The Effect of Mindfulness-Based Stress Reduction (MBSR) on Depression, Cognition, and Immunity in Mild Cognitive Impairment: A Pilot Feasibility Study

References

• Prince M, Bryce R, Albanese E, Wimo A, Ribeiro W, Ferri CP. The global prevalence of dementia: a systematic review and metaanalysis. Alzheimers Dement. 2013;9(1):63–75. doi:10.1016/j.jalz.2012.11.00723305823
   PubMed Web of Science ®Google Scholar
• Albert MS, DeKosky ST, Dickson D, et al. The diagnosis of mild cognitive impairment due to alzheimer’s disease: recommendations from the National Institute on Aging‐Alzheimer’s Association workgroups on diagnostic guidelines for alzheimer’s disease. Alzheimers Dement. 2011;7(3):270–279. doi:10.1016/j.jalz.2011.03.00821514249
   PubMed Web of Science ®Google Scholar
• Orgeta V, Qazi A, Spector A, Orrell M. Psychological treatments for depression and anxiety in dementia and mild cognitive impairment: systematic review and meta-analysis. Br J Psychiat. 2015;207(4):293–298. doi:10.1192/bjp.bp.114.148130
   PubMed Web of Science ®Google Scholar
• Lyketsos CG, Lopez O, Jones B, Fitzpatrick AL, Breitner J, DeKosky S. Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study. JAMA. 2002;288(12):1475–1483. doi:10.1001/jama.288.12.147512243634
   PubMed Web of Science ®Google Scholar
• Lu PH, Edland SD, Teng E, Tingus K, Petersen RC, Cummings JL. Donepezil delays progression to AD in MCI subjects with depressive symptoms. Neurology. 2009;72(24):2115–2121. doi:10.1212/WNL.0b013e3181aa52d319528519
   PubMed Web of Science ®Google Scholar
• Franceschi C, Bonafè M, Valensin S, et al. Inflamm‐aging: an evolutionary perspective on immunosenescence. Ann N Y Acad Sci. 2000;908(1):244–254. doi:10.1111/j.1749-6632.2000.tb06651.x10911963
   PubMed Web of Science ®Google Scholar
• Di Benedetto S, Müller L, Wenger E, Düzel S, Pawelec G. Contribution of neuroinflammation and immunity to brain aging and the mitigating effects of physical and cognitive interventions. Neurosci Biobehav Rev. 2017;75:114–128. doi:10.1016/j.neubiorev.2017.01.04428161508
   PubMed Web of Science ®Google Scholar
• Michaud M, Balardy L, Moulis G, et al. Proinflammatory cytokines, aging, and age-related diseases. J Am Med Dir Assoc. 2013;14(12):877–882. doi:10.1016/j.jamda.2013.05.00923792036
   PubMed Web of Science ®Google Scholar
• Giunta B, Fernandez F, Nikolic WV, et al. Inflammaging as a prodrome to alzheimer’s disease. J Neuroinflammation. 2008;5(1):51. doi:10.1186/1742-2094-5-5119014446
   PubMed Web of Science ®Google Scholar
• Tao Q, Ang TF, DeCarli C, et al. Association of chronic low-grade inflammation with risk of alzheimer disease in ApoE4 carriers. JAMA netw open. 2018;1(6):e183597. doi:10.1001/jamanetworkopen.2018.359730646251
   PubMed Web of Science ®Google Scholar
• Rubio-Perez JM, Morillas-Ruiz JM. A review: inflammatory process in alzheimer’s disease, role of cytokines. Sci World J. 2012;2012.
