407
Views
33
CrossRef citations to date
0
Altmetric
Review

Importance and management of micronutrient deficiencies in patients with Alzheimer’s disease

, &
Pages 531-542 | Published online: 10 May 2013

References

  • FerriCPPrinceMBrayneCAlzheimer’s Disease InternationalGlobal prevalence of dementia: a Delphi consensus studyLancet200536695032112211716360788
  • SteeleMStuchburyGMünchGThe molecular basis of the prevention of Alzheimer’s disease through healthy nutritionExp Gerontol2007421–2283616839733
  • NortonMCDewJSmithHCache County InvestigatorsLifestyle behavior pattern is associated with different levels of risk for incident dementia and Alzheimer’s disease: the Cache County StudyJ Am Geriatr Soc201260340541222316091
  • MayeuxRSternYEpidemiology of Alzheimer diseaseCold Spring Harb Perspect Med201228pii a006239
  • Van DykKSanoMThe impact of nutrition on cognition in the elderlyNeurochem Res2007324–589390417342414
  • Gillete-GuyonnetSNourhashemiFAndrieuSWeight loss in Alzheimer diseaseClin Nutr2000712637S642S
  • SpaccaventoSDel PreteMCracaAFiorePInfluence of nutritional status on cognitive, functional and neuropsychiatric deficits in Alzheimer’s diseaseArch Gerontol Geriatr200948335636018448178
  • VassalloNScerriCMediterranean diet and dementia of the Alzheimer TypeCurr Aging Sci Epub9272012
  • GuYSchupfNCosentinoSALuchsingerJAScarmeasNNutrient intake and plasma β-amyloidNeurology201278231832184022551728
  • CuiKLuoXXuKVen MurthyMRRole of oxidative stress in neurodegeneration: recent developments in assay methods for oxidative stress and nutraceutical antioxidantsProg Neuropsychopharmacol Biol Psychiatry200428577179915363603
  • ChauhanVChauhanAOxidative stress in Alzheimer’s diseasePathophysiology200613319520816781128
  • ZhuXLeeHPerryGSmithMAAlzheimer disease, the two-hit hypothesis: an updateBiochim Biophys Acta20071772449450217142016
  • MarianiEPolidoriMCCherubiniAMecocciPOxidative stress in brain aging, neurodegenerative and vascular diseases: an overviewJ Chromatogr B Analyt Technol Biomed Life Sci200582716575
  • GreenoughMACamakarisJBushAIMetal dyshomeostasis and oxidative stress in Alzheimer’s diseaseNeurochem Int201362554055522982299
  • CastroLFreemanBAReactive oxygen species in human health and diseaseNutrition2001172163165
  • PappLVLuJHolmgrenAKhannaKKFrom selenium to selenoproteins: synthesis, identity, and their role in human healthAntioxid Redox Signal200797755806
  • BerrCBalansardBArnaudJRousselAMAlpérovitchACognitive decline is associated with systemic oxidative stress: the EVA Study. Etude du Vieillissement ArtérielJ Am Geriatr Soc200048101285129111037017
  • GaoSJinYHallKSSelenium level and cognitive function in rural elderly ChineseAm J Epidemiol2007165895596517272290
  • CardosoBROngTPJacob-FilhoWJaluulOFreitasMICozzolinoSMNutritional status of selenium in Alzheimer’s disease patientsBr J Nutr2010103680380619948078
  • VuralHDemirinHKaraYErenIDelibasNAlterations of plasma magnesium, copper, zinc, iron and selenium concentrations and some related erythrocyte antioxidant enzyme activities in patients with Alzheimer’s diseaseJ Trace Elem Med Biol201024316917320569929
  • Ceballos-PicotIMerad-BoudiaMNicoleAPeripheral antioxidant enzyme activities and selenium in elderly subjects and in dementia of Alzheimer’s type – place of the extracellular glutathione peroxidaseFree Radic Biol Med19962045795878904299
  • SmorgonCMariEAttiARTrace elements and cognitive impairment: an elderly cohort studyArch Gerontol Geriatr Suppl2004939340215207438
  • ZhangSRocourtCChengWSelenoproteins and the aging brainMech Ageing Dev2010131425326020219520
  • Fairweather-TaitSJBaoYBroadleyMRSelenium in human health and diseaseAntioxid Redox Signal20111471337138320812787
  • LuTPanYKaoSYGene regulation and DNA damage in the ageing human brainNature2004429699488389115190254
  • MillerJAOldhamMCGeschwindDHA systems level analysis of transcriptional changes in Alzheimer’s disease and normal agingJ Neurosci20082861410142018256261
