DNA Methylation in RARβ Gene as a Mediator of the Association Between Healthy Lifestyle and Breast Cancer: A Case–Control Study

References

• Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. doi:10.3322/caac.2149230207593
   PubMed Web of Science ®Google Scholar
• Fan L, Strasser-Weippl K, Li JJ, et al. Breast cancer in China. Lancet Oncol. 2014;15:e279–289.24872111
   PubMed Web of Science ®Google Scholar
• DeSantis C, Ma J, Bryan L, Jemal A. Breast cancer statistics, 2013. CA Cancer J Clin. 2014;64:52–62.24114568
   PubMed Web of Science ®Google Scholar
• Arthur R, Wassertheil-Smoller S, Manson JE, et al. The combined association of modifiable risk factors with breast cancer risk in the women’s health initiative. Cancer Prev Res. 2018;11:317–326.
   PubMed Web of Science ®Google Scholar
• McKenzie F, Ferrari P, Freisling H, et al. Healthy lifestyle and risk of breast cancer among postmenopausal women in the European prospective investigation into cancer and nutrition cohort study. Int J Cancer. 2015;136:2640–2648.25379993
   PubMed Web of Science ®Google Scholar
• Jones PA, Baylin SB. The epigenomics of cancer. Cell. 2007;128:683–692.17320506
   PubMed Web of Science ®Google Scholar
• Jones PA. Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat Rev Genet. 2012;13:484–492.22641018
   PubMed Web of Science ®Google Scholar
• Yang R, Pfütze K, Zucknick M, et al. DNA methylation array analyses identified breast cancer-associated HYAL2 methylation in peripheral blood. Int J Cancer. 2015;136:1845–1855.25213452
   PubMed Web of Science ®Google Scholar
• Heyn H, Carmona FJ, Gomez A, et al. DNA methylation profiling in breast cancer discordant identical twins identifies DOK7 as novel epigenetic biomarker. Carcinogenesis. 2013;34:102–108.23054610
   PubMed Web of Science ®Google Scholar
• Xu Z, Sandler DP, Taylor JA. Blood DNA methylation and breast cancer: a prospective case-cohort analysis in the sister study. J Natl Cancer Inst. 2020;112(1):87–94. doi:10.1093/jnci/djz06530989176
   PubMedGoogle Scholar
• Houle B, Rochette-Egly C, Bradley WE. Tumor-suppressive effect of the retinoic acid receptor beta in human epidermoid lung cancer cells. Proc Natl Acad Sci U S A. 1993;90:985–989.8381540
   PubMed Web of Science ®Google Scholar
• Roman SD, Clarke CL, Hall RE, Alexander IE, Sutherland RL. Expression and regulation of retinoic acid receptors in human breast cancer cells. Cancer Res. 1992;52:2236–2242.1313739
   PubMed Web of Science ®Google Scholar
• Vuillemenot BR, Pulling LC, Palmisano WA, Hutt JA, Belinsky SA. Carcinogen exposure differentially modulates RAR-beta promoter hypermethylation, an early and frequent event in mouse lung carcinogenesis. Carcinogenesis. 2004;25:623–629.14656941
   PubMed Web of Science ®Google Scholar
• Fang MZ, Chen D, Sun Y, Jin Z, Christman JK, Yang CS. Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy. Clin Cancer Res. 2005;11:7033–7041.16203797
   PubMed Web of Science ®Google Scholar
• Callahan CL, Bonner MR, Nie J, et al. Active and secondhand smoke exposure throughout life and DNA methylation in breast tumors. Cancer Causes Control. 2019;30:53–62.30617699
   PubMed Web of Science ®Google Scholar
• King-Batoon A, Leszczynska JM, Klein CB. Modulation of gene methylation by genistein or lycopene in breast cancer cells. Environ Mol Mutagen. 2008;49:36–45.18181168
   PubMed Web of Science ®Google Scholar
