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Review

Epidemiology and treatment approaches in management of invasive fungal infections

, &
Pages 175-191 | Published online: 19 May 2011

References

  • BaddleyJWAndesDRMarrKAFactors associated with mortality in transplant patients with invasive aspergillosisClin Infect Dis201050121559156720450350
  • KontoyiannisDPMarrKAParkBJProspective surveillance for invasive fungal infections in hematopoietic stem cell transplant recipients, 2001–2006: Overview of the Transplant-Associated Infection Surveillance Network (TRANSNET) DatabaseClin Infect Dis20105081091110020218877
  • ParkBJPappasPGMarrKARecent epidemiology of zygomycosis among organ transplant and stem cell transplant recipients: Results from the TRANSNET surveillance networkAbstract M-618 presented at the 47th Interscience Conference on Antimicrobial Agents and ChemotherapyChicago, ILSeptember 17–20, 2007
  • PappasPGAlexanderBDAndesDRInvasive fungal infections among organ transplant recipients: Results of the Transplant-Associated Infection Surveillance Network (TRANSNET)Clin Infect Dis20105081101111120218876
  • SlavinMAOsborneBAdamsREfficacy and safety of fluconazole prophylaxis for fungal infections after marrow transplantation – a prospective, randomized, double-blind studyJ Infect Dis19951716154515527769290
  • TomblynMChillerTEinseleHGuidelines for preventing infectious complications among hematopoietic cell transplantation recipients: A global perspectiveBiol Blood Marrow Transplant200915101143123819747629
  • MarrKACarterRACrippaFWaldACoreyLEpidemiology and outcome of mould infections in hematopoietic stem cell transplant recipientsClin Infect Dis200234790991711880955
  • BraymanKLStephanianEMatasAJAnalysis of infectious complications occurring after solid-organ transplantationArch Surg1992127138471734849
  • PayaCVFungal infections in solid-organ transplantationClin Infect Dis19931656776888507760
  • CornelyOAMaertensJWinstonDJPosaconazole vs fluconazole or intraconazole prophylaxis in patients with neutropeniaN Engl J Med2007356434835917251531
  • MattiuzziGNKantarjianHFaderlSAmphotericin B lipid complex as prophylaxis of invasive fungal infections in patients with acute myelogenous leukemia and myelodysplastic syndrome undergoing induction chemotherapyCancer2004100358158914745876
  • VreugdenhilGVan DijkeBJDonnellyJPEfficacy of itraconazole in the prevention of fungal infections among neutropenic patients with hematologic malignancies and intensive chemotherapy. A double blind, placebo controlled studyLeuk Lymphoma1993115–63533588124207
  • MenichettiFDel FaveroAMartinoPItraconazole oral solution as prophylaxis for fungal infections in neutropenic patients with hematologic malignancies: A randomized, placebo-controlled, double-blind, multicenter trial. GIMEMA Infection Program. Gruppo Italiano Malattie Ematologiche dell’ AdultoClin Infect Dis199928225025510064240
  • LehrnbecherTFrankCEngelsKKrienerSGrollAHSchwabeDTrends in the postmortem epidemiology of invasive fungal infections at a university hospitalJ Infect201061325926520624423
  • VincentJLRelloJMarshallJInternational study of the prevalence and outcomes of infection in intensive care unitsJAMA2009302212323232919952319
  • HerbrechtRDenningDWPattersonTFBennettJEGreeneREVoriconazole versus amphotericin B for primary therapy of invasive aspergillosisN Engl J Med2002347640841512167683
  • SteinbachWJBenjaminDKJrKontoyiannisDPInfections due to Aspergillus terreus: A multicenter retrospective analysis of 83 casesClin Infect Dis200439219219815307028
  • PfeifferCDGarcia-EffronGZaasAKPerfectJRPerlinDSAlexanderBDBreakthrough invasive candidiasis in patients on micafunginJ Clin Microbiol20104872373238020421445
  • VazquezJAInvasive fungal infections in the intensive care unitSemin Respir Crit Care Med2010311798620101550
  • ArendrupMCEpidemiology of invasive candidiasisCurr Opin Crit Care201016544545220711075
  • HornDLNeofytosDAnaissieEJEpidemiology and outcomes of candidemia in 2019 patients: Data from the prospective antifungal therapy alliance registryClin Infect Dis200948121695170319441981
  • HidronAIEdwardsJRPatelJNHSN annual update: Antimicrobial-resistant pathogens associated with healthcare-associated infections: Annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006–2007Infect Control Hosp Epidemiol20082911996101118947320
  • NeumannPRRakowerSRThe risk of positive cultures for Candida in the critically ill patientCrit Care Med1978627376639536
  • KettDHAzoulayEEcheverriaPMVincentJLCandida bloodstream infections in intensive care units: Analysis of the extended prevalence of infection in a intensive care unit studyCrit Care Med12162010 [Epub ahead of print].
