Suboptimal Use of DOACs Post-Discharge for Geriatric Hip Fractures with Isolated Calf Deep Vein Thrombosis: Do Clinician Prescribing Preferences and Patient Compliance Alters Clinical Outcomes?

References

• Pincus D, Ravi B, Wasserstein D, et al. Association between wait time and 30-day mortality in adults undergoing hip fracture surgery. JAMA. 2017;318:1994–2003. doi:10.1001/jama.2017.17606
   PubMed Web of Science ®Google Scholar
• Yoo J, Lee JS, Kim S, et al. Length of hospital stay after Hip fracture surgery and 1-year mortality. Osteoporos Int. 2019;30:145–153. doi:10.1007/s00198-018-4747-7
   PubMed Web of Science ®Google Scholar
• Chen X, Wang Z, Liu H, et al. Muscular calf vein thrombosis is associated with increased 30-day mortality but not 90-day mortality in older patients with hip fracture. Am J Cardiol. 2022;184:141–146. doi:10.1016/j.amjcard.2022.08.018
   PubMed Web of Science ®Google Scholar
• Gao Y, Long A, Xie Z, et al. The compliance of thromboprophylaxis affects the risk of venous thromboembolism in patients undergoing Hip fracture surgery. SpringerPlus. 2016;5:1362. doi:10.1186/s40064-016-2724-1
   PubMedGoogle Scholar
• Li L, Zhou J, Huang L, et al. Prevention, treatment, and risk factors of deep vein thrombosis in critically ill patients in Zhejiang province, China: a multicenter, prospective, observational study. Ann Med. 2021;53:2234–2245. doi:10.1080/07853890.2021.2005822
   PubMed Web of Science ®Google Scholar
• Stevens SM, Woller SC, Kreuziger LB, et al. Antithrombotic therapy for VTE disease: second update of the CHEST guideline and expert panel report. Chest. 2021;160:e545–e608. doi:10.1016/j.chest.2021.07.055
   PubMed Web of Science ®Google Scholar
• McCormack T, Harrisingh MC, Horner D, Bewley S. Venous thromboembolism in adults: summary of updated NICE guidance on diagnosis, management, and thrombophilia testing. BMJ. 2020;2022:369.
   Google Scholar
• Liu XC, Chen XW, Li ZL, Wang SC, Chen C. Anatomical distribution of lower-extremity deep venous thrombosis in patients with acute stroke. J Stroke Cerebrovasc Dis. 2020;29:104866. doi:10.1016/j.jstrokecerebrovasdis.2020.104866
   PubMed Web of Science ®Google Scholar
• Qiu T, Zhang T, Liu L, et al. The anatomic distribution and pulmonary embolism complications of hospital-acquired lower extremity deep venous thrombosis. J Vasc Surg Venous Lymphat Disord. 2021;9:1391–1398.e1393. doi:10.1016/j.jvsv.2021.03.004
   PubMedGoogle Scholar
• Elfandi A, Anghel S, Sales C. Current management of isolated soleal and gastrocnemius vein thrombosis. J Vasc Surg Venous Lymphat Disord. 2015;3:341–344. doi:10.1016/j.jvsv.2015.02.002
   PubMedGoogle Scholar
• Makedonov I, Galanaud JP, Kahn SR. Significance and management of isolated distal deep vein thrombosis. Curr Opin Hematol. 2021;28:331–338. doi:10.1097/moh.0000000000000670
   PubMed Web of Science ®Google Scholar
• Zhao WG, Yan J-Y, Li X-L, et al. Characteristics and treatment strategy of isolated calf deep venous thrombosis after fractures: a review of recent literature. Orthop Surg. 2022;14:1263–1270. doi:10.1111/os.13292
   PubMed Web of Science ®Google Scholar
• Brewster AC, Jones AE, Johnson SA, Saunders JA, Witt DM. Outcomes of isolated distal thrombosis managed with serial compression ultrasonography. Thromb Res. 2021;208:66–70. doi:10.1016/j.thromres.2021.10.004
   PubMed Web of Science ®Google Scholar
• Palareti G. How I treat isolated distal deep vein thrombosis (IDDVT). Blood. 2014;123:1802–1809. doi:10.1182/blood-2013-10-512616
   PubMed Web of Science ®Google Scholar
• Xia ZN, Xiao K, Zhu W, et al. Risk assessment and management of preoperative venous thromboembolism following femoral neck fracture. J Orthop Surg Res. 2018;13:291. doi:10.1186/s13018-018-0998-4
