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Review

Effects of Anesthesia on Postoperative Recurrence and Metastasis of Malignant Tumors

, , ORCID Icon &
Pages 7619-7633 | Published online: 24 Aug 2020

References

  • Kim R. Effects of surgery and anesthetic choice on immunosuppression and cancer recurrence. J Transl Med. 2018;16(1):8. doi:10.1186/s12967-018-1389-729347949
  • Wang W, Xiao J, Shen S, Wang S, Chen M, Hu Y. Emerging effect of anesthesia on post-operative tumor recurrence and metastasis. J Int Med Res. 2019;47(8):3550–3558. doi:10.1177/030006051986145531296069
  • Sessler DI, Pei L, Huang Y, et al. Recurrence of breast cancer after regional or general anaesthesia: a randomised controlled trial. Lancet. 2019;394(10211):1807–1815. doi:10.1016/S0140-6736(19)32313-X31645288
  • Dong J, Zeng M, Ji N, et al. Impact of anesthesia on long-term outcomes in patients with supratentorial high-grade glioma undergoing tumor resection: a retrospective cohort study. J Neurosurg Anesthesiol. 2020;32(3):227–233. doi:10.1097/ANA.000000000000058830807485
  • Anderson SL, Duke-Novakovski T, Singh B. The immune response to anesthesia: part 2 sedatives, opioids, and injectable anesthetic agents. Vet Anaesth Analg. 2014;41(6):553–566. doi:10.1111/vaa.1219124962601
  • Moradkhani MR, Karimi A. Role of drug anesthesia and cancer. Drug Res (Stuttg). 2018;68(3):125–131. doi:10.1055/s-0043-11907129161749
  • Byrne K, Levins KJ, Buggy DJ. Can anesthetic-analgesic technique during primary cancer surgery affect recurrence or metastasis? Can J Anaesth. 2016;63(2):184–192. doi:10.1007/s12630-015-0523-826497721
  • Dubowitz JA, Sloan EK, Riedel BJ. Implicating anaesthesia and the perioperative period in cancer recurrence and metastasis. Clin Exp Metastasis. 2018;35(4):347–358. doi:10.1007/s10585-017-9862-x28894976
  • Vahabi S, Eatemadi A. Effects of anesthetic and analgesic techniques on cancer metastasis. Biomed Pharmacother. 2017;87:1–7. doi:10.1016/j.biopha.2016.12.07328040593
  • Longhini F, Bruni A, Garofalo E, et al. Anesthetic strategies in oncological surgery: not only a simple sleep, but also impact on immunosuppression and cancer recurrence. Cancer Manag Res. 2020;12:931–940. doi:10.2147/CMAR.S23722432104075
  • Lee EK, Ahn HJ, Zo JI, Kim K, Jung DM, Park JH. Paravertebral block does not reduce cancer recurrence, but is related to higher overall survival in lung cancer surgery: a retrospective cohort study. Anesth Analg. 2017;125(4):1322–1328. doi:10.1213/ANE.000000000000234228857802
  • Fodale V, D’Arrigo MG, Triolo S, Mondello S, La Torre D. Anesthetic techniques and cancer recurrence after surgery. ScientificWorldJournal. 2014;2014:328513. doi:10.1155/2014/32851324683330
  • Liu X, Ma M, Huang H, Wang Y. Effect of perioperative blood transfusion on prognosis of patients with gastric cancer: a retrospective analysis of a single center database. BMC Cancer. 2018;18(1):649. doi:10.1186/s12885-018-4574-429890957
  • Kaye AD, Patel N, Bueno FR, et al. Effect of opiates, anesthetic techniques, and other perioperative factors on surgical cancer patients. Ochsner J. 2014;14(2):216–228.24940132
