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Review

Calcification of Cardiac Valves in Metabolic Bone Disease: An Updated Review of Clinical Studies

, ORCID Icon, , &
Pages 1085-1095 | Published online: 09 Jul 2020

References

  • Barasch E, Gottdiener JS, Marino Larsen EK, Chaves PH, Newman AB. Cardiovascular morbidity and mortality in community-dwelling elderly individuals with calcification of the fibrous skeleton of the base of the heart and aortosclerosis (The Cardiovascular Health Study). Am Cardiol. 2006;97(9):1281–1286. doi:10.1016/j.amjcard.2005.11.065
  • Lindman BR, Clavel MA, Mathieu P, et al. Calcific aortic stenosis. Nature Rev Dis Primers. 2016;3(2):16006. doi:10.1038/nrdp.2016.6
  • Shekar C, Budoff M. Calcification of the heart: mechanisms and therapeutic avenues. Expert Rev Cardiovasc Ther. 2018;16(7):527–536. doi:10.1080/14779072.2018.148428229860888
  • Chester AH. Molecular and cellular mechanisms of valve calcification. Aswan Heart Centre Sci Pract Series. 2011;4. doi:10.5339/ahcsps.2011.4
  • Gomel MA, Lee R, Grande-Allen KJ. Comparing the role of mechanical forces in vascular and valvular calcification progression. Front Cardiovasc Med. 2019;197(5):1–14.
  • Sud K, Agarwal S, Parashar A, et al. Degenerative mitral stenosis: unmet need for percutaneous interventions. Circulation. 2016;133(16):1594–1604. doi:10.1161/CIRCULATIONAHA.115.02018527142604
  • Pawade TA, Newby DE, Dweck MR. Calcification in aortic stenosis: the skeleton key. J Am CollCardiol. 2015;66(5):561–577. doi:10.1016/j.jacc.2015.05.066
  • Kennedy JA, Hua X, Mishra K, Murphy GA, Rosenkranz AC, Horowitz JD. Inhibition of calcifying nodule formation in cultured porcine aortic valve cells by nitric oxide donors. Eur J Pharmacol. 2009;602:28–35. doi:10.1016/j.ejphar.2008.11.02919056377
  • Clark-Greuel JN, Connolly JM, Sorichillo E, et al. Transforming growth Factor-β1 mechanisms in aortic valve calcification: increased alkaline phosphatase and related events. Ann Thorac Surg. 2007;83:946–953. doi:10.1016/j.athoracsur.2006.10.02617307438
  • Walker GA, Masters KS, Shah DN, Anseth KS, Leinwand LA. Valvular myofibroblast activation by transforming growth factor-beta: implications for pathological extracellular matrix remodeling in heart valve disease. Circ Res. 2004;95:253–260. doi:10.1161/01.RES.0000136520.07995.aa15217906
  • Mohler ER, Gannon F, Reynolds C, Zimmerman R, Keane MG, Kaplan FS. Bone formation and inflammation in cardiac valves. Circulation. 2001;103:1522–1528. doi:10.1161/01.CIR.103.11.152211257079
  • Hjortnaes J, Butcher J, Figueiredo JL, et al. Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: a role for inflammation. Eur Heart J. 2010;31(16):1975–1984. doi:10.1093/eurheartj/ehq23720601388
  • Chiyoya M, Seya K, Yu Z, et al. Matrix Gla protein negatively regulates calcification of human aortic valve interstitial cells isolated from calcified aortic valves. J PharmacolSci. 2018;136(4):257–265.
  • Di Minno A, Zanobini M, Myasoedova VA, et al. Could circulating fetuin A be a biomarker of aortic valve stenosis? Int J Cardiol. 2017;249:426–430. doi:10.1016/j.ijcard.2017.05.04028931474
  • Carracedo M, Back M. Fetuin A in aortic stenosis and valve calcification: not crystal clear. Int J Cardiol. 2018;265(15):77–78. doi:10.1016/j.ijcard.2018.04.11529885702
  • Rajamannan NM, Subramaniam M, Caira F, Stock SR, Spelsberg TC. Atorvastatin inhibits hypercholesterolemia-induced calcification in the aortic valves via the Lrp5 receptor pathway. Circulation. 2005;112:1229–1234.