• Imai K, Keele L, Tingley D. A general approach to causal mediation analysis. Psychol Methods. 2010;15:309–334.20954780
   PubMed Web of Science ®Google Scholar
• Cordero F, Ferrero G, Polidoro S, et al. Differentially methylated microRNAs in prediagnostic samples of subjects who developed breast cancer in the european prospective investigation into nutrition and cancer (EPIC-Italy) cohort. Carcinogenesis. 2015;36:1144–1153.26168820
   PubMed Web of Science ®Google Scholar
• Shu XO, Yang G, Jin F, et al. Validity and reproducibility of the food frequency questionnaire used in the Shanghai women’s health study. Eur J Clin Nutr. 2004;58:17–23.14679362
   PubMed Web of Science ®Google Scholar
• Luo J, Margolis KL, Wactawski-Wende J, et al. Association of active and passive smoking with risk of breast cancer among postmenopausal women: a prospective cohort study. BMJ. 2011;342:d1016.21363864
   PubMed Web of Science ®Google Scholar
• Duffy CM, Assaf A, Cyr M, et al. Alcohol and folate intake and breast cancer risk in the WHI observational study. Breast Cancer Res Treat. 2009;116:551–562.18785003
   PubMed Web of Science ®Google Scholar
• Neuhouser ML, Aragaki AK, Prentice RL, et al. Overweight, obesity, and postmenopausal invasive breast cancer risk: a secondary analysis of the women’s health initiative randomized clinical trials. JAMA Oncol. 2015;1:611–621.26182172
   PubMed Web of Science ®Google Scholar
• McTiernan A, Kooperberg C, White E, et al. Recreational physical activity and the risk of breast cancer in postmenopausal women: the women’s health initiative cohort study. JAMA. 2003;290:1331–1336.12966124
   PubMed Web of Science ®Google Scholar
• Prentice RL, Caan B, Chlebowski RT, et al. Low-fat dietary pattern and risk of invasive breast cancer: the women’s health initiative randomized controlled dietary modification trial. JAMA. 2006;295:629–642.16467232
   PubMed Web of Science ®Google Scholar
• Wojdacz TK, Dobrovic A. Methylation-sensitive high resolution melting (MS-HRM): a new approach for sensitive and high-throughput assessment of methylation. Nucleic Acids Res. 2007;35:e41.17289753
   PubMed Web of Science ®Google Scholar
• Rosseel Y. lavaan: an R package for structural equation modeling. J Stat Softw. 2012;48:92173.
   Web of Science ®Google Scholar
• Madigan MP, Ziegler RG, Benichou J, Byrne C, Hoover RN. Proportion of breast cancer cases in the United States explained by well-established risk factors. J Natl Cancer Inst. 1995;87:1681–1685.7473816
   PubMed Web of Science ®Google Scholar
• Hiatt RA, Brody JG. Environmental determinants of breast cancer. Annu Rev Public Health. 2018;39:113–133.29328875
   PubMed Web of Science ®Google Scholar
• Arthur R, Kirsh VA, Kreiger N, Rohan T. A healthy lifestyle index and its association with risk of breast, endometrial, and ovarian cancer among Canadian women. Cancer Causes Control. 2018;29:485–493.29667103
   PubMed Web of Science ®Google Scholar
• McKenzie F, Ellison-Loschmann L, Jeffreys M, Firestone R, Pearce N, Romieu I. Healthy lifestyle and risk of breast cancer for indigenous and non-indigenous women in New Zealand: a case control study. BMC Cancer. 2014;14:12.24410858
   PubMed Web of Science ®Google Scholar
• Terry MB, Delgado-Cruzata L, Vin-Raviv N, Wu HC, Santella RM. DNA methylation in white blood cells: association with risk factors in epidemiologic studies. Epigenetics. 2011;6:828–837.21636973
   PubMed Web of Science ®Google Scholar