  • NeofytosDHornDAnaissieEEpidemiology and outcome of invasive fungal infection in adult hematopoietic stem cell transplant recipients: Analysis of Multicenter Prospective Antifungal Therapy (PATH) Alliance registryClin Infect Dis200948326527319115967
  • AmbrosioniJBouchuiguir-WafaKGarbinoJEmerging invasive zygomycosis in a tertiary care center: Epidemiology and associated risk factorsInt J Infect Dis201014Suppl 3e100e10320335060
  • TrifilioSSinghalSWilliamsSBreakthrough fungal infections after allogeneic hematopoietic stem cell transplantation in patients on prophylactic voriconazoleBone Marrow Transplant200740545145617589527
  • TrifilioSMBennettCLYarnoldPRBreakthrough zygomycosis after voriconazole administration among patients with hematologic malignancies who receive hematopoietic stem-cell transplants or intensive chemotherapyBone Marrow Transplant200739742542917310132
  • SuzukiKSugawaraYSekineTNakaseKKatayamaNBreakthrough disseminated zygomycosis induced massive gastrointestinal bleeding in a patient with acute myeloid leukemia receiving micafunginJ Infect Chemother2009151424519280300
  • Espinel-IngroffAMechanisms of resistance to antifungal agents: Yeasts and filamentous fungiRev Iberoam Micol2008252101106 Spanish.18473504
  • Chapeland-LeclercFHennequinCPaponNAcquisition of flucytosine, azole, and caspofungin resistance in Candida glabrata bloodstream isolates serially obtained from a hematopoietic stem cell transplant recipientAntimicrob Agents Chemother20105431360136220038613
  • LawDMooreCBWardleHMGanguliLAKeaneyMGDenningDWHigh prevalence of antifungal resistance in Candida spp. from patients with acquired immunodeficiency syndromeJ Antimicrob Chemother19943456596687706161
  • WestbrookSDWiederholdNPVallorACLoss of in vitro resistance in Candida glabrata following discontinuation of fluconazole prophylaxis in a hematopoietic stem cell transplantation patientMed Mycol201048355756020370365
  • LaverdièreMLalondeRGBarilJGSheppardDCParkSPerlinDSProgressive loss of echinocandin activity following prolonged use for treatment of Candida albicans oesophagitisJ Antimicrob Chemother200657470570816464893
  • MelladoEGarcia-EffronGAlcazar-FuoliLA new Aspergillus fumigatus resistance mechanism conferring in vitro cross-resistance to azole antifungals involves a combination of cyp51A alterationsAntimicrob Agents Chemother20075161897190417371828
  • RajendranRMowatEMcCullochEAzole resistance of Aspergillus fumigatus biofilms is partly associated with efflux pump activityAntimicrob Agents Chemother2142011 [Epub ahead of print].
