Oxidative stress and its downstream signaling in aging eyes

References

• KrebsHASome aspects of the regulation of fuel supply in omnivorous animalsAdv Enzyme Regul1972103974204569539
   PubMedGoogle Scholar
• CheesemanKHSlaterTFAn introduction to free radical biochemistryBr Med Bull1993494814938221017
   PubMed Web of Science ®Google Scholar
• HaberFWeissJÜber die Katalyse des Hydroperoxydes [On the catalysis of hydroperoxides]Naturwissenschaften193220948950
   Google Scholar
• FentonHJThe oxidation of tartaric acid in presence of ironJ Chem Soc Trans189465899910
   Google Scholar
• GoldsteinSMeyersteinDCzapskiGThe Fenton reagentsFree Radic Biol Med1993154354458225025
   PubMed Web of Science ®Google Scholar
• AmesBNShigenagaMKOxidants are a major contributor to agingAnn N Y Acad Sci199266385961482105
   PubMed Web of Science ®Google Scholar
• SiesHOxidative stress: introductory remarksSiesHOxidative StressLondonAcademic Press198517
   Google Scholar
• D’AutréauxBToledanoMBROS as signalling molecules: mechanisms that generate specificity in ROS homeostasisNat Rev Mol Cell Biol2007881382417848967
   PubMed Web of Science ®Google Scholar
• HalliwellBFree radicals and antioxidants: updating a personal viewNutr Rev20127025726522537212
   PubMed Web of Science ®Google Scholar
• McCordJMFridovichISuperoxide dismutase. An enzymic function for erythrocuprein (hemocuprein)J Biol Chem1969244604960555389100
   PubMed Web of Science ®Google Scholar
• HarmanDAgeing: a theory based on free radical and radiation chemistryJ Gerontol1956229830013332224
   PubMedGoogle Scholar
• GerschmanRFennWAscorbic acid content of adrenal glands of rat in oxygen poisoningAm J Physiol19521766813124487
   PubMed Web of Science ®Google Scholar
• GerschmanRNadigPWSnellACNyeSWEffect of high oxygen concentrations on eyes of newborn miceAm J Physiol1954179639639
   Web of Science ®Google Scholar
• GerschmanRGilbertDLNyeSWFennWInfluence of x-irradiation on oxygen poisoning in miceProc Soc Exp Biol Med195486272913177582
   PubMed Web of Science ®Google Scholar
• AgilADuránRBarreroFPlasma lipid peroxidation in sporadic Parkinson’s. Role of the L-dopaJ Neurol Sci2006240313616219327
   PubMed Web of Science ®Google Scholar
• ChoiJSullardsMCOlzmannJAOxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseasesJ Biol Chem2006281108161082416517609
   PubMed Web of Science ®Google Scholar
• AlalufSMuir-HowieHHuHLEvansAGreenMRAtmospheric oxygen accelerates the induction of a post-mitotic phenotype in human dermal fibroblasts: the key protective role of glutathioneDifferentiation20006614715511100905
   PubMed Web of Science ®Google Scholar
• AlexandrovaMBochevPMarkovaVDynamics of free radical processes in acute ischemic stroke: influence on neurological status and outcomeJ Clin Neurosci20041150150615177393
   PubMed Web of Science ®Google Scholar
• AmesBNShigenagaMKHagenTMOxidants, antioxidants and degenerative diseases of agingProc Natl Acad Sci U S A199390791579228367443
   PubMed Web of Science ®Google Scholar
• ConnerEMGrishamMBInflammation, free radicals, and antioxidantsNutrition1996122742778862535
   PubMed Web of Science ®Google Scholar
• WilliamsDLOxidative stress and the eyeVet Clin North Am Small Anim Pract20083817919218249249
   PubMed Web of Science ®Google Scholar
• SpectorAOxidative stress-induced cataract: mechanism of actionFASEB J19959117311827672510
   PubMed Web of Science ®Google Scholar
• Zanon-MorenoVMarco-VenturaPLleo-PerezAOxidative stress in primary open angle glaucomaJ Glaucoma20081726326818552610
   PubMed Web of Science ®Google Scholar
• Pinazo-DuránMDAzorinIMontoliuCGuerriCRenau-PiquerasJFree radicals are involved in the alcoholic optic neuropathyAlcohol Clin Exp Res199822A84
   Google Scholar