   Web of Science ®Google Scholar
• Le Page A, Garneau H, Dupuis G, et al. Differential phenotypes of myeloid-derived suppressor and T regulatory cells and cytokine levels in amnestic mild cognitive impairment subjects compared to mild alzheimer diseased patients. Front Immunol. 2017;8:783. doi:10.3389/fimmu.2017.0078328736551
   PubMed Web of Science ®Google Scholar
• Le Page A, Lamoureux J, Bourgade K, et al. Polymorphonuclear neutrophil functions are differentially altered in amnestic mild cognitive impairment and mild alzheimer’s disease patients. Journal of Alzheimer’s Disease. 2017;60(1):23–42. doi:10.3233/JAD-170124
   Web of Science ®Google Scholar
• Griciuc A, Serrano-Pozo A, Parrado AR, et al. Alzheimer’s disease risk gene CD33 inhibits microglial uptake of amyloid beta. Neuron. 2013;78(4):631–643. doi:10.1016/j.neuron.2013.04.01423623698
   PubMed Web of Science ®Google Scholar
• Bradshaw EM, Chibnik LB, Keenan BT, et al. CD33 alzheimer’s disease locus: altered monocyte function and amyloid biology. Nat Neurosci. 2013;16(7):848–850. doi:10.1038/nn.343523708142
   PubMed Web of Science ®Google Scholar
• Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E. Mild cognitive impairment: clinical characterization and outcome. Arch Neurol. 1999;56(3):303–308. doi:10.1001/archneur.56.3.30310190820
   PubMed Web of Science ®Google Scholar
• Langa KM, Levine DA. The diagnosis and management of mild cognitive impairment: a clinical review. JAMA. 2014;312(23):2551–2561. doi:10.1001/jama.2014.1380625514304
   PubMed Web of Science ®Google Scholar
• Horrigan BJ. New studies support the therapeutic value of meditation. Explore. 2007;3(5):449–452. doi:10.1016/j.explore.2007.07.00317905353
   PubMedGoogle Scholar
• Marciniak R, Sheardova K, Čermáková P, Hudeček D, Šumec R, Hort J. Effect of meditation on cognitive functions in context of aging and neurodegenerative diseases. Front Behav Neurosci. 2014;8:17. doi:10.3389/fnbeh.2014.0001724478663
   PubMed Web of Science ®Google Scholar
• Kurth F, Cherbuin N, Luders E. Reduced age-related degeneration of the hippocampal subiculum in long-term meditators. Psychiatry Res. 2015;232(3):214–218. doi:10.1016/j.pscychresns.2015.03.00825907419
   PubMed Web of Science ®Google Scholar
• Gard T, Hölzel BK, Lazar SW. The potential effects of meditation on age-related cognitive decline: a systematic review. Ann N Y Acad Sci. 2014;1307:89. doi:10.1111/nyas.1234824571182
   PubMed Web of Science ®Google Scholar
• Tang YY, Hölzel BK, Posner MI. The neuroscience of mindfulness meditation. Nat Rev Neurosci. 2015;16(4):213–225. doi:10.1038/nrn391625783612
   PubMed Web of Science ®Google Scholar
• Gu J, Strauss C, Bond R, Cavanagh K. How do mindfulness-based cognitive therapy and mindfulness-based stress reduction improve mental health and wellbeing? A systematic review and meta-analysis of mediation studies. Clin Psychol Rev. 2015;37:1–2. doi:10.1016/j.cpr.2015.01.00625689576
   PubMed Web of Science ®Google Scholar
• Hofmann SG, Gómez AF. Mindfulness-based interventions for anxiety and depression. Psychiatr Clin. 2017;40(4):739–749. doi:10.1016/j.psc.2017.08.008
   Google Scholar
• Innes KE, Selfe TK, Brown CJ, Rose KM, Thompson-Heisterman A. The effects of meditation on perceived stress and related indices of psychological status and sympathetic activation in persons with alzheimer’s disease and their caregivers: a pilot study. Evid Based Complement Alternat Med. 2012;2012. doi:10.1155/2012/927509
   Web of Science ®Google Scholar
• Khalsa DS, Ashford JW. Stress, meditation, and alzheimer’s disease prevention: where the evidence stands. J Alzheimers Dis. 2015;48(1):1–2. doi:10.3233/JAD-14276626445019
   PubMed Web of Science ®Google Scholar
• Russell-Williams J, Jaroudi W, Perich T, Hoscheidt S, El Haj M, Moustafa AA. Mindfulness and meditation: treating cognitive impairment and reducing stress in dementia. Rev Neurosci. 2018;29(7):791–804. doi:10.1515/revneuro-2017-006629466242
   PubMed Web of Science ®Google Scholar
• Newberg AB, Serruya M, Wintering N, Moss AS, Reibel D, Monti DA. Meditation and neurodegenerative diseases. Ann N Y Acad Sci. 2014;1307(1):112–123. doi:10.1111/nyas.1218723924172
   PubMed Web of Science ®Google Scholar
• Newberg AB, Wintering N, Khalsa DS, Roggenkamp H, Waldman MR. Meditation effects on cognitive function and cerebral blood flow in subjects with memory loss: a preliminary study. J Alzheimers Dis. 2010;20(2):517–526. doi:10.3233/JAD-2010-139120164557
   PubMed Web of Science ®Google Scholar
• Grant JA, Courtemanche J, Duerden EG, Duncan GH, Rainville P. Cortical thickness and pain sensitivity in zen meditators. Emotion. 2010;10(1):43. doi:10.1037/a001833420141301
   PubMed Web of Science ®Google Scholar
• Luders E, Clark K, Narr KL, Toga AW. Enhanced brain connectivity in long-term meditation practitioners. Neuroimage. 2011;57(4):1308–1316. doi:10.1016/j.neuroimage.2011.05.07521664467
   PubMed Web of Science ®Google Scholar
• Wells RE, Yeh GY, Kerr CE, et al. Meditation’s impact on default mode network and hippocampus in mild cognitive impairment: a pilot study. Neurosci Lett. 2013;556:15–19. doi:10.1016/j.neulet.2013.10.00124120430
   PubMed Web of Science ®Google Scholar
• Kabat-Zinn J. Full Catastrophe Living, Revised Edition: How to Cope with Stress, Pain and Illness Using Mindfulness Meditation. Hachette UK; 2013.