  • Yap A, Lopez-Olivo MA, Dubowitz J, Hiller J, Riedel B. Anesthetic technique and cancer outcomes: a meta-analysis of total intravenous versus volatile anesthesia. Can J Anaesth. 2019;66(5):546–561. doi:10.1007/s12630-019-01330-x30834506
  • Jin Z, Li R, Liu J, Lin J. Long-term prognosis after cancer surgery with inhalational anesthesia and total intravenous anesthesia: a systematic review and meta-analysis. Int J Physiol Pathophysiol Pharmacol. 2019;11(3):83–94.31333811
  • Li R, Liu H, Dilger JP, Lin J. Effect of Propofol on breast Cancer cell, the immune system, and patient outcome. BMC Anesthesiol. 2018;18(1):77. doi:10.1186/s12871-018-0543-329945542
  • Jiang S, Liu Y, Huang L, Zhang F, Kang R. Effects of propofol on cancer development and chemotherapy: potential mechanisms. Eur J Pharmacol. 2018;831:46–51. doi:10.1016/j.ejphar.2018.04.00929654781
  • Sahinovic MM, Struys M, Absalom AR. Clinical pharmacokinetics and pharmacodynamics of propofol. Clin Pharmacokinet. 2018;57(12):1539–1558. doi:10.1007/s40262-018-0672-330019172
  • Weir CJ, Mitchell SJ, Lambert JJ. Role of GABAA receptor subtypes in the behavioural effects of intravenous general anaesthetics. Br J Anaesth. 2017;119(suppl_1):i167–i175. doi:10.1093/bja/aex36929161398
  • Lai HC, Lee MS, Lin C, et al. Propofol-based total intravenous anaesthesia is associated with better survival than desflurane anaesthesia in hepatectomy for hepatocellular carcinoma: a retrospective cohort study. Br J Anaesth. 2019;123(2):151–160. doi:10.1016/j.bja.2019.04.05731171343
  • Lai HC, Lee MS, Lin KT, et al. Propofol-based total intravenous anesthesia is associated with better survival than desflurane anesthesia in robot-assisted radical prostatectomy. PLoS One. 2020;15(3):e0230290. doi:10.1371/journal.pone.023029032182262
  • Guerrero Orriach JL, Raigon Ponferrada A, Malo Manso A, et al. Anesthesia in combination with propofol increases disease-free survival in bladder cancer patients who undergo radical tumor cystectomy as compared to inhalational anesthetics and opiate-based analgesia. Oncology. 2020;98(3):161–167. doi:10.1159/00050480731962315
  • Lai HC, Lee MS, Liu YT, et al. Propofol-based intravenous anesthesia is associated with better survival than desflurane anesthesia in pancreatic cancer surgery. PLoS One. 2020;15(5):e0233598. doi:10.1371/journal.pone.023359832437450
  • Lai HC, Lee MS, Lin KT, et al. Propofol-based total intravenous anesthesia is associated with better survival than desflurane anesthesia in intrahepatic cholangiocarcinoma surgery. Medicine (Baltimore). 2019;98(51):e18472. doi:10.1097/MD.000000000001847231861027
  • Oh TK, Kim HH, Jeon YT. Retrospective analysis of 1-year mortality after gastric cancer surgery: total intravenous anesthesia versus volatile anesthesia. Acta Anaesthesiol Scand. 2019;63(9):1169–1177. doi:10.1111/aas.1341431180151
  • Schaefer MS, Raub D, Xu X, et al. Association between propofol dose and 1-year mortality in patients with or without a diagnosis of solid cancer. Br J Anaesth. 2020;124(3):271–280. doi:10.1016/j.bja.2019.11.02831902588
  • Huang YH, Lee MS, Lou YS, et al. Propofol-based total intravenous anesthesia did not improve survival compared to desflurane anesthesia in breast cancer surgery. PLoS One. 2019;14(11):e0224728. doi:10.1371/journal.pone.022472831697743
