References
- PassarinoGDe RangoFMontesantoAHuman longevity: genetics or lifestyle? It takes two to tangoImmun Ageing201613121727053941
- CarmonaJJMichanSBiology of healthy aging and longevityRev Invest Clin201668171627028172
- KenyonCJThe genetics of ageingNature201046450451220336132
- Lopez-OtinCBlascoMAPartridgeLSerranoMKroemerGThe hallmarks of agingCell20131531194121723746838
- KennedyBKBergerSLBrunetAGeroscience: linking aging to chronic diseaseCell201415970971325417146
- Lopez-LluchGNavasPCalorie restriction as an intervention in agingJ Physiol201659482043206026607973
- FontanaLModulating human aging and age-associated diseasesBiochim Biophys Acta20091790101133113819364477
- MostJTostiVRedmanLMFontanaLCalorie restriction in humans: an updateAgeing Res Rev201739364527544442
- SinclairDAToward a unified theory of caloric restriction and longevity regulationMech Ageing Dev2005126987100215893363
- MattsonMPDietary factors, hormesis and healthAgeing Res Rev20087434817913594
- RattanSIHormesis in agingAgeing Res Rev20087637817964227
- MartinsIGalluzziLKroemerGHormesis, cell death and agingAging (Albany NY)2011382182821931183
- TestaGBiasiFPoliGChiarpottoECalorie restriction and dietary restriction mimetics: a strategy for improving healthy aging and longevityCurr Pharm Des2014202950297724079773
- SlonakerJRThe effect of different per cents of protein in the diet VII. Life span and cause of deathAm J Physiol19312266275
- McCayCMCrowellMFMaynardLAThe effect of retarded growth upon the length of life and upon the ultimate body sizeJ Nutr1935106379
- MasoroESubfield history: caloric restriction, slowing aging, and extending lifeSci Aging Knowledge Environ200320038RE212844547
- MairWPiperMDPartridgeLCalories do not explain extension of life span by dietary restriction in DrosophilaPLoS Biol20053e22316000018
- PiperMDPartridgeLDietary restriction in Drosophila: delayed aging or experimental artefact?PLoS Genet2007273e57
- RaubenheimerDSimpsonSJMayntzDNutrition, ecology and nutritional ecology: toward an integrated frameworkFunct Ecol200923416
- PiperMDPartridgeLRaubenheimerDSimpsonSJDietary restriction and aging: a unifying perspectiveCell Metab20111415416021803286
- SimpsonSJRaubenheimerDA multilevel analysis of feeding-behavior – the geometry of nutritional decisionsPhilos Trans R Soc Lond Ser B Biol Sci1993342381402
- SimpsonSJRaubenheimerDCaloric restriction and aging revisited: the need for a geometric analysis of the nutritional bases of agingJ Gerontol A Biol Sci Med Sci20076270771317634316
- RaubenheimerDSimpsonSJTaitAHMatch and mismatch: conservation, physiology, nutritional ecology and the timescales of biological adaptationPhilos Trans R Soc Lond Ser B Biol Sci20123671628164622566672
- Solon-BietSMMcMahonACBallardJWThe ratio of macro-nutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed miceCell Metab20141941843024606899
- LusseauDMitchellSEBarrosCThe effects of graded levels of calorie restriction: IV. Non-linear change in behavioural phenotype of mice in response to short-term calorie restrictionSci Rep201551319826306002
- TaorminaGMirisolaMGCalorie restriction in mammals and simple model organismsBiomed Res Int2014201430869024883306
- SpeakmanJRMitchellSEMazidiMCalories or protein? The effect of dietary restriction on lifespan in rodents is explained by calories aloneExp Gerontol201686283827006163
- SimpsonSJLe CouteurDGRaubenheimerDDietary protein, aging and nutritional geometryAgeing Res Rev201739788628274839
- Le CouteurDGSolon-BietSCoggerVCThe impact of low protein, high carbohydrate diets on aging and lifespanCell Mol Life Sci2016731237125226718486
- NakagawaSLagiszMHectorKLSpencerHGComparative and meta-analytic insights into life-extension via dietary restrictionAging Cell20121140140922268691
- KapahiPKaeberleinMHansenMDietary restriction and lifespan: lessons from invertebrate modelsAgeing Res Rev20173931428007498
- LushchakOStrilbytskaOPiskovatskaVStoreyKBKoliadaAVaisermanAThe role of the TOR pathway in mediating the link between nutrition and longevityMech Ageing Dev201716412713828315697
