Statin Use and Severe Acute Liver Injury Among Patients with Elevated Alanine Aminotransferase

References

• Grundy Scott M, Cleeman James I, Noel Bairey MC, et al. Implications of recent clinical trials for the national cholesterol education program adult treatment panel III guidelines. Circulation. 2004;110(2):227–239. doi:10.1161/01.CIR.0000133317.49796.0E
   Web of Science ®Google Scholar
• Wong ND, Young D, Zhao Y, et al. Prevalence of the American College of Cardiology/American Heart Association statin eligibility groups, statin use, and low-density lipoprotein cholesterol control in US adults using the national health and nutrition examination survey 2011–2012. J Clin Lipidol. 2016;10(5):1109–1118. doi:10.1016/j.jacl.2016.06.011
   PubMed Web of Science ®Google Scholar
• Butalia S, Lee-Krueger RCW, McBrien KA, et al. Barriers and facilitators to using statins: a qualitative study with patients and family physicians. CJC Open. 2020;2(6):530–538. doi:10.1016/j.cjco.2020.07.002
   Google Scholar
• Rzouq FS, Volk ML, Hatoum HH, Talluri SK, Mummadi RR, Sood GK. Hepatotoxicity fears contribute to underutilization of statin medications by primary care physicians. Am J Med Sci. 2010;340(2):89–93. doi:10.1097/MAJ.0b013e3181e15da8
   PubMed Web of Science ®Google Scholar
• Davidson C, Leevy C, Chamberlayne E. Guidelines for Detection of Hepatotoxicity Due to Drugs and Chemcials. Bethesda, MD: National Institutes of Health; 1979:79–313.
   Google Scholar
• Bays H, Cohen DE, Chalasani N, Harrison SA. An assessment by the statin liver safety task force: 2014 update. J Clin Lipidol. 2014;8(3):S47–S57. doi:10.1016/j.jacl.2014.02.011
   PubMed Web of Science ®Google Scholar
• Karahalil B, Hare E, Koç G, Uslu İ, Şentürk K, Özkan Y. Hepatotoxicity associated with statins. Arh Hig Rada Toksikol. 2017;68(4):254–260. doi:10.1515/aiht-2017-68-2994
   PubMed Web of Science ®Google Scholar
• Reuben A, Koch DG, Lee WM. Drug-induced acute liver failure: results of a U.S. multicenter, prospective study. Hepatol Baltim Md. 2010;52(6):2065–2076. doi:10.1002/hep.23937
   PubMed Web of Science ®Google Scholar
• FDA Drug Safety Communication: important safety label changes to cholesterol-lowering statin drugs. FDA; 2019. https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-important-safety-label-changes-cholesterol-lowering-statin-drugs. Accessed May 10, 2021.
   Google Scholar
• Ali MS, Prieto-Alhambra D, Lopes LC, et al. propensity score methods in health technology assessment: principles, extended applications, and recent advances. Front Pharmacol. 2019;10. doi:10.3389/fphar.2019.00973
   Web of Science ®Google Scholar
• Setoguchi S, Glynn RJ, Avorn J, Mogun H, Schneeweiss S. Statins and the risk of lung, breast, and colorectal cancer in the elderly. Circulation. 2007;115(1):27–33. doi:10.1161/CIRCULATIONAHA.106.650176
   PubMed Web of Science ®Google Scholar
• Arnett Donna K, Blumenthal Roger S, Albert Michelle A, et al. 2019 ACC/AHA guideline on the primary prevention of cardiovascular disease: a report of the American College of Cardiology/American heart association task force on clinical practice guidelines. Circulation. 2019;140(11):e596–e646. doi:10.1161/CIR.0000000000000678
   PubMed Web of Science ®Google Scholar
• Christine LB, James AK, Jordi C, et al. Validation of acute liver injury cases in a population-based cohort study of oral antimicrobial users. Curr Drug Saf. 2014;9(1):23–28. doi:10.2174/15748863113086660051
   Google Scholar
• Lo RV, Carbonari DM, Saine ME, et al. Postauthorization safety study of the DPP-4 inhibitor saxagliptin: a large-scale multinational family of cohort studies of five outcomes. BMJ Open Diabetes Res Care. 2017;5:1. doi:10.1136/bmjdrc-2017-000400
   Web of Science ®Google Scholar
• Forns J, Cainzos‐Achirica M, Hellfritzsch M, et al. Validity of ICD‐9 and ICD‐10 codes used to identify acute liver injury: a study in three European data sources. Pharmacoepidemiol Drug Saf. 2019;28(7):965–975. doi:10.1002/pds.4803
   PubMed Web of Science ®Google Scholar