• Sapienza C, Issa JP. Diet, nutrition, and cancer epigenetics. Annu Rev Nutr. 2016;36:665–681.27022771
   PubMed Web of Science ®Google Scholar
• Cortessis VK, Thomas DC, Levine AJ, et al. Environmental epigenetics: prospects for studying epigenetic mediation of exposure-response relationships. Hum Genet. 2012;131:1565–1589.22740325
   PubMed Web of Science ®Google Scholar
• Marczylo EL, Jacobs MN, Gant TW. Environmentally induced epigenetic toxicity: potential public health concerns. Crit Rev Toxicol. 2016;46:676–700.27278298
   PubMed Web of Science ®Google Scholar
• Campión J, Milagro FI, Martínez JA. Individuality and epigenetics in obesity. Obes Rev. 2009;10:383–392.19413700
   PubMed Web of Science ®Google Scholar
• van Driel LM, Eijkemans MJ, de Jonge R, et al. Body mass index is an important determinant of methylation biomarkers in women of reproductive ages. J Nutr. 2009;139:2315–2321.19812220
   PubMed Web of Science ®Google Scholar
• Monteiro JP, Wise C, Morine MJ, et al. Methylation potential associated with diet, genotype, protein, and metabolite levels in the delta obesity vitamin study. Genes Nutr. 2014;9:403.24760553
   PubMed Web of Science ®Google Scholar
• Qin W, Zhu W, Shi H, et al. Soy isoflavones have an antiestrogenic effect and alter mammary promoter hypermethylation in healthy premenopausal women. Nutr Cancer. 2009;61:238–244.19235040
   PubMed Web of Science ®Google Scholar
• Kiseljak-Vassiliades K, Xing M. Association of cigarette smoking with aberrant methylation of the tumor suppressor gene RARβ2 in papillary thyroid cancer. Front Endocrinol. 2011;2:99.
   PubMedGoogle Scholar
• Ottini L, Rizzolo P, Siniscalchi E, et al. Gene promoter methylation and DNA repair capacity in monozygotic twins with discordant smoking habits. Mutat Res Genet Toxicol Environ Mutagen. 2015;779:57–64.25813726
   PubMed Web of Science ®Google Scholar
• Flanagan JM, Munoz-Alegre M, Henderson S, et al. Gene-body hypermethylation of ATM in peripheral blood DNA of bilateral breast cancer patients. Hum Mol Genet. 2009;18:1332–1342.19153073
   PubMed Web of Science ®Google Scholar
• Liu Y, Lee MO, Wang HG, et al. Retinoic acid receptor beta mediates the growth-inhibitory effect of retinoic acid by promoting apoptosis in human breast cancer cells. Mol Cell Biol. 1996;16:1138–1149.8622658
   PubMed Web of Science ®Google Scholar
• Widschwendter M, Berger J, Hermann M, et al. Methylation and silencing of the retinoic acid receptor-beta2 gene in breast cancer. J Natl Cancer Inst. 2000;92:826–832.10814678
   PubMed Web of Science ®Google Scholar
• Lin RK, Hsieh YS, Lin P, et al. The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer patients. J Clin Invest. 2010;120:521–532.20093774
   PubMed Web of Science ®Google Scholar
• Carlin J, George R, Reyes TM. Methyl donor supplementation blocks the adverse effects of maternal high fat diet on offspring physiology. PLoS One. 2013;8:e63549.23658839
   PubMed Web of Science ®Google Scholar
• Tobi EW, Slieker RC, Luijk R, et al. DNA methylation as a mediator of the association between prenatal adversity and risk factors for metabolic disease in adulthood. Sci Adv. 2018;4:eaao4364.29399631
   PubMed Web of Science ®Google Scholar
• Slieker RC, Bos SD, Goeman JJ, et al. Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array. Epigenetics Chromatin. 2013;6:26.23919675
   PubMed Web of Science ®Google Scholar