• MancinoRDi PierroDVaresiCLipid peroxidation and total antioxidant capacity in vitreous, aqueous humor, and blood samples from patients with diabetic retinopathyMol Vis2011171298130421633716
   PubMed Web of Science ®Google Scholar
• MeloPZanon-MorenoVAlvesCJOxidative stress response in the adult rat retina and plasma after repeated administration of methamphetamineNeurochem Int20105643143619948197
   PubMed Web of Science ®Google Scholar
• BeattySKohHPhilMHensonDBoultonMThe role of oxidative stress in the pathogenesis of age-related macular degenerationSurv Ophthalmol20004511513411033038
   PubMed Web of Science ®Google Scholar
• MargrainTHBoultonMMarshallJSlineyDHDo blue light filters confer protection against age-related macular degeneration?Prog Retin Eye Res20042352353115302349
   PubMed Web of Science ®Google Scholar
• RahmanKStudies on free radicals, antioxidants and co-factorsClin Interv Aging2007221923618044138
   PubMed Web of Science ®Google Scholar
• CarochoMFerreiraICA review on antioxidants, prooxidants and related controversy: natural and synthetic compounds, screening and analysis methodologies and future perspectivesFood Chem Toxicol201351152523017782
   PubMed Web of Science ®Google Scholar
• BirbenESahinerUMSackesenCErzurumSKalayciOOxidative stress and antioxidant defenseWorld Allergy Organ J2012591923268465
   PubMedGoogle Scholar
• DolyMDroy-LefaixMTBraquetPOxidative stress in diabetic retinaEXS1992622993071450593
   PubMedGoogle Scholar
• YadavUCKalariyaNMRamanaKVEmerging role of antioxidants in the protection of uveitis complicationsCurr Med Chem20111893194221182473
   PubMed Web of Science ®Google Scholar
• PrasharSPandavSSGuptaANathRAntioxidant enzymes in RBCs as a biological index of age related macular degenerationActa Ophthalmol (Copenh)1993712142188333268
   PubMed Web of Science ®Google Scholar
• PerryHDDry eye disease: pathophysiology, classification, and diagnosisAm J Manag Care200814S79S8718452371
   PubMed Web of Science ®Google Scholar
• TavaresFPFernandesRSBernardesTFBonfioliAASoaresEJDry eye diseaseSemin Ophthalmol201025849320590418
   PubMed Web of Science ®Google Scholar
• LabbéABrignole-BaudouinFBaudouinC[Ocular surface investigations in dry eye]J Fr Ophtalmol2007307697 French17287676
   PubMed Web of Science ®Google Scholar
• ScheinODMuñozBTielschJMBandeen-RocheKWestSPrevalence of dry eye among the elderlyAm J Ophthalmol19971247237289402817
   PubMed Web of Science ®Google Scholar
• MuñozBWestSKRubinGSCauses of blindness and visual impairment in a population of older Americans: the Salisbury Eye Evaluation StudyArch Ophthalmol200011881982510865321
   PubMed Web of Science ®Google Scholar
• MossSEKleinRKleinBELong-term incidence of dry eye in an older populationOptom Vis Sci20088566867418677233
   PubMed Web of Science ®Google Scholar
• SchaumbergDASullivanDABuringJEDanaMRPrevalence of dry eye syndrome among US womenAm J Ophthalmol200313631832612888056
   PubMed Web of Science ®Google Scholar
• GipsonIKSpurr-MichaudSArgüesoPTisdaleANgTFRussoCLMucin gene expression in immortalized human corneal-limbal and conjunctival epithelial cell linesInvest Ophthalmol Vis Sci2003442496250612766048
   PubMed Web of Science ®Google Scholar
• ZuclichJAConnollyJSOcular damage induced by near-ultraviolet laser radiationInvest Ophthalmol Vis Sci197615760764822714
   PubMed Web of Science ®Google Scholar
• HiguchiATakahashiKHirashimaMKawakitaTTsubotaKSelenoprotein P controls oxidative stress in corneaPLoS One20105e991120360971
   PubMed Web of Science ®Google Scholar
• UchinoYKawakitaTIshiiTIshiiNTsubotaKA new mouse model of dry eye disease: oxidative stress affects functional decline in the lacrimal glandCornea201231Suppl 1S63S6723038038
   PubMedGoogle Scholar