   PubMed Web of Science ®Google Scholar
• Xu S, Chen JY, Zheng Q, Shi L, Tan AHC. Is chemoprophylaxis required after total knee and total Hip arthroplasty in the Asian population? A systematic review and network meta-analysis. Thromb Res. 2021;198:86–92. doi:10.1016/j.thromres.2020.11.033
   PubMed Web of Science ®Google Scholar
• Griffiths R, Babu S, Dixon P, et al. Guideline for the management of Hip fractures 2020: guideline by the Association of Anaesthetists. Anaesthesia. 2021;76:225–237. doi:10.1111/anae.15291
   PubMed Web of Science ®Google Scholar
• Ktistakis I, Giannoudis V, Giannoudis PV. Anticoagulation therapy and proximal femoral fracture treatment: an update. EFORT Open Rev. 2016;1:310–315. doi:10.1302/2058-5241.1.160034
   PubMed Web of Science ®Google Scholar
• Sugiyama T. Anticoagulant therapy and hip fracture risk: a possible involvement of physical activity. J Am Coll Cardiol. 2020;75:987. doi:10.1016/j.jacc.2019.11.064
   PubMed Web of Science ®Google Scholar
• Chen C, Liu Y, Wu H, et al. The outcome of isolated calf muscle vein thrombosis after open reduction and internal fixation for closed intra-articular distal femur fractures: a prospective cohort study. BMC Musculoskelet Disord. 2021;22:397. doi:10.1186/s12891-021-04289-3
   PubMed Web of Science ®Google Scholar
• Schulman S. Distal deep vein thrombosis--a benign disease? Thromb Res. 2014;134:5–6. doi:10.1016/j.thromres.2014.04.001
   PubMed Web of Science ®Google Scholar
• Rostagno C, Cartei A, Polidori G, et al. Management of ongoing direct anticoagulant treatment in patients with Hip fracture. Sci Rep. 2021;11:9467. doi:10.1038/s41598-021-89077-8
   PubMedGoogle Scholar
• Needleman L, Cronan JJ, Lilly MP, et al. Ultrasound for lower extremity deep venous thrombosis: multidisciplinary recommendations from the society of radiologists in ultrasound consensus conference. Circulation. 2018;137:1505–1515. doi:10.1161/circulationaha.117.030687
   PubMed Web of Science ®Google Scholar
• Cui Y, Lu Y, Huang Q, et al. Clinical application effects of different preoperative blood management schemes in older patients with delayed intertrochanteric fracture surgery. Clin Interv Aging. 2022;17:825–835. doi:10.2147/cia.s362020
   PubMed Web of Science ®Google Scholar
• Barrosse-Antle ME, Patel KH, Kramer JA, Baston CM. Point-of-care ultrasound for bedside diagnosis of lower extremity DVT. Chest. 2021;160:1853–1863. doi:10.1016/j.chest.2021.07.010
   PubMed Web of Science ®Google Scholar
• Kuczmik W, Wysokinski WE, Macedo T, et al. Calf vein thrombosis outcomes comparing anticoagulation and serial ultrasound imaging management strategies. Mayo Clin Proc. 2021;96:1184–1192. doi:10.1016/j.mayocp.2021.01.024
   PubMed Web of Science ®Google Scholar
• Shah A, Kerner V, Stanworth SJ, Agarwal S. Major haemorrhage: past, present and future. Anaesthesia. 2023;78:93–104. doi:10.1111/anae.15866
   PubMed Web of Science ®Google Scholar
• Kearon C, Akl EA, Ornelas J, et al. Antithrombotic Therapy for VTE Disease: CHEST guideline and expert panel report. Chest. 2016;149:315–352. doi:10.1016/j.chest.2015.11.026
   PubMed Web of Science ®Google Scholar
• Xing F, Li L, Long Y, Xiang Z. Admission prevalence of deep vein thrombosis in elderly Chinese patients with Hip fracture and a new predictor based on risk factors for thrombosis screening. BMC Musculoskelet Disord. 2018;19:444. doi:10.1186/s12891-018-2371-5
   PubMed Web of Science ®Google Scholar
• Zhang BF, Wei X, Huang H, et al. Deep vein thrombosis in bilateral lower extremities after Hip fracture: a retrospective study of 463 patients. Clin Interv Aging. 2018;13:681–689. doi:10.2147/cia.s161191
   PubMed Web of Science ®Google Scholar