  • HowardSJCerarDAndersonMJFrequency and evolution of azole resistance in Aspergillus fumigatus associated with treatment failureEmerg Infect Dis20091571068107619624922
  • SchelenzSAbdallahSGrayGEpidemiology of oral yeast colonization and infection in patients with hematological malignancies, head neck and solid tumorsJ Oral Pathol Med2011401838920923440
  • StorekJDawsonMALimLCEfficacy of donor vaccination before hematopoietic cell transplantation and recipient vaccination both before and early after transplantationBone Marrow Transplant200433333734614647254
  • FishmanJAIssaNCInfection in organ transplantation: Risk factors and evolving patterns of infectionInfect Dis Clin North Am201024227328320466270
  • EgererGGeistMJPosaconazole prophylaxis in patients with acute myelogenous leukaemia – results from an observational studyMycoses201154Suppl 171121126266
  • OraschCWeisserMMertzDComparison of infectious complications during induction/consolidation chemotherapy versus allogeneic hematopoietic stem cell transplantationBone Marrow Transplant201045352152619668238
  • BodeyGPInfectious complications of acute leukemiaMed Times1966949107610855946471
  • PaganoLAkovaMDimopoulosGHerbrechtRDrgonaLBlijlevensNRisk assessment and prognostic factors for mould-related diseases in immunocompromised patientsJ Antimicrob Chemother201166Suppl 1514
  • PortugalRDGarnicaMNucciMIndex to predict invasive mold infection in high-risk neutropenic patients based on the area over the neutrophil curveJ Clin Oncol200927233849385419597026
  • WaldALeisenringWvan BurikJABowdenRAEpidemiology of Aspergillus infections in a large cohort of patients undergoing bone marrow transplantationJ Infect Dis19971756145914669180187
  • JantunenERuutuPNiskanenLIncidence and risk factors for invasive fungal infections in allogeneic BMT recipientsBone Marrow Transplant19971988018089134172
  • Van BurikJACarterSLFreifeldAGHigher risk of cytomegalovirus and aspergillus infections in recipients of T cell-depleted unrelated bone marrow: Analysis of infectious complications in patients treated with T cell depletion versus immunosuppressive therapy to prevent graft-versus-host diseaseBiol Blood Marrow Transplant200713121487149818022579
  • De La RosaGRChamplinREKontoyiannisDPRisk factors for the development of invasive fungal infections in allogeneic blood and marrow transplant recipientsTranspl Infect Dis2002413912123420
  • SchmeiserTWiesnethMBunjesDInfectious complications after allogeneic bone marrow transplantation with and without T-cell depletion of donor marrowInfection19891731241302661437
  • PirschJDMakiDGInfectious complications in adults with bone marrow transplantation and T-cell depletion of donor marrow. Increased susceptibility to fungal infectionsAnn Intern Med198610456196313516042
  • ThurskyKByrnesGGriggASzerJSlavinMRisk factors for post-engraftment invasive aspergillosis in allogeneic stem cell transplantationBone Marrow Transplant200434211512115156166
  • LabbeACSuSHLaverdiereMHigh incidence of invasive aspergillosis associated with intestinal graft-versus-host disease following nonmyeloablative transplantationBiol Blood Marrow Transplant200713101192120017889356
  • AldersonJWVan DinterTGJrOpatowskyMJBurtonECDisseminated aspergillosis following infliximab therapy in an immunosuppressed patient with Crohn’s disease and chronic hepatitis C: A case study and review of the literatureMed Gen Med2005737
  • BochudPYChienJWMarrKAToll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantationN Engl J Med2008359171766177718946062
  • SainzJSalas-AlvaradoILopez-FernandezETNFR1 mRNA expression level and TNFR1 gene polymorphisms are predictive markers for susceptibility to develop invasive pulmonary aspergillosisInt J Immunopathol Pharmacol201023242343620646338
  • CarvalhoACunhaCCarottiAPolymorphisms in Toll-like receptor genes and susceptibility to infections in allogeneic stem cell transplantationExp Hematol20093791022102919539691
  • SeoKWKimDHSohnSKProtective role of interleukin-10 promoter gene polymorphism in the pathogenesis of invasive pulmonary aspergillosis after allogeneic stem cell transplantationBone Marrow Transplant200536121089109516247433
  • PanackalAALiHKontoyiannisDPGeoclimatic influences on invasive aspergillosis after hematopoietic stem cell transplantationClin Infect Dis201050121588159720450414
