63
Views
9
CrossRef citations to date
0
Altmetric
Original Research

Novel Hsp90 Inhibitor C086 Potently Inhibits Non-Small Cell Lung Cancer Cells As A Single Agent Or In Combination With Gefitinib

, , , , , & show all
Pages 8937-8945 | Published online: 16 Oct 2019

References

  • Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA Cancer J Clin. 2018;68(1):7–30. doi:10.3322/caac.2144229313949
  • Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin. 2016;66(2):115–132. doi:10.3322/caac.2133826808342
  • Ourari-Dhahri B, Ben Slima H, Ben Amar J, et al. Management of non small cell lung cancer. Tunis Med. 2012;90(12):847–851.23247782
  • Ramalingam SS, Owonikoko TK, Khuri FR. Lung cancer: new biological insights and recent therapeutic advances. CA Cancer J Clin. 2011;61(2):91–112. doi:10.3322/caac.2010221303969
  • Levitzki A. EGF receptor as a therapeutic target. Lung Cancer. 2003;41:S9–S14. doi:10.1016/S0169-5002(03)00134-X
  • Ferrazzi A, Russo I, Pasello G, Alaibac M. Atypical skin reaction in a patient treated with gefitinib for advanced lung cancer: a case report and review of the literature. Exp Ther Med. 2016;11(1):197–200. doi:10.3892/etm.2015.288126889239
  • Codony-Servat C, Codony-Servat J, Karachaliou N, et al. Activation of signal transducer and activator of transcription 3 (STAT3) signaling in EGFR mutant non-small-cell lung cancer (NSCLC). Oncotarget. 2017;8(29):47305–47316. doi:10.18632/oncotarget.1762528521301
  • Al Mamun Bhuyan A, Wagner T, Cao H, Lang F. Triggering of suicidal erythrocyte death by gefitinib. Cell Physiol Biochem. 2017;41(4):1697–1708. doi:10.1159/00047182328359067
  • Sharma SV, Bell DW, Settleman J, Haber DA. Epidermal growth factor receptor mutations in lung cancer. Nat Rev Cancer. 2007;7(3):169–181. doi:10.1038/nrc208817318210
  • Pao W, Wang TY, Riely GJ, et al. KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib. PLoS Med. 2005;2(1):57–62. doi:10.1371/journal.pmed.0020017
  • Wegele H, Müller L, Buchner J. Hsp70 and Hsp90-a relay team for protein folding. Rev Physiol Biochem Pharmacol. 2004;151:1–44. doi:10.1007/s10254-003-0021-114740253
  • Richter K, Hendershot LM, Freeman BC. The cellular world according to Hsp90. Nat Struct Mol Biol. 2007;14(2):90–94. doi:10.1038/nsmb0207-9017277798
  • Workman P, Burrows F, Neckers L, Rosen N. Drugging the cancer chaperone HSP90: combinatorial therapeutic exploitation of oncogene addiction and tumor stress. Ann N Y Acad Sci. 2007;1113(1):202–216. doi:10.1196/annals.1391.01217513464
  • Isaacs JS, Xu W, Neckers L. Heat shock protein 90 as a molecular target for cancer therapeutics. Cancer Cell. 2003;3(3):213–217.12676580
  • Neckers L, Workman P. Hsp90 molecular chaperone inhibitors: are we there yet? Clin Cancer Res. 2012;18(1):64–76. doi:10.1158/1078-0432.CCR-11-100022215907
  • Neckers L. Heat shock protein 90: the cancer chaperone. J Biosci. 2007;32(3):517–530.17536171
  • Xu W, Neckers L. Targeting the molecular chaperone heat shock protein 90 provides a multifaceted effect on diverse cell signaling pathways of cancer cells. Clin Cancer Res. 2007;13(6):1625–1629. doi:10.1158/1078-0432.CCR-06-227017363512
  • Trepel J, Mollapour M, Giaccone G, Neckers L. Targeting the dynamic HSP90 complex in cancer. Nat Rev Cancer. 2010;10(8):537–549. doi:10.1038/nrc288720651736
  • Gallegos Ruiz MI, Floor K, Roepman P, et al. Integration of gene dosage and gene expression in NSCLC, identification of Hsp90 as potential target. PLoS One. 2008;3(3):e0001722. doi:10.1371/journal.pone.000172218320023