• Weiler N, Schlotmann A, Anton Schnitzbauer A, Zeuzem S, Welker M-W. The epidemiology of acute liver failure. Dtsch Ärztebl Int. 2020;117(4):43–50. doi:10.3238/arztebl.2020.0043
   Web of Science ®Google Scholar
• Austin PC. Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples. Stat Med. 2009;28(25):3083–3107. doi:10.1002/sim.3697
   PubMed Web of Science ®Google Scholar
• Franklin JM, Rassen JA, Ackermann D, Bartels DB, Schneeweiss S. Metrics for covariate balance in cohort studies of causal effects. Stat Med. 2014;33(10):1685–1699. doi:10.1002/sim.6058
   PubMed Web of Science ®Google Scholar
• Schneeweiss S, Patorno E. Conducting real-world evidence studies on the clinical outcomes of diabetes treatments. Endocr Rev. 2021;bnab007. doi:10.1210/endrev/bnab007
   Web of Science ®Google Scholar
• Peña JM, Aspberg S, MacFadyen J, Glynn RJ, Solomon DH, Ridker PM. Statin therapy and risk of fracture: results from the Jupiter randomized clinical trial. JAMA Intern Med. 2015;175(2):171. doi:10.1001/jamainternmed.2014.6388
   PubMed Web of Science ®Google Scholar
• Reid IR, Hague W, Emberson J, et al. Effect of pravastatin on frequency of fracture in the LIPID study: secondary analysis of a randomised controlled trial. LANCET. 2001;357:4. doi:10.1016/S0140-6736(00)04042-3
   Web of Science ®Google Scholar
• McEvoy B, Frimpong E. Testing A noninferiority hypothesis: what to anticipate when the adverse event is rare. J Biopharm Stat. 2013;23(1):122–128. doi:10.1080/10543406.2013.735779
   PubMed Web of Science ®Google Scholar
• Chan KA, Truman A, Gurwitz JH, et al. A cohort study of the incidence of serious acute liver injury in diabetic patients treated with hypoglycemic agents. Arch Intern Med. 2003;163(6):728. doi:10.1001/archinte.163.6.728
   Google Scholar
• Bell LN, Chalasani N. Epidemiology of idiosyncratic drug-induced liver injury. Semin Liver Dis. 2009;29(4):337–347. doi:10.1055/s-0029-1240002
   PubMed Web of Science ®Google Scholar
• Younoszai Z, Zheng L, Stepanova M, Erario M, Cable R, Younossi ZM. Statin use is not associated with liver related mortality. Ann Hepatol. 2014;13(1):84–90. doi:10.1016/S1665-2681(19)30908-1
   Web of Science ®Google Scholar
• Avins AL, Manos MM, Ackerson L, et al. Hepatic effects of lovastatin exposure in patients with liver disease. Drug Saf. 2008;31(4):325–334. doi:10.2165/00002018-200831040-00006
   Web of Science ®Google Scholar
• Simon TG, King LY, Zheng H, Chung RT. Statin use is associated with a reduced risk of fibrosis progression in chronic hepatitis C. J Hepatol. 2015;62(1):18–23. doi:10.1016/j.jhep.2014.08.013
   PubMed Web of Science ®Google Scholar
• Meurer L, Cohen SM. Drug-Induced Liver Injury from Statins. Clin Liver Dis. 2020;24(1):107–119. doi:10.1016/j.cld.2019.09.007
   Web of Science ®Google Scholar
• Francis P, Forman L. Use of statins in patients with and without liver disease. Clin Liver Dis. 2020;15(1):40–45. doi:10.1002/cld.866
   Google Scholar
• Cohen DE, Anania FA, Chalasani N. An assessment of statin safety by hepatologists. Am J Cardiol. 2006;97(8):S77–S81. doi:10.1016/j.amjcard.2005.12.014
   PubMed Web of Science ®Google Scholar
• Khoo S, Wong VW-S, Goh G-B-B, et al. Suboptimal treatment of dyslipidemia in patients with nonalcoholic fatty liver disease. J Gastroenterol Hepatol. 2020;35(2):320–325. doi:10.1111/jgh.14794
   Web of Science ®Google Scholar
• Del Ben M, Baratta F, Polimeni L, et al. Under-prescription of statins in patients with non-alcoholic fatty liver disease. Nutr Metab Cardiovasc Dis. 2017;27(2):161–167. doi:10.1016/j.numecd.2016.09.011
   PubMed Web of Science ®Google Scholar
• van den Berg EH, Wolters AAB, Dullaart RPF, et al. Prescription of statins in suspected non-alcoholic fatty liver disease and high cardiovascular risk, a population-based study. Liver Int off J Int Assoc Study Liver. 2019;39(7):1343–1354. doi:10.1111/liv.14116
   Web of Science ®Google Scholar
• Jose J. Statins and its hepatic effects: newer data, implications, and changing recommendations. J Pharm Bioallied Sci. 2016;8(1):23–28. doi:10.4103/0975-7406.171699
   PubMed Web of Science ®Google Scholar