  • BellingerFPHeQPBellingerMTAssociation of selenoprotein P with Alzheimer’s pathology in human cortexJ Alzheimers Dis200815346547218997300
  • TakemotoASBerryMJBellingerFPRole of selenoprotein P in Alzheimer’s diseaseEthn Dis2010201 Suppl 1S1S92520521393
  • GarciaTEsparzaJLNoguésMRRomeuMDomingoJLGómezMOxidative stress status and RNA expression in hippocampus of an animal model of Alzheimer’s disease after chronic exposure to aluminumHippocampus200920121822519405147
  • TapieroHTownsendDMTewKDThe antioxidant role of selenium and seleno-compoundsBiomed Pharmacother2003573–413414412818475
  • SchuesselKLeutnerSCairnsNJMüllerWEEckertAImpact of gender on upregulation of antioxidant defence mechanisms in Alzheimer’s disease brainJ Neural Transm200411191167118215338332
  • HerbetteSRoeckel-DrevetPDrevetJRSeleno-independent glutathione peroxidases. More than simple antioxidant scavengersFEBS J200727492163218017419737
  • ParudariuMCiobicaAHritcuLStoicaBBildWStefanescuCChanges of some oxidative stress markers in the serum of patients with mild cognitive impairment and Alzheimer’s diseaseNeurosci Lett2010469161019914330
  • RaymanMPFood-chain selenium and human health: emphasis on intakeBr J Nutr2008100225426818346308
  • ThomsonCDChisholmAMcLachlanSKCampbellJMBrazil nuts: an effective way to improve selenium statusAm J Clin Nutr200887237938418258628
  • Stockler-PintoMBMafraDFarageNEBoaventuraGTCozzolinoSMEffect of Brazil nut supplementation on the blood levels of selenium and glutathione peroxidase in hemodialysis patientsNutrition20102611–121065106920018488
  • BehrCSEfeito de uma dieta enriquecida com castanha-do-Brasil (Bertolletia excelsa, L) no estado nutricional relativo ao selênio de idosos não institucionalizados [Effect of a diet enriched with Brazil nut (Bertolletia excelsa, L) on selenium nutritional status of non-institutionalized elderly]Master’s Thesis-FCF-FEA-FSP/USPSao Paulo, Brazil2004
  • CominettiCde BortoliMCGarridoABJrCozzolinoSMBrazilian nut consumption improves selenium status and glutathione peroxidase activity and reduces atherogenic risk in obese womenNutr Res201232640340722749175
  • MachlinLJBendichAFree radical tissue damage, protective role of antioxidant nutrientsFASEB J1987164414453315807
  • TappelALVitamin E as the biological lipid antioxidantVitam Horm196220493510
  • BoothbyLADoeringPLVitamin C and vitamin E for Alzheimer’s diseaseAnn Pharmacother200539122073208016227450
  • MunozAMAgudeloGMLoperaFJNutritional condition in patients with Alzheimer-type dementia from the neurosciences’ group, Medellín 2004Biomédica2006261:113125 Spanish16929909
  • MachadoJCaramCLFrankAALaksJNutritional status in Alzheimer’s diseaseRev Assoc Med Bras200955218819119488656
  • MorrisMCEvansDABieniasJLDietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community studyJAMA2002287243230323712076219
  • DevoreEEGrodsteinFvan RooijFJDietary antioxidants and long-term risk of dementiaArch Neurol201067781982520625087
  • LuchsingerJAMayeuxRDietary factors and Alzheimer’s diseaseLancet Neurol200431057958715380154
  • ZandiPPAnthonyJCKhachaturianASCache County Study GroupReduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County StudyArch Neurol2004611828814732624
  • GraySLAndersonMLCranePKAntioxidant vitamin supplement use and risk of dementia or Alzheimer’s disease in older adultsJ Am Geriatr Soc200856229129518047492
  • BrewerGJWhy vitamin E therapy fails for treatment of Alzheimer’s diseaseJ Alzheimers Dis2010191273020061623
  • CardosoBRCozzolinoSMFOxidative stress in Alzheimer’s disease: the role of vitamins C and ENutrire – Revista da Sociedade Brasileira de Altimentação e Nutrição2009343249259
  • DaiQBorensteinARWuYJacksonJCLarsonEBFruit and vegetable juices and Alzheimer’s disease: the Kame ProjectAm J Med2006119975175916945610
  • DoniniLMDe FeliceMRCannellaCNutritional status determinants and cognition in the elderlyArc Gerontol Geriatr200744Suppl 1143153
