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Review

The prognostic value and mechanisms of lncRNA UCA1 in human cancer

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Pages 7685-7696 | Published online: 14 Aug 2019

References

  • Torre LA, Freddie B, Siegel RL, et al. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65(2):69–90. doi:10.3322/caac.21262
  • Koo MM, Hamilton W, Walter FM, et al. Symptom signatures and diagnostic timeliness in cancer patients: a review of current evidence. Neoplasia. 2018;20(2):165–174. doi:10.1016/j.neo.2017.11.00529253839
  • Nie J, Zhao C, Deng LI, et al. Efficacy of traditional Chinese medicine in treating cancer. Biomed Rep. 2016;4(1):3–14. doi:10.3892/br.2015.53726870326
  • Nakashima L. Evolution of cancer treatment and evolving challenges. Healthc Manage Forum. 2018;31(1):26–28. doi:10.1177/084047041772256829264971
  • Hajjari M, Khoshnevisan A, Shin YK. Molecular function and regulation of long non-coding RNAs: paradigms with potential roles in cancer. Tumor Biol. 2014;35(11):10645–10663. doi:10.1007/s13277-014-2636-z
  • Tang Y, Cheung BB, Atmadibrata B, et al. The regulatory role of long noncoding RNAs in cancer. Cancer Lett. 2017;391:12–19. doi:10.1016/j.canlet.2017.01.01028111137
  • Guo H, Huang S, Li S, et al. Prognostic significance of the long noncoding RNAs in nasopharyngeal carcinoma: a systematic review and meta-analysis. Cancer Manag Res. 2018;10:1763–1779. doi:10.2147/CMAR.S16469529988744
  • Iakes E, David J, Jose Manuel R, et al. Multiple evidence strands suggest that there may be as few as 19,000 human protein-coding genes. Hum Mol Genet. 2014;23(22):5866–5878. doi:10.1093/hmg/ddu30924939910
  • Yamamura S, Imai-Sumida M, Tanaka Y, et al. Interaction and cross-talk between non-coding RNAs. Cell Mol Life Sci. 2018;75(3):467–484. doi:10.1007/s00018-017-2626-628840253
  • Yang S, Sun Z, Zhou Q, et al. MicroRNAs, long noncoding RNAs, and circular RNAs: potential tumor biomarkers and targets for colorectal cancer. Cancer Manag Res. 2018;10:2249–2257. doi:10.2147/CMAR.S16630830100756
  • Quinn JJ, Chang HY. Unique features of long non-coding RNA biogenesis and function. Nat Rev Genet. 2015;17(1):47–62. doi:10.1038/nrg.2015.10
  • Schmitt A, Chang H. Long noncoding RNAs in cancer pathways. Cancer Cell. 2016;29(4):452–463. doi:10.1016/j.ccell.2016.03.01027070700
  • Huang J, Zhou N, Watabe K, et al. Long non-coding RNA UCA1 promotes breast tumor growth by suppression of p27 (Kip1). Cell Death Dis. 2014;5(1):e1008. doi:10.1038/cddis.2013.54124457952
  • Wang X, Fa XE. Knockdown of UCA1 inhibits viability and glycolysis by suppressing PKM2 expression through the mTOR pathway in non-small cell lung cancer cells. RSC Adv. 2018;8(19):10610–10619. doi:10.1039/C8RA00860D
  • Xie XJ, Xu LI, Wang F. Cellular localization and tissue expression pattern of UCA1, a non-coding RNA. J South Med Univ. 2010;30(1):57–60. doi:10.3724/SP.J.1008.2010.01244
  • Wang XS, Zhang Z, Wang HC, et al. Rapid identification of UCA1 as a very sensitive and specific unique marker for human bladder carcinoma. Clin Cancer Res. 2006;12(16):4851–4858. doi:10.1158/1078-0432.CCR-06-013416914571
  • Xue M, Chen W, Li X. Urothelial cancer associated 1: a long noncoding RNA with a crucial role in cancer. J Cancer Res Clin Oncol. 2016;142(7):1–13. doi:10.1007/s00432-015-2042-y25644862
