Quantitative assessment of aberrant P16^INK4a methylation in ovarian cancer: a meta-analysis based on literature and TCGA datasets

References

• TorreLABrayFSiegelRLFerlayJLortet-TieulentJJemalAGlobal cancer statistics, 2012CA Cancer J Clin20156528710825651787
   PubMed Web of Science ®Google Scholar
• PratJNew insights into ovarian cancer pathologyAnn Oncol201223Suppl 10x111x11722987944
   PubMedGoogle Scholar
• SiegelRLMillerKDJemalACancer statistics, 2016CA Cancer J Clin201666173026742998
   PubMed Web of Science ®Google Scholar
• BaiHCaoDYangJLiMZhangZShenKGenetic and epigenetic heterogeneity of epithelial ovarian cancer and the clinical implications for molecular targeted therapyJ Cell Mol Med201620458159326800494
   PubMed Web of Science ®Google Scholar
• YouJSJonesPACancer genetics and epigenetics: two sides of the same coin?Cancer Cell201222192022789535
   PubMed Web of Science ®Google Scholar
• KazanetsAShorstovaTHilmiKMarquesMWitcherMEpigenetic silencing of tumor suppressor genes: paradigms, puzzles, and potentialBiochim Biophys Acta20161865227528827085853
   PubMed Web of Science ®Google Scholar
• MaunakeaAKChepelevICuiKZhaoKIntragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognitionCell Res201323111256126923938295
   PubMed Web of Science ®Google Scholar
• DongALuYLuBGenomic/Epigenomic alterations in ovarian carcinoma: translational insight into clinical practiceJ Cancer20167111441145127471560
   PubMed Web of Science ®Google Scholar
• KoukouraOSpandidosDADaponteASifakisSDNA methylation profiles in ovarian cancer: implication in diagnosis and therapy (Review)Mol Med Rep20141013924821107
   PubMed Web of Science ®Google Scholar
• GlossBSSamimiGEpigenetic biomarkers in epithelial ovarian cancerCancer Lett2014342225726322245949
   PubMed Web of Science ®Google Scholar
• SharplessNEDepinhoRAThe INK4A/ARF locus and its two gene productsCurr Opin Genet Dev199991223010072356
   PubMed Web of Science ®Google Scholar
• SerranoMHannonGJBeachDA new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4Nature199336664567047078259215
   PubMed Web of Science ®Google Scholar
• QinYLiuJYLiBSunZLSunZFAssociation of low p16INK4a and p15INK4b mRNAs expression with their CpG islands methylation with human hepatocellular carcinogenesisWorld J Gastroenterol20041091276128015112341
   PubMed Web of Science ®Google Scholar
• KimBNYamamotoHIkedaKMethylation and expression of p16INK4 tumor suppressor gene in primary colorectal cancer tissuesInt J Oncol20052651217122615809712
   PubMed Web of Science ®Google Scholar
• GaoSJZhangGFZhangRPHigh CpG island methylation of p16 gene and loss of p16 protein expression associate with the development and progression of tetralogy of FallotJ Genet201695483183727994181
   PubMed Web of Science ®Google Scholar
• SharplessNEINK4a/ARF: a multifunctional tumor suppressor locusMutat Res20055761–2223815878778
   PubMed Web of Science ®Google Scholar
• MoselhySSKumosaniTAKamalIHJalalJAJabaarHSDalolAHypermethylation of P15, P16, and E-cadherin genes in ovarian cancerToxicol Ind Health2015311092493023572389
   PubMed Web of Science ®Google Scholar
• di VinciAPerdelliLBanelliBp16(INK4a) promoter methylation and protein expression in breast fibroadenoma and carcinomaInt J Cancer2005114341442115578730
   PubMed Web of Science ®Google Scholar
• ShimaKNoshoKBabaYPrognostic significance of CDKN2A (p16) promoter methylation and loss of expression in 902 colorectal cancers: cohort study and literature reviewInt J Cancer201112851080109420473920
   PubMed Web of Science ®Google Scholar
• BhagatRKumarSSVaderhobliSEpigenetic alteration of p16 and retinoic acid receptor beta genes in the development of epithelial ovarian carcinomaTumour Biol20143599069907824913706
   PubMedGoogle Scholar
• BammidiLSNeerukondaGNMurthySKanapuramRDp16 gene alterations in human ovarian cancers: comparison between tissue and blood samplesInt J Gynecol Cancer201222455356022344043
