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ORIGINAL RESEARCH

The Relative Value of Anti-Obesity Medications Compared to Similar Therapies

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Pages 51-62 | Received 07 Oct 2022, Accepted 11 Jan 2023, Published online: 26 Jan 2023

References

  • Hales CM, Carroll MD, Fryar CD, Ogden CL. Prevalence of obesity and severe obesity among adults: United States, 2017–2018. NCHS. 2020;360:1–8.
  • Ward ZJ, Bleich SN, Cradock AL, et al. Projected U.S. State-level prevalence of adult obesity and severe obesity. N Engl J Med. 2019;381(25):2440–2450. doi:10.1056/NEJMsa1909301
  • Guh DP, Zhang W, Bansback N, Amarsi Z, Birmingham CL, Anis AH. The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis. BMC Public Health. 2009;9:88. doi:10.1186/1471-2458-9-88
  • Haase CL, Eriksen KT, Lopes S, Satylganova A, Schnecke V, McEwan P. Body mass index and risk of obesity-related conditions in a cohort of 2.9 million people: evidence from a UK primary care database. Obes Sci Pract. 2020;7(2):137–147. doi:10.1002/osp4.474
  • Li Q, Blume SW, Huang JC, Hammer M, Ganz ML. Prevalence and healthcare costs of obesity-related comorbidities: evidence from an electronic medical records system in the United States. J Med Econ. 2015;18(12):1020–1028. doi:10.3111/13696998.2015.1067623
  • Meurling IJ, Shea DO, Garvey JF. Obesity and sleep: a growing concern. Curr Opin Pulm Med. 2019;25(6):602–608. doi:10.1097/mcp.0000000000000627
  • Steele CB, Thomas CC, Henley SJ, et al. Vital signs: trends in incidence of cancers associated with overweight and obesity - United States, 2005–2014. MMWR Morb Mortal Wkly Rep. 2017;66(39):1052–1058. doi:10.15585/mmwr.mm6639e1
  • Cawley J, Biener A, Meyerhoefer C, et al. Direct medical costs of obesity in the United States and the most populous states. J Manag Care Spec Pharm. 2021;27(3):354–366. doi:10.18553/jmcp.2021.20410
  • Finkelstein EA, Trogdon JG, Cohen JW, Dietz W. Annual medical spending attributable to obesity: payer-and service-specific estimates. Health Aff. 2009;28(5):w822–W831. doi:10.1377/hlthaff.28.5.w822
  • Kamble PS, Hayden J, Collins J, et al. Association of obesity with healthcare resource utilization and costs in a commercial population. Curr Med Res Opin. 2018;34(7):1335–1343. doi:10.1080/03007995.2018.1464435
  • Kim DD, Basu A. Estimating the medical care costs of obesity in the United States: systematic review, meta-analysis, and empirical analysis. Value Health. 2016;19(5):602–613. doi:10.1016/j.jval.2016.02.008
  • Suehs BT, Kamble P, Huang J, et al. Association of obesity with healthcare utilization and costs in a Medicare population. Curr Med Res Opin. 2017;33(12):2173–2180. doi:10.1080/03007995.2017.1361915
  • Cawley J, Biener A, Meyerhoefer C, et al. Job absenteeism costs of obesity in the United States: National and State-level estimates. J Occup Environ Med. 2021;63(7):565–573. doi:10.1097/jom.0000000000002198
  • Finkelstein E, Fiebelkorn C, Wang G. The costs of obesity among full-time employees. Am J Health Promot. 2005;20(1):45–51. doi:10.4278/0890-1171-20.1.45
  • Finkelstein EA, DiBonaventura M, Burgess SM, Hale BC. The costs of obesity in the workplace. J Occup Environ Med. 2010;52(10):971–976. doi:10.1097/JOM.0b013e3181f274d2
  • Goetzel RZ, Gibson TB, Short ME, et al. A multi-worksite analysis of the relationships among body mass index, medical utilization, and worker productivity. J Occup Environ Med. 2010;52(Suppl1):S52–S58. doi:10.1097/JOM.0b013e3181c95b84
  • Howard JT, Potter LB. An assessment of the relationships between overweight, obesity, related chronic health conditions and worker absenteeism. Obes Res Clin Pract. 2014;8(1):e1–e15. doi:10.1016/j.orcp.2012.09.002
  • Kleinman N, Abouzaid S, Andersen L, Wang Z, Powers A. Cohort analysis assessing medical and nonmedical cost associated with obesity in the workplace. J Occup Environ Med. 2014;56(2):161–170. doi:10.1097/jom.0000000000000099
  • Waters H, Graf M. The costs of chronic disease in the U.S; 2018. Available from: https://milkeninstitute.org/sites/default/files/reports-pdf/ChronicDiseases-HighRes-FINAL.pdf. Accessed October 20, 2021.