  • MorrisMCEvansDATangneyCCRelation of the tocopherol forms to incident Alzheimer disease and to cognitive changeAm J Clin Nutr200581250851415699242
  • TudorRZalewskiPDRatnaikeRNZinc in health and chronic diseaseJ Nutr Health Aging200591455115750665
  • AndreiniCBanciLBertiniIRosatoACounting the zincproteins encoded in the human genomeJ Proteome Res20065119620116396512
  • WardRJDexterDTCrichtonRRChelating agents for neurodegenerative diseasesCurr Med Chem201219172760277222489724
  • FinefrockAEBushAIDoraiswamyPMCurrent status of metals as therapeutic targets in Alzheimer’s diseaseJ Am Geriatr Soc20035181143114812890080
  • BondaDJLeeHGBlairJAZhuXPerryGSmithMARole of metal dyshomeostasis in Alzheimer diseaseMetallomics20113326727021298161
  • FredericksonCJKohJYBushAIThe neurobiology of zinc in health and diseaseNat Rev Neurosci20056644945215891778
  • BorchardtTCamakarisJCappaiRMastersCLBeyreutherKMulthaupGCopper inhibits beta-amyloid production and stimulates the non-amyloidogenic pathway of amyloid-precursor-protein secretionBiochem. J1999344Pt 246146710567229
  • BologninSMessoriLDragoDGabbianiCCendronLZattaPAluminum, copper, iron and zinc differentially alter amyloid-Aβ(1–42) aggregation and toxicityInt J Biochem Cell Biol201143687788521376832
  • SquittiRBarbatiGRossiLExcess of nonceruloplasmin serum copper in AD correlates with MMSE, CSF [beta]-amyloid, and h-tauNeurology2006671768216832081
  • SquittiRBressiFPasqualettiPLongitudinal prognostic value of serum “free” copper in patients with Alzheimer diseaseNeurology2009721505519122030
  • BrewerGJKanzerSHZimmermanEACelminsDFHeckmanSMDickRCopper and ceruloplasmin abnormalities in Alzheimer’s diseaseAm J Alzheimer’s Dis Other Demen201025649049720631161
  • BrewerGJCopper toxicity in Alzheimer’s disease: cognitive loss from ingestion of inorganic copperJ Trace Elem Med Biol2012262–3899222673823
  • BushAIMulthaupGMoirRDA novel zinc(II) binding site modulates the function of the beta A4 amyloid protein precursor of Alzheimer’s diseaseJ Biol Chem19932682216109161128344894
  • BushAIPettingellWHJrParadisMDTanziREModulation of A beta adhesiveness and secretase site cleavage by zincJ Biol Chem19942691612152121588163520
  • BushAIPettingellWHMulthaupGRapid induction of Alzheimer A beta amyloid formation by zincScience19942655177146414678073293
  • TalmardCLeuma YonaRFallerPMechanism of zinc(II)-promoted amyloid formation: zinc(II) binding facilitates the transition from the partially alpha-helical conformer to aggregates of amyloid beta protein (1–28)J Biol Inorg Chem200914344945519083027
  • LovellMAA potential role for alterations of zinc and zinc transport proteins in the progression of Alzheimer’s diseaseJ Alzheimers Dis200916347148319276540
  • WilquetVDe StrooperBAmyloid-beta precursor protein processing in neurodegenerationCurr Opin Neurobiol200414558258815464891
  • CraddockTJTuszynskiJAChopraDThe zinc dyshomeostasis hypothesis of Alzheimer’s diseasePLoS One201273e3355222457776
  • LoefMStillfriedNVWalachHZinc diet and Alzheimer’s disease: a systematic reviewNutr Neurosci201215521222583839
  • Institute of MedicineDietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and ZincWashington, DC2001
  • LoweNMMedinaMWStammersALThe relationship between zinc intake and serum/plasma zinc concentration in adults: a systematic review and dose-response meta-analysis by the EURRECA NetworkBr J Nutr2012108111962197123244547
  • HolickMFVitamin D deficiencyN Engl J Med2007357326628117634462
  • HolickMFBinkleyNCBischoff-FerrariHAGuidelines for preventing and treating vitamin D deficiency and insufficiency revisitedJ Clin Endocrinol Metab20129741153115822442274
  • MechicaJBRaquitismo e osteomalacia [Rickets and osteomalacia]Arq Bras Endocrinal Metab1999436:457466 Portuguese
  • PetersBSMartiniLANutritional aspects of the prevention and treatment of osteoporosisArq Bras Endocrinol Metab2010542179185
  • AnnweilerCBeauchetOVitamin D-mentia: randomized clinical trials should be the next stepNeuroepidemiology2011373–424925822156654
