Paeonol Inhibits Cell Proliferation, Migration and Invasion and Induces Apoptosis in Hepatocellular Carcinoma by Regulating miR-21-5p/KLF6 Axis

References

• Bhawna S, Kumar SU. Hepatoprotective activity of some indigenous plants. Int J Pharmtech Res. 2010;1(4):568–572.
   Google Scholar
• Kmieć Z. Cooperation of liver cells in health and disease. Adv Anat Embryol Cell Biol. 2001;161:III–XIII,1–151. doi:10.1007/978-3-642-56553-3
   PubMedGoogle Scholar
• Khemlina G, Ikeda S, Kurzrock R. The biology of Hepatocellular carcinoma: implications for genomic and immune therapies. Mol Cancer. 2017;16(1):149. doi:10.1186/s12943-017-0712-x28854942
   PubMed Web of Science ®Google Scholar
• Lee Y, Park H, Lee H, et al. The clinicopathological and prognostic significance of the gross classification of hepatocellular carcinoma. J Pathol Transl Med. 2018;52(2):85–92. doi:10.4132/jptm.2017.11.1329172395
   PubMed Web of Science ®Google Scholar
• Grandhi MS, Kim AK, Ronnekleiv-Kelly SM, Kamel IR, Ghasebeh MA, Pawlik TM. Hepatocellular carcinoma: from diagnosis to treatment. Surg Oncol. 2016;25(2):74–85. doi:10.1016/j.suronc.2016.03.00227312032
   PubMed Web of Science ®Google Scholar
• Sanyal A, Poklepovic A, Moyneur E, Barghout V. Population-based risk factors and resource utilization for HCC: US perspective. Curr Med Res Opin. 2010;26(9):2183–2191. doi:10.1185/03007995.2010.50637520666689
   PubMed Web of Science ®Google Scholar
• Forner A, Llovet JM, Bruix J. Hepatocellular carcinoma. Lancet. 2012;379(10127):1245–1255. doi:10.1016/S0140-6736(18)30010-222353262
   PubMedGoogle Scholar
• Bruix J, Sherman M. Management of hepatocellular carcinoma. Hepatology. 2005;42(5):1208–1236. doi:10.1002/hep.2093316250051
   PubMed Web of Science ®Google Scholar
• Ozer Etik D, Suna N, Boyacioglu AS. Management of hepatocellular carcinoma: prevention, surveillance, diagnosis, and staging. Exp Clin Transplant. 2017;15(Suppl 2):31–35. doi:10.6002/ect.TOND16.L928301996
   PubMedGoogle Scholar
• Li L, Chen J, Chen X, et al. Serum miRNAs as predictive and preventive biomarker for pre-clinical hepatocellular carcinoma. Cancer Lett. 2016;373(2):234–240. doi:10.1016/j.canlet.2016.01.02826850373
   PubMed Web of Science ®Google Scholar
• Riley CM, Ren TC. Simple method for the determination of paeonol in human and rabbit plasma by high-performance liquid chromatography using solid-phase extraction and ultraviolet detection. J Chromatogr. 1989;489(2):432–437. doi:10.1016/s0378-4347(00)82926-62753967
   PubMed Web of Science ®Google Scholar
• Ye JM, Deng T, Zhang JB. Influence of paeonol on expression of COX-2 and p27 in HT-29 cells. World J Gastroenterol. 2009;15(35):4410–4414. doi:10.3748/wjg.15.441019764092
   PubMed Web of Science ®Google Scholar
• Chou TC. Anti-inflammatory and analgesic effects of paeonol in carrageenan-evoked thermal hyperalgesia. Br J Pharmacol. 2003;139(6):1146–1152. doi:10.1038/sj.bjp.070536012871833
   PubMed Web of Science ®Google Scholar
• Mi XJ, Chen SW, Wang WJ, et al. Anxiolytic-like effect of paeonol in mice. Pharmacol Biochem Behav. 2005;81(3):683–687. doi:10.1016/j.pbb.2005.04.01615970315
   PubMed Web of Science ®Google Scholar
• Zuzic M, Rojo Arias JE, Wohl SG, Busskamp V. Retinal miRNA functions in health and disease. Genes. 2019;10(5):377. doi:10.3390/genes10050377
   PubMed Web of Science ®Google Scholar
• Shirjang S, Mansoori B, Asghari S, et al. MicroRNAs in cancer cell death pathways: apoptosis and necroptosis. Free Radic Biol Med. 2019;139:1–15. doi:10.1016/j.freeradbiomed31102709
   PubMed Web of Science ®Google Scholar
• Subramaniam S, Jeet V, Clements JA, Gunter JH, Batra J. Emergence of MicroRNAs as Key players in cancer cell metabolism. Clin Chem. 2019;65(9):1090–1101. doi:10.1373/clinchem.2018.29965131101638
   PubMed Web of Science ®Google Scholar
• Specjalski K, Jassem E. MicroRNAs: potential biomarkers and targets of therapy in allergic diseases? Arch Immunol Ther Exp. 2019;67(4):213–223. doi:10.1007/s00005-019-00547-4
   PubMed Web of Science ®Google Scholar
• Ma JH, Bu X, Wang JJ, Xie YX. MicroRNA-29-3p regulates hepatocellular carcinoma progression through NF-κB pathway. Clin Lab. 2019;65(5):undefined. doi:10.7754/Clin.Lab.2018.181012
   Web of Science ®Google Scholar