  • BlumbergHMJarvisWRSoucieJMRisk factors for candidal bloodstream infections in surgical intensive care unit patients: The NEMIS prospective multicenter study. The National Epidemiology of Mycosis SurveyClin Infect Dis200133217718611418877
  • SegalBHAspergillosisN Engl J Med2009360181870188419403905
  • BodeyGBueltmannBDuguidWFungal infections in cancer patients: An international autopsy surveyEur J Clin Microbiol Infect Dis1992112991091396746
  • SicklesEAGreeneWHWiernikPHClinical presentation of infection in granulocytopenic patientsArch Intern Med197513557157191052668
  • ViscoliCGirmeniaCMarinusACandidemia in cancer patients: A prospective, multicenter surveillance study by the Invasive Fungal Infection Group (IFIG) of the European Organization for Research and Treatment of Cancer (EORTC)Clin Infect Dis19992851071107910452637
  • PaganoLAntinoriAAmmassariARetrospective study of candidemia in patients with hematological malignancies. Clinical features, risk factors and outcome of 76 episodesEur J Haematol1999632778510480286
  • FineJDMillerJAHarristTJHaynesHACutaneous lesions in disseminated candidiasis mimicking ecthyma gangrenosumAm J Med1981705113311357234879
  • KanskiJPavesioCTuftSEndophthalmitisOcular Inflammatory DiseasePhiladelphia, PAElsevier2006
  • RabinoviciRSzewczykDOvadiaPGreenspanJRSivalingamJJCandida pericarditis: Clinical profile and treatmentAnn Thorac Surg1997634120012049124944
  • PaganoLMeleLFianchiLChronic disseminated candidiasis in patients with hematologic malignancies. Clinical features and outcome of 29 episodesHaematologica200287553554112010669
  • MillerDJMejicanoGCVertebral osteomyelitis due to Candida species: Case report and literature reviewClin Infect Dis200133452353011462190
  • SinghNHusainSAspergillus infections after lung transplantation: Clinical differences in type of transplant and implications for managementJ Heart Lung Transplant200322325826612633692
  • Kleinschmidt-DeMastersBKCentral nervous system aspergillosis: A 20-year retrospective seriesHum Pathol200233111612411823982
  • WalshTJHierDBCaplanLRFungal infections of the central nervous system: comparative analysis of risk factors and clinical signs in 57 patientsNeurology19853511165416574058755
  • De PauwBWalshTJDonnellyJPRevised Definitions of Invasive Fungal Disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus GroupClin Infect Dis200846121813182118462102
  • AnaissieEBodeyGPKantarjianHFluconazole therapy for chronic disseminated candidiasis in patients with leukemia and prior amphotericin B therapyAm J Med19919121421501867240
  • SamuelsBIPaganiJJLibshitzHIRadiographic features of candida infectionsBodeyGPCandidiasis: Pathogenesis, Diagnosis and TreatmentsNew York, NYRaven Press1993
  • SemelkaRCShoenutJPGreenbergHMBowEJDetection of acute and treated lesions of hepatosplenic candidiasis: Comparison of dynamic contrast-enhanced CT and MR imagingJ Magn Reson Imaging1992233413451627870
  • SemelkaRCKelekisNLSallahSWorawattanakulSAscherSMHepatosplenic fungal disease: Diagnostic accuracy and spectrum of appearances on MR imagingAJR Am J Roentgenol19971695131113169353448
  • Ostrosky-ZeichnerLAlexanderBDKettDHMulticenter clinical evaluation of the (1 ≥ 3) beta-D-glucan assay as an aid to diagnosis of fungal infections in humansClin Infect Dis200541565465916080087
  • LoganPMPrimackSLMillerRRMullerNLInvasive aspergillosis of the airways: Radiographic, CT, and pathologic findingsRadiology199419323833887972747
  • KuhlmanJEFishmanEKSiegelmanSSInvasive pulmonary aspergillosis in acute leukemia: Characteristic findings on CT, the CT halo sign, and the role of CT in early diagnosisRadiology198515736116143864189
  • NucciMAnaissieECutaneous infection by Fusarium species in healthy and immunocompromised hosts: Implications for diagnosis and managementClin Infect Dis200235890992012355377
  • KrcmeryVJrKunovaEJesenskaZInvasive mold infections in cancer patients: 5 years’ experience with Aspergillus, Mucor, Fusarium and Acremonium infectionsSupport Care Cancer19964139458771293
  • MarrKALaverdiereMGugelALeisenringWAntifungal therapy decreases sensitivity of the Aspergillus galactomannan enzyme immunoassayClin Infect Dis200540121762176915909264
  • WheatLJApproach to the diagnosis of invasive aspergillosis and candidiasisClin Chest Med2009302367377viii19375641