  • KalueffAVTuohimaaPNeurosteroid hormone vitamin D and its utility in clinical nutritionCurr Opin Clin Nutr Metab Care2007101121917143049
  • EylesDWSmithSKinobeRHewisonMMcGrathJJDistribution of the vitamin D receptor and 1 alpha-hydroxylase in human brainJ Chem Neuroanat2005291213015589699
  • AnnweilerCSchottAMAllaliGAssociation of vitamin D deficiency with cognitive impairment in older women: cross-sectional studyNeurology2010741273219794127
  • SlininYPaudelMLTaylorBCOsteoporotic Fractures in Men (MrOS) Study Research Group25-Hydroxyvitamin D levels and cognitive performance and decline in elderly menNeurology2010741334119940271
  • LlewellynDJLangIALangaKMVitamin D and risk of cognitive decline in elderly personsArch Intern Med2010170131135114120625021
  • BreitlingLPPernaLMüllerHRaumEKliegelMBrennerHVitamin D and cognitive functioning in the elderly population in GermanyExp Gerontol201247112212722123431
  • AnnweilerCSchottAMRollandYBlainHHerrmannFRBeauchetODietary intake of vitamin D and cognition in older women: a large population-based studyNeurology201075201810181621079183
  • MasoumiAGoldensonBGhirmaiS1alpha,25-dihydroxyvitamin D3 interacts with curcuminoids to stimulate amyloid-beta clearance by macrophages of Alzheimer’s disease patientsJ Alzheimers Dis200917370371719433889
  • MizwickiMTMenegazDZhangJGenomic and nongenomic signaling induced by 1α,25(OH)2-vitamin D3 promotes the recovery of amyloid-β phagocytosis by Alzheimer’s disease macrophagesJ Alzheimers Dis2012291516222207005
  • AnnweilerCFantinoBGautierJBeaudenonMThierySBeauchetOCognitive effects of vitamin D supplementation in older outpatients visiting a memory clinic: a pre-post studyJ Am Geriatr Soc201260479379522494292
  • SteinMSSchererSCLaddKSHarrisonLCA randomized controlled trial of high-dose vitamin D2 followed by intranasal insulin in Alzheimer’s diseaseJ Alzheimers Dis201126347748421694461
  • AnnweilerCLlewellynDJBeauchetOLow Serum vitamin D concentrations in Alzheimer’s disease: a systematic review and meta-analysisJ Alzheimers Dis201333365967423042216
  • Institute of MedicineDietary Reference Intakes for Calcium and Vitamin DWashington, DCInstitute of Medicine2010
  • MorrisMCSchneiderJATangneyCCThoughts on B-vitamins and dementiaJ Alzheimers Dis20069442943316917152
  • SavageDGLindenbaumJNeurological complications of acquired cobalamin deficiency: clinical aspectsBaillieres Clin Haematol1995836576788534966
  • AndrèsELoukiliNHNoelEVitamin B12 (cobalamin) deficiency in elderly patientsCMAJ2004171325125915289425
  • LanskaDJChapter 30: historical aspects of the major neurological vitamin deficiency disorders: the water-soluble B vitaminsHandb Clin Neurol20099544547619892133
  • SeshadriSBeiserASelhubJPlasma homocysteine as a risk factor for dementia and Alzheimer’s diseaseN Engl J Med2002346747648311844848
  • RavagliaGFortiPMaioliFHomocysteine and folate as risk factors for dementia and Alzheimer diseaseAm J Clin Nutr200582363664316155278
  • EliasMFSullivanLMD’AgostinoRBHomocysteine and cognitive performance in the Framingham offspring study: age is importantAm J Epidemiol2005162764465316107567
  • SchaferJHGlassTABollaKIMintzMJedlickaAESchwartzBSHomocysteine and cognitive function in a population-based study of older adultsJ Am Geriatr Soc200553338138815743278
  • LuchsingerJATangMXSheaSMillerJGreenRMayeuxRPlasma homocysteine levels and risk of Alzheimer diseaseNeurology200462111972197615184599
  • SeshadriSElevated plasma homocysteine levels: risk factor or risk marker for the development of dementia and Alzheimer’s disease?J Alzheimers Dis20069439339816917147
  • AisenPSSchneiderLSSanoMAlzheimer Disease Cooperative StudyHigh-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trialJAMA2008300151774178318854539
  • SmithADSmithSMde JagerCAHomocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trialPLoS One201059e1224420838622
