Diagnostic Significance of Downregulated circMORC3 as a Molecular Biomarker of Hypopharyngeal Squamous Cell Carcinoma: A Pilot Study

References

• Gourin CG, Terris DJ. Carcinoma of the hypopharynx. Surg Oncol Clin N Am. 2004;13(1):81–98. doi:10.1016/S1055-3207(03)00122-415062363
   PubMedGoogle Scholar
• Qian Y, Liu D, Cao S, et al. Upregulation of the long noncoding RNA UCA1 affects the proliferation, invasion, and survival of hypopharyngeal carcinoma. Mol Cancer. 2017;16(1):68. doi:10.1186/s12943-017-0635-628327194
   PubMedGoogle Scholar
• Zhou L, Cheng L, Tao L, Jia X, Lu Y, Liao P. Detection of hypopharyngeal squamous cell carcinoma using serum proteomics. Acta Otolaryngol. 2006;126(8):853–860. doi:10.1080/0001648050052520516846929
   PubMed Web of Science ®Google Scholar
• Kwon DI, Miles BA, Education Committee of the American H, Neck S. Hypopharyngeal carcinoma: do you know your guidelines? Head Neck. 2018;41(3):569–76.30570183
   PubMed Web of Science ®Google Scholar
• Memczak S, Jens M, Elefsinioti A, et al. Circular RNAs are a large class of animal RNAs with regulatory potency. Nature. 2013;495(7441):333–338. doi:10.1038/nature1192823446348
   PubMed Web of Science ®Google Scholar
• Shang Q, Yang Z, Jia R, Ge S. The novel roles of circRNAs in human cancer. Mol Cancer. 2019;18(1):6. doi:10.1186/s12943-018-0934-630626395
   PubMed Web of Science ®Google Scholar
• Xia S, Feng J, Chen K, et al. CSCD: a database for cancer-specific circular RNAs. Nucleic Acids Res. 2018;46(D1):D925–D9. doi:10.1093/nar/gkx86329036403
   PubMed Web of Science ®Google Scholar
• Salzman J, Chen RE, Olsen MN, Wang PL, Brown PO. Cell-type specific features of circular RNA expression. PLoS Genet. 2013;9(9):e1003777. doi:10.1371/journal.pgen.100377724039610
   PubMed Web of Science ®Google Scholar
• Memczak S, Papavasileiou P, Peters O, Rajewsky N. Identification and characterization of circular RNAs as a new class of putative biomarkers in human blood. PLoS ONE. 2015;10(10):e0141214. doi:10.1371/journal.pone.014121426485708
   PubMed Web of Science ®Google Scholar
• Zhao SY, Wang J, Ouyang SB, Huang ZK, Liao L. Salivary circular RNAs Hsa_Circ_0001874 and Hsa_Circ_0001971 as novel biomarkers for the diagnosis of oral squamous cell carcinoma. Cell Physiol Biochem. 2018;47(6):2511–2521. doi:10.1159/00049162429991057
   PubMedGoogle Scholar
• Li Y, Zheng Q, Bao C, et al. Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis. Cell Res. 2015;25(8):981–984. doi:10.1038/cr.2015.8226138677
   PubMed Web of Science ®Google Scholar
• Guo Y, Yang J, Huang Q, et al. Circular RNAs and their roles in head and neck cancers. Mol Cancer. 2019;18(1):44. doi:10.1186/s12943-019-1003-530898135
   PubMedGoogle Scholar
• Cai J, Chen Z, Zuo X. circSMARCA5 functions as a diagnostic and prognostic biomarker for gastric cancer. Dis Markers. 2019;2019:2473652.30956729
   PubMed Web of Science ®Google Scholar
• Gu W, Sun Y, Zheng X, et al. Identification of gastric cancer-related circular RNA through microarray analysis and bioinformatics analysis. Biomed Res Int. 2018;2018:2381680. doi:10.1155/2018/238168029744354
   PubMed Web of Science ®Google Scholar
• Li P, Chen S, Chen H, et al. Using circular RNA as a novel type of biomarker in the screening of gastric cancer. Clin Chim Acta. 2015;444:132–136. doi:10.1016/j.cca.2015.02.01825689795
   PubMed Web of Science ®Google Scholar
• Huang M, He YR, Liang LC, Huang Q, Zhu Z. Circular RNA hsa_circ_0000745 may serve as a diagnostic marker for gastric cancer. World J Gastroenterol. 2017;23(34):6330–6338. doi:10.3748/wjg.v23.i34.633028974900
   PubMed Web of Science ®Google Scholar
• Li WH, Song YC, Zhang H, et al. Decreased expression of Hsa_circ_00001649 in gastric cancer and its clinical significance. Dis Markers. 2017;2017:4587698. doi:10.1155/2017/458769828167847
   PubMed Web of Science ®Google Scholar
• Fan L, Cao Q, Liu J, Zhang J, Li B. Circular RNA profiling and its potential for esophageal squamous cell cancer diagnosis and prognosis. Mol Cancer. 2019;18(1):16. doi:10.1186/s12943-018-0936-430674324
   PubMed Web of Science ®Google Scholar
• Xia W, Qiu M, Chen R, et al. Circular RNA has_circ_0067934 is upregulated in esophageal squamous cell carcinoma and promoted proliferation. Sci Rep. 2016;6:35576. doi:10.1038/srep3557627752108