  • Wong-BeringerAJacobsRAGuglielmoBJLipid formulations of amphotericin B: Clinical efficacy and toxicitiesClin Infect Dis19982736036189770163
  • MesserSAMoetGJKirbyJTJonesRNActivity of contemporary antifungal agents, including the novel echinocandin anidulafungin, tested against Candida spp., Cryptococcus spp., and Aspergillus spp.: Report from the SENTRY Antimicrobial Surveillance Program (2006 to 2007)J Clin Microbiol20094761942194619386851
  • DannaouiEMeletiadisJMoutonJWMeisJFVerweijPEEurofung Network. In vitro susceptibilities of zygomycetes to conventional and new antifungalsJ Infect Dis20035114552
  • BaddleyJWMarrKAAndesDRPatterns of susceptibility of Aspergillus isolates recovered from patients enrolled in the Transplant-Associated Infection Surveillance NetworkJ Clin Microbiol200947103271327519692558
  • PfallerMAZhangJMesserSAIn vitro activities of voriconazole, fluconazole, and itraconazole against 566 clinical isolates of Cryptococcus neoformans from the United States and AfricaAntimicrob Agents Chemother19994311691709869586
  • DiekemaDMesserSAHollisRJJonesRNPfallerMAActivities of caspofungin, itraconazole, posaconazole, ravuconazole, voricaonzole, and amphotericin B against 448 recent clinical isolates of filamentous fungiJ Clin Microbiol20034183623362612904365
  • Dodds AshleyESLewisRLewisJSMarinCAndesDPharmacology of systemic antifungal agentsClin Infect Dis200643SupplS28S39
  • TrifilioSOrtizRPennickGVoriconazole therapeutic drug monitoring in allogeneic hematopoietic stem cell transplant recipientsBone Marrow Transplant200535550951315654347
  • SummersKKHardinTCGoreSJGraybillJRTherapeutic drug monitoring of systemic antifungal therapyJ Antimicrob Chemother19974067537649462426
  • PascualACalandraTBolaySBuclinTBilleJMarchettiOVoriconazole therapeutic drug monitoring in patients with invasive mycoses improves efficacy and safety outcomesClin Infect Dis200846220121118171251
  • Mora-DuarteJBettsRRotsteinCComparison of caspofungin and amphotericin B for invasive candidiasisN Engl J Med2002347252020202912490683
  • PappasPGRotsteinCMBettsRFMicafungin versus caspofungin for treatment of candidemia and other forms of invasive candidiasisClin Infect Dis200745788389317806055
  • MooreCBDenningDWTolerance and fungicidality in vitro of caspofungin, micafungin and anidulafungin against Candida guilliermondiiAbstract M-230 presented at the 42nd Annual Interscience Conference on Antimicrobial Agents and ChemotherapySeptember 27–30, 2002San Diego, CA
  • ThompsonGR3rdCadenaJPattersonTFOverview of antifungal agentsClin Chest Med2009302203215v19375628
  • WalshTJAnaissieEJDenningDWTreatment of aspergillosis: Clinical practice guidelines of the Infectious Diseases Society of AmericaClin Infect Dis20084632760
  • WalshTJRaadIPattersonTFTreatment of invasive aspergillosis with posaconazole in patients who are refractory to or intolerant of conventional therapy: An externally controlled trialClin Infect Dis200744121217143808
  • DenningDWMarrKALauWMMicafungin (FK463), alone or in combination with other systemic antifungal agents, for the treatment of acute invasive aspergillosisJ Infect200653533734916678903
  • BettsRGlasmacherAMaertensJEfficacy of caspofungin against invasive Candida or invasive Aspergillus infections in neutropenic patientsCancer2006106246647316353208
  • MaertensJRaadIPetrikkosGEfficacy and safety of caspofungin for treatment of invasive aspergillosis in patients refractory to or intolerant of conventional antifungal therapyClin Infect Dis200439111563157115578352
  • PappasPGKauffmanCAAndesDClinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of AmericaClin Infect Dis200948550353519191635
  • ChamilosGLewisREKontoyiannisDPDelaying amphotericin B-based frontline therapy significantly increases mortality among patients with hematologic malignancy who have zygomycosisClin Infect Dis200847450350918611163
  • ManavathuEKCutrightJLChandrasekarPHOrganism-dependent fungicidal activities of azolesAntimicrob Agents Chemother19984211301830219797246
  • Lass-FlorlCMayrAPerkhoferSActivities of antifungal agents against yeasts and filamentous fungi: Assessment according to the Methodology of the European Committee on Antimicrobial Susceptibility TestingAntimicrob Agents Chemother200852103637364118694949