• NakamuraSShibuyaMNakashimaHInvolvement of oxidative stress on corneal epithelial alterations in a blink-suppressed dry eyeInvest Ophthalmol Vis Sci2007481552155817389484
   PubMed Web of Science ®Google Scholar
• VanDerMeidKRSuSPKrenzerKLWardKWZhangJZA method to extract cytokines and matrix metalloproteinases from Schirmer strips and analyze using LuminexMol Vis2011171056106321552500
   PubMed Web of Science ®Google Scholar
• Enríquez-de-SalamancaACastellanosESternMETear cytokine and chemokine analysis and clinical correlations in evaporative-type dry eye diseaseMol Vis20101686287320508732
   PubMed Web of Science ®Google Scholar
• BaudouinCBrignoleFBecquetFPisellaPJGoguelAFlow cytometry in impression cytology specimens. A new method for evaluation of conjunctival inflammationInvest Ophthalmol Vis Sci199738145814649191610
   PubMed Web of Science ®Google Scholar
• Pinazo-DuránMDGalbis-EstradaCPons-VázquezSCantú-DibildoxJMarco-RamírezCBenítez-del-CastilloJEffects of a nutraceutical formulation based on the combination of antioxidants and ω-3 essential fatty acids in the expression of inflammation and immune response mediators in tears from patients with dry eye disordersClin Interv Aging2013813914823430672
   PubMed Web of Science ®Google Scholar
• Galbis-EstradaCPinazo-DuránMDCantú-DibildoxJMarco-RamírezCDiaz-LlopisMBenítez-del-CastilloJPatients undergoing antihypertensive treatment with antihypertensive eye drops responded positively with respect to their ocular surface disorder to oral supplementation with antioxidants and essential fatty acidsClin Interv Aging2013871171923818768
   PubMed Web of Science ®Google Scholar
• TsubotaKKawashimaMInabaTThe antiaging approach for the treatment of dry eyeCornea201231Suppl 1S3S823038031
   PubMedGoogle Scholar
• WeinrebRNKhawPTPrimary open-angle glaucomaLancet20043631711172015158634
   PubMed Web of Science ®Google Scholar
• OsborneNNWoodJPChidlowGBaeJHMelenaJNashMSGanglion cell death in glaucoma: what do we really know?Br J Ophthalmol19998398098610413706
   PubMed Web of Science ®Google Scholar
• HuangWDobberfuhlAFilippopoulosTTranscriptional up-regulation and activation of initiating caspases in experimental glaucomaAm J Pathol200516767368116127148
   PubMed Web of Science ®Google Scholar
• Pinazo-DuránMDGallego-PinazoRZanón-MorenoVSerranoMGlaucoma genetics – regulation of cell surviving and death in the retinaRumelktSGlaucoma: Basic and Clinical ConceptsRijeka, CroatiaInTech2011207224
   Google Scholar
• SaccàSCIzzottiAOxidative stress and glaucoma: injury in the anterior segment of the eyeProg Brain Res200817338540718929123
   PubMed Web of Science ®Google Scholar
• TezelGOxidative stress in glaucomatous neurodegeneration: mechanisms and consequencesProg Retin Eye Res20062549051316962364
   PubMed Web of Science ®Google Scholar
• Pinazo-DuránMDZanón-MorenoVGarcía-MedinaJJGallego-PinazoREvaluation of presumptive biomarkers of oxidative stress, immune response and apoptosis in primary open-angle glaucomaCurr Opin Ophthalmol20131398107
   Google Scholar
• BazanNGSurvival signaling in retinal pigment epithelial cells in response to oxidative stress: significance in retinal degenerationsAdv Exp Med Biol200657253154017249620
   PubMed Web of Science ®Google Scholar
• KennedyCJRakoczyPEConstableIJLipofuscin of the retinal pigment epithelium: a reviewEye (Lond)199597637718849547
   PubMed Web of Science ®Google Scholar
• CaiJNelsonKCWuMSternbergPJrJonesDPOxidative damage and protection of the RPEProg Retin Eye Res20001920522110674708
   PubMed Web of Science ®Google Scholar
• MukherjeePKMarcheselliVLSerhanCNBazanNGNeuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stressProc Natl Acad Sci U S A20041018491849615152078