- ZainalTAOberleyTDAllisonDBSzwedaLIWeindruchRCaloric restriction of rhesus monkeys lowers oxidative damage in skeletal muscleFASEB J200014121825183610973932
- BlackAAllisonDBShapsesSACalorie restriction and skeletal mass in rhesus monkeys (Macaca mulatta): evidence for an effect mediated through changes in body sizeJ Gerontol A Biol Sci Med Sci2001563B98B10711253152
- MattisonJARothGSBeasleyTMImpact of caloric restriction on health and survival in rhesus monkeys from the NIA studyNature201248931832122932268
- ColmanRJBeasleyTMKemnitzJWJohnsonSCWeindruchRAndersonRMCaloric restriction reduces age-related and all-cause mortality in rhesus monkeysNat Commun20145355724691430
- Velthuis-te WierikEJWesterterpKRvan den BergHImpact of a moderately energy-restricted diet on energy metabolism and body composition in non-obese menInt J Obes Relat Metab Disord1995193183247647823
- Velthuis-te WierikEJvan den BergHSchaafsmaGHendriksHFBrouwerAEnergy restriction, a useful intervention to retard human ageing? Results of a feasibility studyEur J Clin Nutr1994481381488194495
- Velthuis-te WierikEJvan LeeuwenREHendriksHFShort-term moderate energy restriction does not affect indicators of oxidative stress and genotoxicity in humansJ Nutr1995125263126397562100
- DasSKGilhoolyCHGoldenJKLong-term effects of 2 energy-restricted diets differing in glycemic load on dietary adherence, body composition, and metabolism in CALERIE: a 1-y randomized controlled trialAm J Clin Nutr2007851023103017413101
- HeilbronnLKde JongeLFrisardMIEffect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trialJAMA20062951539154816595757
- RacetteSBWeissEPVillarealDTOne year of caloric restriction in humans: feasibility and effects on body composition and abdominal adipose tissueJ Gerontol Ser A Biol Sci Med Sci20066194395016960025
- Larson-MeyerDEHeilbronnLKRedmanLMEffect of calorie restriction with or without exercise on insulin sensitivity, beta-cell function, fat cell size, and ectopic lipid in overweight subjectsDiabetes Care2006291337134416732018
- LefevreMRedmanLMHeilbronnLKCaloric restriction alone and with exercise improves CVD risk in healthy non-obese individualsAtherosclerosis200920320621318602635
- CivitareseAECarlingSHeilbronnLKCalorie restriction increases muscle mitochondrial biogenesis in healthy humansPLoS Med20074e7617341128
- RochonJBalesCWRavussinEDesign and conduct of the CALERIE study: comprehensive assessment of the long-term effects of reducing intake of energyJ Gerontol Ser A Biol Sci Med Sci2011669710820923909
- FontanaLVillarealDTWeissEPCalorie restriction or exercise: effects on coronary heart disease risk factors. A randomized: controlled trialAm J Physiol Endocrinol Metab2007293E197E20217389710
- WeissEPRacetteSBVillarealDTImprovements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trialAm J Clin Nutr2006841033104217093155
- RavussinERedmanLMRochonJA 2-year randomized controlled trial of human caloric restriction: feasibility and effects on predictors of health span and longevityJ Gerontol Ser A Biol Sci Med Sci2015701097110426187233
- FontanaLMeyerTEKleinSHolloszyJOLong-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humansProc Natl Acad Sci U S A20041016659666315096581
- MeyerTEKovacsSJEhsaniAAKleinSHolloszyJOFontanaLLong-term caloric restriction ameliorates the decline in diastolic function in humansJ Am Coll Cardiol20064739840216412867
- FontanaLKleinSHolloszyJOEffects of long-term calorie restriction and endurance exercise on glucose tolerance, insulin action, and adipokine productionAge2010329710819904628
- SteinPKSoareAMeyerTECangemiRHolloszyJOFontanaLCaloric restriction may reverse age-related autonomic decline in humansAging Cell20121164465022510429
- MartinCKAntonSDHanHExamination of cognitive function during six months of calorie restriction: results of a randomized controlled trialRejuvenation Res20071017919017518698
- VillarealDTFontanaLDasSKEffect of two-year caloric restriction on bone metabolism and bone mineral density in non-obese younger adults: a randomized clinical trialJ Bone Miner Res201631405126332798
