuisDAIzaolaOInfluence of visfatin on histopathological changes of non-alcoholic fatty liver diseaseDig Dis Sci20095481772177719005759
- JarrarMHBaranovaACollantesRAdipokines and cytokines in non-alcoholic fatty liver diseaseAliment Pharmacol Ther200827541242118081738
- AuguetTTerraXPorrasJAPlasma visfatin levels and gene expression in morbidly obese women with associated fatty liver diseaseClin Biochem201346320220823174488
- VidelaLAPettinelliPMisregulation of PPAR functioning and its pathogenic consequences associated with nonalcoholic fatty liver disease in human obesityPPAR Res2012201210743423304111
- OliverWRJrShenkJLSnaithMRA selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transportProc Natl Acad Sci U S A20019895306531111309497
- LiuSHatanoBZhaoMRole of peroxisome proliferator-activated receptor {delta}/{beta} in hepatic metabolic regulationJ Biol Chem201128621237124721059653
- RisérusUSprecherDJohnsonTActivation of peroxisome proliferator-activated receptor (PPAR)delta Promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese menDiabetes200857233233918024853
- OoiEMMWattsGFSprecherDLChanDCBarrettPHRMechanism of action of a peroxisome proliferator-activated receptor (PPAR)-delta agonist on lipoprotein metabolism in dyslipidemic subjects with central obesityJ Clin Endocrinol Metab20119610E1568E157621816786
- HaiderDGSchindlerKSchallerGPragerGWolztMLudvikBIncreased plasma visfatin concentrations in morbidly obese subjects are reduced after gastric bandingJ Clin Endocrinol Metab20069141578158116449335
- TackeFLueddeTTrautweinCInflammatory pathways in liver homeostasis and liver injuryClin Rev Allergy Immunol200936141218600481
- Neuschwander-TetriBAHepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: the central role of nontriglyceride fatty acid metabolitesHepatology201052277478820683968
- FuSYangLLiPAberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesityNature2011473734852853121532591
- RicchiMOdoardiMRCarulliLDifferential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytesJ Gastroenterol Hepatol200924583084019207680
- HanMSParkSYShinzawaKLysophosphatidylcholine as a death effector in the lipoapoptosis of hepatocytesJ Lipid Res2008491849717951222
- NolanCJLarterCZLipotoxicity: why do saturated fatty acids cause and monounsaturates protect against it?J Gastroenterol Hepatol200924570370619646010
- Orellana-GavaldaJMHerreroLMalandrinoMIMolecular therapy for obesity and diabetes based on a long-term increase in hepatic fatty-acid oxidationHepatology201153382183221319201
- EndoMMasakiTSeikeMYoshimatsuHTNF-alpha induces hepatic steatosis in mice by enhancing gene expression of sterol regulatory element binding protein-1c (SREBP-1c)Exp Biol Med (Maywood)2007232561462117463157
- FeldsteinAEWieckowskaALopezARLiuYCZeinNNMcCulloughAJCytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: a multicenter validation studyHepatology20095041072107819585618
- FeldsteinAENovel insights into the pathophysiology of nonalcoholic fatty liver diseaseSemin Liver Dis201030439140120960378
- AbdelmegeedMABanerjeeAYooSHCritical role of cytochrome P450 2E1 (CYP2E1) in the development of high fat-induced non-alcoholic steatohepatitisJ Hepatol201257486086622668639
- SethRKDasSKumarACYP2E1-dependent and leptin-mediated hepatic CD57 expression on CD8+ T cells aid progression of environment-linked nonalcoholic steatohepatitisToxicol Appl Pharmacol20142741425424211274
- DasSSethRKKumarAPurinergic receptor X7 is a key modulator of metabolic oxidative stress-mediated autophagy and inflammation in experimental nonalcoholic steatohepatitisAm J Physiol Gastrointest Liver Physiol201330512G950G96324157968
- Di MarzoVPiscitelliFMechoulamRCannabinoids and endocannabinoids in metabolic disorders with focus on diabetesHandb Exp Pharmacol20112037510421484568
- PacherPMechoulamRIs lipid signaling through cannabinoid 2 receptors part of a protective system?Prog Lipid Res201150219321121295074
- PacherPBátkaiSKunosGThe endocannabinoid system as an emerging target of pharmacotherapyPharmacol Rev200658338946216968947
- CotaDMarsicanoGTschapMThe endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesisJ Clin Invest2003112342343112897210
- Osei-HyiamanDDePetrilloMPacherPEndocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesityJ Clin Invest200511551298130515864349
- JeongWOsei-HyiamanDParkOParacrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liverCell Metab20087322723518316028
- MallatATeixeira-ClercFDeveauxVManinSLotersztajnSThe endocannabinoid system as a key mediator during liver diseases: new insights and therapeutic openingsBr J Pharmacol201116371432144021457226
- Osei-HyiamanDLiuJZhouLHepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in miceJ Clin Invest200811893160316918677409
- TamJVemuriVKLiuJPeripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesityJ Clin Invest201012082953296620664173
- Gary-BoboMElachouriGGallasJFRimonabant reduces obesity-associated hepatic steatosis and features of metabolic syndrome in obese Zucker fa/fa ratsHepatology200746112212917526015
- JourdanTDemizieuxLGrestiJAntagonism of peripheral hepatic cannabinoid receptor-1 improves liver lipid metabolism in mice: evidence from cultured explantsHepatology201255379079921987372
- JourdanTDjaoutiLDemizieuxLGrestiJVergèsBDegracePCB1 antagonism exerts specific molecular effects on visceral and subcutaneous fat and reverses liver steatosis in diet-induced obese miceDiabetes201059492693420110567
- ChandaDKimDKLiTCannabinoid receptor type 1 (CB1R) signaling regulates hepatic gluconeogenesis via induction of endoplasmic reticulum-bound transcription factor cAMP-responsive element-binding protein H (CREBH) in primary hepatocytesJ Biol Chem201128632279712797921693703
- HézodeCRoudot-ThoravalFNguyenSDaily cannabis smoking as a risk factor for progression of fibrosis in chronic hepatitis CHepatology2005421637115892090
- Muñoz-LuqueJRosJFernández-VaroGRegression of fibrosis after chronic stimulation of cannabinoid CB2 receptor in cirrhotic ratsJ Pharmacol Exp Ther2008324247548318029545
- Teixeira-ClercFJulienBGrenardPCB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosisNat Med200612667167616715087
- Van GaalLPi-SunyerXDesprésJPMcCarthyCScheenAEfficacy and safety of rimonabant for improvement of multiple cardiometabolic risk factors in overweight/obese patients: pooled 1-year data from the Rimonabant in Obesity (RIO) programDiabetes Care200831Suppl 2S229S24018227491