  • Van BurikJAHareRSSolomonHFCorradoMLKontoyiannisDPPosaconazole is effective as salvage therapy in zygomycosis: A retrospective summary of 91 casesClin Infect Dis2006427e61e6516511748
  • RexJHPappasPGKarchmerAWA randomized and blinded multicenter trial of high-dose fluconazole plus placebo versus fluconazole plus amphotericin B as therapy for candidemia and its consequences in nonneutropenic subjectsClin Infect Dis200336101221122812746765
  • MarrKABoeckhMCarterRAKimHWCoreyLCombination antifungal therapy for invasive aspergillosisClin Infect Dis200439679780215472810
  • CaillotDThiebautAHerbrechtRLiposomal amphotericin B in combination with caspofungin for invasive aspergillosis in patients with hematologic malignancies: A randomized pilot study (Combistrat trial)Cancer2007110122740274617941026
  • Cuenca-EstrellaMGomez-LopezAGarcia-EffronGCombined activity in vitro of caspofungin, amphotericin B, and azole agents against itraconazole-resistant clinical isolates of Aspergillus fumigatusAntimicrob Agents Chemother20054931232123515728937
  • SchaffnerAAnnetteBAmphotericin B refractory aspergillosis after itraconazole: Evidence for significant antagonismMycoses19933611–124214247935575
  • PoppAIWhiteMHQuadriTWalsheLArmstrongDAmphotericin B with and without itraconazole for invasive aspergillosis: A three-year retrospective studyInt J Infect Dis19993315716010460928
  • ChandrasekarPHCutrightJLManavathuEKEfficacy of voriconazole plus amphotericin B or micafungin in a guinea-pig model of invasive pulmonary aspergillosisClin Microbiol Infect2004101092592815373889
  • O’ShaughnessyEMMeletiadisJStergiopoulouTDemchokJPWalshTJAntifungal interactions within the triple combination of amphotericin B, caspofungin and voriconazole against Aspergillus speciesJ Antimicrob Chemother20065861168117617071635
  • MeletiadisJStergiopoulouTO’ShaughnessyEMPeterJWalshTJConcentration-dependent synergy and antagonism within a triple antifungal drug combination against Aspergillus species: Analysis by a new response surface modelAntimicrob Agents Chemother20075162053206417387150
  • IbrahimASEdwardsJEJrFuYSpellbergBDeferiprone iron chelation as a novel therapy for experimental mucormycosisJ Antimicrob Chemother20065851070107316928702
  • SpellbergBWalshTJKontoyiannisDPEdwardsJJrIbrahimASRecent advances in the management of mucormycosis: From bench to bedsideClin Infect Dis200948121743175119435437
  • BoelaertJRde LochtMVan CutsemJMucormycosis during deferoxamine therapy is a siderophore-mediated infection. In vitro and in vivo animal studiesJ Clin Invest1993915197919868486769
  • KasapogluFCoskunHOzmenOAAkalinHEnerBAcute invasive fungal rhinosinusitis: Evaluation of 26 patients treated with endonasal or open surgical proceduresOtolaryngol Head Neck Surg2010143561462020974328
  • TumbarelloMPosteraroBTrecarichiEMBiofilm production by Candida species and inadequate antifungal therapy as predictors of mortality for patients with candidemiaJ Clin Microbiol20074561843185017460052
  • NucciMAnaissieEBettsRFEarly removal of central venous catheter in patients with candidemia does not improve outcome: Analysis of 842 patients from 2 randomized clinical trialsClin Infect Dis201051329530320578829
  • ItoJIKriengkauykiatJDadwalSSArfonsLMLazarusHMApproaches to the early treatment of invasive fungal infectionLeuk Lymphoma20105191623163120629521
  • MichalletMItoJIApproaches to the management of invasive fungal infections in hematologic malignancy and hematopoietic cell transplantationJ Clin Oncol200927203398340919487382
  • FreifeldAGBowEJSepkowitzKAClinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the Infectious Diseases Society of AmericaClin Infect Dis2011524e56e9321258094
  • MaertensJTheunissenKLodewyckTLagrouKVan EldereJAdvances in the serological diagnosis of invasive Aspergillus infections in patients with haematological disordersMycoses200750Suppl 121717394605
  • UllmannAJLiptonJHVesoleDHPosaconazole or fluconazole for prophylaxis in severe graft-versus-host diseaseN Engl J Med2007357433534717251530
  • MarrKACrippaFLeisenringWItraconazole versus fluconazole for prevention of fungal infections in patients receiving allogeneic stem cell transplantsBlood200410341527153314525770