- KaluDNHardinRRCockerhamRYuBPNorlingBKEganJWLifelong food restriction prevents senile osteopenia and hyperparathyroidism in F344 ratsMech Ageing Dev1984261031126748753
- LuTPanYKaoS-YGene regulation and DNA damage in the ageing human brainNature200442988389115190254
- VeraEBernardes de JesusBForondaMFloresJMBlascoMATelomerase reverse transcriptase synergizes with calorie restriction to increase health span and extend mouse longevityPLoS One20138e5376023349740
- BenayounBAPollinaEABrunetAEpigenetic regulation of ageing: linking environmental inputs to genomic stabilityNat Rev Mol Cell Biol20151659361026373265
- FontanaLPartridgeLPromoting health and longevity through diet: from model organisms to humansCell201516110611825815989
- TaylorRCDillinAAging as an event of proteostasis collapseCold Spring Harb Perspect Biol20113a00444
- DokladnyKZuhlMNMandellMRegulatory coordination between two major intracellular homeostatic systems: heat shock response and autophagyJ Biol Chem2013288149591497223576438
- PesceVCormioAFracassoFAge-related mitochondrial genotypic and phenotypic alterations in human skeletal muscleFree Radic Biol Med200130111223123311368920
- LezzaAMFallacaraFPPesceVLeeuwenburghCCantatorePGadaletaMNLocalization of abasic sites and single-strand breaks in mitochondrial DNA from brain of aged rat, treated or not with caloric restriction dietNeurochem Res200833122609261418946734
- ChistiakovDASobeninIARevinVVOrekhovANBobryshevYVMitochondrial aging and age-related dysfunction of mitochondriaBiomed Res Int2014201423846324818134
- PiccaAPesceVFracassoFJosephAMLeeuwenburghCLezzaAMAging and calorie restriction oppositely affect mitochondrial biogenesis through TFAM binding at both origins of mitochondrial DNA replication in rat liverPLoS One201389e7464424058615
- PiccaAFracassoFPesceVAge- and calorie restriction-related changes in rat brain mitochondrial DNA and TFAM bindingAge (Dordr)20133551607162022945739
- PiccaALezzaAMRegulation of mitochondrial biogenesis through TFAM-mitochondrial DNA interactions: useful insights from aging and calorie restriction studiesMitochondrion20152511677526437364
- RugarliETrifunovicAIs mitochondrial free radical theory of aging getting old?Biochim Biophys Acta20151847111345134626282072
- PiccaAPesceVSiragoGFracassoFLeeuwenburghCLezzaAM“What makes some rats live so long?” The mitochondrial contribution to longevity through balance of mitochondrial dynamics and mtDNA contentExp Gerontol20168512334027620821
- RistowMSchmeisserSExtending life span by increasing oxidative stressFree Radic Biol Med20115132733621619928
- BarjaGThe mitochondrial free radical theory of agingProg Mol Biol Transl Sci201412712725149212
- YuBPMembrane alteration as a basis of aging and the protective effects of calorie restrictionMech Ageing Dev20051261003101015893361
- Lopez-DominguezJARamseyJJTranDThe influence of dietary fat source on life span in calorie restricted miceJ Gerontol A Biol Sci Med Sci2015701181118825313149
- GenovaMLLenazGThe interplay between respiratory supercomplexes and ROS in agingAntioxid Redox Signal20152320823825711676
- KwonJHanEBuiCBAssurance of mitochondrial integrity and mammalian longevity by the p62-Keap1-Nrf2-Nqo1 cascadeEMBO Rep20121315015622222206
- HyunDHEmersonSSJoDGMattsonMPde CaboRCalorie restriction up-regulates the plasma membrane redox system in brain cells and suppresses oxidative stress during agingProc Natl Acad Sci U S A2006103199081991217167053
- Rodriguez-BiesENavasPLopez-LluchGAge-dependent effect of every-other-day feeding and aerobic exercise in ubiquinone levels and related antioxidant activities in mice muscleJ Gerontol A Biol Sci Med Sci201570334324496576
- ShortKRBigelowMLKahlJDecline in skeletal muscle mitochondrial function with aging in humansProc Natl Acad Sci U S A20051025618562315800038
- FeigeJNLagougeMAuwerxJDietary manipulation of mouse metabolismCurr Protoc Mol Biol200866 Chapter 29:Unit 29B.5