  • Garvey WT, Mechanick JI, Brett EM, et al. American Association of Clinical Endocrinologists and American College of Endocrinology comprehensive clinical practice guidelines for medical care of patients with obesity. Endocr Pract. 2016;22(Suppl 3):1–203. doi:10.4158/ep161365.Gl
  • Jensen MD, Ryan DH, Apovian CM, et al. 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society. J Am Coll Cardiol. 2014;63(25):2985–3023. doi:10.1016/j.jacc.2013.11.004
  • Bailey-Davis L, Wood GC, Benotti P, et al. Impact of sustained weight loss on cardiometabolic outcomes. Am J Cardiol. 2022;162:66–72. doi:10.1016/j.amjcard.2021.09.018
  • Wood GC, Bailey-Davis L, Benotti P, et al. Effects of sustained weight loss on outcomes associated with obesity comorbidities and healthcare resource utilization. PLoS One. 2021;16(11):e0258545. doi:10.1371/journal.pone.0258545
  • Cawley J, Meyerhoefer C, Biener A, Hammer M, Wintfeld N. Savings in medical expenditures associated with reductions in body mass index among US Adults with obesity, by diabetes status. Pharmacoeconomics. 2015;33(7):707–722. doi:10.1007/s40273-014-0230-2
  • Ding Y, Fan X, Blanchette CM, Smolarz BG, Weng W, Ramasamy A. Economic value of non surgical weight loss in adults with obesity. J Manag Care Spec Pharm. 2021;27(1):37–50. doi:10.18553/jmcp.2020.20036
  • Douketis JD, Macie C, Thabane L, Williamson DF. Systematic review of long-term weight loss studies in obese adults: clinical significance and applicability to clinical practice. Int J Obes. 2005;29(10):1153–1167. doi:10.1038/sj.ijo.0802982
  • Ghanemi A, Yoshioka M, St-Amand J. Broken Energy homeostasis and obesity pathogenesis: the surrounding concepts. J Clin Med. 2018;7(11). doi:10.3390/jcm7110453
  • Wing RR, Phelan S. Long-term weight loss maintenance. Am J Clin Nutr. 2005;82(1Suppl):222s–225s. doi:10.1093/ajcn/82.1.222S
  • Wharton S, Lau DCW, Vallis M, et al. Obesity in adults: a clinical practice guideline. Can Med Assoc J. 2020;192(31):E875–E891. doi:10.1503/cmaj.191707
  • Bray GA, Ryan DH. Evidence-based weight loss interventions: individualized treatment options to maximize patient outcomes. Diabetes Obes Metab. 2021;23(Suppl 1):50–62. doi:10.1111/dom.14200
  • Friedrichsen M, Breitschaft A, Tadayon S, Wizert A, Skovgaard D. The effect of semaglutide 2.4 mg once weekly on energy intake, appetite, control of eating, and gastric emptying in adults with obesity. Diabetes Obes Metab. 2021;23(3):754–762. doi:10.1111/dom.14280
  • Khera R, Murad MH, Chandar AK, et al. Association of pharmacological treatments for obesity with weight loss and adverse events: a systematic review and meta-analysis. JAMA. 2016;315(22):2424–2434. doi:10.1001/jama.2016.7602
  • Wadden TA, Bailey TS, Billings LK, et al. Effect of subcutaneous semaglutide vs placebo as an adjunct to intensive behavioral therapy on body weight in adults with overweight or obesity: the STEP 3 randomized clinical trial. JAMA. 2021;325(14):1403–1413. doi:10.1001/jama.2021.1831
  • Franz MJ, VanWormer JJ, Crain AL, et al. Weight-loss outcomes: a systematic review and meta-analysis of weight-loss clinical trials with a minimum 1-year follow-up. J Am Diet Assoc. 2007;107(10):1755–1767. doi:10.1016/j.jada.2007.07.017
  • Gadde KM, Allison DB, Ryan DH, et al. Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): a randomised, placebo-controlled, Phase 3 trial. Lancet. 2011;377(9774):1341–1352. doi:10.1016/s0140-6736(11)60205-5