   PubMed Web of Science ®Google Scholar
• Abou-ZeidAAAzzamAZKamelNAMethylation status of the gene promoter of cyclin-dependent kinase inhibitor 2A (CDKN2A) in ovarian cancerScand J Clin Lab Invest201171754254721728901
   PubMed Web of Science ®Google Scholar
• DhillonVSAslamMHusainSAThe contribution of genetic and epigenetic changes in granulosa cell tumors of ovarian originClin Cancer Res200410165537554515328194
   PubMed Web of Science ®Google Scholar
• OzdemirFAltinisikJKaratekeACoksuerHBuyruNMethylation of tumor suppressor genes in ovarian cancerExp Ther Med2012461092109623226780
   PubMed Web of Science ®Google Scholar
• ShenWJDaiDQGuoKJXmLPromoter hypermethylation of RASSF1A, BRCA1 and p16 gene in epithelial ovarian cancer and its clinical significanceChin J Cancer Prev Treat2008157530533
   Google Scholar
• TamKFLiuVWLiuSSMethylation profile in benign, borderline and malignant ovarian tumorsJ Cancer Res Clin Oncol2007133533134117177027
   PubMed Web of Science ®Google Scholar
• LiMHuangZJDongWHDisfigurement of p16INK4A gene expression in development of ovarian cancer and the mechanismZhonghua Fu Chan Ke Za Zhi200641640841216831366
   PubMedGoogle Scholar
• LiuZWangLEWangLMethylation and messenger RNA expression of p15INK4b but not p16INK4a are independent risk factors for ovarian cancerClin Cancer Res200511134968497616000597
   PubMed Web of Science ®Google Scholar
• MakarlaPBSaboorianMHAshfaqRPromoter hypermethylation profile of ovarian epithelial neoplasmsClin Cancer Res200511155365536916061849
   PubMed Web of Science ®Google Scholar
• RathiAVirmaniAKSchorgeJOMethylation profiles of sporadic ovarian tumors and nonmalignant ovaries from high-risk womenClin Cancer Res20028113324333112429618
   PubMed Web of Science ®Google Scholar
• XiaoXCaiFNiuXShiHZhongYAssociation between P16INK4a promoter methylation and ovarian cancer: a meta-analysis of 12 published studiesPLoS One2016119e016325727648827
   PubMed Web of Science ®Google Scholar
• JiangYYanFLiangLWanYLiuJChengWMeta-analysis demonstrates no association between P16 INK4A promoter methylation and epithelial ovarian cancerArch Gynecol Obstet2017295369770428000027
   PubMed Web of Science ®Google Scholar
• StangACritical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analysesEur J Epidemiol201025960360520652370
   PubMed Web of Science ®Google Scholar
• BradburnMJDeeksJJBerlinJARussell LocalioAMuch ado about nothing: a comparison of the performance of meta-analytical methods with rare eventsStat Med2007261537716596572
   PubMed Web of Science ®Google Scholar
• National Institutes of HealthNational Cancer InstituteNational Human Genome Resarch InstituteThe Cancer Genome Atlas Available from: https://cancergenome.nih.gov/Accessed August 19, 2018
   Google Scholar
• Cancer Genome Atlas Research NetworkIntegrated genomic analyses of ovarian carcinomaNature2011474735360961521720365
   PubMed Web of Science ®Google Scholar
• HoCMHuangCJHuangCYWuYYChangSFChengWFPromoter methylation status of HIN-1 associated with outcomes of ovarian clear cell adenocarcinomaMol Cancer2012115322871047
   PubMed Web of Science ®Google Scholar
• Cul’bováMLasabovaZStanclovaAMetylácia vybraných tumor-supresorických génov v benígnych a malígnych ovariálnych nádoroch [Methylation of selected tumor-suppressor genes in benign and malignant ovarian tumors]Ceska/Gynekol2011764274279 Czech
   Google Scholar
• GuXHLuYMaDLiuXSGuoSWModel of aberrant DNA methylation patterns and its applications in epithelial ovarian cancerZhonghua Fu Chan Ke Za Zhi2009441075475920078962
   PubMedGoogle Scholar
• WuQLotheRAAhlquistTDNA methylation profiling of ovarian carcinomas and their in vitro models identifies HOXA9, HOXB5, SCGB3A1, and CRABP1 as novel targetsMol Cancer200764517623056
   PubMed Web of Science ®Google Scholar
• YangHJLiuVWWangYTsangPCNganHYDifferential DNA methylation profiles in gynecological cancers and correlation with clinicopathological dataBMC Cancer2006621216928264