  • Chen C, Liu Y, Chen YZ, Xu JH. C086, a novel analog of curcumin, induces growth inhibition and down-regulation of NFκB in colon cancer cells and xenograft tumors. Cancer Biol Ther. 2011;12(9):797–807. doi:10.4161/cbt.12.9.1767121900746
  • Huang W, Ye M, Zhang LR, et al. FW-04-806 inhibits proliferation and induces apoptosis in human breast cancer cells by binding to N-terminus of Hsp90 and disrupting Hsp90-Cdc37 complex formation. Mol Cancer. 2014;13(1):150. doi:10.1186/1476-4598-13-15024927996
  • Wu LX, Yu J, Chen RJ, et al. Dual inhibition of Bcr-Abl and Hsp90 by C086 potently inhibits the proliferation of imatinib-resistant CML cells. Clin Cancer Res. 2015;21(4):833–843. doi:10.1158/1078-0432.CCR-13-331725501124
  • Huang W, Wu QD, Zhang M, et al. Novel Hsp90 inhibitor FW-04-806 displays potent antitumor effects in HER2-positive breast cancer cells as a single agent or in combination with lapatinib. Cancer Lett. 2015;356(2):862–871. doi:10.1016/j.canlet.2014.10.04025449780
  • Gao PZ, Wu H, Guo J, Xu YM. Study on the interaction between breviscapinum and bovine serum albumin by fluorescence spectrometry. Chin JMAP. 2012;29(2):106–109. doi:10.13748/j.cnki.issn1007-7693.2012.02.025
  • Meng A, Wang Y, Brown SA, Van Zant G, Zhou DH. Ionizing radiation and busulfan inhibit murine bone marrow cell hematopoietic function via apoptosis-dependent and -independent mechanisms. Exp Hematol. 2003;31(12):1348–1356. doi:10.1016/j.exphem14662344
  • Chen JJ, Guo QJ, He XM, Yang SX, Chen C, Zhang LR. Study on a screening model for inhibitor of Hsp90 ATPase activity. J Xiamen Univ. 2010;49(5):711–716.
  • Chou TC. Drug combination studies and their synergy quantification using the Chou-Talalay method. Cancer Res. 2010;70(2):440–446. doi:10.1158/0008-5472.CAN-09-194720068163
  • Chou TC. Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol Rev. 2006;58(3):621–681. doi:10.1124/pr.58.3.1016968952
  • Patel BB, Sengupta R, Qazi S, et al. Curcumin enhances the effects of 5-fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF-1R. Int J Cancer. 2008;122(2):267–273. doi:10.1002/ijc.2309717918158
  • Kamat AM, Sethi G, Aggarwal BB. Curcumin potentiates the apoptotic effects of chemotherapeutic agents and cytokines through down-regulation of nuclear factor-κB and nuclear factor-κB-regulated gene products in IFN-α-sensitive and IFN-α-resistant human bladder cancer cells. Mol Cancer Ther. 2007;6(3):1022–1030. doi:10.1158/1535-7163.MCT-06-054517363495
  • Sung B, Kunnumakkara AB, Sethi G, et al. Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model. Mol Cancer Ther. 2009;8(4):959–970. doi:10.1158/1535-7163.MCT-08-090519372569
  • Shimamura T, Lowell AM, Engelman JA, Shapiro GI. Epidermal growth factor receptors harboring kinase domain mutations associate with the heat shock protein 90 chaperone and are destabilized following exposure to geldanamycins. Cancer Res. 2005;65(14):6401–6408. doi:10.1158/0008-5472.CAN-05-093316024644
  • Shimamura T, Li DN, Ji HB, et al. Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance. Cancer Res. 2008;68(14):5827–5838. doi:10.1158/0008-5472.CAN-07-542818632637
  • Ahsan A, Ramanand SG, Whitehead C, et al. Wild-type EGFR is stabilized by direct interaction with HSP90 in cancer cells and tumors. Neoplasia. 2012;14(8):670–677. doi:10.1593/neo.1298622952420
  • Supko JG, Hickman RL, Grever MR, Malspeis L. Preclinical pharmacologic evaluation of geldanamycin as an antitumor agent. Cancer Chemother Pharmacol. 1995;36(4):305–315. doi:10.1007/BF006890487628050