• Lv L, Wang X, Ma T. microRNA-944 inhibits the malignancy of hepatocellular carcinoma by directly targeting IGF-1R and deactivating the PI3K/Akt signaling pathway. Cancer Manag Res. 2019;11:2531–2543. doi:10.2147/CMAR.S19981831114322
   PubMed Web of Science ®Google Scholar
• Cui Y, Xu HF, Liu MY, et al. Mechanism of exosomal microRNA-224 in development of hepatocellular carcinoma and its diagnostic and prognostic value. World J Gastroenterol. 2019;25(15):1890–1898. doi:10.3748/wjg.v25.i15.189031057302
   PubMed Web of Science ®Google Scholar
• Zhong XZ, Deng Y, Chen G, Yang H. Investigation of the clinical significance and molecular mechanism of miR-21-5p in hepatocellular carcinoma: a systematic review based on 24 studies and bioinformatics investigation. Oncol Lett. 2019;17(1):230–246. doi:10.3892/ol.2018.962730655760
   PubMed Web of Science ®Google Scholar
• Yoon JS, Kim G, Lee YR, et al. Clinical significance of microRNA-21 expression in disease progression of patients with hepatocellular carcinoma. Biomark Med. 2018;12(10):1105–1114. doi:10.2217/bmm-2018-009630191729
   PubMed Web of Science ®Google Scholar
• El-Tawdi AH, Matboli M, Shehata HH, et al. Evaluation of circulatory RNA-based biomarker panel in hepatocellular carcinoma. Mol Diagn Ther. 2016;20(3):265–277. doi:10.1007/s40291-016-0200-927113935
   PubMed Web of Science ®Google Scholar
• Wen Y, Han J, Chen J, et al. Plasma miRNAs as early biomarkers for detecting hepatocellular carcinoma. Int J Cancer. 2015;137(7):1679–1690. doi:10.1002/ijc.2954425845839
   PubMed Web of Science ®Google Scholar
• Wang J, Chu Y, Xu M, Zhang X, Zhou Y, Xu M. miR-21 promotes cell migration and invasion of hepatocellular carcinoma by targeting KLF5. Oncol Lett. 2019;17(2):2221–2227. doi:10.3892/ol.2018.984330675287
   PubMed Web of Science ®Google Scholar
• McConnell BB, Yang VW. Mammalian Krüppel-like factors in health and diseases. Physiol Rev. 2010;90(4):1337–1381. doi:10.1152/physrev.00058.200920959618
   PubMed Web of Science ®Google Scholar
• He AD, Xie W, Song W, et al. Platelet releasates promote the proliferation of hepatocellular carcinoma cells by suppressing the expression of KLF6. Sci Rep. 2017;7(1):3989. doi:10.1038/s41598-017-02801-128638139
   PubMed Web of Science ®Google Scholar
• Wang S, Kang L, Chen X, Zhou H. Frequent down-regulation and deletion of KLF6 in primary hepatocellular carcinoma. J Huazhong Univ Sci Technolog Med Sci. 2010;30(4):470–476. doi:10.1007/s11596-010-0451-320714872
   PubMedGoogle Scholar
• Wu J, Sun C, Wang R, et al. Cardioprotective effect of paeonol against epirubicin-induced heart injury via regulating miR-1 and PI3K/AKT pathway. Chem Biol Interact. 2018;286:17–25. doi:10.1016/j.cbi.2018.02.03529505745
   PubMed Web of Science ®Google Scholar
• Chunhu Z, Suiyu H, Meiqun C, Guilin X, Yunhui L. Antiproliferative and apoptotic effects of paeonol on human hepatocellular carcinoma cells. Anticancer Drugs. 2008;19(4):401–409. doi:10.1097/CAD.0b013e3282f7f4eb18454050
   PubMed Web of Science ®Google Scholar
• Chen B, Ning M, Yang G. Effect of paeonol on antioxidant and immune regulatory activity in hepatocellular carcinoma rats. Molecules. 2012;17(4):4672–4683. doi:10.3390/molecules1704467222522397
   PubMed Web of Science ®Google Scholar
• Li FC, Zhou XL, Mao HL. [A study of paeonol injection on immune functions in rats]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1994;14(1):37–38. Chinese.8044001
   PubMedGoogle Scholar
• Li X, Wu X. MiR-21-5p promotes the progression of non-small-cell lung cancer by regulating the expression of SMAD7. Onco Targets Ther. 2018;11:8445–8454. doi:10.2147/OTT.S17239330568467
   PubMed Web of Science ®Google Scholar
• Park SK, Park YS, Ahn JY, et al. MiR 21-5p as a predictor of recurrence in young gastric cancer patients. J Gastroenterol Hepatol. 2016;31(8):1429–1435. doi:10.1111/jgh.1330026824898
   PubMed Web of Science ®Google Scholar
• Pu C, Huang H, Wang Z, et al. Extracellular vesicle-associated mir-21 and mir-144 are markedly elevated in serum of patients with hepatocellular carcinoma. Front Physiol. 2018;9:930. doi:10.3389/fphys.2018.0093030065664
   PubMed Web of Science ®Google Scholar
• Lee UE, Ghiassi-Nejad Z, Paris AJ, et al. Tumor suppressor activity of KLF6 mediated by downregulation of the PTTG1 oncogene. FEBS Lett. 2010;584(5):1006–1010. doi:10.1016/j.febslet.2010.01.04920116377
   PubMed Web of Science ®Google Scholar