   PubMed Web of Science ®Google Scholar
• BazanNGNeuroprotectin D1 (NPD1): a DHA-derived mediator that protects brain and retina against cell injury-induced oxidative stressBrain Pathol20051515916615912889
   PubMed Web of Science ®Google Scholar
• CalandriaJMMukherjeePKde Rivero VaccariJCZhuMPetasisNABazanNGAtaxin-1 poly(Q)-induced proteotoxic stress and apoptosis are attenuated in neural cells by docosahexaenoic acid-derived neuroprotectin D1J Biol Chem2012287237262373922511762
   PubMed Web of Science ®Google Scholar
• KleinRPetoTBirdAVannewkirkMRThe epidemiology of age related macular degenerationAm J Ophthalmol200413748649515013873
   PubMed Web of Science ®Google Scholar
• CurcioCAJohnsonMRudolfMHuangJDThe oil spill in ageing Bruch membraneBr J Ophthalmol2011951638164521890786
   PubMed Web of Science ®Google Scholar
• FaghirZBazanNGPI3K/Akt and mTOR/p70S6K pathways mediate neuroprotectin D1-induced retinal pigment epithelial cell survival during oxidative stress-induced apoptosisExp Eye Res20109071872520230819
   PubMed Web of Science ®Google Scholar
• KlettnerAOxidative stress induced cellular signaling in RPE cellsFront Biosci (Schol Ed)2012439241122202067
   PubMedGoogle Scholar
• KoenekoopRThe gene for Stargardt disease, ABCA4, is a major retinal gene: a mini-reviewOphthalmic Genet200324758012789571
   PubMedGoogle Scholar
• NowakJZOxidative stress, polyunsaturated fatty acids-derived oxidation products and bisretinoids as potential inducers of CNS diseases: focus on age-related macular degenerationPharmacol Rep20136528830423744414
   PubMed Web of Science ®Google Scholar
• CastilhoAAveleiraCALealECHeme oxygenase-1 protects retinal endothelial cells against high glucose- and oxidative/nitrosative stress-induced toxicityPLoS One20127e4242822879979
   PubMed Web of Science ®Google Scholar
• SparrowJRZhouJBen-ShabatSVollmerHItagakiYNakanishiKInvolvement of oxidative mechanisms in blue-light-induced damage to A2E-laden RPEInvest Ophthalmol Vis Sci20024341222122711923269
   PubMed Web of Science ®Google Scholar
• MalekiSGopalakrishnanSGhanianZOptical imaging of mitochondrial redox state in rodent model of retinitis pigmentosaJ Biomed Opt2013181600423291617
   PubMed Web of Science ®Google Scholar
• ZhuoYLuoHZhangKLeber hereditary optic neuropathy and oxidative stressProc Natl Acad Sci U S A2012109198821988323197830
   PubMed Web of Science ®Google Scholar
• Pinazo-DuránMDVerdejoCAzorínIRenau-PiquerasJIborraFJColocalization of aldehyde dehydrogenases and Fe/NADPH-induced lipid peroxidation in tissue sections of rat retinaOphthalmic Res200032616810754436
   PubMed Web of Science ®Google Scholar
• Galbis-EstradaCPons-VázquezSGallego-PinazoRGlutathione-dependent formaldehyde dehydrogenase (ADH3) and low km mitochondrial aldehyde dehydrogenase (ALDH2). New evidence for differential expression in the rat retina in response to oxidative stressFree Radic Res201246778422117533
   PubMed Web of Science ®Google Scholar
• RogersBSSymonsRCKomeimaKDifferential sensitivity of cones to iron-mediated oxidative damageInvest Ophthalmol Vis Sci20074843844517197565
   PubMed Web of Science ®Google Scholar
• DentchevTHahnPDunaiefJLStrong labeling for iron and the iron-handling proteins ferritin and ferroportin in the photoreceptor layer in age-related macular degenerationArch Ophthalmol20051231745174616344450
   PubMedGoogle Scholar
• HeXHahnPIacovelliJIron homeostasis and toxicity in retinal degenerationProg Retin Eye Res20072664967317921041
   PubMed Web of Science ®Google Scholar
• SongDSongYHadziahmetovicMZhongYDunaiefJLSystemic administration of the iron chelator deferiprone protects against light-induced photoreceptor degeneration in the mouse retinaFree Radic Biol Med201253647122579919
