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Original Research

The Changes in Medication Prescribing Among the Older People with Cognitive Impairment in the Acute Care Setting

ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon
Pages 865-876 | Published online: 08 Jun 2020

References

  • World Health Organization. World Report on Ageing and Health. Geneva: World Health Organization; 2015 Available from http://www.who.int/ageing/events/world-report-2015-launch. Accessed 912, 2019.
  • Population projections australia, 2017 to 2066, catalogue no. 3222.0, ABS. Canberra: australian bureau of statistics (ABS); 2018 Available from: https://www.abs.gov.au/3222.0MediaRelease 12017 (base)-2066. Accessed 912, 2019..
  • Andrew MK, Rockwood K. Making our health and care systems fit for an ageing population: considerations for Canada. Can Geriatr J. 2014;17(4):133–135. doi:10.5770/cgj.17.16325452826
  • Cornwell J, Levenson R, Sonola L, Poteliakhoff E. Continuity of care for older hospital patients: a call for action; 2012 Available from: http://www.kingsfund.org.uk/publications/continuity-care-older-hospitalpatients. Accessed 912, 2019..
  • Pedersen MK, Meyer G, Uhrenfeldt L. Risk factors for acute care hospital readmission in older persons in western countries: a systematic review. JBI Database System Rev Implement Rep. 2017;15(2):454–485. doi:10.11124/JBISRIR-2016-003267
  • Li CL, Chu SJ, Sheu JT, Huang LY. Impact of physical activity on hospitalization in older adults: a nationwide cohort from Taiwan. Arch Gerontol Geriatr. 2011;53(2):141–145. doi:10.1016/j.archger.2010.09.01421067830
  • Albert SM, Colombi A, Hanlon J. Potentially inappropriate medications and risk of hospitalization in retirees: analysis of a US retiree health claims database. Drugs Aging. 2010;27(5):407–415. doi:10.2165/11315990-000000000-0000020450238
  • Reynish EL, Hapca SM, De Souza N, Cvoro V, Donnan PT, Guthrie B. Epidemiology and outcomes of people with dementia, delirium, and unspecified cognitive impairment in the general hospital: prospective cohort study of 10,014 admissions. BMC Med. 2017;15(1):140. doi:10.1186/s12916-017-0899-028747225
  • Wilson RS, Hebert LE, Scherr PA, Dong X, Leurgens SE, Evans DA. Cognitive decline after hospitalization in a community population of older persons. Neurology. 2012;78(13):950–956. doi:10.1212/WNL.0b013e31824d589422442434
  • Marcantonio ER. Delirium in hospitalized older adults. N Eng J Med. 2017;377(15):1456–1466. doi:10.1056/NEJMcp1605501
  • Leto L, Feola M. Cognitive impairment in heart failure patients. J Geriatr Cardiol. 2014;11(4):316–328. doi:10.11909/j.issn.1671-5411.2014.04.00725593581
  • Morris C, Mitchell JW, Moorey H, Younan HC, Tadros G, Turner AM. Memory, attention, and fluency deficits in COPD may be a specific form of cognitive impairment. ERJ Open Res. 2019;5(2):00229–2018. doi:10.1183/23120541.00229-201831149625
  • Fogg C, Griffiths P, Meredith P, Bridges J. Hospital outcomes of older people with cognitive impairment: an integrative review. Int J Geriatr Psychiatry. 2018;33(9):1177–1197. doi:10.1002/gps.4919
  • Patterson SM, Hughes C, Kerse N, Cardwell CR, Bradley MC. Interventions to improve the appropriate use of polypharmacy for older people. Cochrane Database Syst Rev. 2012;5:CD008165.
