kshv-mir-k12-1-5p promotes cell growth and metastasis by targeting SOCS6 in Kaposi’s sarcoma cells

References

• Hengge UR, Ruzicka T, Tyring SK, et al. Update on Kaposi‘s sarcoma and other HHV8 associated diseases. Part 1: epidemiology, environmental predispositions, clinical manifestations, and therapy. Lancet Infect Dis. 2002;2:281–292.12062994
   PubMed Web of Science ®Google Scholar
• Wu XJ, Pu XM, Kang XJ, et al. One hundred and five Kaposi sarcoma patents: a clinical study in Xinjiang, Northwest of China. Acad Dermatol Venereol. 2014;28(11):1545–1552. doi:10.1111/jdv.12349
   PubMed Web of Science ®Google Scholar
• Wang X, He B, Zhang Z, et al. Human herpesvirus-8 in northwestern China: epidemiology and characterization among blood donors. Virol J. 2010;7:62. doi:10.1186/1743-422X-7-6220236530
   PubMed Web of Science ®Google Scholar
• O‘Hara AJ, Wang L, Dezube BJ, et al. Tumor suppressor microRNAs are underrepresented in primary effusion lymphoma and Kaposi sarcoma. Blood. 2009;113:5938–5941. doi:10.1182/blood-2008-09-17916819252139
   PubMed Web of Science ®Google Scholar
• Ruksha TG, Komina AV, Palkina NV. MicroRNA in skin diseases. Eur J Dermatol. 2017;27(4):343–352. doi:10.1684/ejd.2017.302428524065
   PubMed Web of Science ®Google Scholar
• Engels BM, Hutvagner G. Principles and effects of microRNA-mediated post-transcriptional gene regulation. Oncogene. 2006;25(46):6163–6169. doi:10.1038/sj.onc.120990917028595
   PubMed Web of Science ®Google Scholar
• Gottwein E, Mukherjee N, Sachse C, et al. A viral microRNA functions as an orthologue of cellular miR-155. Nature. 2007;450(7172):1096–1099. doi:10.1038/nature0599218075594
   PubMed Web of Science ®Google Scholar
• Liu Y, Sun R, Lin X, Liang D, Deng Q Lan K. Kaposi‘s sarcoma-associated herpesvirus-encoded microRNA miR-K12-11 attenuates transforming growth factor beta signaling through suppression of SMAD5. J Virol. 2012;86(3):1372–1381. doi:10.1128/JVI.06245-1122013049
   PubMed Web of Science ®Google Scholar
• Tiifekci KU, Meuwissen PAL, Genc S. The role of microRNAs in biological processes. Methods Mol Biol. 2014;1107:15–31. doi:10.1007/978-1-62703-748-8_224272429
   PubMedGoogle Scholar
• Zhang W, Han S, Sun K. Combined analysis of gene expression, miRNA expression and DNA methylation profiles of osteosarcoma. Oncol Rep. 2017;37(2):1175–1181. doi:10.3892/or.2016.532428000890
   PubMed Web of Science ®Google Scholar
• Kim J, Yao F, Xiao Z, Sun Y, Ma L. MicroRNAs and metastasis: small RNAs play big roles. Cancer Metastasis Rev. 2018;37(1):5–15. doi:10.1007/s10555-017-9712-y29234933
   PubMed Web of Science ®Google Scholar
• Felekkis K, Touvana E, Stefanou C, Deltas C. microRNAs: a newly described class of encoded molecules that play a role in health and disease. Hippokratia. 2010;14(4):236–240.21311629
   PubMed Web of Science ®Google Scholar
• Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell. 2005;120(1):15–20. doi:10.1016/j.cell.2004.12.03515652477
   PubMed Web of Science ®Google Scholar
• Lim LP, Lau NC, Garrett-Engele P, et al. Microarray analysis shows that some microRNAs down regulate large numbers of target mRNAs. Nature. 2005;433(7027):769–773. doi:10.1038/nature0331515685193
   PubMed Web of Science ®Google Scholar
• Mouillet JF, Ouyang Y, Coyne CB, Sadovsky Y. MicroRNAs in placental health and disease. Am J Obstet Gynecol. 2015;213(4 Suppl):S163–S172. doi:10.1016/j.ajog.2015.05.05726428496