   PubMed Web of Science ®Google Scholar
• Li J, Ni S, Zhou C, Ye M. The expression profile and clinical application potential of hsa_circ_0000711 in colorectal cancer. Cancer Manag Res. 2018;10:2777–2784. doi:10.2147/CMAR.S17238830147374
   PubMed Web of Science ®Google Scholar
• Tian J, Xi X, Wang J, et al. CircRNA hsa_circ_0004585 as a potential biomarker for colorectal cancer. Cancer Manag Res. 2019;11:5413–5423. doi:10.2147/CMAR.S19943631354349
   PubMed Web of Science ®Google Scholar
• Hong G, Qiu H, Wang C, et al. The emerging role of MORC family proteins in cancer development and bone homeostasis. J Cell Physiol. 2017;232(5):928–934. doi:10.1002/jcp.v232.527791268
   PubMed Web of Science ®Google Scholar
• Zhang Y, Klein BJ, Cox KL, et al. Mechanism for autoinhibition and activation of the MORC3 ATPase. Proc Natl Acad Sci U S A. 2019;116(13):6111–6119. doi:10.1073/pnas.181952411630850548
   PubMed Web of Science ®Google Scholar
• Gonzalez-Fernandez R, Morales M, Avila J, Martin-Vasallo P. Changes in leukocyte gene expression profiles induced by antineoplastic chemotherapy. Oncol Lett. 2012;3(6):1341–1349. doi:10.3892/ol.2012.66922783446
   PubMed Web of Science ®Google Scholar
• Takahashi K, Yoshida N, Murakami N, et al. Dynamic regulation of p53 subnuclear localization and senescence by MORC3. Mol Biol Cell. 2007;18(5):1701–1709. doi:10.1091/mbc.e06-08-074717332504
   PubMed Web of Science ®Google Scholar
• Glazar P, Papavasileiou P, Rajewsky N. circBase: a database for circular RNAs. RNA. 2014;20(11):1666–1670. doi:10.1261/rna.043687.11325234927
   PubMed Web of Science ®Google Scholar
• Brierley JD, Gospodarowicz MK, Wittekind C. TNM Classification of Malignant Tumours. John Wiley & Sons; 2016.
   Google Scholar
• Kristensen LS, Hansen TB, Veno MT, Kjems J. Circular RNAs in cancer: opportunities and challenges in the field. Oncogene. 2018;37(5):555–565. doi:10.1038/onc.2017.36128991235
   PubMed Web of Science ®Google Scholar
• Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646–674. doi:10.1016/j.cell.2011.02.01321376230
   PubMed Web of Science ®Google Scholar
• Su M, Xiao Y, Ma J, et al. Circular RNAs in Cancer: emerging functions in hallmarks, stemness, resistance and roles as potential biomarkers. Mol Cancer. 2019;18(1):90. doi:10.1186/s12943-019-1002-630999909
   PubMed Web of Science ®Google Scholar
• Zhong Y, Du Y, Yang X, et al. Circular RNAs function as ceRNAs to regulate and control human cancer progression. Mol Cancer. 2018;17(1):79. doi:10.1186/s12943-018-0827-829626935
   PubMed Web of Science ®Google Scholar
• Cao S, Wei D, Li X, et al. Novel circular RNA expression profiles reflect progression of patients with hypopharyngeal squamous cell carcinoma. Oncotarget. 2017;8(28):45367–45379. doi:10.18632/oncotarget.1748828514762
   PubMedGoogle Scholar
• Lv T, Miao YF, Jin K, et al. Dysregulated circular RNAs in medulloblastoma regulate proliferation and growth of tumor cells via host genes. Cancer Med. 2018;7(12):6147–6157. doi:10.1002/cam4.161330402980
   PubMed Web of Science ®Google Scholar
• He R, Liu P, Xie X, et al. circGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a. J Exp Clin Cancer Res: CR. 2017;36(1):145. doi:10.1186/s13046-017-0614-129037220
   PubMed Web of Science ®Google Scholar
• Bahn JH, Zhang Q, Li F, et al. The landscape of microRNA, Piwi-interacting RNA, and circular RNA in human saliva. Clin Chem. 2015;61(1):221–230. doi:10.1373/clinchem.2014.23043325376581
   PubMed Web of Science ®Google Scholar
• Chen S, Li T, Zhao Q, Xiao B, Guo J. Using circular RNA hsa_circ_0000190 as a new biomarker in the diagnosis of gastric cancer. Clinica Chimica Acta. 2017;466:167–171. doi:10.1016/j.cca.2017.01.025
   PubMed Web of Science ®Google Scholar
• Sun H, Tang W, Rong D, et al. Hsa_circ_0000520, a potential new circular RNA biomarker, is involved in gastric carcinoma. Cancer Biomark. 2018;21(2):299–306. doi:10.3233/CBM-17037929103021
   PubMed Web of Science ®Google Scholar
• Jones CM, Athanasiou T. Summary receiver operating characteristic curve analysis techniques in the evaluation of diagnostic tests. Ann Thorac Surg. 2005;79(1):16–20. doi:10.1016/j.athoracsur.2004.09.04015620907
   PubMed Web of Science ®Google Scholar