  • Clague F, Mercer SW, McLean G, Reynish E, Guthrie B. Comorbidity and polypharmacy in people with dementia: insights from a large, population-based cross-sectional analysis of primary care data. Age Ageing. 2017;46(1):33–39. doi:10.1093/ageing/afw17628181629
  • Hubbard RE, Peel NM, Scott IA, et al. Polypharmacy among inpatients aged 70 years or older in Australia. Med J Aust. 2015;202(7):373–377. doi:10.5694/mja13.0017225877120
  • Campanelli CM. American Geriatrics Society 2012 Beers Criteria Update Expert Panel. American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2012;60(4):616–631. doi:10.1111/j.1532-5415.2012.03923.x22376048
  • Fick DM Semla TP Beizer J, et alBy the 2019 American geriatrics society beers criteria update expert panel. American geriatrics society 2015 updated beers criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2015;63(11):2227–2246. doi:10.1111/jgs.1370226446832
  • Gallagher P, Ryan C, Byrne S, Kennedy J, O’Mahony D. STOPP (screening tool of older person’s prescriptions) and START (screening tool to alert doctors to right treatment). Consensus validation. Int J Clin Pharmacol Ther. 2008;46(2):72–83. doi:10.5414/CPP4607218218287
  • Sönnerstam E, Sjölander M, Gustafsson M. An evaluation of the prevalence of potentially inappropriate medications in older people with cognitive impairment living in Northern Sweden using the EU(7)-PIM list. Eur J Clin Pharmacol. 2017;73(6):735–742. doi:10.1007/s00228-017-2218-228246889
  • Bajcar JM, Wang L, Moineddin R, Nie JX, Tracy CS, Upshur REG. From pharmaco-therapy to pharmaco-prevention: trends in prescribing to older adults in Ontario, Canada, 1997–2006. BMC Fam Pract. 2010;11(1):75. doi:10.1186/1471-2296-11-7520929561
  • Jay S, Babak BB, Sarah A. Empagliflozin in the treatment of type 2 diabetes: evidence to date. Drug Des Devel Ther. 2015;9:5793–5803. doi:10.2147/DDDT.S69926
  • Gao L, Maidment I, Matthews FE, Robinson L, Brayne C. Medication usage change in older people (65+) in England over 20 years: findings from CFAS I and CFAS II. Age Ageing. 2018;47(2):220–225. doi:10.1093/ageing/afx15829036509
  • Fried TR, Tinetti ME, Iannone L. Primary care clinicians’ experiences with treatment decision making for older persons with multiple conditions. Arch Intern Med. 2011;171(1):75–80. doi:10.1001/archinternmed.2011.42420837819
  • Oktora MP, Denig P, Bos JHJ, Schuiling-Veninga CCM, Hak E. Trends in polypharmacy and dispensed drugs among adults in the Netherlands as compared to the United States. PLoS One. 2019;14(3):e0214240. doi:10.1371/journal.pone.021424030901377
  • Charlesworth CJ, Smit E, Lee DS, Alramadhan F, Odden MC. Polypharmacy among adults aged 65 years and older in the United States: 1988–2010. J Gerontol a Biol Sci Med Sci. 2015;70(8):989–995. doi:10.1093/gerona/glv01325733718
  • Farrell B, Pottie K, Thompson W, et al. Deprescribing proton pump inhibitors: evidence-based clinical practice guideline. Can Fam Physician. 2017;63(5):354–364.28500192
  • Gnjidic D, Hilmer SN, Blyth FM, et al. Polypharmacy cutoff and outcomes: five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes. J Clin Epidemiol. 2012;65(9):989–995. doi:10.1016/j.jclinepi.2012.02.01822742913