  • Greenway FL, Fujioka K, Plodkowski RA, et al. Effect of naltrexone plus bupropion on weight loss in overweight and obese adults (COR-I): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2010;376(9741):595–605. doi:10.1016/s0140-6736(10)60888-4
  • Pi-Sunyer X, Astrup A, Fujioka K, et al. A randomized, controlled trial of 3.0 mg of liraglutide in weight management. NEJM. 2015;373(1):11–22. doi:10.1056/NEJMoa1411892
  • Ara R, Blake L, Gray L, et al. What is the clinical effectiveness and cost-effectiveness of using drugs in treating obese patients in primary care? A systematic review. Health Technol Assess. 2012;16(5):iii–xiv, 1–195. doi:10.3310/hta16050
  • Lacey LA, Wolf A, O’Shea D, Erny S, Ruof J. Cost-effectiveness of orlistat for the treatment of overweight and obese patients in Ireland. Int J Obes. 2005;29(8):975–982. doi:10.1038/sj.ijo.0802947
  • Neovius M, Narbro K. Cost-effectiveness of pharmacological anti-obesity treatments: a systematic review. Int J Obes. 2008;32(12):1752–1763. doi:10.1038/ijo.2008.189
  • Zohrabian A. Clinical and economic considerations of antiobesity treatment: a review of orlistat. Clinicoecon Outcomes Res. 2010;2:63–74. doi:10.2147/ceor.s5101
  • Greenway FL, Ryan DH, Bray GA, Rood JC, Tucker EW, Smith SR. Pharmaceutical cost savings of treating obesity with weight loss medications. Obes Res. 1999;7(6):523–531. doi:10.1002/j.1550-8528.1999.tb00709.x
  • Ciciurkaite G, Moloney ME, Brown RL. The incomplete medicalization of obesity: physician office visits, diagnoses, and treatments, 1996–2014. Public Health Rep. 2019;134(2):141–149. doi:10.1177/0033354918813102
  • Hampp C, Kang EM, Borders-Hemphill V. Use of prescription antiobesity drugs in the United States. Pharmacotherapy. 2013;33(12):1299–1307. doi:10.1002/phar.1342
  • MacEwan J, Kan H, Chiu K, Poon JL, Shinde S, Ahmad NN. Antiobesity medication use among overweight and obese adults in the United States: 2015–2018. Endocr Pract. 2021;27(11):1139–1148. doi:10.1016/j.eprac.2021.07.004
  • Samaranayake NR, Ong KL, Leung RY, Cheung BM. Management of obesity in the National Health and Nutrition Examination Survey (NHANES), 2007–2008. Ann Epidemiol. 2012;22(5):349–353. doi:10.1016/j.annepidem.2012.01.001
  • Saxon DR, Iwamoto SJ, Mettenbrink CJ, et al. Antiobesity medication use in 2.2 million adults across eight large health care organizations: 2009–2015. Obesity. 2019;27(12):1975–1981. doi:10.1002/oby.22581
  • Xia Y, Kelton CML, Guo JJ, Bian B, Heaton PC. Treatment of obesity: pharmacotherapy trends in the United States from 1999 to 2010. Obesity. 2015;23(8):1721–1728. doi:10.1002/oby.21136
  • Baum C, Andino K, Wittbrodt E, Stewart S, Szymanski K, Turpin R. The challenges and opportunities associated with reimbursement for obesity pharmacotherapy in the USA. Pharmacoeconomics. 2015;33(7):643–653. doi:10.1007/s40273-015-0264-0
  • Bessesen DH, Van Gaal LF. Progress and challenges in anti-obesity pharmacotherapy. Lancet Diabetes Endocrinol. 2018;6(3):237–248. doi:10.1016/s2213-8587(17)30236-x
  • Gomez G, Stanford FC. US health policy and prescription drug coverage of FDA-approved medications for the treatment of obesity. Int J Obes. 2018;42(3):495–500. doi:10.1038/ijo.2017.287
  • Jannah N, Hild J, Gallagher C, Dietz W. Coverage for obesity prevention and treatment services: analysis of Medicaid and state employee health insurance programs. Obesity. 2018;26(12):1834–1840. doi:10.1002/oby.22307
  • IQVIA Insitute. IQVIA SMART internal database; 2022.