  • MuskietFAFokkemaMRSchaafsmaABoersmaERCrawfordMAIs docosahexaenoic acid (DHA) essential? Lessons from DHA status regulation, our ancient diet, epidemiology and randomized controlled trialsJ Nutr2004134118318614704315
  • FreemantleEVandalMTremblay-MercierJOmega-3 fatty acids, energy substrates, and brain function during agingProstaglandins Leukot Essent Fatty Acids200675321322016829066
  • YehudaSRabinovitzSMostofskyDIEssential fatty acids and the brain: from infancy to agingNeurobiol Aging200526Suppl 19810216226347
  • OsterTPillotTDocosahexaenoic acid and synaptic protection in Alzheimer’s disease miceBiochim Biophys Acta20101801879179820211757
  • HashimotoMTozawaRKatakuraMProtective effects of prescription n-3 fatty acids against impairment of spatial cognitive learning ability in amyloid β-infused ratsFood Funct20112738639421894325
  • WhelanJRustCInnovative dietary sources of n-3 fatty acidsAnnu Rev Nutr2006267510316848701
  • CalonFOmega-3 polyunsaturated fatty acids in Alzheimer’s disease: key questions and partial answersCurr Alzheimer Res20118547047821605051
  • Barberger-GateauPRaffaitinCLetenneurLDietary patterns and risk of dementia: the Three-City cohort studyNeurology200769201921193017998483
  • KotaniSSakaguchiEWarashinaSDietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunctionNeurosci Res200656215916416905216
  • ChiuCCSuKPChengTCThe effects of omega-3 fatty acids monotherapy in Alzheimer’s disease and mild cognitive impairment: a preliminary randomized double-blind placebo-controlled studyProg Neuropsychopharmacol Biol Psychiatry20083261538154418573585
  • Yurko-MauroKMcCarthyDRomDMIDAS InvestigatorsBeneficial effects of docosahexaenoic acid on cognition in age-related cognitive declineAlzheimers Dement20106645646420434961
  • QuinnJFRamanRThomasRGDocosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trialJAMA2010304171903191121045096
  • Freund-LeviYEriksdotter-JönhagenMCederholmTOmega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: a randomized double-blind trialArch Neurol200663101402140817030655
  • Barberger-GateauPSamieriCFéartCPlourdeMDietary omega 3 polyunsaturated fatty acids and Alzheimer’s disease: interaction with apolipoprotein E genotypeCurr Alzheimer Res20118547949121605054
  • CalonFColeGNeuroprotective action of omega-3 polyunsaturated fatty acids against neurodegenerative diseases: evidence from animal studiesProstaglandins Leukot Essent Fatty Acids2007775–628729318037281
  • GuYScarmeasNDietary patterns in Alzheimer’s disease and cognitive agingCurr Alzheimer Res20118551051921605048
  • ScarmeasNLuchsingerJASchupfNPhysical activity, diet, and risk of Alzheimer diseaseJAMA2009302662763719671904
  • ScarmeasNSternYMayeuxRLuchsingerJAMediterranean diet, Alzheimer disease, and vascular mediationArch Neurol200663121709171717030648
  • ScarmeasNSternYMayeuxRManlyJJSchupfNLuchsingerJAMediterranean diet and mild cognitive impairmentArch Neurol200966221622519204158
  • SmithPJBlumenthalJABabyakMAEffects of the dietary approaches to stop hypertension diet, exercise, and caloric restriction on neurocognition in overweight adults with high blood pressureHypertension20105561331133820305128
  • AkbaralyTNSingh-ManouxAMarmotMGBrunnerEJEducation attenuates the association between dietary patterns and cognitionDement Geriatr Cogn Disord200927214715419182482
  • GuYNievesJWSternYLuchsingerJAScarmeasNFood combination and Alzheimer disease risk: a protective dietArch Neurol201067669970620385883
  • PsaltopoulouTKyrozisAStathopoulosPTrichopoulosDVassilopoulosDTrichopoulouADiet, physical activity and cognitive impairment among elders: the EPIC-Greece cohort (European Prospective Investigation into Cancer and Nutrition)Public Health Nutr200811101054106218205988
  • FéartCSamieriCRondeauVAdherence to a Mediterranean diet, cognitive decline, and risk of dementiaJAMA2009302663864819671905
  • SolfrizziVFrisardiVSeripaDMediterranean diet in predementia and dementia syndromesCurr Alzheimer Res20118552054221605047