- BaurJAChenDChiniENDietary restriction: standing up for sirtuinsScience20103291012101320798296
- PiccaAPesceVFracassoFJosephA-MLeeuwenburghCLezzaAMSA comparison among the tissue-specific effects of aging and calorie restriction on TFAM amount and TFAM-binding activity to mtDNA in ratBiochim Biophys Acta201418402184219124631828
- NisoliETonelloCCardileACalorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOSScience200531031431716224023
- MattagajasinghIKimCSNaqviASIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthaseProc Natl Acad Sci U S A2007104148551486017785417
- HandschinCSpiegelmanBMPeroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolismEndocr Rev20062772873517018837
- RuetenikABarrientosADietary restriction, mitochondrial function and aging: from yeast to humansBiochim Biophys Acta201518471434144725979234
- Martin-MontalvoAde CaboRMitochondrial metabolic reprogramming induced by calorie restrictionAntioxid Redox Signal20131931032022901095
- NemotoSFergussonMMFinkelTSIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1αJ Biol Chem2005280164561646015716268
- JagerSHandschinCSt-PierreJSpiegelmanBMAMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alphaProc Natl Acad Sci U S A2007104120171202217609368
- Lopez-LluchGIrustaPMNavasPde CaboRMitochondrial biogenesis and healthy agingExp Gerontol20084381381918662766
- WeberTAReichertASImpaired quality control of mitochondria: aging from a new perspectiveExp Gerontol20104550351120451598
- ProllaTAMattsonMPMolecular mechanisms of brain aging and neurodegenerative disorders: lessons from dietary restrictionTrends Neurosci20012411 SupplS21S3111881742
- GhoshSWandersDStoneKPVanNTCortezCCGettysTWA systems biology analysis of the unique and overlapping transcriptional responses to caloric restriction and dietary methionine restriction in ratsFASEB J20142862577259024571921
- FieldAEAdamsPDTargeting chromatin aging – the epigenetic impact of longevity-associated interventionsExp Gerontol2017948293327986499
- GutPVerdinEThe nexus of chromatin regulation and intermediary metabolismNature201350248949824153302
- RakyanVKDownTAMaslauSHuman aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domainsGenome Res20102043443920219945
- KimCHLeeEKChoiYJShort-term calorie restriction ameliorates genome wide, age-related alterations in DNA methylationAging Cell20161510741081
- LiYTollefsbolTOP16INK4A suppression by glucose restriction contributes to human cellular lifespan extension through SIRT1-mediated epigenetic and genetic mechanismsPLoS One201162e1742121390332
- ZentnerGEHenikoffSRegulation of nucleosome dynamics by histone modificationsNat Struct Mol Biol20132025926623463310
- PelegSFellerCLadurnerAGImhofAThe metabolic impact on histone acetylation and transcription in ageingTrends Biochem Sci20164170071127283514
- KaeberleinMMcVeyMGuarenteLThe SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanismsGenes Dev1999132570258010521401
- SatohABraceCSRensingNSirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LHCell Metab20131841643024011076
- VazquezBNThackrayJKSerranoLSirtuins and DNA damage repair: SIRT7 comes to playNucleus2017810711528406750
- ImaiSGuarenteLTen years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseasesTrends Pharmacol Sci20103121222020226541
- YangHYangTBaurJANutrient-sensitive mitochondrial NAD+ levels dictate cell survivalCell20071301095110717889652
- VerdinENAD+ in aging, metabolism, and neurodegenerationScience20153501208121326785480
- GuarenteLCalorie restriction and sirtuins revisitedGenes Dev2013272072208524115767
- Fernandez-MarcosPJAuwerxJRegulation of PGC-1α, a nodal regulator of mitochondrial biogenesisAm J Clin Nutr201193884S890S21289221
- KaeberleinMKirklandKTFieldsSKennedyBKSir2-independent life span extension by calorie restriction in yeastPLoS Biol200429E29615328540
- FabrizioPGattazzoCBattistellaLSir2 blocks extreme lifespan extensionCell200512365566716286010
- LiYXuWMcBurneyMWLongoVDSirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neuronsCell Metab20088384818590691