  • Bortnik AE, Xu S, Kim RS, et al. Biomarkers of mineral metabolism and progression of aortic valve and mitral annular calcification: the multi-ethnic study of atherosclerosis. Atherosclerosis. 2019;285:79–86. doi:10.1016/j.atherosclerosis.2019.04.21531048102
  • Iwata S, Hyodo E, Yanagi S, et al. Parathyroid hormone and systolic blood pressure accelerate the progression of aortic valve stenosis in chronic hemodialysis patients. Int J Cardiol. 2013;163(3):256–259. doi:10.1016/j.ijcard.2011.06.02521705098
  • Iwata S, Walker MD, Di Tullio MR, et al. Aortic valve calcification in mild primary hyperparathyroidism. J Clin Endocrinol Metab. 2012;97(1):132–137. doi:10.1210/jc.2011-210722031523
  • Osman L, Chester AH, Amrani M, Yacoub MH, Smolenski RT. A novel role of extracellular nucleotides in valve calcification: a potential target for atorvastatin. Circulation. 2006;114:I566–I572. doi:10.1161/CIRCULATIONAHA.105.00121416820639
  • Mori H, Oku Y, Hashiba K, Seto M, Mameya G. The relationship of osteoporosis to mitral annular and aortic valvular calcification in elderly women. J Cardiography. 1990;20(2):393–399.
  • Ouchy Y, Akishita M, de Souza AC, Nakamura T, Orimo H. Age-related loss of bone mass and aortic/aortic valve calcification—re evaluation of recommended dietary allowance of calcium in the elderly. Ann N Y Acad Sci. 1993;676:297–307. doi:10.1111/j.1749-6632.1993.tb38743.x8489141
  • Sugihara N, Matsuzaki M. The influence of severe bone loss on mitral annular calcification in postmenopausal osteoporosis of elderly Japanese women. Jpn Circ J. 1993;57(1):14–26. doi:10.1253/jcj.57.148437338
  • Davutoglu V, Yilmaz M, Soydinc S, et al. Mitral annular calcification is associated with osteoporosis in women. Am Heart J. 2004;147:1113–1116. doi:10.1016/j.ahj.2003.12.00215199364
  • Aksoy Y, Yagmur C, Tekin GO, et al. Aortic valve calcification: association with bone mineral density and cardiovascular risk factors. Coron Artery Dis. 2005;16:379–383. doi:10.1097/00019501-200509000-0000716118543
  • Pfister R, Michels G, Sharp SJ, Luben R, Wareham NJ, Khaw KT. Inverse association between bone mineral density and risk of aortic stenosis in men and women in EPIC-Norfolk prospective study. Int J Cardiol. 2015;178:29–30. doi:10.1016/j.ijcard.2014.10.06525464212
  • Choi HS, Rhee Y, Hur NW, Chung N, Lee EJ, Lim SK. Association between low bone mass and aortic valve sclerosis in Koreans. Clin Endocrinol. 2009;71:792–797. doi:10.1111/j.1365-2265.2009.03543.x
  • Tohiono S, Tohno Y, Minami T, et al. Accumulation of calcium and phosphorus in the mitral valve in comparison with the abdominal aorta and the scaphoid bone. Biol Trace Elem Res. 2000;77:33–42. doi:10.1385/BTER:77:1:3311097469
  • Celick A, Davutoglu V, Sarica K, et al. Relationship between renal stone formation, mitral annular calcification and bone resorption markers. Ann Saudi Med. 2010;30(4):301–305. doi:10.4103/0256-4947.6526420622348
  • Hasserius R, Karlsson MK, Nilsson BE, Redlund-Johnell I, Johnell O. European vertebral osteoporosis study.Prevalent vertebral deformities predict increased mortality and increased fracture rate in both men and women: a 10-year population-based study of 598 individuals from the Swedish cohort in the European vertebral osteoporosis study. Osteoporos Int. 2003;14(1):61–68. doi:10.1007/s00198-002-1316-912577186
  • Bandeira E, Neves AP, Costa C, Bandeira F. Association between vascular calcification and osteoporosis in men with type 2 diabetes. J Clin Densitom. 2012;15(1):55–60. doi:10.1016/j.jocd.2011.07.00222071025