  • Yazarlou F, Modarressi MH, Mowla SJ, et al. Urinary exosomal expression of long non-coding RNAs as diagnostic marker in bladder cancer. Cancer Manag Res. 2018;10:6357–6365. doi:10.2147/CMAR.S18610830568497
  • Li Z, Dou P, Liu T, He S. Application of long noncoding RNAs in osteosarcoma: biomarkers and therapeutic targets. Cell Physiol Biochem. 2017;42(4):1407–1419. doi:10.1159/00047920528715796
  • Sun XD, Chen H, Wei Q, et al. Clinical significance of UCA1 to predict metastasis and poor prognosis of digestive system malignancies: a meta-analysis. Gastroenterol Res Pract. 2016;2016(1):1–11. doi:10.1155/2016/3729830
  • Song W, Gobe GC. Understanding molecular pathways and targets of Brachyury in epithelial-mesenchymal transition (EMT) in human cancers. Curr Cancer Drug Targets. 2016;16(7):586–593. doi:10.2174/156800961666616032811333827018266
  • Chen YC, Statt S, Wu R, et al. High mobility group box 1-induced epithelial mesenchymal transition in human airway epithelial cells. Sci Rep. 2016;6:18815. doi:10.1038/srep1881526739898
  • Xue M, Pang H, Li X, et al. Long non-coding RNA urothelial cancer-associated 1 promotes bladder cancer cell migration and invasion by way of the hsa-miR-145-ZEB1/2-FSCN1 pathway. Cancer Sci. 2016;107(1):18–27. doi:10.1111/cas.1284426544536
  • Luo J, Chen J, Li H, et al. LncRNA UCA1 promotes the invasion and EMT of bladder cancer cells by regulating the miR-143/HMGB1 pathway. Oncol Lett. 2017;14(5):5556–5562. doi:10.3892/ol.2017.688629113184
  • Gou L, Liu M, Xia J, et al. BMP9 promotes the proliferation and migration of bladder cancer cells through up-regulating lncRNA UCA1. Int J Mol Sci. 2018;19(4):1116. doi:10.3390/ijms19041116
  • Tay Y, Rinn J, Pier Paolo P. The multilayered complexity of ceRNA crosstalk and competition. Nature. 2014;505(7483):344–352. doi:10.1038/nature1298624429633
  • Cesana M, Cacchiarelli D, Legnini I, et al. A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA. Cell. 2011;147(2):358–369. doi:10.1016/j.cell.2011.09.02822000014
  • Zhao G, Fu Y, Su Z, et al. How long non-coding RNAs and microRNAs mediate the endogenous RNA network of head and neck squamous cell carcinoma: a comprehensive analysis. Cell Physiol Biochem. 2018;50(1):332–341. doi:10.1159/00049400930282065
  • Zheng C, Li X, Qian B, et al. The lncRNA myocardial infarction associated transcript-centric competing endogenous RNA network in non-small-cell lung cancer. Cancer Manag Res. 2018;10:1155–1162. doi:10.2147/CMAR.S16339529795987
  • Bian Z, Jin L, Zhang J, et al. LncRNA-UCA1 enhances cell proliferation and 5-fluorouracil resistance in colorectal cancer by inhibiting miR-204-5p. Sci Rep. 2016;6:23892. doi:10.1038/srep2389227046651
  • Ni B, Yu X, Guo X, et al. Increased urothelial cancer associated 1 is associated with tumor proliferation and metastasis and predicts poor prognosis in colorectal cancer. Int J Oncol. 2015;47(4):1329–1338. doi:10.3892/ijo.2015.310926238511
  • Li C, Liang G, Yang S, et al. Dysregulated lncRNA-UCA1 contributes to the progression of gastric cancer through regulation of the PI3K-Akt-mTOR signaling pathway. Oncotarget. 2017;8(55):93476–93491. doi:10.18632/oncotarget.1928129212166
  • Qin L, Jia Z, Xie D, Liu Z. Knockdown of long noncoding RNA urothelial carcinoma-associated 1 inhibits cell viability, migration, and invasion by regulating microRNA-182 in gastric carcinoma. J Cell Biochem. 2018;119(12):10075–10086. doi:10.1002/jcb.2734430129054