  • Kabiri M, Sexton Ward A, Ramasamy A, et al. The societal value of broader access to antiobesity medications. Obesity. 2020;28(2):429–436. doi:10.1002/oby.22696
  • Health Action Council (UnitedHealth Care U, OptumRx). Finding the uncommon: revealing disparities in care and prescribing for common conditions; 2021. Available from: https://healthactioncouncil.org/getmedia/cd194241-db0a-4db0-81c9-cfedc980b3f5/HAC-White-Paper.pdf. Accessed January 12, 2023.
  • Evernorth. Drug trend report; 2020. Available from: https://www.evernorth.com/drug-trend-report. Accessed January 12, 2023.
  • IQVIA Insitute. Medicine spending and affordability in the United States: understanding patients’ costs for medicines; 2020. Available from: https://www.iqvia.com/insights/the-iqvia-institute/reports/medicine-spending-and-affordability-in-the-us. Accessed January 12, 2023.
  • Blue Cross Blue Shield Association and Blue Health Intelligence. Prescription drug costs trend update; 2018. Available from: https://www.bcbs.com/sites/default/files/file-attachments/health-of-america-report/HoA-Rx-Costs-Trend-Update.pdf. Accessed January 12, 2023.
  • IngenioRx. Taking a total view: linking pharmacy + medical drug trends. Commercial Report; 2017. Available from: https://uploads-ssl.webflow.com/59d2aa5c83887e00019716cc/5aec7315d0dbd43962508a77_2017%20Total%20View%20Drug%20Trend%20Report20180504.pdf. Accessed January 1, 2023.
  • Kaiser Family Foundation. How does prescription drug spending and use compare across large employer plans, medicare part D, and Medicaid?; 2019. Available from: https://www.kff.org/medicare/issue-brief/how-does-prescription-drug-spending-and-use-compare-across-large-employer-plans-medicare-part-d-and-medicaid/. Accessed January 12, 2023.
  • Kaiser Family Foundation. 2020 employer health benefits survey; 2020. Available from: https://files.kff.org/attachment/Report-Employer-Health-Benefits-2020-Annual-Survey.pdf. Accessed January 12, 2023.
  • Centers for Disease Control and Prevention (CDC). Health-Plan and employer-based wellness programs to reduce diabetes risk: the Kaiser Permanente Northern California NEXT-D study; 2013. Available from: https://www.cdc.gov/pcd/issues/2013/pdf/12_0146.pdf. Accessed January 12, 2023.
  • Abraham JM, Feldman R, Nyman JA, Barleen N. What factors influence participation in an exercise-focused, employer-based wellness program? INQUIRY. 2011;48(3):221–241. doi:10.5034/inquiryjrnl_48.03.01
  • Rubino D, Abrahamsson N, Davies M, et al. Effect of continued weekly subcutaneous semaglutide vs placebo on weight loss maintenance in adults with overweight or obesity: the STEP 4 randomized clinical trial. JAMA. 2021;325(14):1414–1425. doi:10.1001/jama.2021.3224
  • Kolla BP, He JP, Mansukhani MP, Frye MA, Merikangas K. Excessive sleepiness and associated symptoms in the U.S. adult population: prevalence, correlates, and comorbidity. Sleep Health. 2020;6(1):79–87. doi:10.1016/j.sleh.2019.09.004
  • Olesen J, Dodick DW, Ducros A, et al. Headache classification committee of the International Headache Society (IHS). The international classification of headache disorders, 3rd edition. Cephalalgia. 2018;38(1):1–211. doi:10.1177/0333102417738202
  • Wolfe F, Smythe HA, Yunus MB, et al. The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. Report of the multicenter criteria committee. Arthritis Rheum. 1990;33(2):160–172. doi:10.1002/art.1780330203
  • Burke MV, Hays JT, Ebbert JO. Varenicline for smoking cessation: a narrative review of efficacy, adverse effects, use in at-risk populations, and adherence. Patient Prefer Adherence. 2016;10:435–441. doi:10.2147/PPA.S83469
  • Tonstad S, Arons C, Rollema H, et al. Varenicline: mode of action, efficacy, safety and accumulated experience salient for clinical populations. Curr Med Res Opin. 2020;36(5):713–730. doi:10.1080/03007995.2020.1729708
  • Chapman JL, Kempler L, Chang CL, et al. Modafinil improves daytime sleepiness in patients with mild to moderate obstructive sleep apnoea not using standard treatments: a randomised placebo-controlled crossover trial. Thorax. 2014;69(3):274. doi:10.1136/thoraxjnl-2013-203796
  • Golicki D, Bala MM, Niewada M, Wierzbicka A. Modafinil for narcolepsy: systematic review and meta-analysis. Med Sci Monit. 2010;16(8):Ra177–Ra186.