  • Enlund M, Berglund A, Ahlstrand R, et al. Survival after primary breast cancer surgery following propofol or sevoflurane general anesthesia-a retrospective, multicenter, database analysis of 6305 Swedish patients. Acta Anaesthesiol Scand. 2020;64(8):1048–1054. doi:10.1111/aas.1364432415980
  • Cata JP, Forget P. Paravertebral block with propofol anaesthesia does not improve survival compared with sevoflurane anaesthesia for breast cancer surgery: independent discussion of a randomised controlled trial. Br J Anaesth. 2020;124(1):19–24. doi:10.1016/j.bja.2019.09.03931727343
  • Wang J, Cheng CS, Lu Y, et al. Novel findings of anti-cancer property of propofol. Anticancer Agents Med Chem. 2018;18(2):156–165. doi:10.2174/187152061766617091212032728901262
  • Farooqi AA, Adylova A, Sabitaliyevich UY, Attar R, Sohail MI, Yilmaz S. Recent updates on true potential of an anesthetic agent as a regulator of cell signaling pathways and non-coding RNAs in different cancers: focusing on the brighter side of propofol. Gene. 2020;737:144452. doi:10.1016/j.gene.2020.14445232044408
  • Deng F, Ouyang M, Wang X, et al. Differential role of intravenous anesthetics in colorectal cancer progression: implications for clinical application. Oncotarget. 2016;7(47):77087–77095. doi:10.18632/oncotarget.1280027780923
  • Xu YB, Jiang W, Zhao FR, et al. Propofol suppresses invasion and induces apoptosis of osteosarcoma cell in vitro via downregulation of TGF-β1 expression. Eur Rev Med Pharmacol Sci. 2016;20(7):1430–1435.27097968
  • Liu Z, Zhang J, Hong G, Quan J, Zhang L, Yu M. Propofol inhibits growth and invasion of pancreatic cancer cells through regulation of the miR-21/Slug signaling pathway. Am J Transl Res. 2016;8(10):4120–4133.27829997
  • Zhang L, Wang N, Zhou S, Ye W, Jing G, Zhang M. Propofol induces proliferation and invasion of gallbladder cancer cells through activation of Nrf2. J Exp Clin Cancer Res. 2012;31(1):66. doi:10.1186/1756-9966-31-6622901367
  • Singh V, Gillespie TW, Harvey RD. Intranasal ketamine and its potential role in cancer-related pain. Pharmacotherapy. 2018;38(3):390–401. doi:10.1002/phar.209029396996
  • Visser E, Schug SA. The role of ketamine in pain management. Biomed Pharmacother. 2006;60(7):341–348. doi:10.1016/j.biopha.2006.06.02116854557
  • Quibell R, Fallon M, Mihalyo M, Twycross R, Wilcock A. Ketamine. J Pain Symptom Manage. 2015;50(2):268–278. doi:10.1016/j.jpainsymman.2015.06.00226096492
  • Melamed R, Bar-Yosef S, Shakhar G, Shakhar K, Ben-Eliyahu S. Suppression of natural killer cell activity and promotion of tumor metastasis by ketamine, thiopental, and halothane, but not by propofol: mediating mechanisms and prophylactic measures. Anesth Analg. 2003;97(5):1331–1339. doi:10.1213/01.ANE.0000082995.44040.0714570648
  • He H, Chen J, Xie WP, et al. Ketamine used as an acesodyne in human breast cancer therapy causes an undesirable side effect, upregulating anti-apoptosis protein Bcl-2 expression. Genet Mol Res. 2013;12(2):1907–1915. doi:10.4238/2013.January.4.723315866
  • Malsy M, Gebhardt K, Gruber M, Wiese C, Graf B, Bundscherer A. Effects of ketamine, s-ketamine, and MK 801 on proliferation, apoptosis, and necrosis in pancreatic cancer cells. BMC Anesthesiol. 2015;15:111. doi:10.1186/s12871-015-0076-y26219286