• Zhao K, Wang Z, Tian S, et al. Incidence of and risk factors for pre-operative deep venous thrombosis in geriatric intertrochanteric fracture patients. Int Orthop. 2022;46:351–359. doi:10.1007/s00264-021-05215-x
   PubMed Web of Science ®Google Scholar
• Ding K, Wang H, Jia Y, et al. Incidence and risk factors associated with preoperative deep venous thrombosis in the young and middle-aged patients after Hip fracture. J Orthop Surg Res. 2022;17:15. doi:10.1186/s13018-021-02902-8
   PubMed Web of Science ®Google Scholar
• Barnett K, Mercer SW, Norbury M, et al. Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study. Lancet. 2012;380:37–43. doi:10.1016/s0140-6736(12)60240-2
   PubMed Web of Science ®Google Scholar
• Arahata M, Asakura H. Antithrombotic therapies for elderly patients: handling problems originating from their comorbidities. Clin Interv Aging. 2018;13:1675–1690. doi:10.2147/cia.s174896
   PubMed Web of Science ®Google Scholar
• Wattanaruengchai P, Nathisuwan S, Rattanavipanon W, et al. Prescriber compliance to direct oral anticoagulant labels and impact on outcomes in Thailand. Br J Clin Pharmacol. 2021;87:1390–1400. doi:10.1111/bcp.14535
   PubMed Web of Science ®Google Scholar
• Pandya EY, Bajorek B. Factors affecting patients’ perception on, and adherence to, anticoagulant therapy: anticipating the role of direct oral anticoagulants. Patient. 2017;10:163–185. doi:10.1007/s40271-016-0180-1
   PubMedGoogle Scholar
• Holbrook A, Wang M, Swinton M, et al. Barriers and facilitators for optimizing oral anticoagulant management: perspectives of patients, caregivers, and providers. PLoS One. 2021;16:e0257798. doi:10.1371/journal.pone.0257798
   PubMed Web of Science ®Google Scholar
• Al-Jabi SW, Dalu AA, Koni AA, et al. The relationship between self-efficacy and treatment satisfaction among patients with anticoagulant therapy: a cross-sectional study from a developing country. Thromb J. 2022;20:15. doi:10.1186/s12959-022-00374-2
   PubMed Web of Science ®Google Scholar
• Afzal SK, Hasan SS, Babar ZU. A systematic review of patient-reported outcomes associated with the use of direct-acting oral anticoagulants. Br J Clin Pharmacol. 2019;85:2652–2667. doi:10.1111/bcp.13985
   PubMed Web of Science ®Google Scholar
• Singh K, Yakoub D, Giangola P, et al. Early follow-up and treatment recommendations for isolated calf deep venous thrombosis. J Vasc Surg. 2012;55:136–140. doi:10.1016/j.jvs.2011.07.088
   PubMed Web of Science ®Google Scholar
• Forster R, Stewart M. Anticoagulants (extended duration) for prevention of venous thromboembolism following total Hip or knee replacement or Hip fracture repair. Cochrane Database Syst Rev. 2016;3:Cd004179. doi:10.1002/14651858.CD004179.pub2
   PubMedGoogle Scholar
• Moreno JP, Bautista M, Castro J, Bonilla G, Llinás A. Extended thromboprophylaxis for Hip or knee arthroplasty. Does the administration route and dosage regimen affect adherence? A cohort study. Int Orthop. 2020;44:237–243. doi:10.1007/s00264-019-04454-3
   PubMed Web of Science ®Google Scholar
• Mainbourg S, Cucherat M, Provencher S, et al. Twice- or once-daily dosing of direct oral anticoagulants, a systematic review and meta-analysis. Thromb Res. 2021;197:24–32. doi:10.1016/j.thromres.2020.10.011
   PubMed Web of Science ®Google Scholar
• Randelli F, Cimminiello C, Capozzi M, Bosco M, Cerulli G. Real life thromboprophylaxis in orthopedic surgery in Italy. Results of the GIOTTO study. Thromb Res. 2016;137:103–107. doi:10.1016/j.thromres.2015.11.007
   PubMed Web of Science ®Google Scholar
• Markel A. Should preoperative duplex for orthopedic operations be performed? The answer seems to be negative. Thromb Res. 2015;136:841–842. doi:10.1016/j.thromres.2015.08.012
   PubMed Web of Science ®Google Scholar