   PubMed Web of Science ®Google Scholar
• WileyAKatsarosDChenHAberrant promoter methylation of multiple genes in malignant ovarian tumors and in ovarian tumors with low malignant potentialCancer2006107229930816773633
   PubMed Web of Science ®Google Scholar
• KatsarosDChoWSingalRMethylation of tumor suppressor gene p16 and prognosis of epithelial ovarian cancerGynecol Oncol200494368569215350359
   PubMed Web of Science ®Google Scholar
• HashiguchiYTsudaHYamamotoKInoueTIshikoOOgitaSCombined analysis of p53 and RB pathways in epithelial ovarian cancerHum Pathol200132998899611567230
   PubMed Web of Science ®Google Scholar
• BrownIMilnerBRooneyPHaitesNInactivation of the p16INK4A gene by methylation is not a frequent event in sporadic ovarian carcinomaOncol Rep2001861359136211605066
   PubMed Web of Science ®Google Scholar
• StrathdeeGAppletonKIllandMPrimary ovarian carcinomas display multiple methylator phenotypes involving known tumor suppressor genesAm J Pathol200115831121112711238060
   PubMed Web of Science ®Google Scholar
• MccluskeyLLChenCDelgadilloEFelixJCMuderspachLIDubeauLDifferences in p16 gene methylation and expression in benign and malignant ovarian tumorsGynecol Oncol199972187929889036
   PubMed Web of Science ®Google Scholar
• Milde-LangoschKOconEBeckerGLöningTp16/MTS1 inactivation in ovarian carcinomas: high frequency of reduced protein expression associated with hypermethylation or mutation in endometrioid and mucinous tumorsInt J Cancer199879161659495360
   PubMed Web of Science ®Google Scholar
• ShihYCKerrJLiuJRare mutations and no hypermethylation at the CDKN2A locus in epithelial ovarian tumoursInt J Cancer19977055085119052747
   PubMed Web of Science ®Google Scholar
• FerlayJSoerjomataramIDikshitRCancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012Int J Cancer20151365E359E38625220842
   PubMed Web of Science ®Google Scholar
• XingXCaiWShiHThe prognostic value of CDKN2A hypermethylation in colorectal cancer: a meta-analysisBr J Cancer2013108122542254823703248
   PubMed Web of Science ®Google Scholar
• LiJZhouCZhouHThe association between methylated CDKN2A and cervical carcinogenesis, and its diagnostic value in cervical cancer: a meta-analysisTher Clin Risk Manag2016121249126027574435
   PubMed Web of Science ®Google Scholar
• WangXZhuYBCuiHPYuTTTtYAberrant promoter methylation of p15 (INK4b) and p16 (INK4a) genes may contribute to the pathogenesis of multiple myeloma: a meta-analysisTumour Biol20143599035904324908414
   PubMedGoogle Scholar
• TangBLiYQiGClinicopathological significance of CDKN2A promoter hypermethylation frequency with pancreatic cancerSci Rep201551356326338139
   PubMed Web of Science ®Google Scholar
• HoganCImpact of interactions between normal and transformed epithelial cells and the relevance to cancerCell Mol Life Sci201269220321321877117
   PubMed Web of Science ®Google Scholar
• FraserHBLamLLNeumannSMKoborMSPopulation-specificity of human DNA methylationGenome Biol2012132R822322129
   PubMed Web of Science ®Google Scholar
• KaderFGhaiMDNA methylation-based variation between human populationsMol Genet Genomics2017292153527815639
   PubMed Web of Science ®Google Scholar
• KurdyukovSBullockMDNA methylation analysis: choosing the right methodBiology2016513
   PubMedGoogle Scholar
• ChangHYiBLiLMethylation of tumor associated genes in tissue and plasma samples from liver disease patientsExp Mol Pathol20088529610018691570
   PubMed Web of Science ®Google Scholar
• ZhuWQinWHewettJESauterERQuantitative evaluation of DNA hypermethylation in malignant and benign breast tissue and fluidsInt J Cancer2010126247448219618401
   PubMed Web of Science ®Google Scholar
• NiederacherDYanHYAnHXBenderHGBeckmannMWCDKN2A gene inactivation in epithelial sporadic ovarian cancerBr J Cancer199980121920192610471040
   PubMed Web of Science ®Google Scholar