   PubMed Web of Science ®Google Scholar
• ArdenGBSivaprasadSHypoxia and oxidative stress in the causation of diabetic retinopathyCurr Diabetes Rev2011729130421916837
   PubMedGoogle Scholar
• SonSMRole of vascular reactive oxygen species in development of vascular abnormalities in diabetesDiabetes Res Clin Pract200677Suppl 1S65S7017467110
   PubMed Web of Science ®Google Scholar
• GuptaMMChariSLipid peroxidation and antioxidant status in patients with diabetic retinopathyIndian J Physiol Pharmacol20054918719216170987
   PubMedGoogle Scholar
• VerdejoCMarcoPRenau-PiquerasJPinazo-DuranMDLipid peroxidation in proliferative vitreoretinopathiesEye (Lond)19991318318810450379
   PubMed Web of Science ®Google Scholar
• RobisonWGJrJacotJLKatzMLGloverJPRetinal vascular changes induced by the oxidative stress of alpha-tocopherol deficiency contrasted with diabetic microangiopathyJ Ocul Pharmacol Ther20001610912010803422
   PubMed Web of Science ®Google Scholar
• Martín-GallánPCarrascosaAGussinyéMDomínguezCBiomarkers of diabetes-associated oxidative stress and antioxidant status in young diabetic patients with or without subclinical complicationsFree Radic Biol Med2003341563157412788476
   PubMed Web of Science ®Google Scholar
• ValkoMLeibfritzDMoncolJCroninMTMazuzMTelsenJFree radicals and antioxidants in normal physiological functions and human diseaseInt J Biochem Cell Biol200739448416978905
   PubMed Web of Science ®Google Scholar
• PácalLVarvařovskáJRušavýZParameters of oxidative stress, DNA damage and DNA repair in type 1 and type 2 diabetes mellitusArch Physiol Biochem201111722223021338322
   PubMedGoogle Scholar
• DolinoyDCHuangDJirtleRLMaternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early developmentProc Natl Acad Sci U S A2007104130561306117670942
   PubMed Web of Science ®Google Scholar
• US Department of Health and Human ServicesDietary guidelines for Americans, 2010 Available from: http://www.dietaryguidelines.govAccessed December 19, 2013
   Google Scholar
• KeysAMenottiAKarvonenMJThe diet and 15-year death rate in the seven countries studyAm J Epidemiol19861249039153776973
   PubMed Web of Science ®Google Scholar
• KeysAMediterranean diet and public health: personal reflectionsAm J Clin Nutr1995611321S1323S7754982
   PubMed Web of Science ®Google Scholar
• SofiFCesariFAbbateRGensiniGFCasiniAAdherence to Mediterranean diet and health status: meta-analysisBMJ2008377a134418786971
   PubMed Web of Science ®Google Scholar
• Serra-MajemLRomanBEstruchRScientific evidence of interventions using the Mediterranean diet: a systematic reviewNutr Rev200664S27S4716532897
   PubMed Web of Science ®Google Scholar
• DelcourtCKorobelikJFBarberger-GateauPNutrition and age-related eye diseases: the ALIENOR (Antioxydants, LIpides Essentiels, Nutrition et Maladies OculaiRes) studyJ Nutr Health Aging20091485486121125205
   PubMed Web of Science ®Google Scholar
• MaletFLe GoffMColinJDry eye disease in French elderly subjects: the Alienor StudyActa Ophthalmol Epub672013
   Web of Science ®Google Scholar
• QuarantaLBettelliSUvaMGSemeraroFTuranoRGandolfoEEffect of Ginkgo biloba extract on preexisting visual field damage in normal tension glaucomaOphthalmology2003110235936212578781
   PubMed Web of Science ®Google Scholar
• RitchRPotential role for Ginko biloba extract in the treatment of glaucomaMed Hypotheses20005422123510790757
   PubMed Web of Science ®Google Scholar
• ColemanALStoneKLKodjebachevaGGlaucoma risk and the consumption of fruits and vegetables among older women in the study of osteoporotic fracturesAm J Ophthalmol20081451081108918355790
   PubMed Web of Science ®Google Scholar
• KangJHPasqualeLRWillettWCDietary fat consumption and primary open-angle glaucomaAm Soc Clin Nutr20047957555764
