The lncRNA HOXA11-AS regulates Rab3D expression by sponging miR-125a-5p promoting metastasis of osteosarcoma

References

• Ottaviani G, Jaffe N. The epidemiology of osteosarcoma. Cancer Treat Res. 2009;152:3–13. doi:10.1007/978-1-4419-0284-9_120213383
   PubMedGoogle Scholar
• Meazza C, Scanagatta P. Metastatic osteosarcoma: a challenging multidisciplinary treatment. Expert Rev Anticancer Ther. 2016;16(5):543–545. doi:10.1586/14737140.2016.116869726999418
   PubMed Web of Science ®Google Scholar
• Anderson ME. Update on survival in osteosarcoma. Orthop Clin North Am. 2016;47(1):283–292. doi:10.1016/j.ocl.2015.08.02226614941
   PubMed Web of Science ®Google Scholar
• Wang J, Samuels DC, Zhao S, Xiang Y, Zhao YY, Guo Y. Current research on non-coding ribonucleic acid (RNA). Genes (Basel). 2017;8(12):366. doi:10.3390/genes8120366
   PubMed Web of Science ®Google Scholar
• Tay Y, Rinn J, Pandolfi PP. The multilayered complexity of ceRNA crosstalk and competition. Nature. 2014;505:344–352. doi:10.1038/nature1298624429633
   PubMed Web of Science ®Google Scholar
• Cesana M, Daley GQ. Deciphering the rules of ceRNA networks. Proc Natl Acad Sci U S A. 2013;110(18):7112–7113. doi:10.1073/pnas.130532211023620514
   PubMed Web of Science ®Google Scholar
• Karreth FA, Pandolfi PP. ceRNA cross-talk in cancer: when ce-bling rivalries go awry. Cancer Discov. 2013;3(10):1113–1121. doi:10.1158/2159-8290.CD-13-020224072616
   PubMed Web of Science ®Google Scholar
• Nunes FD, de Almeida FC, Tucci R, de Sousa SC. Homeobox genes: a molecular link between development and cancer. Pesqui Odontol Bras. 2003;17(1):94–98. 12908068
   PubMedGoogle Scholar
• Wang Q, Zhang J, Liu Y, et al. A novel cell cycle-associated lncRNA, HOXA11-AS, is transcribed from the 5-prime end of the HOXA transcript and is a biomarker of progression in glioma. Cancer Lett. 2016;373:251–259. doi:10.1016/j.canlet.2016.01.03926828136
   PubMed Web of Science ®Google Scholar
• Chen J, Fu Z, Ji C, et al. Systematic gene microarray analysis of the lncRNA expression profiles in human uterine cervix carcinoma. Biomed Pharmacother. 2015;72:83–90. doi:10.1016/j.biopha.2015.04.01026054679
   PubMed Web of Science ®Google Scholar
• Richards EJ, Permuth-Wey J, Li Y, et al. A functional variant in HOXA11-AS, a novel long noncoding RNA, inhibits the oncogenic phenotype of epithelial ovarian cancer. Oncotarget. 2015;6:34745–34757. 26430965
   PubMedGoogle Scholar
• Liang J, Lv J, Liu Z. Identification of stage-specific biomarkers in lung adenocarcinoma based on RNA-seq data. Tumour Biol. 2015;36:6391–6399. doi:10.1007/s13277-015-3327-025861020
   PubMedGoogle Scholar
• Chen D, Sun Q, Zhang L, et al. The lncRNA HOXA11-AS functions as a competing endogenous RNA to regulate PADI2 expression by sponging miR-125a-5p in liver metastasis of colorectal cancer. Oncotarget. 2017;8(41):70642–70652. doi:10.18632/oncotarget.1995629050308
   PubMedGoogle Scholar
• Zhang Z, Zhang S, Ma P, et al. Lin28B promotes melanoma growth by mediating a microRNA regulatory circuit. Carcinogenesis. 2015;36:937–945. doi:10.1093/carcin/bgv08526071398
   PubMed Web of Science ®Google Scholar
• Sun L, Zhang B, Liu Y, Shi L, Li H, Lu S. MiR125a-5p acting as a novel Gab2 suppressor inhibits invasion of glioma. Mol Carcinog. 2016;55:40–51. doi:10.1002/mc.2225625598421
   PubMed Web of Science ®Google Scholar