   Google Scholar
• Kabat-Zinn J. Wherever You Go, There You Are: Mindfulness Meditation in Everyday Life. Hachette Books; 2009.
   Google Scholar
• Crane RS. Implementing mindfulness in the mainstream: making the path by walking it. Mindfulness. 2017;8(3):585–594. doi:10.1007/s12671-016-0632-728515799
   PubMed Web of Science ®Google Scholar
• Moss AS, Reibel DK, Greeson JM, et al. An adapted mindfulness-based stress reduction program for elders in a continuing care retirement community: quantitative and qualitative results from a pilot randomized controlled trial. J Appl Gerontol. 2015;34(4):518–538. doi:10.1177/073346481455941125492049
   PubMed Web of Science ®Google Scholar
• Creswell JD, Irwin MR, Burklund LJ, et al. Mindfulness-based stress reduction training reduces loneliness and pro-inflammatory gene expression in older adults: a small randomized controlled trial. Brain Behav Immun. 2012;26(7):1095–1101. doi:10.1016/j.bbi.2012.07.00622820409
   PubMed Web of Science ®Google Scholar
• Ernst S, Welke J, Heintze C, et al. Effects of mindfulness-based stress reduction on quality of life in nursing home residents: a feasibility study. Complement Med Res. 2008;15(2):74–81. doi:10.1159/000121479
   Web of Science ®Google Scholar
• Larouche E, Hudon C, Goulet S. Mindfulness mechanisms and psychological effects for aMCI patients: a comparison with psychoeducation. Complement Ther Clin Pract. 2019;34:93–104. doi:10.1016/j.ctcp.2018.11.00830712752
   PubMed Web of Science ®Google Scholar
• Siang-Ted K, Fam J, Feng L, et al. Mindfulness modulates biomarkers and cognition in elderly with mild cognitive impairment (MCI): a randomized controlled trial (RCT). Psychoneuroendocrinology. 2017;83:46. doi:10.1016/j.psyneuen.2017.07.363
   Web of Science ®Google Scholar
• Wong WP, Coles J, Chambers R, Wu DB, Hassed C. The effects of mindfulness on older adults with mild cognitive impairment. J Alzheimers Dis Rep. 2017;1(1):181–193. doi:10.3233/ADR-17003130480237
   PubMedGoogle Scholar
• Zanesco AP, King BG, MacLean KA, Saron CD. Cognitive aging and long-term maintenance of attentional improvements following meditation training. Journal of Cognitive Enhancement. 2018;2(3):259–275. doi:10.1007/s41465-018-0068-1
   Google Scholar
• Kaliman P, Alvarez-Lopez MJ, Cosín-Tomás M, Rosenkranz MA, Lutz A, Davidson RJ. Rapid changes in histone deacetylases and inflammatory gene expression in expert meditators. Psychoneuroendocrinology. 2014;40:96–107. doi:10.1016/j.psyneuen.2013.11.00424485481
   PubMed Web of Science ®Google Scholar
• Black DS, Slavich GM. Mindfulness meditation and the immune system: a systematic review of randomized controlled trials. Ann N Y Acad Sci. 2016;1373(1):13. doi:10.1111/nyas.1299826799456
   PubMed Web of Science ®Google Scholar
• Hearps AC, Martin GE, Angelovich TA, et al. Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function. Aging Cell. 2012;11(5):867–875. doi:10.1111/j.1474-9726.2012.00851.x22708967
   PubMed Web of Science ®Google Scholar
• Wong KL, Yeap WH, Tai JJY, Ong SM, Dang TM, Wong SC. The three human monocyte subsets: implications for health and disease. Immunol Res. 2012;53(1–3):41–57. doi:10.1007/s12026-012-8297-322430559
   PubMed Web of Science ®Google Scholar
• Ziegler‐Heitbrock L. The CD14+ CD16+ blood monocytes: their role in infection and inflammation. J Leukoc Biol. 2007;81(3):584–592. doi:10.1189/jlb.080651017135573
   PubMed Web of Science ®Google Scholar
• Jose SS, Bendickova K, Kepak T, Krenova Z, Fric J. Chronic inflammation in immune aging: role of pattern recognition receptor crosstalk with the telomere complex? Front Immunol. 2017;8:1078. doi:10.3389/fimmu.2017.0107828928745
   PubMed Web of Science ®Google Scholar
• Wells RE, Kerr CE, Wolkin J, et al. Meditation for adults with mild cognitive impairment: a pilot randomized trial. J Am Geriatr Soc. 2013;61(4):642–645. doi:10.1111/jgs.1217923581918
   PubMed Web of Science ®Google Scholar
• Astin JA. Stress reduction through mindfulness meditation. Psychother Psychosom. 1997;66(2):97–106. doi:10.1159/0002891169097338
   PubMed Web of Science ®Google Scholar
• Shapiro SL, Schwartz GE, Bonner G. Effects of mindfulness-based stress reduction on medical and premedical students. J Behav Med. 1998;21(6):581–599. doi:10.1023/A:10187008298259891256
   PubMed Web of Science ®Google Scholar
• Schure MB, Christopher J, Christopher S. Mind–body medicine and the art of self‐care: teaching mindfulness to counseling students through yoga, meditation, and qigong. J Couns Dev. 2008;86(1):47–56.
