BHLHE41 promotes U87 and U251 cell proliferation via ERK/cyclinD1 signaling pathway

References

• Rossner MJ, Dorr J, Gass P, Schwab MH, Nave KA. Sharps: mammalian enhancer-of-split- and hairy-related proteins coupled to neuronal stimulation. Mol Cell Neurosci. 1997;10(3–4):460–475.9532582
   PubMed Web of Science ®Google Scholar
• Honma S, Kawamoto T, Takagi Y, et al. Dec1 and Dec2 are regulators of the mammalian molecular clock. Nature. 2002;419(6909):841–844. doi:10.1038/nature0112312397359
   PubMed Web of Science ®Google Scholar
• Liu Z, Li Z, Mao K, et al. Dec2 promotes Th2 cell differentiation by enhancing Il-2r signaling. J Immunol. 2009;183(10):6320–6329. doi:10.4049/jimmunol.090097519880450
   PubMed Web of Science ®Google Scholar
• Ozaki N, Noshiro M, Kawamoto T, et al. Regulation of basic helix-loop-helix transcription factors Dec1 and Dec2 by roralpha and their roles in adipogenesis. Genes Cells. 2012;17(2):109–121. doi:10.1111/j.1365-2443.2011.01574.x22244086
   PubMed Web of Science ®Google Scholar
• Sato F, Bhawal UK, Yoshimura T, Muragaki Y. Dec1 and Dec2 crosstalk between circadian rhythm and tumor progression. J Cancer. 2016;7(2):153–159. doi:10.7150/jca.1374826819638
   PubMed Web of Science ®Google Scholar
• Sato H, Wu Y, Kato Y, et al. Dec2 expression antagonizes cisplatininduced apoptosis in human esophageal squamous cell carcinoma. Mol Med Rep. 2017;16(1):43–48. doi:10.3892/mmr.2017.657128498447
   PubMed Web of Science ®Google Scholar
• Liu Q, Wu Y, Yoshizawa T, et al. Basic helix-loop-helix transcription factor Dec2 functions as an anti-apoptotic factor during paclitaxel-induced apoptosis in human prostate cancer cells. Int J Mol Med. 2016;38(6):1727–1733. doi:10.3892/ijmm.2016.279827840924
   PubMed Web of Science ®Google Scholar
• Asanoma K, Liu G, Yamane T, et al. Regulation of the mechanism of twist1 transcription by Bhlhe40 and Bhlhe41 in cancer cells. Mol Cell Biol. 2015;35(24):4096–4109. doi:10.1128/MCB.00678-1526391953
   PubMed Web of Science ®Google Scholar
• Jiang B, Mu W, Wang J, et al. Microrna-138 functions as a tumor suppressor in osteosarcoma by targeting differentiated embryonic chondrocyte gene 2. J Exp Clin Cancer Res. 2016;35:69. doi:10.1186/s13046-016-0444-627095063
   PubMed Web of Science ®Google Scholar
• Wu Y, Sato H, Suzuki T, et al. Involvement of C-Myc in the proliferation of Mcf-7 human breast cancer cells induced by Bhlh transcription factor Dec2. Int J Mol Med. 2015;35(3):815–820. doi:10.3892/ijmm.2014.204225524285
   PubMed Web of Science ®Google Scholar
• Hu T, He N, Yang Y, Yin C, Sang N, Yang Q. Dec2 expression is positively correlated with Hif-1 activation and the invasiveness of human osteosarcomas. J Exp Clin Cancer Res. 2015;34:22. doi:10.1186/s13046-015-0135-825884381
   PubMed Web of Science ®Google Scholar
• Li P, Jia YF, Ma XL, et al. Dec2 suppresses tumor proliferation and metastasis by regulating Erk/Nf-Kappab pathway in gastric cancer. Am J Cancer Res. 2016;6(8):1741–1757.27648362
   PubMed Web of Science ®Google Scholar
• Sato F, Kawamura H, Wu Y, et al. The basic helix-loop-helix transcription factor Dec2 inhibits Tgf-beta-induced tumor progression in human pancreatic cancer Bxpc-3 cells. Int J Mol Med. 2012;30(3):495–501. doi:10.3892/ijmm.2012.103722735690
   PubMed Web of Science ®Google Scholar
• Hymowitz SG, Malek S. Targeting the Mapk pathway in Ras mutant cancers. Cold Spring Harb Perspect Med. 2018;8(11):a031492. doi:10.1101/cshperspect.a03149229440321
   PubMed Web of Science ®Google Scholar
• Sun Y, Liu WZ, Liu T, Feng X, Yang N, Zhou HF. Signaling pathway of Mapk/Erk in cell proliferation, differentiation, migration, senescence and apoptosis. J Recept Signal Transduct Res. 2015;35(6):600–604. doi:10.3109/10799893.2015.103041226096166
   PubMed Web of Science ®Google Scholar
• Papa S, Choy PM, Bubici C. The Erk and Jnk pathways in the regulation of metabolic reprogramming. Oncogene. 2018;38(13):2223–2240. doi:10.1038/s41388-018-0582-8
   PubMed Web of Science ®Google Scholar
• Liu F, Yang X, Geng M, Huang M. Targeting Erk, an Achilles’ Heel of the Mapk pathway, in cancer therapy. Acta Pharm Sin B. 2018;8(4):552–562. doi:10.1016/j.apsb.2018.01.00830109180
   PubMed Web of Science ®Google Scholar