  • Goadsby PJ, Reuter U, Lanteri-Minet M, et al. Long-term efficacy and safety of erenumab. Neurology. 2021;96(22):e2724. doi:10.1212/WNL.0000000000012029
  • Ornello R, Casalena A, Frattale I, et al. Real-life data on the efficacy and safety of erenumab in the Abruzzo region, central Italy. J Headache Pain. 2020;21(1):32. doi:10.1186/s10194-020-01102-9
  • Reuter U, Ehrlich M, Gendolla A, et al. Erenumab versus topiramate for the prevention of migraine - a randomised, double-blind, active-controlled Phase 4 trial. Cephalalgia. 2022;42(2):108–118. doi:10.1177/03331024211053571
  • Bhusal S, Diomampo S, Magrey MN. Clinical utility, safety, and efficacy of pregabalin in the treatment of fibromyalgia. Drug Healthc Patient Saf. 2016;8:13–23. doi:10.2147/DHPS.S95535
  • Derry S, Cording M, Wiffen PJ, Law S, Phillips T, Moore RA. Pregabalin for pain in fibromyalgia in adults. Cochrane Database Syst Rev. 2016;9(9):Cd011790. doi:10.1002/14651858.CD011790.pub2
  • Straube S, Derry S, Moore RA, McQuay HJ. Pregabalin in fibromyalgia: meta-analysis of efficacy and safety from company clinical trial reports. Rheumatology. 2010;49(4):706–715. doi:10.1093/rheumatology/kep432
  • Suehs BT, Davis C, Galaznik A, Joshi AV, Zou KH, Patel NC. Association of out-of-pocket pharmacy costs with adherence to varenicline. J Manag Care Spec Pharm. 2014;20(6):592–600. doi:10.18553/jmcp.2014.20.6.592
  • Yue X, Guo JJ, Wigle PR. Trends in utilization, spending, and prices of smoking-cessation medications in Medicaid programs: 25 Years Empirical Data Analysis, 1991–2015. Am Health Drug Benefits. 2018;11(6):275–285.
  • Zeng F, Chen CI, Mastey V, Zou KH, Harnett J, Patel BV. Effects of copayment on initiation of smoking cessation pharmacotherapy: an analysis of varenicline reversed claims. Clin Ther. 2011;33(2):225–234. doi:10.1016/j.clinthera.2011.02.013
  • Hypersomnia Foundation. Our struggle for prescription drug coverage – 2019 survey results. Available from: https://www.hypersomniafoundation.org/our-struggle-for-prescription-drug-coverage-2019-survey-results/. Accessed March 9, 2022.
  • Beasley D. Amgen’s new migraine drug hits insurance hurdles. Reuters. Available from: https://www.reuters.com/article/us-amgen-pricing-migraine/amgens-new-migraine-drug-hits-insurance-hurdles-idUSKBN1KG0CT. Accessed March 9, 2022.
  • Pearson SD, Beinfeld M, Fluetsch N, Grady M, Shah K, Emond SK. Assessment of barriers to fair access; 2021. Available from: https://icer.org/wp-content/uploads/2021/05/Barriers-to-Fair-Access-Assessment-Final-Report-120121.pdf. Accessed January 12, 2023.