   Web of Science ®Google Scholar
• Greeson JM, Webber DM, Smoski MJ, et al. Changes in spirituality partly explain health-related quality of life outcomes after mindfulness-based stress reduction. J Behav Med. 2011;34(6):508–518. doi:10.1007/s10865-011-9332-x21360283
   PubMed Web of Science ®Google Scholar
• Carmody J, Baer RA. Relationships between mindfulness practice and levels of mindfulness, medical and psychological symptoms and well-being in a mindfulness-based stress reduction program. J Behav Med. 2008;31(1):23–33. doi:10.1007/s10865-007-9130-717899351
   PubMed Web of Science ®Google Scholar
• Birnie K, Speca M, Carlson LE. Exploring self‐compassion and empathy in the context of mindfulness‐based stress reduction (MBSR). Stress Health. 2010;26(5):359–371. doi:10.1002/smi.1305
   Web of Science ®Google Scholar
• Moss AS, Wintering N, Roggenkamp H, et al. Effects of an 8-week meditation program on mood and anxiety in patients with memory loss. J Altern Complement Med. 2012;18(1):48–53. doi:10.1089/acm.2011.005122268968
   PubMed Web of Science ®Google Scholar
• Kaufman Y, Anaki D, Binns M, Freedman M. Cognitive decline in alzheimer disease: impact of spirituality, religiosity, and QOL. Neurology. 2007;68(18):1509–1514. doi:10.1212/01.wnl.0000260697.66617.5917470754
   PubMed Web of Science ®Google Scholar
• Hosseini S, Chaurasia A, Oremus M. The effect of religion and spirituality on cognitive function: a systematic review. Gerontologist. 2019;59(2):76–85. doi:10.1093/geront/gnx024
   PubMed Web of Science ®Google Scholar
• Coin A, Perissinotto E, Najjar M, et al. Does religiosity protect against cognitive and behavioral decline in alzheimer’s dementia? Curr Alzheimer Res. 2010;7(5):445–452. doi:10.2174/15672051079138388620088813
   PubMed Web of Science ®Google Scholar
• Maruff P, Lim YY, Darby D, et al. Clinical utility of the cogstate brief battery in identifying cognitive impairment in mild cognitive impairment and alzheimer’s disease. BMC Psychol. 2013;1(1):30. doi:10.1186/2050-7283-1-3025566378
   PubMedGoogle Scholar
• Sheardova K, Vyhnalek M, Nedelska Z, et al. Czech Brain Aging Study (CBAS): prospective multicentre cohort study on risk and protective factors for dementia in the Czech Republic. BMJ Open. 2019;9(12):e030379. doi:10.1136/bmjopen-2019-030379
   Web of Science ®Google Scholar
• Mozolic JL, Long AB, Morgan AR, Rawley-Payne M, Laurienti PJ. A cognitive training intervention improves modality-specific attention in a randomized controlled trial of healthy older adults. Neurobiol Aging. 2011;32(4):655–668. doi:10.1016/j.neurobiolaging.2009.04.01319428142
   PubMed Web of Science ®Google Scholar
• Legault C, Jennings JM, Katula JA, et al., SHARP-P Study Group. Designing clinical trials for assessing the effects of cognitive training and physical activity interventions on cognitive outcomes: the Seniors Health and Activity Research Program Pilot (SHARP-P) study, a randomized controlled trial. BMC Geriatr. 2011;11(1):27. doi:10.1186/1471-2318-11-2721615936
   PubMed Web of Science ®Google Scholar
• Smith GE, Housen P, Yaffe K, et al. A cognitive training program based on principles of brain plasticity: results from the Improvement in Memory with Plasticity‐based Adaptive Cognitive Training (IMPACT) Study. J Am Geriatr Soc. 2009;57(4):594–603. doi:10.1111/j.1532-5415.2008.02167.x19220558
   PubMed Web of Science ®Google Scholar
• Santorelli SF, Kabat-Zinn J, Blacker M, Meleo-Meyer F, Koerbel L. Mindfulness-Based Stress Reduction (MBSR) Authorized Curriculum Guide. Center for Mindfulness in Medicine, Health Care, and Society (CFM). University of Massachusetts Medical School; 2017.