  • Silva HC, Pinheiro MM, Genaro PS, et al. Higher prevalence of morphometric vertebral fractures in patients with recent coronary events independently of BMD measurements. Bone. 2013;52(2):562–567. doi:10.1016/j.bone.2012.11.00423142805
  • Buckens CF, de Jong PA, Verkooijen HM, Verhaar HJ, Mali WP, van der Graaf Y. PROVIDI study group. Vertebral fractures on routine chest computed tomography: relation with arterial calcifications and future cardiovascular events. Int J Cardiovasc Imaging. 2015;31(2):437–445. doi:10.1007/s10554-014-0567-925451815
  • Schulz EJ, Arfai K, Liu X, Sayre J, Gilsanz V. Aortic calcification and the risk of osteoporosis and fractures. J Clin Endocrinol Metab. 2004;89(9):4246–4253. doi:10.1210/jc.2003-03096415356016
  • Szulc P, Kiel DP, Delmas PD. Calcifications in the abdominal aorta predict fractures in men: MINOS study. J Bone Miner Res. 2008;23(1):95–102. doi:10.1359/jbmr.07090317892380
  • Gondrie MJ, Mali WP, Buckens CF, Jacobs PC, Grobbee DE, van derGraaf Y. The PROgnostic value of unrequested information in diagnostic imaging (PROVIDI) study: rationale and design. Eur J Epidemiol. 2010;25(10):751–758. doi:10.1007/s10654-010-9514-920890635
  • Chan JJ, Cupples LA, Kiel D, O’Donnell CJ, Hoffmann U, Samelson EJ. QCT volumetric bone mineral density and vascular and valvular calcification: the framingham study. J Bone Miner Res. 2015;30(10):1767–1774. doi:10.1002/jbmr.253025871790
  • Messera D, Xu S, Bartz TM, et al. Relationship of bone mineral density with valvular and annular calcification in community-dwelling older people: the cardiovascular health study. Arch Osteoporos. 2017;12(1):52. doi:10.1007/s11657-017-0347-y28560501
  • Roberts WC, Waller BF. Effect of chronic hypercalcemia on the heart. An analysis of 18 necropsy patients. Am J Med. 1981;71(3):371–384. doi:10.1016/0002-9343(81)90163-77282728
  • Nierdle B, Stefenelli T, Glogar D, Woloszczuk W, Roka R, Mayr H. Cardiac calcific deposits in patients with primary hyperparathyroidism: preliminary results of a prospective echocardiographic study. Surgery. 1990;108(6):1052–1056.2247830
  • Stefenelli T, Mayr H, Bergler-Klein J, Globits S, Woloszczuk W, Niederle B. Primary hyperparathyroidism: incidence of cardiac abnormalities and partial reversibility after successful parathyroidectomy. Am J Med. 1993;95(2):197–202. doi:10.1016/0002-9343(93)90260-V8356983
  • Stefenelli T, Abela C, Frank H, et al. Cardiac abnormalities in patients with primary hyperparathyroidism: implications for follow-up. J Clin Endocrinol Metab. 1997;82(1):106–112. doi:10.1210/jcem.82.1.36668989242
  • Langle F, Abela C, Koller-Strametz J, et al. Primary hyperparathyroidism and the heart: cardiac abnormalities correlated to clinical and biochemical data. World J Surg. 1994;18(4):619–624. doi:10.1007/BF03537807725754
  • Dalberg K, Brodin LA, Juhlin-Dannfelt A, Farnebo LO. Cardiac function in primary hyperparathyroidism before and after operation. An echocardiographic study. Eur J Surg. 1996;162(3):171–176.8695729
  • Walker MD, Fleischer JB, Di Tullio MR, et al. Cardiac structure and diastolic function in mild primary hyperparathyroidism. J Clin Endocrinol Metab. 2010;95(5):2172–2179. doi:10.1210/jc.2009-207220228165
  • Mishra AK, Agarwal A, Kumar S, Mishra SK. Assessment of cardiovascular system abnormalities in patients with advanced primary hyperparathyroidism by detailed echocardiographic analysis: a prospective study. World J Endoc Surg. 2017;9(2):46–50. doi:10.5005/jp-journals-10002-1209