- LongoVDLinking sirtuins, IGF-I signaling, and starvationExp Gerontol200944707418638538
- HerranzDMunoz-MartinMCanameroMSirt1 improves healthy ageing and protects from metabolic syndrome-associated cancerNat Commun20101320975665
- BurnettCValentiniSCabreiroFAbsence of effects of Sir2 overexpression on lifespan in C. elegans and DrosophilaNature201147748248521938067
- MouchiroudLHoutkooperRHMoullanNThe NAD(+)/sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signalingCell201315443044123870130
- ImaiSIGuarenteLIt takes two to tango: NAD+ and sirtuins in aging/longevity controlNPJ Aging Mech Dis201621601728721271
- FangEFScheibye-KnudsenMChuaKFMattsonMPCroteauDLBohrVANuclear DNA damage signalling to mitochondria in ageingNat Rev Mol Cell Biol20161730832126956196
- Sampaio-MarquesBFelgueirasCSilvaASNCA (α-synuclein)-induced toxicity in yeast cells is dependent on sirtuin 2 (Sir2)-mediated mitophagyAutophagy201281494150922914317
- HuangRXuYWanWDeacetylation of nuclear LC3 drives autophagy initiation under starvationMol Cell20155745646625601754
- PriceNLGomesAPLingAJSIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial functionCell Metab20121567569022560220
- GibsonBAKrausWLNew insights into the molecular and cellular functions of poly(ADP-ribose) and PARPsNat Rev Mol Cell Biol20121341142422713970
- FangEFScheibye-KnudsenMBraceLEDefective mitophagy in XPA via PARP-1 hyperactivation and NAD+/SIRT1 reductionCell2014157488289624813611
- Scheibye-KnudsenMMitchellSJFangEFA high fat diet and NAD+ rescue premature aging in Cockayne syndromeCell Metab201420584085525440059
- TatarMBartkeAAntebiAThe endocrine regulation of aging by insulin-like signalsScience20032991346135112610294
- SelmanCLingardSChoudhuryAIEvidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null miceFASEB J20082280781817928362
- KenyonCThe first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageingPhilos Trans R Soc Lond B Biol Sci201136691621115525
- GotoTTakanoMTranscriptional role of FOXO1 in drug resistance through antioxidant defense systemsAdv Exp Med Biol200966517117920429424
- ArgentinoDPDominiciFPAl-RegaieyKBonkowskiMSBartkeATurynDEffects of long-term caloric restriction on early steps of the insulin-signaling system in mouse skeletal muscleJ Gerontol A Biol Sci Med Sci200560283415741279
- LaplanteMSabatiniDMmTOR signaling in growth control and diseaseCell201214927429322500797
- LongoVDAntebiABartkeAInterventions to slow aging in humans: are we ready?Aging Cell201514449751025902704
- SarbassovDDAliSMSenguptaSProlonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKBMol Cell20062215916816603397
- KimYMKimDHdRAGging amino acid-mTORC1 signaling by SH3BP4Mol Cell20133516
- JohnsonSCRabinovitchPSKaeberleinMmTOR is a key modulator of ageing and age-related diseaseNature201349333834523325216
- HeissCSpyridopoulosIHaendelerJInterventions to slow cardiovascular aging: dietary restriction, drugs and novel moleculesExp Gerontol Epub2017627
- HardieDGSensing of energy and nutrients by AMP-activated protein kinaseAm J Clin Nutr201193891S896S21325438
- CantòCAuwerxJCalorie Restriction: is AMPK a key sensor and effector?Physiology20112621422421841070
- GreerELDowlatshahiDBankoMRAn AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegansCurr Biol2007171646165617900900
- ApfeldJO’ConnorGMcDonaghTDiStefanoPSCurtisRThe AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegansGenes Dev2004183004300915574588
- TohyamaDYamaguchiAA critical role of SNF1A/dAMPKalpha (Drosophila AMP-activated protein kinase alpha) in muscle on longevity and stress resistance in Drosophila melanogasterBiochem Biophys Res Commun201039411211820184862
- GonzalezAAKumarRMulliganJDDavisAJWeindruchRSaupeKWMetabolic adaptations to fasting and chronic caloric restriction in heart, muscle, and liver do not include changes in AMPK activityAm J Physiol Endocrinol Metab2004287E1032E103715251868
- ChungHYKimHJKimKWChoiJSYuBPMolecular inflammation hypothesis of aging based on the anti-aging mechanism of calorie restrictionMicrosc Res Tech20025926427212424787