  • Gong P, Qiao F, Wu H, et al. LncRNA UCA1 promotes tumor metastasis by inducing miR-203/ZEB2 axis in gastric cancer. Cell Death Dis. 2018;9(12):1158. doi:1038/s41419-018-1170-030464170
  • Gu L, Lu LS, Zhou DL, et al. UCA1 promotes cell proliferation and invasion of gastric cancer by targeting CREB1 sponging to miR-590-3p. Cancer Med. 2018;7(4):1253–1263. doi:10.1002/cam4.131029516678
  • Li J, Gao J, Kan A, et al. SNHG and UCA1 as prognostic molecular biomarkers in hepatocellular carcinoma: recent research and meta-analysis. Minerva Med. 2017;108(6):568–574. doi:10.23736/S0026-4806.17.05094-728466631
  • Qin LT, Tang RX, Lin P, et al. Biological function of UCA1 in hepatocellular carcinoma and its clinical significance: investigation with in vitro and meta-analysis. Pathol Res Pract. 2018;214(9):1260–1272. doi:10.1016/j.prp.2018.03.02530017333
  • Wang F, Ying HQ, He BS, et al. Upregulated lncRNA-UCA1 contributes to progression of hepatocellular carcinoma through inhibition of miR-216b and activation of FGFR1/ERK signaling pathway. Oncotarget. 2015;6(10):7899–7917. doi:10.18632/oncotarget.321925760077
  • Xiao JN, Yan TH, Yu RM, et al. Long non-coding RNA UCA1 regulates the expression of Snail2 by miR-203 to promote hepatocellular carcinoma progression. J Cancer Res Clin Oncol. 2017;143(6):981–990. doi:10.1007/s00432-017-2370-128271214
  • Liu H, Wang G, Yang L, et al. Knockdown of long non-coding RNA UCA1 increases the tamoxifen sensitivity of breast cancer cells through inhibition of Wnt/β-catenin pathway. PLOS One. 2016;11(12):e0168406. doi:10.1371/journal.pone.016840627977766
  • Wu C, Luo J. Long non-coding RNA (lncRNA) Urothelial Carcinoma-Associated 1 (UCA1) enhances tamoxifen resistance in breast cancer cells via inhibiting mTOR signaling pathway. Med Sci Monit. 2016;22:3860–3867. doi:10.12659/msm.90068927765938
  • Zhu HY, Bai WD, Ye XM, et al. Long non-coding RNA UCA1 desensitizes breast cancer cells to trastuzumab by impeding miR-18a repression of Yes-associated protein 1. Biochem Biophys Res Commun. 2018;496(4):1308–1313. doi:10.1016/j.bbrc.2018.02.00629408336
  • Jiao C, Song Z, Chen J, et al. lncRNA-UCA1 enhances cell proliferation through functioning as a ceRNA of Sox4 in esophageal cancer. Oncol Rep. 2016;36(5):2960–2966. doi:10.3892/or.2016.512127667646
  • Du Z, Sun T, Hacisuleyman E, et al. Integrative analyses reveal a long noncoding RNA-mediated sponge regulatory network in prostate cancer. Nat Commun. 2016;7:10982. doi:10.1038/ncomms1098226975529
  • Nie W, Ge HJ, Yang XQ, et al. LncRNA- UCA1 exerts oncogenic functions in non-small cell lung cancer by targeting miR-193a-3p. Cancer Lett. 2016;371(1):99–106. doi:10.1016/j.canlet.2015.11.02426655272
  • Wu H, Zhou C. Long non-coding RNA UCA1 promotes lung cancer cell proliferation and migration via microRNA-193a/HMGB1 axis. Biochem Biophys Res Commun. 2018;496(2):738–745. doi:10.1016/j.bbrc.2018.01.09729355524
  • Wang X, Yang B, Ma B. The UCA1/miR-204/Sirt1 axis modulates docetaxel sensitivity of prostate cancer cells. Cancer Chemother Pharmacol. 2016;78(5):1025–1031. doi:10.1007/s00280-016-3158-827686228
  • Fotouhi GA, Taeb S, Huang X, et al. Long non-coding RNA urothelial carcinoma associated 1 (UCA1) mediates radiation response in prostate cancer. Oncotarget. 2016;8(3):4668–4689. doi:10.18632/oncotarget.13576
  • Zhang X, Gao F, Zhou L, et al. UCA1 regulates the growth and metastasis of pancreatic cancer by sponging MiR-135a. Oncol Res. 2017;25(9):1529–1541. doi:10.3727/096504017X1488898768315228315290