  • Maher RL Jr, Hanlon JT, Hajjar ER. Clinical consequences of polypharmacy in elderly. Expert Opin Drug Saf. 2014;13(1):57–65. doi:10.1517/14740338.2013.82766024073682
  • Rodrigues MC, Oliveira C. Drug-drug interactions and adverse drug reactions in polypharmacy among older adults: an integrative review. Rev Lat Am Enfermagem. 2016;24:e2800. doi:10.1590/1518-8345.1316.280027598380
  • Wastesson JW, Morin L, Tan ECK, Johnell K. An update on the clinical consequences of polypharmacy in older adults: a narrative review. Expert Opin Drug Saf. 2018;17(12):1185–1196. doi:10.1080/14740338.2018.154684130540223
  • Moore AR, O’Keeffe ST. Drug-induced cognitive impairment in the elderly. Drugs Aging. 1999;15(1):15–28. doi:10.2165/00002512-199915010-0000210459729
  • Reeve E, Trenaman SC, Rockwood K, Hilmer SN. Pharmacokinetic and pharmacodynamic alterations in older people with dementia. Expert Opin Drug Metab Toxicol. 2017;13(6):651–668. doi:10.1080/17425255.2017.132587328460576
  • Mangoni AA, Jackson SH. Age-related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications. Br J of Clin Pharmacol. 2004;57(1):6–14. doi:10.1046/j.1365-2125.2003.02007.x14678335
  • Lau DT, Kasper JD, Potter DE, Lyles A, Bennett RG. Hospitalization and death associated with potentially inappropriate medication prescriptions among elderly nursing home residents. Arch Intern Med. 2005;165(1):68–74. doi:10.1001/archinte.165.1.6815642877
  • Cahir C, Fahey T, Teeling M, Teljeur C, Feely J, Bennett K. Potentially inappropriate prescribing and cost outcomes for older people: a national population study. Br J Clin Pharmacol. 2010;69(5):543–552. doi:10.1111/j.1365-2125.2010.03628.x20573091
  • Chen CC, Cheng SH. Potentially inappropriate medication and health care outcomes: an instrumental variable approach. Health Serv Res. 2016;51(4):1670–1691. doi:10.1111/1475-6773.1241726601656
  • Poudel A, Peel NM, Nissen L, Mitchell C, Gray LC, Hubbard RE. Potentially inappropriate prescribing in older patients discharged from acute care hospitals to residential aged care facilities. Ann Pharmacother. 2014;48(11):1425–1433. doi:10.1177/106002801454856825159001
  • Widagdo IS, Nyfort-Hansen K, Kowalski SR. Prevalence of potentially inappropriate medication use in elderly hospitalized patients. J Pharm Pract Res. 2011;41(2):122–125. doi:10.1002/j.2055-2335.2011.tb00678.x
  • Wahab MS, Nyfort-Hansen K, Kowalski SR. Inappropriate prescribing in hospitalised Australian elderly as determined by the STOPP criteria. Int J Clin Pharm. 2012;34(6):855–862. doi:10.1007/s11096-012-9681-822864867
  • Basger BJ, Chen TF, Moles RJ. Application of a prescribing indicators tool to assist in identifying drug-related problems in a cohort of older Australians. Int J Pharm Pract. 2012;20(3):172–182. doi:10.1111/j.2042-7174.2011.00177.x22554160
  • Redston MR, Hilmer SN, McLachlan AJ, Clough AJ, Gnjidic D. Prevalence of potentially inappropriate medication use in older inpatients with and without cognitive impairment: a systematic review. J Alzheimers Dis. 2018;61(4):1639–1652. doi:10.3233/JAD-17084229278890
  • von Renteln-kruse W, Neumann L, Klugmann B, et al. Geriatric patients with cognitive impairment: patient characteristics and treatment results on a specialized ward. Dtsch Arztebl Int. 2015;11297:103–112.
