76
Views
17
CrossRef citations to date
0
Altmetric
Original Research

DNA methylation-mediated Klotho silencing is an independent prognostic biomarker of head and neck squamous carcinoma

, , , , &
Pages 1383-1390 | Published online: 12 Feb 2019

References

  • FerlayJSoerjomataramIDikshitRCancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012Int J Cancer20151365E359E38625220842
  • BraakhuisBJLeemansCRVisserOIncidence and survival trends of head and neck squamous cell carcinoma in the Netherlands between 1989 and 2011Oral Oncol201450767067524735546
  • LefebvreJLCurrent clinical outcomes demand new treatment options for SCCHNAnn Oncol200516suppl_6vi7vi1215987995
  • AbramovitzLRubinekTLigumskyHKL1 internal repeat mediates Klotho tumor suppressor activities and inhibits bFGF and IGF-I signaling in pancreatic cancerClin Cancer Res201117134254426621571866
  • ImuraAIwanoATohyamaOSecreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membraneFEBS Lett20045651–314314715135068
  • TakahashiYKuro-OMIshikawaFAging mechanismsProc Natl Acad Sci U S A20009723124071240811035783
  • Kuro-OMMatsumuraYAizawaHMutation of the mouse Klotho gene leads to a syndrome resembling ageingNature1997390665545519363890
  • WolfILevanon-CohenSBoseSKlotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancerOncogene200827567094710518762812
  • RubinekTShulmanMIsraeliSEpigenetic silencing of the tumor suppressor Klotho in human breast cancerBreast Cancer Res Treat2012133264965722042362
  • GiganteMLucarelliGDivellaCSoluble serum αKlotho is a potential predictive marker of disease progression in clear cell renal cell carcinomaMedicine20159445e191726559258
  • DaiDWangQLiXLiuJMaXXuWKlotho inhibits human follicular thyroid cancer cell growth and promotes apoptosis through regulation of the expression of stanniocalcin-1Oncol Rep201635155255826531219
  • UsudaJIchinoseSIshizumiTKlotho predicts good clinical outcome in patients with limited-disease small cell lung cancer who received surgeryLung Cancer201174233233721529984
  • AdhikariBRUeharaOMatsuokaHImmunohistochemical evaluation of Klotho and DNA methyltransferase 3a in oral squamous cell carcinomasMed Mol Morphol201750315516028303350
  • LuLKatsarosDWileyAde la LongraisIAPuopoloMYuHKlotho expression in epithelial ovarian cancer and its association with insulin-like growth factors and disease progressionCancer Invest200826218519218259951
  • TangXFanZWangYExpression of Klotho and β-catenin in esophageal squamous cell carcinoma, and their clinicopathological and prognostic significanceDis Esophagus201629320721425287007
  • SchuebelKEChenWCopeLComparing the DNA hypermethylome with gene mutations in human colorectal cancerPLoS Genet2007391709172317892325
  • AlsofyaniAAAlsiaryRASamkariAPrognostic potential of KLOTHO and SFRP1 promoter methylation in head and neck squamous cell carcinomaJ Appl Genet201758445946528812223
  • PerveezMAjazMAfrozeDPromoter hypermethylation of KLOTHO; an anti-senescence related gene in colorectal cancer patients of Kashmir valleyMol Biol Res Commun20154421722427844013
  • LeeJJeongDJKimJThe anti-aging gene KLOTHO is a novel target for epigenetic silencing in human cervical carcinomaMol Cancer20109110920482749
  • LuLZhuGZengHXuQHolzmannKHigh tRNA transferase NSUN2 gene expression is associated with poor prognosis in head and neck squamous carcinomaCancer Invest201836424625329775108
  • Cancer Genome Atlas Research NetworkComprehensive molecular characterization of gastric adenocarcinomaNature2014513751720220925079317
  • LigumskyHRubinekTMerenbakh-LaminKTumor suppressor activity of Klotho in breast cancer is revealed by structure–function analysisMol Cancer Res201513101398140726113466
  • WangYChenLHuangGKlotho sensitizes human lung cancer cell line to cisplatin via PI3k/Akt pathwayPLoS One201382e5739123437382
  • XieBZhouJYuanLEpigenetic silencing of Klotho expression correlates with poor prognosis of human hepatocellular carcinomaHum Pathol201344579580123123137
  • PanJZhongJGanLHKlotho, an anti-senescence related gene, is frequently inactivated through promoter hypermethylation in colorectal cancerTumour Biol201132472973521523445
  • WangLWangXWangXKlotho is silenced through promoter hypermethylation in gastric cancerAm J Cancer Res20111111111921969138
  • KurosuHYamamotoMClarkJDSuppression of aging in mice by the hormone KlothoScience200530957421829183316123266
  • LiuHFergussonMMCastilhoRMAugmented Wnt signaling in a mammalian model of accelerated agingScience2007317583980380617690294
  • DoiSZouYTogaoOKlotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in miceJ Biol Chem2011286108655866521209102
  • ZhuYZhangWWangPSmoking and gender modify the effect of TWIST on patient survival in head and neck squamous carcinomaOncotarget2017849858168582729156759
  • TsaiKDLeeWXChenWUpregulation of PRMT6 by LPS suppresses Klotho expression through interaction with NF-κB in glomerular mesangial cellsJ Cell Biochem201811943404341629131380
  • YangWWangXLiXThe specific methylation characteristics of cancer related genes in Chinese colorectal cancer patientsTumour Biol20143588267827924852431
  • DemokanSDalayNRole of DNA methylation in head and neck cancerClin Epigenetics20112212315022704334
  • WorshamMJStephenJKChenKMDelineating an epigenetic continuum in head and neck cancerCancer Lett2014342217818422388100
  • SannigrahiMKSinghVSharmaRPandaNKKhullarMRole of autophagy in head and neck cancer and therapeutic resistanceOral Dis201521328329124797102
  • HuZZhongZHuangSDecreased expression of Beclin-1 is significantly associated with a poor prognosis in oral tongue squamous cell carcinomaMol Med Rep20161421567157327356955
  • ShuGXieBRenFRestoration of Klotho expression induces apoptosis and autophagy in hepatocellular carcinoma cellsCell Oncol2013362121129
  • XieBZhouJShuGRestoration of Klotho gene expression induces apoptosis and autophagy in gastric cancer cells: tumor suppressive role of Klotho in gastric cancerCancer Cell Int20131311823432957
  • BlancoSKurowskiANicholsJWattFMBenitahSAFryeMThe RNA-methyltransferase Misu (NSun2) poises epidermal stem cells to differentiatePLoS Genet2011712e100240322144916
  • HussainSBenaventeSBNascimentoEThe nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stabilityJ Cell Biol20091861274019596847
  • FryeMWattFMThe RNA methyltransferase Misu (NSun2) mediates Myc-induced proliferation and is upregulated in tumorsCurr Biol2006161097198116713953
  • FryeMDragoniIChinSFGenomic gain of 5p15 leads to overexpression of Misu (NSUN2) in breast cancerCancer Lett20102891718019740597
  • ChangBKimJJeongDKlotho inhibits the capacity of cell migration and invasion in cervical cancerOncol Rep20122831022102822710352