   Google Scholar
• Gates NJ, Sachdev PS, Singh MA, Valenzuela M. Cognitive and memory training in adults at risk of dementia: a systematic review. BMC Geriatr. 2011;11(1):55. doi:10.1186/1471-2318-11-5521942932
   PubMed Web of Science ®Google Scholar
• Kelly ME, Loughrey D, Lawlor BA, Robertson IH, Walsh C, Brennan S. The impact of cognitive training and mental stimulation on cognitive and everyday functioning of healthy older adults: a systematic review and meta-analysis. Ageing Res Rev. 2014;15:28–43. doi:10.1016/j.arr.2014.02.00424607830
   PubMed Web of Science ®Google Scholar
• Suchá J. Cvičení paměti pro každý věk: testy na paměť a logiku. Portál; 2007.
   Google Scholar
• Suchá J. Skupinové hry pro cvičení paměti v každém věku. Portál; 2012.
   Google Scholar
• Bílková J. Kognitivní Trénink pro třetí věk: 100 cvičení pro rozvoj koncentrace, kreativity, paměti a verbálních dovedností. Grada; 2016.
   Google Scholar
• Bezdicek O, Lukavsky J, Stepankova H, et al. The Prague Stroop test: normative standards in older Czech adults and discriminative validity for mild cognitive impairment in Parkinson’s disease. J Clin Exp Neuropsychol. 2015;37(8):794–807. doi:10.1080/13803395.2015.105710626313510
   PubMed Web of Science ®Google Scholar
• Bezdicek O, Libon DJ, Stepankova H, et al. Development, validity, and normative data study for the 12-word Philadelphia verbal learning test [czP (r) VLT-12] among older and very old Czech adults. Clin Neuropsychol. 2014;28(7):1162–1181. doi:10.1080/13854046.2014.95266625247611
   PubMed Web of Science ®Google Scholar
• Tombaugh TN, Kozak J, Rees L. Normative data stratified by age and education for two measures of verbal fluency: FAS and animal naming. Arch Clin Neuropsychol. 1999;14(2):167–177.14590600
   PubMed Web of Science ®Google Scholar
• Sheikh JI, Yesavage JA. Geriatric Depression Scale (GDS): recent evidence and development of a shorter version. Clin Gerontol. 1986.
   Google Scholar
• Beck AT, Epstein N, Brown G, Steer RA. An inventory for measuring clinical anxiety: psychometric properties. J Consult Clin Psychol. 1988;56(6):893. doi:10.1037/0022-006X.56.6.8933204199
   PubMed Web of Science ®Google Scholar
• Ziegler-Heitbrock L, Ancuta P, Crowe S, et al. Nomenclature of monocytes and dendritic cells in blood. Blood. 2010;116(16):e74–e80. doi:10.1182/blood-2010-02-25855820628149
   PubMed Web of Science ®Google Scholar
• Fisher J. Development and application of a spiritual well-being questionnaire called SHALOM. Religions. 2010;1(1):105–121. doi:10.3390/rel1010105
   Web of Science ®Google Scholar
• Marciniak R, Serek J, Sheardova K, Hudecek D, Hort J. SHALOM questionnaire psychometric characteristics of elderly Czech population. Cesk Psychol. 2017;61(3):230–244.