  • Tepper DE. Calcitonin gene-related protein (CGRP)-targeted treatments for migraine prevention. Headache. 2019;59(3):477–480. doi:10.1111/head.13492
  • Stacey BR, Liss J, Behar R, et al. A systematic review of the effectiveness of policies restricting access to pregabalin. BMC Health Serv Res. 2017;17(1):600. doi:10.1186/s12913-017-2503-x
  • Barnett PG, Ignacio RV, Kim HM, et al. Cost-effectiveness of real-world administration of tobacco pharmacotherapy in the United States Veterans Health Administration. Addiction. 2019;114(8):1436–1445. doi:10.1111/add.14621
  • Lee LJ, Li Q, Bruno M, et al. Healthcare costs of smokers using varenicline versus nicotine-replacement therapy patch in the United States: evidence from real-world practice. Adv Ther. 2019;36(2):365–380. doi:10.1007/s12325-018-0858-y
  • Lipton RB, Brennan A, Palmer S, et al. Estimating the clinical effectiveness and value-based price range of erenumab for the prevention of migraine in patients with prior treatment failures: a US societal perspective. J Med Econ. 2018;21(7):666–675. doi:10.1080/13696998.2018.1457533
  • Sussman M, Benner J, Neumann P, Menzin J. Cost-effectiveness analysis of erenumab for the preventive treatment of episodic and chronic migraine: results from the US societal and payer perspectives. Cephalalgia. 2018;38(10):1644–1657. doi:10.1177/0333102418796842
  • Lloyd A, Boomershine CS, Choy EH, Chandran A, Zlateva G. The cost-effectiveness of pregabalin in the treatment of fibromyalgia: US perspective. J Med Econ. 2012;15(3):481–492. doi:10.3111/13696998.2012.660254
  • Skaer TL. Fibromyalgia: disease synopsis, medication cost effectiveness and economic burden. Pharmacoeconomics. 2014;32(5):457–466. doi:10.1007/s40273-014-0137-y
  • Burch R, Rizzoli P, Loder E. The prevalence and impact of migraine and severe headache in the United States: figures and trends from government health studies. Headache. 2018;58(4):496–505. doi:10.1111/head.13281
  • Centers for Disease Control and Prevention (CDC). Smoking and tobacco use. Available from: https://www.cdc.gov/tobacco/data_statistics/index.htm. Accessed May 25, 2021.
  • National Fibromyalgia Association. Fibromyalgia Prevalence. Available from: https://www.fmaware.org/fibromyalgia-prevalence/. Accessed May 27, 2021.
  • Bonafede M, Sapra S, Shah N, Tepper S, Cappell K, Desai P. Direct and indirect healthcare resource utilization and costs among migraine patients in the United States. Headache. 2018;58(5):700–714. doi:10.1111/head.13275
  • Rojewski AM, Baldassarri S, Cooperman NA, et al. Exploring issues of comorbid conditions in people who smoke. Nicotine Tob Res. 2016;18(8):1684–1696. doi:10.1093/ntr/ntw016
  • Benca RM. Narcolepsy and excessive daytime sleepiness: diagnostic considerations, epidemiology, and comorbidities. J Clin Psychiatry. 2007;68(Suppl 13):5–8.
  • Kim SC, Landon JE, Solomon DH. Clinical characteristics and medication uses among fibromyalgia patients newly prescribed amitriptyline, duloxetine, gabapentin, or pregabalin. Arthritis Care Res. 2013;65(11):1813–1819. doi:10.1002/acr.22071
  • Pfizer Inc. Chantix: package insert; 2019.
  • Pfizer Inc. Lyrica: package insert; 2020.
  • Amgen, Inc. Aimovig: package insert; 2021.
  • Teva Pharmaceuticas USA, Inc. Provigil: package insert; 2015.
  • IQVIA. US claims–IQVIA PharMetrics Plus. Available from: https://www.iqvia.com/library/fact-sheets/iqvia-pharmetrics-plus. Accessed March 7, 2022.
  • Dee A, Kearns K, O’Neill C, et al. The direct and indirect costs of both overweight and obesity: a systematic review. BMC Res Notes. 2014;7:242. doi:10.1186/1756-0500-7-242
  • Frech FQC, Gore M, Zhang Q. Cost implications of early treatment initiation among patients with newly diagnosed fibromyalgia. Am J Pharm Benefits. 2017;9(6):200–207.