  • Zhou Y, Chen Y, Ding W, et al. LncRNA UCA1 impacts cell proliferation, invasion, and migration of pancreatic cancer through regulating miR-96/FOXO3. IUBMB Life. 2018;70(4):276–290. doi:10.1002/iub.169929500870
  • Chen P, Wan D, Zheng D, et al. Long non-coding RNA UCA1 promotes the tumorigenesis in pancreatic cancer. Biomed Pharmacother. 2016;83:1220–1226. doi:10.1016/j.biopha.2016.08.04127562722
  • Zhang L, Cao X, Zhang L, Zhang X, Sheng H, Tao K. UCA1 overexpression predicts clinical outcome of patients with ovarian cancer receiving adjuvant chemotherapy. Cancer Chemother Pharmacol. 2016;77(3):629–634. doi:10.1007/s00280-016-2963-426851957
  • Wang J, Ye C, Liu J, Hu Y. UCA1 confers paclitaxel resistance to ovarian cancer through miR-129/ABCB1 axis. Biochem Biophys Res Commun. 2018;501(4):1034–1040. doi:10.1016/j.bbrc.2018.05.10429777711
  • Fang Z, Wu L, Wang L, Yang Y, Meng Y, Yang H. Increased expression of the long non-coding RNA UCA1 in tongue squamous cell carcinomas: a possible correlation with cancer metastasis. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;117(1):89–95. doi:10.1016/j.oooo.2013.09.00724332332
  • Zhang TH, Liang LZ, Liu XL, et al. LncRNA UCA1/miR-124 axis modulates TGFβ1-induced epithelial-mesenchymal transition and invasion of tongue cancer cells through JAG1/Notch signaling. J Cell Biochem. 2019;120(6):10495–10504. doi:10.1002/jcb.28334
  • Tian Y, Zhang X, Hao Y, Fang Z, He Y. Potential roles of abnormally expressed long noncoding RNA UCA1 and Malat-1 in metastasis of melanoma. Melanoma Res. 2014;24(4):335–341. doi:10.1097/CMR.000000000000008024892958
  • Wei Y, Sun Q, Zhao L, et al. LncRNA UCA1-miR-507-FOXM1 axis is involved in cell proliferation, invasion and G0/G1 cell cycle arrest in melanoma. Med Oncol. 2016;33(8):88. doi:10.1007/s12032-016-0804-227389544
  • Lu HW, Liu XD. UCA1 promotes papillary thyroid carcinoma development by stimulating cell proliferation via Wnt pathway. Eur Rev Med Pharmacol Sci. 2018;22(17):5576–5582. doi:10.26355/eurrev_201809_1582130229831
  • Liu H, Li R, Guan L, Jiang T. Knockdown of lncRNA UCA1 inhibits proliferation and invasion of papillary thyroid carcinoma through regulating miR-204/IGFBP5 axis. Onco Targets Ther. 2018;11:7197–7204. doi:10.2147/OTT.S17546730425512
  • Zhu G, Liu X, Su Y, Kong F, Hong X, Lin Z. Knockdown of Urothelial Carcinoma-Associated 1 suppressed cell growth and migration through regulating miR-301a and CXCR4 in osteosarcoma MHCC97 cells. Oncol Res. 2018;27(1):55–64. doi:10.3727/096504018X1520114370585529523218
  • Li T, Xiao Y, Huang T. HIF-1α-induced upregulation of lncRNA UCA1 promotes cell growth in osteosarcoma by inactivating the PTEN/AKT signaling pathway. Oncol Rep. 2018;39(3):1072–1080. doi:10.3892/or.2018.618229328452
  • Sun Y, Jin JG, Mi WY, Zhang SR, Meng Q, Zhang ST. Long noncoding RNA UCA1 targets miR-122 to promote proliferation, migration, and invasion of glioma cells. Oncol Res. 2018;26(1):103–110. doi:10.3727/096504017X1493486012286428548636
  • He Z, Wang Y, Huang G, Wang Q, Zhao D, Chen L. The lncRNA UCA1 interacts with miR-182 to modulate glioma proliferation and migration by targeting iASPP. Arch Biochem Biophys. 2017;623–624:1–8. doi:10.1016/j.abb.2017.01.013
  • Zhang ZS, Wang J, Zhu BQ, Ge L. Long noncoding RNA UCA1 promotes multiple myeloma cell growth by targeting TGF-β. Eur Rev Med Pharmacol Sci. 2018;22(5):1374–1379. doi:10.26355/eurrev_201803_1448129565496