   PubMed Web of Science ®Google Scholar
• Wu XJ, Pu XM, Zhao ZF, et al. The expression profiles of microRNAs in Kaposi’s sarcoma. Tumour Biol. 2015;36(1):437–446. doi:10.1007/s13277-014-2626-125266797
   PubMedGoogle Scholar
• Kabir NN, Sun J, Ronnstrand L, Kazi JU. SOCS6 is a selective suppressor of receptor tyrosine kinase signaling. Tumour Biol. 2014;35(11):10581–10589. doi:10.1007/s13277-014-2542-425172101
   PubMedGoogle Scholar
• Xue X, Liu Y, Wang Y, et al. MiR-21 and MiR-155 promote non-small cell lung cancer progression by downregulating SOCS1, SOCS6, and PTEN. Oncotarget. 2016;7(51):84508–84519. doi:10.18632/oncotarget.1302227811366
   PubMedGoogle Scholar
• Bellezza I, Neuwirt H, Nemes C, et al. Suppressor of cytokine signaling-3 antagonizes cAMP effects on proliferation and apoptosis and is expressed in human prostate cancer. Am J Pathol. 2006;169(6):2199–2208. doi:10.2353/ajpath.2006.06017117148681
   PubMed Web of Science ®Google Scholar
• Arias C, Weisburd B, Stern-Ginossar N, et al. KSHV 2.0: a comprehensive annotation of the Kaposi’s sarcoma-associated herpesvirus genome using next- generation sequencing reveals novel genomic and functional features. PLoS Pathog. 2014;10(1):e1003847. doi:10.1371/journal.ppat.100384724453964
   PubMed Web of Science ®Google Scholar
• Viollet C, Davis DA, Reczko M, et al. Next-generation sequencing analysis reveals differential expression profiles of MiRNA-mRNA target pairs in KSHV-infected cells. PLoS One. 2015;10(5):e0126439. doi:10.1371/journal.pone.012643925942495
   PubMed Web of Science ®Google Scholar
• Rosario SA, Santiago GE, Mesri EA, Verdun RE. Kaposi’s sarcoma-associated herpesvirus-encoded viral IL-6 (vIL-6) enhances immunoglobulin class-switch recombination. Front Microbiol. 2018;9:3119. doi:10.3389/fmicb.2018.0311930619193
   PubMed Web of Science ®Google Scholar
• Stürzl M, Gaus D, Dirks WG, Ganem D, Jochmann R. Kaposi‘s sarcoma-derived cell line SLKK is not of endothelial origin, but is a contaminant from a known renal carcinoma cell line. Int J Cancer. 2013;132(8):1954–1958. doi:10.1002/ijc.2784922987579
   PubMed Web of Science ®Google Scholar
• Wang W, Yang J, Yu F, et al. MicroRNA-122-3p inhibits tumor cell proliferation and induces apoptosis by targeting Forkhead box O in A549 cells. Oncol Lett. 2018;15(2):2695–2699. doi:10.3892/ol.2017.757729434994
   PubMed Web of Science ®Google Scholar
• Li Y, Xu J, Shao T, Zhang Y, Chen H, Li X. RNA function prediction. Methods Mol Biol. 2017;1654:17–28. doi:10.1007/978-1-4939-7231-9_228986780
   PubMedGoogle Scholar
• Zhao Y, Song Y, Yao L, Song G, Teng C. Circulating microRNAs: promising biomarkers involved in several cancers and other diseases. DNA Cell Biol. 2017;36(2):77–94. doi:10.1089/dna.2016.342628060535
   PubMed Web of Science ®Google Scholar
• Goto Y, Kurozumi A, Arai T, et al. Impact of novel miR-145-3p regulatory networks on survival in patients with castration-resistant prostate cancer. Br J Cancer. 2017;117(3):409–420. doi:10.1038/bjc.2017.19128641312
   PubMed Web of Science ®Google Scholar
• Han C, Seebacher NA, Hornicek FJ, Kan Q, Duan Z. Regulation of microRNAs function by circular RNAs in human cancer. Oncotarget. 2017;8:64622–64637. doi:10.18632/oncotarget.1993028969099
   PubMedGoogle Scholar
• Celano M, Rosignolo F, Maggisano V, et al. MicroRNAs as biomarkers in thyroid carcinoma. Int J Enomics. 2017;2017:6496570.
