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Original Research

The Electronic Frailty Index is Associated with Increased Infection and All-Cause Mortality Among Older Patients with Primary Lung Cancer: A Cohort Study

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Pages 1825-1833 | Published online: 11 Oct 2021

References

  • Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424.30207593
  • Chen G, Feng J, Zhou C, et al. Quality of life (QoL) analyses from OPTIMAL (CTONG-0802), a Phase III, randomised, open-label study of first-line erlotinib versus chemotherapy in patients with advanced EGFR mutation-positive non-small-cell lung cancer (NSCLC). Ann Oncol. 2013;24(6):1615–1622. doi:10.1093/annonc/mdt01223456778
  • Franco I, Chen YH, Chipidza F, et al. Use of frailty to predict survival in elderly patients with early stage non-small-cell lung cancer treated with stereotactic body radiation therapy. J Geriatr Oncol. 2018;9(2):130–137. doi:10.1016/j.jgo.2017.09.00228941581
  • Anderson LJ, Albrecht ED, Garcia JM. Update on management of cancer-related cachexia. Curr Oncol Rep. 2017;19(1):3. doi:10.1007/s11912-017-0562-028138933
  • Collins J, Noble S, Chester J, Coles B, Byrne A. The assessment and impact of sarcopenia in lung cancer: a systematic literature review. BMJ Open. 2014;4(1):e003697. doi:10.1136/bmjopen-2013-003697
  • Antonio M, Saldaña J, Linares J, et al. Geriatric assessment may help decision-making in elderly patients with inoperable, locally advanced non-small-cell lung cancer. Br J Cancer. 2018;118(5):639–647. doi:10.1038/bjc.2017.45529381689
  • Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. Lancet. 2013;381(9868):752–762. doi:10.1016/S0140-6736(12)62167-923395245
  • Rockwood K, Mitnitski A. Frailty in relation to the accumulation of deficits. J Gerontol A Biol Sci Med Sci. 2007;62(7):722–727. doi:10.1093/gerona/62.7.72217634318
  • Hajek A, Bock JO, Saum KU, et al. Frailty and healthcare costs-longitudinal results of a prospective cohort study. Age Ageing. 2018;47(2):233–241. doi:10.1093/ageing/afx15729036424
  • Clegg A, Bates C, Young J, et al. Development and validation of an electronic frailty index using routine primary care electronic health record data. Age Ageing. 2016;45(3):353–360. doi:10.1093/ageing/afw03926944937
  • Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56(3):M146–M156. doi:10.1093/gerona/56.3.M14611253156
  • Collard RM, Boter H, Schoevers RA, Oude Voshaar RC. Prevalence of frailty in community-dwelling older persons: a systematic review. J Am Geriatr Soc. 2012;60(8):1487–1492. doi:10.1111/j.1532-5415.2012.04054.x22881367
  • Ellis G, Whitehead MA, Robinson D, O’Neill D, Langhorne P. Comprehensive geriatric assessment for older adults admitted to hospital: meta-analysis of randomised controlled trials. BMJ. 2011;343:d6553. doi:10.1136/bmj.d655322034146
  • Chowdhury R, Peel NM, Krosch M, Hubbard RE. Frailty and chronic kidney disease: a systematic review. Arch Gerontol Geriatr. 2017;68:135–142. doi:10.1016/j.archger.2016.10.00727810661
  • Mitnitski AB, Mogilner AJ, Rockwood K. Accumulation of deficits as a proxy measure of aging. Sci World J. 2001;1:323–336. doi:10.1100/tsw.2001.58
  • Searle SD, Mitnitski A, Gahbauer EA, Gill TM, Rockwood K. A standard procedure for creating a frailty index. BMC Geriatr. 2008;8(1):24. doi:10.1186/1471-2318-8-2418826625
  • Kulminski AM, Ukraintseva SV, Kulminskaya IV, Arbeev KG, Land K, Yashin AI. Cumulative deficits better characterize susceptibility to death in elderly people than phenotypic frailty: lessons from the Cardiovascular Health Study. J Am Geriatr Soc. 2008;56(5):898–903. doi:10.1111/j.1532-5415.2008.01656.x18363679
  • Kojima G, Iliffe S, Walters K. Frailty index as a predictor of mortality: a systematic review and meta-analysis. Age Ageing. 2018;47(2):193–200. doi:10.1093/ageing/afx16229040347
  • Blodgett JM, Theou O, Howlett SE, Wu FC, Rockwood K. A frailty index based on laboratory deficits in community-dwelling men predicted their risk of adverse health outcomes. Age Ageing. 2016;45(4):463–468. doi:10.1093/ageing/afw05427076524
  • Wang Y, Zhang R, Shen Y, Su L, Dong B, Hao Q. Prediction of chemotherapy adverse reactions and mortality in older patients with primary lung cancer through frailty index based on routine laboratory data. Clin Interv Aging. 2019;14:1187–1197. doi:10.2147/CIA.S20187331308642