   Web of Science ®Google Scholar
• Tan J, Tsakok FH, Ow EK, et al. Study protocol for a randomized controlled trial of choral singing intervention to prevent cognitive decline in at-risk older adults living in the community. Front Aging Neurosci. 2018;10:195. doi:10.3389/fnagi.2018.0019530042673
   PubMed Web of Science ®Google Scholar
• Sellami M, Gasmi M, Denham J, et al. Effects of acute and chronic exercise on immunological parameters in the elderly aged: can physical activity counteract the effects of aging? Front Immunol. 2018;9:2187. doi:10.3389/fimmu.2018.0218730364079
   PubMed Web of Science ®Google Scholar
• Makizako H, Tsutsumimoto K, Doi T, et al. Effects of exercise and horticultural intervention on the brain and mental health in older adults with depressive symptoms and memory problems: study protocol for a randomized controlled trial [UMIN000018547]. Trials. 2015;16(1):499. doi:10.1186/s13063-015-1032-326537979
   PubMed Web of Science ®Google Scholar
• Panza F, Frisardi V, Capurso C, et al. Late-life depression, mild cognitive impairment, and dementia: possible continuum? Am J Geriatr Psychiatry. 2010;18(2):98–116. doi:10.1097/JGP.0b013e3181b0fa1320104067
   PubMed Web of Science ®Google Scholar
• Monastero R, Mangialasche F, Camarda C, Ercolani S, Camarda R. A systematic review of neuropsychiatric symptoms in mild cognitive impairment. J Alzheimers Dis. 2009;18(1):11–30. doi:10.3233/JAD-2009-112019542627
   PubMed Web of Science ®Google Scholar
• Rosenberg PB, Mielke MM, Appleby BS, Oh ES, Geda YE, Lyketsos CG. The association of neuropsychiatric symptoms in MCI with incident dementia and alzheimer disease. Am J Geriatr Psychiatry. 2013;21(7):685–695. doi:10.1016/j.jagp.2013.01.00623567400
   PubMed Web of Science ®Google Scholar
• Larouche E, Hudon C, Goulet S. Potential benefits of mindfulness-based interventions in mild cognitive impairment and alzheimer’s disease: an interdisciplinary perspective. Behav Brain Res. 2015;276:199–212. doi:10.1016/j.bbr.2014.05.05824893317
   PubMed Web of Science ®Google Scholar
• Carlson LE, Speca M, Patel KD, Goodey E. Mindfulness-based stress reduction in relation to quality of life, mood, symptoms of stress and levels of cortisol, dehydroepiandrosterone sulfate (DHEAS) and melatonin in breast and prostate cancer outpatients. Psychoneuroendocrinology. 2004;29(4):448–474. doi:10.1016/S0306-4530(03)00054-414749092
   PubMed Web of Science ®Google Scholar
• Matousek RH, Pruessner JC, Dobkin PL. Changes in the cortisol awakening response (CAR) following participation in mindfulness-based stress reduction in women who completed treatment for breast cancer. Complement Ther Clin Pract. 2011;17(2):65–70. doi:10.1016/j.ctcp.2010.10.00521457893
   PubMedGoogle Scholar
• Bränström R, Kvillemo P, Åkerstedt T. Effects of mindfulness training on levels of cortisol in cancer patients. Psychosomatics. 2013;54(2):158–164. doi:10.1016/j.psym.2012.04.00723218058
   PubMed Web of Science ®Google Scholar
• Carlson LE, Doll R, Stephen J, et al. Randomized controlled trial of mindfulness-based cancer recovery versus supportive expressive group therapy for distressed survivors of breast cancer. J Clin Oncol. 2013;31(25):3119–3126. doi:10.1200/JCO.2012.47.521023918953
   PubMed Web of Science ®Google Scholar
• Marcus MT, Fine PM, Moeller FG, et al. Change in stress levels following mindfulness-based stress reduction in a therapeutic community. Addict Disord Their Treat. 2003;2(3):63–68. doi:10.1097/00132576-200302030-00001
   Google Scholar
• Kox M, Stoffels M, Smeekens SP, et al. The influence of concentration/meditation on autonomic nervous system activity and the innate immune response: a case study. Psychosom Med. 2012;74(5):489–494. doi:10.1097/PSY.0b013e3182583c6d22685240
   PubMed Web of Science ®Google Scholar
• Rosenkranz MA, Davidson RJ, MacCoon DG, Sheridan JF, Kalin NH, Lutz A. A comparison of mindfulness-based stress reduction and an active control in modulation of neurogenic inflammation. Brain Behav Immun. 2013;27:174–184. doi:10.1016/j.bbi.2012.10.01323092711
   PubMed Web of Science ®Google Scholar
• Bhasin MK, Dusek JA, Chang BH, et al. Relaxation response induces temporal transcriptome changes in energy metabolism, insulin secretion and inflammatory pathways. PLoS One. 2013;8(5). doi:10.1371/journal.pone.0062817