   PubMed Web of Science ®Google Scholar
• Shomali N, Mansoori B, Mohammadi A, Shirafkan N, Ghasabi M, Baradaran B. MiR-146a functions as a small silent player in gastric cancer. Biomed Pharmacother. 2017;96:238–245. doi:10.1016/j.biopha.2017.09.13828987948
   PubMed Web of Science ®Google Scholar
• Hu M, Wang C, Li W, et al. A KSHV microRNA directly targets G protein-coupled receptor kinase 2 to promote the migration and invasion of endothelial cells by inducing CXCR2 and activating AKT signaling. PLoS Pathog. 2015;11:e1005171. doi:10.1371/journal.ppat.100517126402907
   PubMed Web of Science ®Google Scholar
• Purushothaman P, Uppal T, Sarkar R, et al. KSHV-mediated angiogenesis in tumor progression. Viruses. 2016;8(7):198.
   PubMed Web of Science ®Google Scholar
• Gay LA, Sethuraman S, Thomas M, Turner PC, Renne R. Modified cross-linking, ligation, and sequencing of hybrids (qCLASH) identifies Kaposi‘s sarcoma-associated herpesvirus MicroRNA Targets In Endothelial Cells. J Virol. 2018;92(8):e02138–17. doi:10.1128/JVI.02138-1729386283
   PubMed Web of Science ®Google Scholar
• Haecker I, Gay LA, Yang Y, et al. Ago HITS-CLIP expands understanding of Kaposi‘s sarcoma-associated herpesvirus miRNA function in primary effusion lymphomas. PLoS Pathog. 2012;8(8):e1002884. doi:10.1371/journal.ppat.100288422927820
   PubMed Web of Science ®Google Scholar
• Kaplan LD. Human herpesvirus-8: Kaposi sarcoma, multicentric Castleman disease, and primary effusion lymphoma. Hematology Am Soc Hematol Educ Program. 2013;2013(1):103–108．. doi:10.1182/asheducation-2013.1.103
   PubMedGoogle Scholar
• Grundhoff A, Sullivan CS. Virus-encoded microRNAs. Virology. 2011;411(2):325–343. doi:10.1016/j.virol.2011.01.00221277611
   PubMed Web of Science ®Google Scholar
• Catrina Ene AM, Borze I, Guled M, et al. MicroRNA expression profiles in Kaposi‘s sarcoma. Pathol Oncol Res. 2014;20(1):153–159. doi:10.1007/s12253-013-9678-124027049
   PubMed Web of Science ®Google Scholar
• Yu F, Yao H, Zhu P, et al. let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell. 2007;13l(6):1109–1123. doi:10.1016/j.cell.2007.10.054
   Google Scholar
• Yu F, Jiao Y, Zhu Y, et al. MicroRNA 34c gene down-regulation via DNA methylation promotes self-renewal and epithelial-mesenchymal transition in breast tumor-initiating cells. J Biol Chem. 2012;287(1):465–473. doi:10.1074/jbc.M111.28076822074923
   PubMed Web of Science ®Google Scholar
• Qin J, Li W, Gao SJ, Lu C. KSHV microRNAs: tricks of the devil. Trends Microbiol. 2017;25(8):648–661. doi:10.1016/j.tim.2017.02.00228259385
   PubMed Web of Science ®Google Scholar
• Sandal T. Molecular aspects of the mammalian cell cycle and cancer. Oncologist. 2002;7:73–81.11854549
   PubMed Web of Science ®Google Scholar
• Wu J, Ji A, Wang X, et al. MicroRNA-195-5p, a new of Fra-1, suppresses the migration and invasion regulator of prostate cancer cells. J Transl Med. 2015;13:289. doi:10.1186/s12967-015-0541-x26337460
   PubMed Web of Science ®Google Scholar