- SalvioliSCapriMValensinSTieriPMontiDOttavianiEFranceschiCInflamm-aging, cytokines and aging: state of the art, new hypotheses on the role of mitochondria and new perspectives from systems biologyCurr Pharm Des2006123161317116918441
- GotoMInflammaging (inflammation + aging): a driving force for human aging based on an evolutionarily antagonistic pleiotropy theory?Biosci Trends2008221823020103932
- SolanaRPawelecGTarazonaRAging and innate immunityImmunity20062449149416713963
- CandoreGCarusoCJirilloEMagroneTVastoSLow grade inflammation as a common pathogenetic denominator in age-related diseases: novel drug targets for anti-ageing strategies and successful ageing achievementCurr Pharm Des20101658459620388068
- FeldmanNRotter-MaskowitzAOkunEDAMPs as mediators of sterile inflammation in aging-related pathologiesAgeing Res Rev201524293925641058
- PiccaALezzaAMSLeeuwenburghCFueling inflamm-aging through mitochondrial dysfunction: mechanisms and molecular targetsInt J Mol Sci2017185 pii: E933
- PawelecGGoldeckDDerhovanessianEInflammation, ageing and chronic diseaseCurr Opin Immunol201429232824762450
- FranceschiCCampisiJChronic inflammation (inflammaging) and its potential contribution to age-associated diseasesJ Gerontol A Biol Sci Med Sci201469 Suppl1S4S924833586
- HorrilloDSierraJArribasCAge-associated development of inflammation in Wistar rats: effects of caloric restrictionArch Physiol Biochem201111714015021635187
- ChungHYLeeEKChoiYJMolecular inflammation as an underlying mechanism of the aging process and age-related diseasesJ Dent Res20119083084021447699
- ZhouYXuBCMaheshwariHGA mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse)Proc Natl Acad Sci U S A19979413215132209371826
- IkenoYHubbardGBLeeSReduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout miceJ Gerontol A Biol Sci Med Sci20096452252919228785
- TrainerPJDrakeWMKatznelsonLTreatment of acromegaly with the growth hormone-receptor antagonist pegvisomantN Engl J Med20003421171117710770982
- Van der LelyAJBillerBMBrueTLong-term safety of pegvisomant in patients with acromegaly: comprehensive review of 1288 subjects in ACROSTUDYJ Clin Endocrinol Metab2012971589159722362824
- KopchickJJParkinsonCStevensECTrainerPJGrowth hormone receptor antagonists: discovery, development, and use in patients with acromegalyEndocr Rev20022362364612372843
- HowitzKTBittermanKJCohenHYSmall molecule activators of sirtuins extend Saccharomyces cerevisiae lifespanNature200342519119612939617
- HubbardBPSinclairDASmall molecule SIRT1 activators for the treatment of aging and age-related diseasesTrends Pharmacol Sci20143514615424439680
- TimmersSKoningsEBiletLCalorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humansCell Metab20111461262222055504
- PearsonKJBaurJALewisKNResveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life spanCell Metab2008815716818599363
- MinorRKBaurJAGomesAPSRT1720 improves survival and healthspan of obese miceSci Rep201117022355589
- WangGHanTNijhawanDP7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvageCell20141581324133425215490
- CantoCHoutkooperRHPirinenEThe NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet induced obesityCell Metab20121583884722682224
- KennedyBKPennypackerJKDrugs that modulate aging: the promising yet difficult path aheadTransl Res201416345646524316383
- WilkinsonJEBurmeisterLBrooksSVRapamycin slows aging in miceAging Cell20121167568222587563
- SharpZDAging and TOR: interwoven in the fabric of lifeCell Mol Life Sci20116858759720960025
- HarrisonDEStrongRSharpZDRapamycin fed late in life extends lifespan in genetically heterogeneous miceNature200946039239519587680
- SelmanCTulletJMWieserDRibosomal protein S6 kinase 1 signaling regulates mammalian life spanScience200932614014419797661
- KamadaYSekitoTOhsumiYAutophagy in yeast: a TOR-mediated response to nutrient starvationCurr Top Microbiol Immunol2004279738414560952
- TothMLSigmondTBorsosELongevity pathways converge on autophagy genes to regulate life span in Caenorhabditis elegansAutophagy2008433033818219227