   Web of Science ®Google Scholar
• Zanon-MorenoVAsensio-MarquezEMCiancotti-OliverLEffects of polymorphisms in vitamin E-, vitamin C-, and glutathione peroxidase-related genes on serum biomarkers and associations with glaucomaMol Vis20131923124223401652
   PubMed Web of Science ®Google Scholar
• Zanon-MorenoVCiancotti-OlivaresLAsencioJAssociation between a SLC23A2 gene variation, plasma vitamin C levels, and risk of glaucoma in a Mediterranean populationMol Vis2011172997300422171153
   PubMed Web of Science ®Google Scholar
• VandenLangenbergGMMares-PerlmanJAKleinRKleinBEBradyWEPaltaMAssociations between antioxidant and zinc intake and the 5-year incidence of early age-related maculopathy in the Beaver Dam Eye StudyAm J Epidemiol19981482042149676703
   PubMed Web of Science ®Google Scholar
• Van LeeuwenRBoekhoornSVingerlingJRDietary intake of antioxidants and risk of age-related macular degenerationJAMA20052943101310716380590
   PubMed Web of Science ®Google Scholar
• Age-Related Eye Disease Study Research GroupA randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no 8Arch Ophthalmol20011191417143611594942
   PubMed Web of Science ®Google Scholar
• ConnorKMSanGiovanniJPLofqvistCIncreased dietary intake of omega-3-polyunsaturated fatty acids reduces pathological retinal angiogenesisNat Med20071386887317589522
   PubMed Web of Science ®Google Scholar
• SeddonJMGeorgeSRosnerBCigarette smoking, fish consumption, omega-3 fatty acid intake, and associations with age-related macular degeneration: the US Twin Study of Age-Related Macular DegenerationArch Ophthalmol2006124995100116832023
   PubMed Web of Science ®Google Scholar
• SanGiovanniJPChewEYAgrónEThe relationship of dietary omega-3 long-chain polyunsaturated fatty acid intake with incident age-related macular degeneration. AREDS report no. 23Arch Ophthalmol20081261274127918779490
   PubMed Web of Science ®Google Scholar
• KrinskyNILandrumJTBoneRABiologic mechanisms of the protective role of lutein and zeaxanthin in the eyeAnnu Rev Nutr20032317120112626691
   PubMed Web of Science ®Google Scholar
• SembaRDDagnelieGAre lutein and zeaxanthin conditionally essential nutrients for eye health?Med Hypotheses20036146547213679014
   PubMed Web of Science ®Google Scholar
• SchweigertFJReimannJMicronutrients and their relevance for the eye – function of lutein, zeaxanthin and omega-3 fatty acidsKlin Monbl Augenheilkd2011228537543 German20740395
   PubMed Web of Science ®Google Scholar
• MoellerSMParekhNTinkerLAssociations between intermediate age-related macular degeneration and lutein and zeaxanthin in the Carotenoids in Age-Related Eye Disease study (CAREDS): ancillary study of the Women’s Health InitiativeArch Ophthalmol20061241151116216908818
   PubMed Web of Science ®Google Scholar
• TanJSWangJJFloodVRochtchinaESmithWMitchellPDietary antioxidants and the long-term incidence of age-related macular degeneration: the Blue Mountains Eye StudyOphthalmology200811533434117664009
   PubMed Web of Science ®Google Scholar
• Age-Related Eye Disease Study Research GroupSanGiovanniJPChewEYThe relationship of dietary carotenoid and vitamin A, E, and C intake with age-related macular degeneration in a case control study: AREDS report no 22Arch Ophthalmol20071251225123217846363
   PubMed Web of Science ®Google Scholar
• SeddonJMAjaniUASperdutoRDDietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. Eye Disease Case-Control Study GroupJAMA1994272141314207933422
   PubMed Web of Science ®Google Scholar
• DelcourtCCristolJPTessierFLégerCLDescompsBPapozLAge-related macular degeneration and antioxidant status in the POLA study. POLA Study Group. Pathologies Oculaires Liées à l’AgeArch Ophthalmol19991171384139010532448
   PubMed Web of Science ®Google Scholar