• Wang G, Mao W, Zheng S, Ye J. Epidermal growth factor receptor-regulated miR-125a-5p—a metastatic inhibitor of lung cancer. FEBS J. 2009;276:5571–5578. doi:10.1111/j.1742-4658.2009.07238.x19702827
   PubMed Web of Science ®Google Scholar
• Sun Y, Liu X, Zhang Q, et al. Oncogenic potential of TSTA3 in breast cancer and its regulation by the tumor suppressors miR-125a-5p and miR-125b. Tumour Biol. 2016;37:4963–4972. doi:10.1007/s13277-015-4178-426531722
   PubMedGoogle Scholar
• Jiang L, Huang Q, Zhang S, et al. Hsa-miR-125a-3p and hsa-miR-125a-5p are downregulated in non-small cell lung cancer and have inverse effects on invasion and migration of lung cancer cells. BMC Cancer. 2010;10:318. doi:10.1186/1471-2407-10-66320569443
   PubMed Web of Science ®Google Scholar
• Tang H, Li RP, Liang P, Zhou YL, Wang GW. miR-125a inhibits the migration and invasion of liver cancer cells via suppression of the PI3K/AKT/mTOR signaling pathway. Oncol Lett. 2015;10:681–686. doi:10.3892/ol.2015.326426622553
   PubMed Web of Science ®Google Scholar
• Xu Y, Huang Z, Liu Y. Reduced miR-125a-5p expression is associated with gastric carcinogenesis through the targeting of E2F3. Mol Med Rep. 2014;10:2601–2608. doi:10.3892/mmr.2014.256725231560
   PubMed Web of Science ®Google Scholar
• Kim JK, Noh JH, Jung KH, et al. Sirtuin7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors MiR-125a-5p and MiR-125b. Hepatology. 2013;57:1055–1067. doi:10.1002/hep.2610123079745
   PubMed Web of Science ®Google Scholar
• Nishida N, Mimori K, Fabbri M, et al. MicroRNA-125a-5p is an independent prognostic factor in gastric cancer and inhibits the proliferation of human gastric cancer cells in combination with trastuzumab. Clin Cancer Res. 2011;17:2725–2733. doi:10.1158/1078-0432.CCR-10-213221220473
   PubMed Web of Science ®Google Scholar
• Hsieh TH, Hsu CY, Tsai CF, et al. miR-125a-5p is a prognostic biomarker that targets HDAC4 to suppress breast tumorigenesis. Oncotarget. 2015;6:494–509. doi:10.18632/oncotarget.267425504437
   PubMedGoogle Scholar
• Hsieh TH, Hsu CY, Tsai CF, et al. HDAC inhibitors target HDAC5, upregulate microRNA-125a-5p, and induce apoptosis in breast cancer cells. Mol Ther. 2015;23:656–666. doi:10.1038/mt.2014.24725531695
   PubMed Web of Science ®Google Scholar
• Stenmark H. Rab GTPases as coordinators of vesicle traffic. Nat Rev Mol Cell Biol. 2009;10(8):513–525. doi:10.1038/nrm272819603039
   PubMed Web of Science ®Google Scholar
• Jiashi W, Chuang Q, Zhenjun Z, Guangbin W, Bin L, Ming H. MicroRNA-506-3p inhibits osteosarcoma cell proliferation and metastasis by suppressing RAB3D expression. Aging (Albany NY). 2018;10:1294–1305. doi:10.18632/aging.10146829905536
   PubMedGoogle Scholar
• Sun M, Nie F, Wang Y, et al. LncRNA HOXA11-AS promotes proliferation and invasion of gastric cancer by scaffolding the chromatin modification factors PRC2, LSD1, and DNMT1. Cancer Res. 2016;76(21):6299–6310. doi:10.1158/0008-5472.CAN-16-035627651312
   PubMed Web of Science ®Google Scholar
• Goldenring JR. A central role for vesicle trafficking in epithelial neoplasia: intracellular highways to carcinogenesis. Nat Rev Cancer. 2013;13(11):813–820. doi:10.1038/nrc360124108097
   PubMed Web of Science ®Google Scholar
• Luo Y, Ye GY, Qin SL, et al. High expression of Rab3D predicts poor prognosis and associates with tumor progression in colorectal cancer. Int J Biochem Cell Biol. 2016;75:53–62. doi:10.1016/j.biocel.2016.03.01727046094
   PubMed Web of Science ®Google Scholar