- SoefjeSAKarnadABrennerAJCommon toxicities of mammalian target of rapamycin inhibitorsTarget Oncol2011612512921499766
- LaneMAIngramDKRothGS2-Deoxy-D-glucose feeding in rats mimics physiologic effects of calorie restrictionJ Anti Aging Med19981327337
- SchulzTJZarseKVoigtAUrbanNBirringerMRistowMGlucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stressCell Metab2007628029317908557
- IngramDKRothGSGlycolytic inhibition as a strategy for developing calorie restriction mimeticsExp Gerontol20114614815421167272
- WanRCamandolaSMattsonMPDietary supplementation with 2-deoxy-D-glucose improves cardiovascular and neuroendocrine stress adaptation in ratsAm J Physiol Heart Circ Physiol2004287H1186H119315317676
- MinorRKSmithDLJrSossongAMChronic ingestion of 2-deoxy-D-glucose induces cardiac vacuolization and increases mortality in ratsToxicol Appl Pharmacol201024333233920026095
- RudermanNBCarlingDPrentkiMCacicedoJMAMPK, insulin resistance, and the metabolic syndromeJ Clin Investig20131232764277223863634
- SlackCFoleyAPartridgeLActivation of AMPK by the putative dietary restriction mimetic metformin is insufficient to extend lifespan in DrosophilaPLoS One20127e4769923077661
- SongYMLeeYHKimJWMetformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathwayAutophagy201511465925484077
- MadirajuAKErionDMRahimiYMetformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenaseNature201451054254624847880
- BrandhorstSChoiIYWeiMA periodic diet that mimics fasting promotes multi-system regeneration, enhanced cognitive performance, and healthspanCell Metab2015221869926094889
- LongoVDMattsonMPFasting: molecular mechanisms and clinical applicationsCell Metab20141918119224440038
- PedersenANKondrupJBorsheimEHealth effects of protein intake in healthy adults: a systematic literature reviewFood Nutr Res201357121245
- LevineMESuarezJABrandhorstSLow protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older populationCell Metab20141940741724606898
- FontanaLCummingsNEArriola ApeloSIDecreased consumption of branched-chain amino acids improves metabolic healthCell Rep20161652053027346343
- LeesEKKrolEGrantLMethionine restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21Aging Cell20141381782724935677
- MillerRABuehnerGChangYHarperJMSiglerRSmith-WheelockMMethionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistanceAging Cell2005411912515924568
- OrentreichNMatiasJRDeFeliceAZimmermanJALow methionine ingestion by rats extends life spanJ Nutr19931232692748429371
- CummingsNELammingDWRegulation of metabolic health and aging by nutrient-sensitive signaling pathwaysMol Cell Endocrinol2017455132227884780
- JensenMDRyanDHApovianCM2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American college of cardiology/American heart association task force on practice guidelines and the obesity societyJ Am Coll Cardiol2014632985302324239920
- LandiFCalvaniRCesariMSarcopenia as the biological substrate of physical frailtyClin Geriatr Med20153136737426195096
- NowsonCO’ConnellSProtein requirements and recommendations for older people: a reviewNutrients201576874689926287239
- Paddon-JonesDRasmussenBBDietary protein recommendations and the prevention of sarcopeniaCurr Opin Clin Nutr Metab Care200912869019057193
- WolfeRRMillerSLMillerKBOptimal protein intake in the elderlyClin Nutr20082767568418819733
- Le CouteurDGSolon-BietSWahlDDietary protein, ageing and the Okinawan ratioAge Ageing20164544344727130207
- VolpiECampbellWWDwyerJTIs the optimal level of protein intake for older adults greater than the recommended dietary allowance?J Gerontol A Biol Sci Med Sci20136867768123183903
- BaumJIKimIYWolfeRRProtein consumption and the elderly: what is the optimal level of intake?Nutrients20168359378
- MooreDRKeeping older muscle young through dietary protein and physical activityAdv Nutr20145599S607S25469405
- Solon-BietSMMitchellSJde CaboRRaubenheimerDLe CouteurDGSimpsonSJMacronutrients and caloric intake in health and longevityJ Endocrinol20152261R17R2826021555