• Mares-PerlmanJAFisherAIKleinRLutein and zeaxanthin in the diet and serum and their relation to age-related maculopathy in the third national health and nutrition examination surveyAm J Epidemiol200115342443211226974
   PubMed Web of Science ®Google Scholar
• RicherSStilesWStatkuteLDouble-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: the Veterans LAST study (Lutein Antioxidant Supplementation Trial)Optometry20047521623015117055
   PubMedGoogle Scholar
• Age-Related Eye Disease Study 2 Research GroupLutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trialJAMA20133092005201523644932
   PubMed Web of Science ®Google Scholar
• Mayer-DavisEJBellRAReboussinBARushingJMarshallJAHammanRFAntioxidant nutrient intake and diabetic retinopathy: the San Luis Valley Diabetes StudyOphthalmology1998105226422709855158
   PubMed Web of Science ®Google Scholar
• WeinerDETighiouartHReynoldsRSeddonJMKidney function, albuminuria and age-related macular degeneration in NHANES IIINephrol Dial Transplant2011263159316521339308
   PubMed Web of Science ®Google Scholar
• No authors listedDiabetes Control and Complications Trial (DCCT): results of feasibility study. The DCCT Research GroupDiabetes Care1987101192882967
   PubMed Web of Science ®Google Scholar
• MillenAEGruberMKleinRKleinBEPaltaMMaresJARelations of serum ascorbic acid and alpha-tocopherol to diabetic retinopathy in the Third National Health and Nutrition Examination SurveyAm J Epidemiol200315822523312882944
   PubMed Web of Science ®Google Scholar
• RoySKhannaSAlessioHMAnti-angiogenic property of edible berriesFree Radic Res20023691023103112448828
   PubMed Web of Science ®Google Scholar
• BrownleeMBiochemistry and molecular cell biology of diabetic complicationsNature201141481382011742414
   PubMed Web of Science ®Google Scholar
• Garcia-MedinaJJPinazo-DuranMDGarcia-MedinaMZanon-MorenoVPons-VazquezSA 5-year follow-up of antioxidant supplementation in type 2 diabetic retinopathyEur J Ophthalmol20112163764321218388
   PubMed Web of Science ®Google Scholar
• LonnEBoschJYusufSEffects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trialJAMA20052931338134715769967
   PubMed Web of Science ®Google Scholar
• Rodríguez-CastillaVCuadradoCPozoSMoreirasOConcentraciones plasmáticas de carotenos y vitaminas antioxidantes en personas de edad avanzada: influencia del tabaquismo. Proyecto HALE [Plasmatic concentrations of carotenoids and antioxidant vitamins in elder people: influence of smoking. Hale Project]Clin Investig Arterioscler200517101111
   Google Scholar
• No authors listedThe effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. The Alpha Tocopherol, Beta Carotene Cancer Prevention Study GroupN Engl J Med1994330102910358127329
   PubMed Web of Science ®Google Scholar
• OmennGSGoodmanGEThornquistMDEffects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular diseaseN Engl J Med1996334115011558602180
   PubMed Web of Science ®Google Scholar
• FosmireGJZinc toxicityAm J Clin Nutr1990512252272407097
   PubMed Web of Science ®Google Scholar
• BlockKIKochACMeadMNTothyPKNewmanRAGyllenhaalCImpact of antioxidant supplementation on chemotherapeutic toxicity: a systematic review of the evidence from randomized controlled trialsInt J Cancer2008151231227123918623084
   PubMed Web of Science ®Google Scholar
• SelmanCMcLarenJSCollinsARDuthieGGSpeakmanJRDeleterious consequences of antioxidant supplementation on lifespan in a wild-derived mammalBiol Lett2013915
   Web of Science ®Google Scholar
• Food and Nutrition Board, Institute of MedicineCopper. Dietary reference intakes for vitamin A, vitamin K, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zincWashington, D.C.National Academy Press2001224257
   Google Scholar