  • Amaram-Davila J, Davis M, Reddy A. Opioids and cancer mortality. Curr Treat Options Oncol. 2020;21(3):22. doi:10.1007/s11864-020-0713-732095929
  • Wong SS, Cheung CW. Optimization of opioid utility in cancer pain populations. Ann Palliat Med. 2020;9(2):558–570. doi:10.21037/apm.2020.03.0432233627
  • Cruickshank M, Henderson L, MacLennan G, et al. Alpha-2 agonists for sedation of mechanically ventilated adults in intensive care units: a systematic review. Health Technol Assess. 2016;20(25):v–117. doi:10.3310/hta20250
  • Levins KJ, Prendeville S, Conlon S, Buggy DJ. The effect of anesthetic technique on µ-opioid receptor expression and immune cell infiltration in breast cancer. J Anesth. 2018;32(6):792–796. doi:10.1007/s00540-018-2554-030229370
  • Connolly C, Buggy DJ. Opioids and tumour metastasis: does the choice of the anesthetic-analgesic technique influence outcome after cancer surgery? Curr Opin Anaesthesiol. 2016;29(4):468–474. doi:10.1097/ACO.000000000000036027214644
  • Singleton PA, Lingen MW, Fekete MJ, Garcia JG, Moss J. Methylnaltrexone inhibits opiate and VEGF-induced angiogenesis: role of receptor transactivation. Microvasc Res. 2006;72(1–2):3–11. doi:10.1016/j.mvr.2006.04.00416820176
  • Yamamizu K, Furuta S, Hamada Y, et al. к Opioids inhibit tumor angiogenesis by suppressing VEGF signaling. Sci Rep. 2013;3:3213. doi:10.1038/srep03213
  • Chong D, Shao L, Yang Y, Wang R, Yang C, Zhang B. Correlations of cancer pain degree with levels of β-EP, CGRP and PGE2 and the effects of oxycontin on them. J BUON. 2018;23(5):1552–1557.30570885
  • Farooqui M, Li Y, Rogers T, et al. COX-2 inhibitor celecoxib prevents chronic morphine-induced promotion of angiogenesis, tumour growth, metastasis and mortality, without compromising analgesia. Br J Cancer. 2007;97(11):1523–1531. doi:10.1038/sj.bjc.660405717971769
  • Schoos A, Gabriel C, Knab VM, Fux DA. Activation of HIF-1α by δ-opioid receptors induces COX-2 expression in breast cancer cells and leads to paracrine activation of vascular endothelial cells. J Pharmacol Exp Ther. 2019;370(3):480–489. doi:10.1124/jpet.119.25750131300611
  • Tuerxun H, Cui J. The dual effect of morphine on tumor development. Clin Transl Oncol. 2019;21(6):695–701. doi:10.1007/s12094-018-1974-530470993
  • Dupoiron D. Intrathecal therapy for pain in cancer patients. Curr Opin Support Palliat Care. 2019;13(2):75–80. doi:10.1097/SPC.000000000000042730896454
  • Koodie L, Yuan H, Pumper JA, et al. Morphine inhibits migration of tumor-infiltrating leukocytes and suppresses angiogenesis associated with tumor growth in mice. Am J Pathol. 2014;184(4):1073–1084. doi:10.1016/j.ajpath.2013.12.01924495739
  • Kim MH, Oh JE, Park S, et al. Tramadol use is associated with enhanced postoperative outcomes in breast cancer patients: a retrospective clinical study with in vitro confirmation. Br J Anaesth. 2019;123(6):865–876. doi:10.1016/j.bja.2019.09.00431591020
  • Feng Z, Lu X, Gan L, Zhang Q, Lin L. Xanthones, a promising anti-inflammatory scaffold: structure, activity, and drug likeness analysis. Molecules. 2020;25(3):598. doi:10.3390/molecules25030598