   Web of Science ®Google Scholar
• Black DS, Cole SW, Irwin MR, et al. Yogic meditation reverses NF-κB and IRF-related transcriptome dynamics in leukocytes of family dementia caregivers in a randomized controlled trial. Psychoneuroendocrinology. 2013;38(3):348–355. doi:10.1016/j.psyneuen.2012.06.01122795617
   PubMed Web of Science ®Google Scholar
• Rodriguez JJ, Noristani HN, Verkhratsky A. The serotonergic system in ageing and alzheimer’s disease. Prog Neurobiol. 2012;99(1):15–41. doi:10.1016/j.pneurobio.2012.06.01022766041
   PubMed Web of Science ®Google Scholar
• Bujatti M, Riederer P. Serotonin, noradrenaline, dopamine metabolites in transcendental meditation-technique. J Neural Transm. 1976;39(3):257–267. doi:10.1007/BF1256514789821
   PubMed Web of Science ®Google Scholar
• Schutte NS, Malouff JM. A meta-analytic review of the effects of mindfulness meditation on telomerase activity. Psychoneuroendocrinology. 2014;42:45–48. doi:10.1016/j.psyneuen.2013.12.01724636500
   PubMed Web of Science ®Google Scholar
• Yadav RK, Ray RB, Vempati R, Bijlani RL. Effect of a comprehensive yoga-based lifestyle modification program on lipid peroxidation. Indian J Physiol Pharmacol. 2005;49:358–362.16440857
   PubMedGoogle Scholar
• Schneider RH, Nidich SI, Salerno JW, et al. Lower lipid peroxide levels in practitioners of the transcendental meditation [registered sign] program. Psychosom Med. 1998;60(1):38–41. doi:10.1097/00006842-199801000-000089492237
   PubMed Web of Science ®Google Scholar
• Kim DH, Moon YS, Kim HS, et al. Effect of zen meditation on serum nitric oxide activity and lipid peroxidation. Prog Neuropsychopharmacol Biol Psychiatry. 2005;29(2):327–331. doi:10.1016/j.pnpbp.2004.11.01915694242
   PubMed Web of Science ®Google Scholar
• Sinha S, Singh SN, Monga YP, Ray US. Improvement of glutathione and total antioxidant status with yoga. J Altern Complement Med. 2007;13(10):1085–1090. doi:10.1089/acm.2007.056718166119
   PubMed Web of Science ®Google Scholar
• Sharma H, Datta P, Singh A, et al. Gene expression profiling in practitioners of Sudarshan Kriya. J Psychosom Res. 2008;64(2):213–218. doi:10.1016/j.jpsychores.2007.07.00318222135
   PubMed Web of Science ®Google Scholar
• Dusek JA, Otu HH, Wohlhueter AL, et al. Genomic counter-stress changes induced by the relaxation response. PLoS One. 2008;3(7):e2576. doi:10.1371/journal.pone.000257618596974
   PubMed Web of Science ®Google Scholar
• Martarelli D, Cocchioni M, Scuri S, Pompei P. Diaphragmatic breathing reduces postprandial oxidative stress. J Altern Complement Med. 2011;17(7):623–628. doi:10.1089/acm.2010.066621688985
   PubMed Web of Science ®Google Scholar
• Gallegos AM, Hoerger M, Talbot NL, et al. Toward identifying the effects of the specific components of mindfulness-based stress reduction on biologic and emotional outcomes among older adults. J Altern Complement Med. 2013;19(10):787–792. doi:10.1089/acm.2012.002823383976
   PubMed Web of Science ®Google Scholar
• Hölzel BK, Carmody J, Vangel M, et al. Mindfulness practice leads to increases in regional brain gray matter density. Psychiatry Res. 2011;191(1):36–43. doi:10.1016/j.pscychresns.2010.08.00621071182
   PubMed Web of Science ®Google Scholar
• Fox KC, Nijeboer S, Dixon ML, et al. Is meditation associated with altered brain structure? A systematic review and meta-analysis of morphometric neuroimaging in meditation practitioners. Neurosci Biobehav Rev. 2014;43:48–73. doi:10.1016/j.neubiorev.2014.03.01624705269
   PubMed Web of Science ®Google Scholar
• Malinowski P. Neural mechanisms of attentional control in mindfulness meditation. Front Neurosci. 2013;7:8. doi:10.3389/fnins.2013.0000823382709
   PubMed Web of Science ®Google Scholar
• Malinowski P, Shalamanova L. Meditation and cognitive ageing: the role of mindfulness meditation in building cognitive reserve. Journal of Cognitive Enhancement. 2017;1(2):96–106. doi:10.1007/s41465-017-0022-7
   Google Scholar
• Kertzman S, Reznik I, Hornik-Lurie T, Weizman A, Kotler M, Amital D. Stroop performance in major depression: selective attention impairment or psychomotor slowness? J Affect Disord. 2010;122(1–2):167–173. doi:10.1016/j.jad.2009.08.00919732958
   PubMed Web of Science ®Google Scholar