• Wakimoto R, Ono M, Takeshima M, Higuchi T, Nakano S. Differential anticancer activity of pterostilbene against three subtypes of human breast cancer cells. Anticancer Res. 2017;37(11):6153–6159. doi:10.21873/anticanres.1206429061796
   PubMed Web of Science ®Google Scholar
• Bahrami A, Hesari A, Khazaei M, Hassanian SM, Ferns GA, Avan A. The therapeutic potential of targeting the Braf mutation in patients with colorectal cancer. J Cell Physiol. 2018;233(3):2162–2169. doi:10.1002/jcp.2595228407239
   PubMed Web of Science ®Google Scholar
• Ebisuya M, Kondoh K, Nishida E. The duration, magnitude and compartmentalization of Erk Map kinase activity: mechanisms for Providing Signaling Specificity. J Cell Sci. 2005;118(Pt 14):2997–3002. doi:10.1242/jcs.0250516014377
   PubMed Web of Science ®Google Scholar
• Marshall CJ. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell. 1995;80(2):179–185. doi:10.1016/0092-8674(95)90401-87834738
   PubMed Web of Science ®Google Scholar
• Dent P. Erk plays the baddie (again). Cancer Biol Ther. 2013;14(11):997–998. doi:10.4161/cbt.2637724025356
   PubMed Web of Science ®Google Scholar
• Fujimoto K, Shen M, Noshiro M, et al. Molecular cloning and characterization of Dec2, a new member of basic helix-loop-helix proteins. Biochem Biophys Res Commun. 2001;280(1):164–171. doi:10.1006/bbrc.2000.413311162494
   PubMed Web of Science ®Google Scholar
• Chandrashekar DS, Bashel B, Balasubramanya SAH, et al. UALCAN: a portal for facilitating tumor subgroup gene expression and survival analyses. Neoplasia. 2017;19(8):649–658. doi:10.1016/j.neo.2017.05.00228732212
   PubMed Web of Science ®Google Scholar
• Kageyama R, Shimojo H, Ohtsuka T. Dynamic control of neural stem cells by Bhlh factors. Neurosci Res. 2018;138:12–18. doi:10.1016/j.neures.2018.09.005
   PubMed Web of Science ®Google Scholar
• Lasky JL, Wu H. Notch signaling, brain development, and human disease. Pediatr Res. 2005;57(5 Pt 2):104R–09R. doi:10.1203/01.PDR.0000159632.70510.3D
   PubMed Web of Science ®Google Scholar
• Sun Y, Zhang H, Wang L, et al. Loss of the basic helix-loop-helix transcription factor Bhlhe41 induces cell death and impairs neurite outgrowth in neuro2a cells. Mol Cell Biochem. 2018;450(1–2):167-174. doi:10.1007/s11010-018-3383-z
   Web of Science ®Google Scholar
• Liang Y, Zhang P, Li S, Li H, Song S, Lu B. Microrna-873 acts as a tumor suppressor in esophageal cancer by inhibiting differentiated embryonic chondrocyte expressed gene 2. Biomed Pharmacother. 2018;105:582–589. doi:10.1016/j.biopha.2018.05.15229890466
   PubMed Web of Science ®Google Scholar
• Sato F, Muragaki Y, Kawamoto T, Fujimoto K, Kato Y, Zhang Y. Rhythmic expression of Dec2 protein in vitro and in vivo. Biomed Rep. 2016;4(6):704–710. doi:10.3892/br.2016.65627284410
   PubMedGoogle Scholar
• Whittaker SR, Mallinger A, Workman P, Clarke PA. Inhibitors of cyclin-dependent kinases as cancer therapeutics. Pharmacol Ther. 2017;173:83–105. doi:10.1016/j.pharmthera.2017.02.00828174091
   PubMed Web of Science ®Google Scholar
• VanArsdale T, Boshoff C, Arndt KT, Abraham RT. Molecular pathways: targeting the cyclin D-Cdk4/6 axis for cancer treatment. Clin Cancer Res. 2015;21(13):2905–2910. doi:10.1158/1078-0432.CCR-14-081625941111
   PubMed Web of Science ®Google Scholar
• Choi YJ, Li X, Hydbring P, et al. The requirement for Cyclin D function in tumor maintenance. Cancer Cell. 2012;22(4):438–451. doi:10.1016/j.ccr.2012.09.01523079655
   PubMed Web of Science ®Google Scholar
• Yaguchi K, Yamamoto T, Shimada M, et al. Ploidy-dependent change in cyclin D2 expression and sensitization to Cdk4/6 inhibition in human somatic haploid cells. Biochem Biophys Res Commun. 2018;504(1):231–237. doi:10.1016/j.bbrc.2018.08.16030193733
   PubMed Web of Science ®Google Scholar
• Bousoik E, Montazeri Aliabadi H. “Do we know jack” about Jak? A closer look at Jak/Stat signaling pathway. Front Oncol. 2018;8:287. doi:10.3389/fonc.2018.0028730109213
   PubMed Web of Science ®Google Scholar
• Forrest MP, Waite AJ, Martin-Rendon E, Blake DJ. Knockdown of human Tcf4 affects multiple signaling pathways involved in cell survival, epithelial to mesenchymal transition and neuronal differentiation. PLoS One. 2013;8(8):e73169. doi:10.1371/journal.pone.007316924058414
   PubMed Web of Science ®Google Scholar