  • Zappavigna S, Cossu AM, Grimaldi A, et al. Anti-inflammatory drugs as anticancer agents. Int J Mol Sci. 2020;21(7):2605. doi:10.3390/ijms21072605
  • Ye Y, Wang X, Jeschke U, von Schönfeldt V. COX-2-PGE(2)-EPs in gynecological cancers. Arch Gynecol Obstet. 2020;301(6):1365–1375. doi:10.1007/s00404-020-05559-632363546
  • Majidi A, Na R, Dixon-Suen S, Jordan SJ, Webb PM. Common medications and survival in women with ovarian cancer: a systematic review and meta-analysis. Gynecol Oncol. 2020;157(3):678–685. doi:10.1016/j.ygyno.2020.03.02832317171
  • Woolbright BL, Pilbeam CC, Taylor JA. Prostaglandin E2 as a therapeutic target in bladder cancer: from basic science to clinical trials. Prostaglandins Other Lipid Mediat. 2020;148:106409. doi:10.1016/j.prostaglandins.2020.10640931931078
  • Choi JE, Villarreal J, Lasala J, et al. Perioperative neutrophil: lymphocyte ratio and postoperative NSAID use as predictors of survival after lung cancer surgery: a retrospective study. Cancer Med. 2015;4(6):825–833. doi:10.1002/cam4.42825756351
  • Wen QP, Miao Z, Wu P, et al. Whole-course application of dexmedetomidine combined with ketorolac in nonnarcotic postoperative analgesia for patients with lung cancer undergoing thoracoscopic surgery: a randomized control trial. Pain Physician. 2020;23(2):E185–E193.32214297
  • Forget P, De Kock M. Perspectives in anaesthesia for cancer surgery. J Cancer Res Clin Oncol. 2014;140(3):353–359. doi:10.1007/s00432-013-1522-124077864
  • Jiao B, Yang C, Huang NN, Yang N, Wei J, Xu H. Relationship between volatile anesthetics and tumor progression: unveiling the mystery. Curr Med Sci. 2018;38(6):962–967. doi:10.1007/s11596-018-1970-630536056
  • Xu Y, Jiang W, Xie S, Xue F, Zhu X. The role of inhaled anesthetics in tumorigenesis and tumor immunity. Cancer Manag Res. 2020;12:1601–1609. doi:10.2147/CMAR.S24428032184663
  • Evans DR, Fowler-Williams C, Ma D. Is volatile anesthesia during cancer surgery likely to increase the metastatic risk? Int Anesthesiol Clin. 2016;54(4):92–107. doi:10.1097/AIA.000000000000011527623130
  • Mitsui Y, Hou L, Huang X, Odegard KC, Pereira LM, Yuki K. Volatile anesthetic sevoflurane attenuates toll-like receptor 1/2 activation. Anesth Analg. 2020;131(2):631–639. doi:10.1213/ANE.000000000000474132149756
  • de Sousa GC, Cruz FF, Heil LB, et al. Intraoperative immunomodulatory effects of sevoflurane versus total intravenous anesthesia with propofol in bariatric surgery (the OBESITA trial): study protocol for a randomized controlled pilot trial. Trials. 2019;20(1):300. doi:10.1186/s13063-019-3399-z31138279
  • Liu S, Gu X, Zhu L, et al. Effects of propofol and sevoflurane on perioperative immune response in patients undergoing laparoscopic radical hysterectomy for cervical cancer. Medicine (Baltimore). 2016;95(49):e5479. doi:10.1097/MD.000000000000547927930529
  • Shi QY, Zhang SJ, Liu L, et al. Sevoflurane promotes the expansion of glioma stem cells through activation of hypoxia-inducible factors in vitro. Br J Anaesth. 2015;114(5):825–830. doi:10.1093/bja/aeu40225492570
  • Hirai T, Konishi Y, Mizuno S, Rui Z, Sun Y, Nishiwaki K. Differential effects of sevoflurane on the growth and apoptosis of human cancer cell lines. J Anesth. 2020;34(1):47–57. doi:10.1007/s00540-019-02701-w31667585