• Rosenberg PB, Mielke MM, Xue QL, Carlson MC. Depressive symptoms predict incident cognitive impairment in cognitive healthy older women. Am J Geriatr Psychiatry. 2010;18(3):204–211. doi:10.1097/JGP.0b013e3181c5348720224517
   PubMed Web of Science ®Google Scholar
• Feliu‐Soler A, Pérez‐Aranda A, Andrés‐Rodríguez L, et al. Digging into the construct of fibrofog: psychometric properties of the Spanish version of the multidimensional inventory of subjective cognitive impairment in patients with fibromyalgia. J Appl Biobehav Res. 2018;23(2):12134. doi:10.1111/jabr.12134
   Web of Science ®Google Scholar
• Gilbertson MW, Shenton ME, Ciszewski A, et al. Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma. Nat Neurosci. 2002;5(11):1242–1247. doi:10.1038/nn95812379862
   PubMed Web of Science ®Google Scholar
• Wager-Smith K, Markou A. Depression: a repair response to stress-induced neuronal microdamage that can grade into a chronic neuroinflammatory condition? Neurosci Biobehav Rev. 2011;35(3):742–764. doi:10.1016/j.neubiorev.2010.09.01020883718
   PubMed Web of Science ®Google Scholar
• Heneka MT, O’Banion MK, Terwel D, Kummer MP. Neuroinflammatory processes in alzheimer’s disease. J Neural Transm. 2010;117(8):919–947.20632195
   PubMed Web of Science ®Google Scholar
• Lao SA, Kissane D, Meadows G. Cognitive effects of MBSR/MBCT: a systematic review of neuropsychological outcomes. Conscious Cogn. 2016;45:109–123. doi:10.1016/j.concog.2016.08.01727580462
   PubMed Web of Science ®Google Scholar
• Quintana-Hernandez DJ, Miro-Barrachina MT, Ibanez-Fernandez IJ, et al. Mindfulness in the maintenance of cognitive capacities in alzheimer’s disease: a randomized clinical trial. J Alzheimers Dis. 2016;50(1):217–232. doi:10.3233/JAD-14300926639952
   PubMed Web of Science ®Google Scholar
• Bower JE, Crosswell AD, Stanton AL, et al. Mindfulness meditation for younger breast cancer survivors: a randomized controlled trial. Cancer. 2015;121(8):1231–1240. doi:10.1002/cncr.2919425537522
   PubMed Web of Science ®Google Scholar
• Malarkey WB, Jarjoura D, Klatt M. Workplace based mindfulness practice and inflammation: a randomized trial. Brain Behav Immun. 2013;27:145–154. doi:10.1016/j.bbi.2012.10.00923078984
   PubMed Web of Science ®Google Scholar
• Parsons CE, Crane C, Parsons LJ, Fjorback LO, Kuyken W. Home practice in mindfulness-based cognitive therapy and mindfulness-based stress reduction: a systematic review and meta-analysis of participants’ mindfulness practice and its association with outcomes. Behav Res Ther. 2017;95:29–41. doi:10.1016/j.brat.2017.05.00428527330
   PubMed Web of Science ®Google Scholar
• Alexander C, Langer E, Newman R, Chandler H, Davies J. Aging, mindfulness and meditation. J Pers Soc Psychol. 1989;57:950–964. doi:10.1037/0022-3514.57.6.9502693686
   PubMed Web of Science ®Google Scholar
• Prakash R, Rastogi P, Dubey I, Abhishek P, Chaudhury S, Small BJ. Long-term concentrative meditation and cognitive performance among older adults. Aging Neuropsycholo Cognition. 2012;19(4):479–494. doi:10.1080/13825585.2011.630932
   PubMed Web of Science ®Google Scholar
• Pérez-Aranda A, Feliu-Soler A, Montero-Marín J, et al. A randomized controlled efficacy trial of mindfulness-based stress reduction compared with an active control group and usual care for fibromyalgia: the EUDAIMON study. Pain. 2019;160(11):2508–2523. doi:10.1097/j.pain.000000000000165531356450
   PubMed Web of Science ®Google Scholar
• Eyre HA, Siddarth P, Acevedo B, et al. A randomized controlled trial of Kundalini yoga in mild cognitive impairment. Int Psychogeriatr. 2017;29(4):557–567. doi:10.1017/S104161021600215528088925
   PubMed Web of Science ®Google Scholar
• Innes KE, Selfe TK, Brundage K, et al. Effects of meditation and music-listening on blood biomarkers of cellular aging and alzheimer’s disease in adults with subjective cognitive decline: an exploratory randomized clinical trial. J Alzheimers Dis. 2018;66(3):947–970. doi:10.3233/JAD-18016430320574
   PubMed Web of Science ®Google Scholar
• Innes KE, Selfe TK, Khalsa DS, Kandati S, Ashford JW. Meditation and music improve memory and cognitive function in adults with subjective cognitive decline: a pilot randomized controlled trial. J Alzheimers Dis. 2017;56(3):899–916. doi:10.3233/JAD-16086728106552
   PubMed Web of Science ®Google Scholar