  • Harrison CV, Lennox B. Heart block in osteitis deformans. Br Heart J. 1948;10(3):167–176. doi:10.1136/hrt.10.3.16718610105
  • King M, Huang JM, Glassman E. Paget’s disease with cardiac calcification and complete heart block. Am J Med. 1969;46(2):302–304. doi:10.1016/0002-9343(69)90014-X5775006
  • Strickberger SA, Schulman SP, Hutchins GM. Association of Paget’s disease of bone with calcific aortic valve disease. Am J Med. 1987;82(5):953–956. doi:10.1016/0002-9343(87)90157-43578364
  • Hultgren HN. Osteitis deformans (Paget’s disease) and calcific disease of the heart valves. Am J Cardiol. 1998;81(12):1461–1464. doi:10.1016/S0002-9149(98)00213-69645898
  • Merlotti D, Gennari L, Galli B, et al. Characteristics and familial aggregation of Paget’s disease of bone in Italy. J Bone Miner Res. 2005;20(8):1356–1364. doi:10.1359/JBMR.05032216007333
  • Hofbauer LC, Brueck CC, Shanahan CM, Schoppet M, Dobnig H. Vascular calcification and osteoporosis from clinical observation towards molecular understanding. Osteoporos Int. 2007;18(3):251–259. doi:10.1007/s00198-006-0282-z17151836
  • Aksoy O, Cam A, Goel SS, et al. Do bisphosphonates slow the progression of aortic stenosis? J Am Coll Cardiol. 2012;59(16):1452–1459. doi:10.1016/j.jacc.2012.01.02422497825
  • Ortlepp JR, Hoffmann R, Ohme F, Lauscher J, Bleckmann F, Hanrath P. The vitamin D receptor genotype predisposes to the development of calcific aortic valve stenosis. Heart. 2001;85(6):635–638. doi:10.1136/heart.85.6.63511359741
  • Bellavia D, Costa V, De Luca A, et al. Vitamin D level between calcium-phosphorus homeostasis and immune system: new perspective in osteoporosis. Curr Osteoporos Rep. 2016. doi:10.1007/s11914-016-0331-2
  • Etta PK, Sharma RK, Gupta A. Study of chronic kidney disease-mineral bone disorders in newly detected advanced renal failure patients: a hospital-based cross-sectional study. Saudi J Kidney Dis Transpl. 2017;28(4):874–885.28748891
  • Nam HS, Shin MH, Kweon SS, et al. Association of estrogen receptor-alpha gene polymorphisms with bone mineral density in postmenopausal Korean women. J Bone Miner Metab. 2005;23(1):84–89. doi:10.1007/s00774-004-0545-8
  • Long JR, Zhang YY, Liu PY, et al. Association of estrogen receptor alpha and vitamin D receptor gene polymorphisms with bone mineral density in Chinese males. Calcif Tissue Int. 2004;74(3):270–276. doi:10.1007/s00223-003-0087-414595531
  • Nordstrom P, Glader CA, Dahlén G, et al. Oestrogen receptor alpha gene polymorphism is related to aortic valve sclerosis in postmenopausal women. J Intern Med. 2003;254(2):140–146. doi:10.1046/j.1365-2796.2003.01179.x12859695
  • Bortnik AE, Bartz TM, Ix JH, et al. Association of inflammatory, lipid and mineral markers with cardiac calcification in older adults. Heart. 2016;102(22):1826–1834. doi:10.1136/heartjnl-2016-30940427411840
  • Marx SJ. Hyperparathyroid and hypoparathyroid disorders. N Engl J Med. 2000;343(25):1863–1875. doi:10.1056/NEJM20001221343250811117980
  • Walker MD, Rundek T, Homma S, et al. Effect of parathyroidectomy on subclinical cardiovascular disease in mild primary hyperparathyroidism. Eur J Endocrinol. 2012;167(2):277–285. doi:10.1530/EJE-12-012422660025
  • Schmitz F, Ewering S, Zerres K, Klomfass S, Hoffmann R, Ortlepp JR. Parathyroid hormone gene variant and calcific aortic stenosis. J Heart Valve Dis. 2009;18(3):262–267.19557980