• Nola S, Sin S, Bonin F, Lidereau R, Driouch K. A methodological approach to unravel organ-specific breast cancer metastasis. J Mammary Gland Biol Neoplasia. 2012;17:135–145. doi:10.1007/s10911-012-9256-222628182
   PubMed Web of Science ®Google Scholar
• Dahlke C, Maul K, Christalla T, et al. A microRNA encoded by Kaposi sarcoma-associated herpesvirus promotes B-cell expansion in vivo. PLoS One. 2012;7:e49435. doi:10.1371/journal.pone.004943523185331
   PubMed Web of Science ®Google Scholar
• Forte E, Raja AN, Shamulailatpam P, et al. MicroRNA-mediated transformation by the Kaposi‘s sarcoma-associated herpesvirus Kaposin locus. J Virol. 2015;89(4):2333–2341. doi:10.1128/JVI.03317-1425505059
   PubMed Web of Science ®Google Scholar
• Lei X, Zhu Y, Jones T, Bai Z, Huang Y, Gao S-J. A Kaposi‘s sarcoma-associated herpesvirus microRNA and its variants target the transforming growth factor β pathway to promote cell survival. J Virol. 2012;86:11698–11711. doi:10.1128/JVI.06855-1122915806
   PubMed Web of Science ®Google Scholar
• Qin Z, Dai L, Defee M, et al. Kaposi‘s sarcoma-associated herpesvirus suppression of DUSP1 facilitates cellular pathogenesis following de novo infection. J Virol. 2013;87:621–635. doi:10.1128/JVI.01441-1223097457
   PubMed Web of Science ®Google Scholar
• Suffert G, Malterer G, Hausser J, et al. Kaposi‘s sarcoma herpesvirus microRNAs target caspase 3 and regulate apoptosis. PLoS Pathog. 2011;7(12):e1002405. doi:10.1371/journal.ppat.100240522174674
   PubMed Web of Science ®Google Scholar
• Kim HS, Shen Q, Nam SW. Histone deacetylases and their regulatory MicroRNAs in hepatocarcinogenesis. J Korean Med Sci. 2015;30(10):1375–1380. doi:10.3346/jkms.2015.30.10.137526425032
   PubMed Web of Science ®Google Scholar
• Quan L, Qiu T, Liang J, Li M, Zhang Y, Tao K. Identification of target genes regulated by KSHV miRNAs in KSHV-infected lymphoma cells. Pathol Oncol Res. 2015;21(4):875–880. doi:10.1007/s12253-015-9902-225648438
   PubMed Web of Science ®Google Scholar
• Trengove MC, Ward AC. SOCS proteins in development and disease. Am J Clin Exp Immunol. 2013;2(1):1–29.23885323
   PubMedGoogle Scholar
• Qi X, Li J, Zhou C, Lv C, Tian M. MiR-142-3p suppresses SOCS6 expression and promotes cell proliferation in nasopharyngeal carcinoma. Cell Physiol Biochem. 2015;36(5):1743–1752. doi:10.1159/00043014726183850
   PubMedGoogle Scholar
• Tanaka T, Arai M, Jiang X, et al. Downregulation of microRNA-431 by human interferon-beta inhibits viability of medulloblastoma and glioblas- toma cells via upregulation of SOCS6. Int J Oncol. 2014;44(5):1685–1690. doi:10.3892/ijo.2014.231724584142
   PubMed Web of Science ®Google Scholar
• Wu K, Hu G, He X, et al. MicroRNA-424-5p suppresses the expression of SOCS6 in pancreatic cancer. Pathol Oncol Res. 2013;19(4):739–748. doi:10.1007/s12253-013-9637-x23653113
   PubMed Web of Science ®Google Scholar
• Wu Q, Luo G, Yang Z, et al. miR-17-5p promotes proliferation by targeting SOCS6 in gastric cancer cells. FEBS Lett. 2014;588(12):2055–2062. doi:10.1016/j.febslet.2014.04.03624801601
   PubMed Web of Science ®Google Scholar