  • Yang YT, Wang YF, Lai JY, et al. Long non-coding RNA UCA1 contributes to the progression of oral squamous cell carcinoma by regulating the WNT/β-catenin signaling pathway. Cancer Sci. 2016;107(11):1581–1589. doi:10.1111/cas.1305827560546
  • Fang Z, Zhao J, Xie W, Sun Q, Wang H, Qiao B. LncRNA UCA1 promotes proliferation and cisplatin resistance of oral squamous cell carcinoma by sunppressing miR-184 expression. Cancer Med. 2017;6(12):2897–2908. doi:10.1002/cam4.125329125238
  • Yan Q, Tian Y, Hao F. Downregulation of lncRNA UCA1 inhibits proliferation and invasion of cervical cancer cells through miR-206 expression. Oncol Res. 2018. doi:10.3727/096504018X15185714083446
  • Fan L, Huang C, Li J, Gao T, Lin Z, Yao T. Long noncoding RNA urothelial cancer associated 1 regulates radioresistance via the hexokinase 2/glycolytic pathway in cervical cancer. Int J Mol Med. 2018;42(4):2247–2259. doi:10.3892/ijmm.2018.377830015920
  • Pang A, Carbini M, Moreira AL, et al. Carcinosarcomas and related cancers: tumors caught in the act of epithelial-mesenchymal transition. J Clin Oncol. 2017;36(2):210–216. doi:10.1200/JCO.2017.74.952329220296
  • Feng G, Kazuko H, Sen-Itiroh H. Specific glycosphingolipids mediate epithelial-to-mesenchymal transition of human and mouse epithelial cell lines. Proc Natl Acad Sci U S A. 2009;106(18):7461–7466. doi:10.1073/pnas.090236810619380734
  • Sun Y, Liu WZ, Liu T, et al. Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis. J Recept Signal Transduct Res. 2015;35(6):600–604. doi:10.3109/10799893.2015.103041226096166
  • Dienstmann R, Rodon J, Prat A, et al. Genomic aberrations in the FGFR pathway: opportunities for targeted therapies in solid tumors. Ann Oncol. 2014;25(3):552–563. doi:10.1093/annonc/mdu20324265351
  • Xiao C, Wu CH, Hu HZ. LncRNA UCA1 promotes epithelial-mesenchymal transition (EMT) of breast cancer cells via enhancing Wnt/β-catenin signaling pathway. Eur Rev Med Pharmacol Sci. 2016;20(13):2819–2824.27424981
  • Hu JJ, Song W, Zhang SD, et al. HBx-upregulated lncRNA UCA1 promotes cell growth and tumorigenesis by recruiting EZH2 and repressing p27Kip1/CDK2 signaling. Sci Rep. 2016;6:23521. doi:10.1038/srep2352127009634
  • Lee JJ, Kim M, Kim HP. Epigenetic regulation of long noncoding RNA UCA1 by SATB1 in breast cancer. BMB Rep. 2016;49(10):578–583.doi:10.5483/bmbrep.2016.49.10.15627697109
  • Wang ZQ, Cai Q, Hu L, et al. Long noncoding RNA UCA1 induced by SP1 promotes cell proliferation via recruiting EZH2 and activating AKT pathway in gastric cancer. Cell Death Dis. 2017;8(6):e2839. doi:10.1038/cddis.2017.51828569779
  • Ge M, Liu H, Zhang Y, et al. The anti-hepatic fibrosis effects of dihydrotanshinone I are mediated by disrupting the yes-associated protein and transcriptional enhancer factor D2 complex and stimulating autophagy. Br J Pharmacol. 2017;174(10):1147–1160. doi:10.1111/bph.1376628257144
  • Hiemer SE, Szymaniak AD, Varelas X. The transcriptional regulators TAZ and YAP direct transforming growth factor β-induced tumorigenic phenotypes in breast cancer cells. J Biol Chem. 2014;289(19):13461–13474. doi:10.1074/jbc.M113.52911524648515
  • Zhang M, Zhao Y, Zhang Y, et al. LncRNA UCA1 promotes migration and invasion in pancreatic cancer cells via the Hippo pathway. Biochim Biophys Acta Mol Basis Dis. 2018;1864(5 Pt A):1770–1782. doi:10.1016/j.bbadis.2018.03.00529510195