  • Polidoro A, Dornbusch T, Vestri A, Di Bona S, Alessandri C. Frailty and disability in the elderly: a diagnostic dilemma. Arch Gerontol Geriatr. 2011;52(2):e75–e78. doi:10.1016/j.archger.2010.06.00120615558
  • Rodriguez-Mañas L, Fried LP. Frailty in the clinical scenario. Lancet. 2015;385(9968):e7–e9. doi:10.1016/S0140-6736(14)61595-625468154
  • Dent E, Kowal P, Hoogendijk EO. Frailty measurement in research and clinical practice: a review. Eur J Intern Med. 2016;31:3–10. doi:10.1016/j.ejim.2016.03.00727039014
  • Shen Y, Hao Q, Wang Y, et al. The association between preoperative modified frailty index and postoperative complications in Chinese elderly patients with hip fractures. BMC Geriatr. 2021;21(1):370. doi:10.1186/s12877-021-02330-734134662
  • Ju C, Zhou J, Lee S, et al. Derivation of an electronic frailty index for predicting short-term mortality in heart failure: a machine learning approach. ESC Heart Fail. 2021;8(4):2837–2845. doi:10.1002/ehf2.1335834080784
  • Cohen HJ, Smith D, Sun CL, et al. Frailty as determined by a comprehensive geriatric assessment-derived deficit-accumulation index in older patients with cancer who receive chemotherapy. Cancer. 2016;122(24):3865–3872. doi:10.1002/cncr.3026927529755
  • Royston P, Parmar MK. Restricted mean survival time: an alternative to the hazard ratio for the design and analysis of randomized trials with a time-to-event outcome. BMC Med Res Methodol. 2013;13(1):152. doi:10.1186/1471-2288-13-15224314264
  • Dehbi HM, Royston P, Hackshaw A. Life expectancy difference and life expectancy ratio: two measures of treatment effects in randomised trials with non-proportional hazards. BMJ. 2017;357:j2250. doi:10.1136/bmj.j225028546261
  • Udo EE, Al-Sweih N, John P, Chugh TD. Antibiotic resistance of enterococci isolated at a teaching hospital in Kuwait. Diagn Microbiol Infect Dis. 2002;43(3):233–238. doi:10.1016/S0732-8893(02)00397-812106957
  • Liu H, Liu B, Zheng F, Chen X, Ye L, He Y. Distribution of pathogenic bacteria in lower respiratory tract infection in lung cancer patients after chemotherapy and analysis of integron resistance genes in respiratory tract isolates of uninfected patients. J Thorac Dis. 2020;12(8):4216–4223. doi:10.21037/jtd-20-92832944333
  • Brundle C, Heaven A, Brown L, et al. Convergent validity of the electronic frailty index. Age Ageing. 2019;48(1):152–156. doi:10.1093/ageing/afy16230321256
  • Kernick D, Chew-Graham CA, O’Flynn N. Clinical assessment and management of multimorbidity: NICE guideline. Br J Gen Pract. 2017;67(658):235–236. doi:10.3399/bjgp17X69085728450343
  • Howlett SE, Rockwood MR, Mitnitski A, Rockwood K. Standard laboratory tests to identify older adults at increased risk of death. BMC Med. 2014;12(1):171. doi:10.1186/s12916-014-0171-925288274
  • Krishnan M, Beck S, Havelock W, Eeles E, Hubbard RE, Johansen A. Predicting outcome after hip fracture: using a frailty index to integrate comprehensive geriatric assessment results. Age Ageing. 2014;43(1):122–126. doi:10.1093/ageing/aft08423832264
  • Rockwood K, Rockwood MR, Mitnitski A. Physiological redundancy in older adults in relation to the change with age in the slope of a frailty index. J Am Geriatr Soc. 2010;58(2):318–323. doi:10.1111/j.1532-5415.2009.02667.x20370858
  • Rockwood MR, Howlett SE, Rockwood K. Orthostatic hypotension (OH) and mortality in relation to age, blood pressure and frailty. Arch Gerontol Geriatr. 2012;54(3):e255–260. doi:10.1016/j.archger.2011.12.00922240412
  • Stow D, Matthews FE, Barclay S, et al. Evaluating frailty scores to predict mortality in older adults using data from population based electronic health records: case control study. Age Ageing. 2018;47(4):564–569. doi:10.1093/ageing/afy02229546362
  • Moorhouse P, Mallery LH. Palliative and therapeutic harmonization: a model for appropriate decision-making in frail older adults. J Am Geriatr Soc. 2012;60(12):2326–2332. doi:10.1111/j.1532-5415.2012.04210.x23110462
  • Rockwood K, Mitnitski A, Song X, Steen B, Skoog I. Long-term risks of death and institutionalization of elderly people in relation to deficit accumulation at age 70. J Am Geriatr Soc. 2006;54(6):975–979. doi:10.1111/j.1532-5415.2006.00738.x16776795
  • Kahlon S, Pederson J, Majumdar SR, et al. Association between frailty and 30-day outcomes after discharge from hospital. CMAJ. 2015;187(11):799–804. doi:10.1503/cmaj.15010026009583
  • Singh M, Stewart R, White H. Importance of frailty in patients with cardiovascular disease. Eur Heart J. 2014;35(26):1726–1731. doi:10.1093/eurheartj/ehu19724864078