  • Gray LC, Bernabei R, Berg K, et al. Standardizing assessment of elderly people in acute care: the interRAI Acute Care instrument. J Am Geriatr Soc. 2008;56(3):536–541. doi:10.1111/j.1532-5415.2007.01590.x18179498
  • Lakhan P, Jones M, Wilson A, Courtney M, Hirdes J, Gray LC. A prospective cohort study of geriatric syndromes among older medical patients admitted to acute care hospitals. J Am Geriatr Soc. 2011;59(11):2001–2008. doi:10.1111/j.1532-5415.2011.03663.x22092231
  • Travers C, Byrne GJ, Pachana NA, Klein K, Gray L. Validation of the interRAI Cognitive Performance Scale against independent clinical diagnosis and the Mini-Mental State Examination in older hospitalized patients. J Nutr Health Aging. 2013;17(5):435–439. doi:10.1007/s12603-012-0439-823636544
  • Gray L, Ariño-Blasco S, Berg K, et al. interRAI Acute Care (AC) Assessment Form and User’s Manual. Washington, DC: interRAI; 2010.
  • Gray LC, Berg K, Fries BE, et al. Sharing clinical information across care settings: the birth of an integrated assessment system. BMC Health Serv Res. 2009;9(1):71. doi:10.1186/1472-6963-9-7119402891
  • WHO Collaborating Centre for Drug Statistics Methodology. Guidelines for ATC classification and DDD assignment; 2019 Oslo Available from: http://www.whocc.no/filearchive/publications/2019_guidelines_web.pdf. Accessed 95, 2019..
  • Onder G, Liperoti R, Fialova D, et al. Polypharmacy in nursing home in Europe: results from the SHELTER study. J Gerontol a Biol Sci Med Sci. 2012;67(6):698–704. doi:10.1093/gerona/glr23322219520
  • Beers MH. Explicit criteria for determining potentially inappropriate medication use by the elderly. An update. Arch Intern Med. 1997;157(14):1531–1536. doi:10.1001/archinte.1997.004403500310039236554
  • Fick DM Semla TP Steinman M, et al. By the 2019 American geriatrics society beers criteria update expert panel. American geriatrics society 2019 updated AGS beers criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2019;67(4):674–694. doi:10.1111/jgs.1576730693946
  • Triplitt C. Drug interactions of medications commonly used in diabetes. Diabetes Spectrum. 2006;19(4):202–211. doi:10.2337/diaspect.19.4.202
  • Reuters T. Micromedex® HealthCare Series (Internet Database) Version 2.0. Greenwood Village, Colorado: Thomson Healthcare Inc; 2013 Available from http://www.micromedexsolutions.com. Accessed 95, 2019.
  • Craftman AG, Johnell K, Fastbom J, Westerbotn M, von Strauss E. Time trends in 20 years of medication use in older adults: findings from three elderly cohorts in Stockholm, Sweden. Arch Gerontol Geriatr. 2016;63:28–35. doi:10.1016/j.archger.2015.11.01026791168
  • How CH. Novel oral anticoagulants for atrial fibrillation. Singapore Med J. 2015;56(12):657–658. doi:10.11622/smedj.201518426702159
  • Haasum Y, Fastbom J, Fratiglioni L, Kareholt I, Johnell K. Pain treatment in elderly persons with and without dementia: a population-based study of institutionalized and home-dwelling elderly. Drugs Aging. 2011;28(4):283–293. doi:10.2165/11587040-000000000-0000021428463
  • Franchi C, Tettamanti M, Pasina L, et al. Changes in drug prescribing to Italian community-dwelling elderly people: the EPIFARM-Elderly Project 2000–2010. Eur J Clin Pharmacol. 2014;70(4):437–443. doi:10.1007/s00228-013-1621-624398968
  • Trifan A, Stanciu C, Girleanu I, et al. Proton pump inhibitors therapy and risk of Clostridium difficile infection: systematic review and meta-analysis. World J Gastroenterol. 2017;23(35):6500–6515. doi:10.3748/wjg.v23.i35.650029085200