  • Walitt B, Nahin RL, Katz RS, Bergman MJ, Wolfe F. The prevalence and characteristics of fibromyalgia in the 2012 National Health Interview Survey. PLoS One. 2015;10(9):e0138024–e0138024. doi:10.1371/journal.pone.0138024
  • Tepper SJ, Fang J, Vo P, et al. Impact of erenumab on acute medication usage and health care resource utilization among migraine patients: a US claims database study. J Headache Pain. 2021;22(1):27. doi:10.1186/s10194-021-01238-2
  • Yucel A, Thach A, Kumar S, Loden C, Bensink M, Goldfarb N. Estimating the economic burden of migraine on US employers. Am J Manag Care. 2020;26(12):e403–e408. doi:10.37765/ajmc.2020.88547
  • Knauert M, Naik S, Gillespie MB, Kryger M. Clinical consequences and economic costs of untreated obstructive sleep apnea syndrome. World J Otorhinolaryngol Head Neck Surg. 2015;1(1):17–27. doi:10.1016/j.wjorl.2015.08.001
  • Sassani A, Findley LJ, Kryger M, Goldlust E, George C, Davidson TM. Reducing motor-vehicle collisions, costs, and fatalities by treating obstructive sleep apnea syndrome. Sleep. 2004;27(3):453–458. doi:10.1093/sleep/27.3.453
  • Carlton RR, Lunascek T, Dammerman O. Healthcare resource utilization before and after initiation of armodafinil treatment for wakefulness. Sleep. 2011;34:5.
  • Faust E, Pivneva I, Yang K, et al. Real-world treatment profiles, clinical outcomes, and healthcare resource utilization of patients with migraine prescribed erenumab: a multicenter chart-review study of US headache centers. Neurol Ther. 2021;10(1):293–306. doi:10.1007/s40120-021-00245-4
  • Harnett J, Margolis J, Cao Z, et al. Real-world evaluation of health-care resource utilization and costs in employees with fibromyalgia treated with pregabalin or duloxetine. Pain Pract. 2011;11(3):217–229. doi:10.1111/j.1533-2500.2010.00440.x
  • Gartner Glossary. Small and Midsize Business (SMB). Available from: https://www.gartner.com/en/information-technology/glossary/smbs-small-and-midsize-businesses. Accessed March 8, 2022.
  • U.S. Bureau of Labor Statistics. Occupational employment and wage statistics. Available from: https://www.bls.gov/oes/current/oes_nat.htm. Accessed May 25, 2021.
  • Bilger M, Finkelstein EA, Kruger E, Tate DF, Linnan LA. The effect of weight loss on health, productivity, and medical expenditures among overweight employees. Med Care. 2013;51(6):471–477. doi:10.1097/MLR.0b013e318286e437
  • Kolotkin RL, Gabriel Smolarz B, Meincke HH, Fujioka K. Improvements in health-related quality of life over 3 years with liraglutide 3.0 mg compared with placebo in participants with overweight or obesity. Clin Obes. 2018;8(1):1–10. doi:10.1111/cob.12226
  • Managed Markets Insight & Technology LLC. Formulary Lookup; 2021. Available from: www.formularylookup.com. Accessed June 16, 2021.
  • National Institute for Health and Care Excellence (NICE). NICE recommends new drug for people living with obesity. Available from: https://www.nice.org.uk/news/article/nice-recommends-new-drug-for-people-living-with-obesity. Accessed March 10, 2022.
  • Halpern MT, Shikiar R, Rentz AM, Khan ZM. Impact of smoking status on workplace absenteeism and productivity. Tob Control. 2001;10(3):233–238. doi:10.1136/tc.10.3.233
  • Reynolds AC, Appleton SL, Gill TK, et al. Sickness absenteeism is associated with sleep problems independent of sleep disorders: results of the 2016 Sleep Health Foundation national survey. Sleep Health. 2017;3(5):357–361. doi:10.1016/j.sleh.2017.06.003
  • Michel P, Dartigues JF, Duru G, Moreau J, Salamon R, Henry P. Incremental absenteeism due to headaches in migraine: results from the Mig-Access French national cohort. Cephalalgia. 1999;19(5):503–510. doi:10.1046/j.1468-2982.1999.019005503.x
  • Chandran A, Schaefer C, Ryan K, Baik R, McNett M, Zlateva G. The comparative economic burden of mild, moderate, and severe fibromyalgia: results from a retrospective chart review and cross-sectional survey of working-age U.S. adults. J Manag Care Pharm. 2012;18(6):415–426. doi:10.18553/jmcp.2012.18.6.415