  • Benzonana LL, Perry NJ, Watts HR, et al. Isoflurane, a commonly used volatile anesthetic, enhances renal cancer growth and malignant potential via the hypoxia-inducible factor cellular signaling pathway in vitro. Anesthesiology. 2013;119(3):593–605. doi:10.1097/ALN.0b013e31829e47fd23774231
  • Zhu M, Li M, Zhou Y, et al. Isoflurane enhances the malignant potential of glioblastoma stem cells by promoting their viability, mobility in vitro and migratory capacity in vivo. Br J Anaesth. 2016;116(6):870–877. doi:10.1093/bja/aew12427199319
  • Zhang W, Shao X. Isoflurane promotes non-small cell lung cancer malignancy by activating the Akt-mammalian target of rapamycin (mTOR) signaling pathway. Med Sci Monit. 2016;22:4644–4650. doi:10.12659/MSM.89843427897153
  • Kawaraguchi Y, Horikawa YT, Murphy AN, et al. Volatile anesthetics protect cancer cells against tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via caveolins. Anesthesiology. 2011;115(3):499–508. doi:10.1097/ALN.0b013e3182276d4221862885
  • Sneyd JR. Thiopental to desflurane - an anaesthetic journey. Where are we going next? Br J Anaesth. 2017;119(suppl_1):i44–i52. doi:10.1093/bja/aex32829161390
  • Iwasaki M, Zhao H, Jaffer T, et al. Volatile anaesthetics enhance the metastasis related cellular signalling including CXCR2 of ovarian cancer cells. Oncotarget. 2016;7(18):26042–26056. doi:10.18632/oncotarget.830427028996
  • Müller-Edenborn B, Roth-Z’graggen B, Bartnicka K, et al. Volatile anesthetics reduce invasion of colorectal cancer cells through down-regulation of matrix metalloproteinase-9. Anesthesiology. 2012;117(2):293–301. doi:10.1097/ALN.0b013e3182605df122739763
  • Reichle FM, Conzen PF. Halogenated inhalational anaesthetics. Best Pract Res Clin Anaesthesiol. 2003;17(1):29–46. doi:10.1053/bean.2002.026512751547
  • Woo JH, Baik HJ, Kim CH, et al. Effect of propofol and desflurane on immune cell populations in breast cancer patients: a randomized trial. J Korean Med Sci. 2015;30(10):1503–1508. doi:10.3346/jkms.2015.30.10.150326425050
  • Heavner JE. Local anesthetics. Curr Opin Anaesthesiol. 2007;20(4):336–342. doi:10.1097/ACO.0b013e3281c10a0817620842
  • Liu H, Dilger JP, Lin J. Effects of local anesthetics on cancer cells. Pharmacol Ther. 2020;212:107558. doi:10.1016/j.pharmthera.2020.10755832343985
  • Pérez-González O, Cuéllar-Guzmán LF, Soliz J, Cata JP. Impact of regional anesthesia on recurrence, metastasis, and immune response in breast cancer surgery: a systematic review of the literature. Reg Anesth Pain Med. 2017;42(6):751–756. doi:10.1097/AAP.000000000000066228953508
  • Sen S, Koyyalamudi V, Smith DD, et al. The role of regional anesthesia in the propagation of cancer: a comprehensive review. Best Pract Res Clin Anaesthesiol. 2019;33(4):507–522. doi:10.1016/j.bpa.2019.07.00431791567
  • Sakaguchi M, Kuroda Y, Hirose M. The antiproliferative effect of lidocaine on human tongue cancer cells with inhibition of the activity of epidermal growth factor receptor. Anesth Analg. 2006;102(4):1103–1107. doi:10.1213/01.ane.0000198330.84341.3516551906
  • Siekmann W, Tina E, Von Sydow AK, Gupta A. Effect of lidocaine and ropivacaine on primary (SW480) and metastatic (SW620) colon cancer cell lines. Oncol Lett. 2019;18(1):395–401. doi:10.3892/ol.2019.1033231497075