  • Thong BKS, Ima-Nirwana S, Chin KY. Proton pump inhibitors and fracture risk: a review of current evidence and mechanisms involved. Int J Environ Res Public Health. 2019;16(9):pii:E1571. doi:10.3390/ijerph16091571
  • Othman F, Card TR, Crooks CJ. Proton pump inhibitor prescribing patterns in the UK: a primary care database study. Pharmacoepidemiol Drug Saf. 2016;25(9):1079–1087. doi:10.1002/pds.404327255671
  • Maes ML, Fixen DR, Linnebur SA. Adverse effects of proton-pump inhibitor use in older adults: a review of the evidence. Ther Adv Drug Saf. 2017;8(9):273–297. doi:10.1177/204209861771538128861211
  • Nobili A, Marengoni A, Tettamanti M, et al. Association between clusters of diseases and polypharmacy in hospitalized elderly patients: results from the REPOSI study. Eur J Intern Med. 2011;22(6):597–602. doi:10.1016/j.ejim.2011.08.02922075287
  • Holt S, Schmiedl S, Thürmann PA. Potentially inappropriate medications in the elderly: the PRISCUS list. Dtsch Arztebl Int. 2010;107(31–32):543–551. doi:10.3238/arztebl.2010.054320827352
  • Laroche ML, Charmes JP, Merle L. Potentially inappropriate medications in the elderly: a French consensus panel list. Eur J Clin Pharmacol. 2007;63(8):725–731. doi:10.1007/s00228-007-0324-217554532
  • Cerejeira J, Lagarto L, Mukaetova-Ladinska EB. Behavioral and psychological symptoms of dementia. Front Neurol. 2012;3:73. doi:10.3389/fneur.2012.0007322586419
  • Gustafsson M, Karlsson S, Lovheim H. Inappropriate long-term use of antipsychotic drugs is common among people with dementia living in specialized care units. BMC Pharmacol Toxicol. 2013;14(1):10. doi:10.1186/2050-6511-14-1023391323
  • Park H, Satoh H, Miki A, Urushihara H, Sawada Y. Medications associated with falls in older people: systematic review of publications from a recent 5-year period. Eur J Clin Pharmacol. 2015;71(12):1429–1440. doi:10.1007/s00228-015-1955-326407688
  • Raut A, Vohra F, Surve R, Pawar A. A study of prescribing pattern, comorbidities, and cost analysis in elderly hospitalized patients in Pune. Chrismed J Health Res. 2016;3(3):191–196. doi:10.4103/2348-3334.183739
  • Wucherer D, Thyrian JR, Eichler T, et al. Drug-related problems in community-dwelling primary care patients screened positive for dementia. Int Psychogeriatr. 2017;29(11):1857–1868. doi:10.1017/S104161021700144228780910
  • Wucherer D, Eichler T, Hertel J, et al. Potentially inappropriate medication in community-dwelling primary care patients who were screened positive for dementia. J Alzheimers Dis. 2017;55(2):691–701. doi:10.3233/JAD-16058127716668
  • Kaufmann CP, Stampfli D, Hersberger KE, Lampert ML. Determination of risk factors for drug-related problems: a multidisciplinary triangulation process. BMJ Open. 2015;5(3):e006376. doi:10.1136/bmjopen-2014-006376
  • Lau DT, Mercaldo ND, Harris AT, Trittschuh E, Shega J, Weintraub S. Polypharmacy and potentially inappropriate medication use among community-dwelling elders with dementia. Alzheimer Dis Assoc Disord. 2010;24(1):56–63. doi:10.1097/WAD.0b013e31819d6ec919561441
  • Shi BY. The importance and strategy of diabetes prevention. Chronic Dis Transl Med. 2016;2(4):204–207. doi:10.1016/j.cdtm.2016.11.01329063043
  • Harrison SL, Kouladjian O’Donnell L, Bradley CE, et al. Associations between the drug burden index, potentially inappropriate medications and quality of life in residential aged care. Drugs Aging. 2018;35(1):83–91. doi:10.1007/s40266-017-0513-329322470
  • Kanagaratnam L, Dramé M, Trenque T, et al. Adverse drug reactions in elderly patients with cognitive disorders: a systematic review. Maturitas. 2016;85:56–63. doi:10.1016/j.maturitas.2015.12.01326857880