  • Van BurikJARatanatharathornVStepanDEMicafungin versus fluconazole for prophylaxis against invasive fungal infections during neutropenia in patients undergoing hematopoietic stem cell transplantationClin Infect Dis200439101407141615546073
  • MarrKASeidelKSlavinMAProlonged fluconazole prophylaxis is associated with persistent protection against candidiasis-related death in allogeneic marrow transplant recipients: Long-term follow-up of a randomized, placebo-controlled trialBlood20009662055206110979947
  • PeelMMamaiAFanWNew beta-1,3-glucan synthase (GS) inhibitors with potent antifungal activityAbstract presented at the 49th Interscience Conference on Antimicrobial Agents and ChemotherapySan Francisco, CASeptember 12–15, 2009
  • PerkhoferSLechnerVLass-FlorlCIn vitro activity of isavuconazole against Aspergillus species and zygomycetes according to the methodology of the European Committee on Antimicrobial Susceptibility TestingAntimicrob Agents Chemother20095341645164719164153
  • WatanabeNHoriiTMiyazakiMHataKE1210, a new broad-spectrum antifungal, inhibits glycosylphosphatidylinositol (GPI) biosynthesis and effects Candida albicans cell characteristicsAbstract F1-841 presented at the 50th Interscience Conference on Antimicrobial Agents and ChemotherapyBoston, MASeptember 12–15, 2010
  • MiyazakiMHoriiTHataKWatanabeNIn vitro antifungal activity of E1210: A novel antifungal with activity against clinically important yeasts and mouldsAbstract F1-840 presented at the 50th Interscience Conference on Antimicrobial Agents and ChemotherapyBoston, MASeptember 12–15, 2010
  • WarnPASharpAGouldJEfficacy of FG3409 a new antifungal agent, in reducing tissue burden in murine models of disseminated aspergillosisAbstract F1-1182 presented at the 48th Interscience Conference on Antimicrobial Agents and ChemotherapyWashington, DCOctober 25–28, 2008
  • LawDFothergrillAWChenSCSorrellTCBirchMThe activity of FG3622 and FG3409 against Scedosporium sppAbstract F1-858 presented at the 50th Interscience Conference on Antimicrobial Agents and ChemotherapyBoston, MASeptember 12–15, 2010
  • KrysanDBaxterBKDidoneLPhosphoinositide-dependent kinase 1 (PDK1) inhibitors are a novel class of cell wall-targeted antifungal small moleculesAbstract F1-859 presented at the 50th Interscience Conference on Antimicrobial Agents and ChemotherapyBoston, MASeptember 12–15, 2010
  • NguyenDLiJAkacheBMGCD290: A novel small molecule, modulates azole antifungal activity through specific inhibition of the histone deacetylase HOS2Abstract M-1919 presented at the 49th Interscience Conference on Antimicrobial Agents and ChemotherapySan Francisco, CASeptember 12–15, 2009
  • Krishnan-NatesanSSwaminathanSChandrasekarPExtended spectrum triazole plus type II topoisomerase inhibitor (TI) against azole-resistant (R) isolates of Aspergillus: Synergistic interaction in vitroAbstract M-396 presented at 50th Interscience Conference on Antimicrobial Agents and ChemotherapyBoston, MASeptember 12–15, 2010
  • McKeeJRabinowBCookCGassJNanosuspension formulation of itraconazole eliminates the negative inotropic effect of Sporanox in dogsJ Med Toxicol20106333133620238196
  • SegalBHKwon-ChungJWalshTJImmunotherapy for fungal infectionsClin Infect Dis200642450751516421795
  • RomaniLCell mediated immunity to fungi: A reassessmentMed Mycol200846651551919180748
  • CenciEMencacciABacciABistoniFKurupVPRomaniLT cell vaccination in mice with invasive pulmonary aspergillosisJ Immunol2000165138138810861075
  • BeckOKoehlUTramsenLEnumeration of functionally active anti-Aspergillus T-cells in human peripheral bloodJ Immunol Methods20083351–2414518395221
  • PerruccioKTostiABurchielliETransferring functional immune responses to pathogens after haploidentical hematopoietic transplantationBlood2005106134397440616123217
  • ItoJILyonsJMVaccination of corticosteroid immunosuppressed mice against invasive pulmonary aspergillosisJ Infect Dis2002186686987112198627
  • BozzaSGazianoRLipfordGBVaccination of mice against invasive aspergillosis with recombinant Aspergillus proteins and CpG oligode-oxynucleotides as adjuvantsMicrobes Infect20024131281129012443892
  • BozzaSMontagnoliCGazianoRDendritic cell-based vaccination against opportunistic fungiVaccine200422785786415040938
  • CassoneAFungal vaccines: Real progress from real challengesLancet Infect Dis20088211412418222162