  • Lirk P, Hollmann MW, Fleischer M, Weber NC, Fiegl H. Lidocaine and ropivacaine, but not bupivacaine, demethylate deoxyribonucleic acid in breast cancer cells in vitro. Br J Anaesth. 2014;113(Suppl 1):i32–38. doi:10.1093/bja/aeu20124946779
  • Chang YC, Hsu YC, Liu CL, Huang SY, Hu MC, Cheng SP. Local anesthetics induce apoptosis in human thyroid cancer cells through the mitogen-activated protein kinase pathway. PLoS One. 2014;9(2):e89563. doi:10.1371/journal.pone.008956324586874
  • Zanni MP, Mauri-Hellweg D, Brander C, et al. Characterization of lidocaine-specific T cells. J Immunol. 1997;158(3):1139–1148.9013953
  • Chamaraux-Tran TN, Piegeler T. The amide local anesthetic lidocaine in cancer surgery-potential antimetastatic effects and preservation of immune cell function? A narrative review. Front Med (Lausanne). 2017;4:235. doi:10.3389/fmed.2017.0023529326939
  • Azuma Y, Ohura K. Immunological modulation by lidocaine-epinephrine and prilocaine-felypressin on the functions related to natural immunity in neutrophils and macrophages. Curr Drug Targets Immune Endocr Metabol Disord. 2004;4(1):29–36. doi:10.2174/156800804333997415032623
  • Kim R. Anesthetic technique for cancer surgery: harm or benefit for cancer recurrence? Eur J Surg Oncol. 2018;44(5):557–558. doi:10.1016/j.ejso.2018.02.20729530344
  • Iwasaki M, Edmondson M, Sakamoto A, Ma D. Anesthesia, surgical stress, and “long-term” outcomes. Acta Anaesthesiol Taiwan. 2015;53(3):99–104. doi:10.1016/j.aat.2015.07.00226235899
  • Tseng KS, Kulkarni S, Humphreys EB, et al. Spinal anesthesia does not impact prostate cancer recurrence in a cohort of men undergoing radical prostatectomy: an observational study. Reg Anesth Pain Med. 2014;39(4):284–288. doi:10.1097/AAP.000000000000010824918335
  • Short TG, Leslie K, Chan MT, Campbell D, Frampton C, Myles P. Rationale and design of the balanced anesthesia study: a prospective randomized clinical trial of two levels of anesthetic depth on patient outcome after major surgery. Anesth Analg. 2015;121(2):357–365. doi:10.1213/ANE.000000000000079725993386
  • Looney M, Doran P, Buggy DJ. Effect of anesthetic technique on serum vascular endothelial growth factor C and transforming growth factor β in women undergoing anesthesia and surgery for breast cancer. Anesthesiology. 2010;113(5):1118–1125. doi:10.1097/ALN.0b013e3181f79a6920930611
  • Poeran J, Mazumdar M, Memtsoudis SG. Anesthesia, outcomes, and public health: changing health care while “asleep”. Reg Anesth Pain Med. 2014;39(3):192–194. doi:10.1097/AAP.000000000000008524682083
  • Tai YH, Wu HL, Mandell MS, Tsou MY, Chang KY. The association of allogeneic blood transfusion and the recurrence of hepatic cancer after surgical resection. Anaesthesia. 2020;75(4):464–471. doi:10.1111/anae.1486231573678
  • Le-Wendling L, Nin O, Capdevila X. Cancer recurrence and regional anesthesia: the theories, the data, and the future in outcomes. Pain Med. 2016;17(4):756–775. doi:10.1111/pme.1289326441010
  • Neri D, Sondel PM. Immunocytokines for cancer treatment: past, present and future. Curr Opin Immunol. 2016;40:96–102. doi:10.1016/j.coi.2016.03.00627060634
  • Budhwani M, Mazzieri R, Dolcetti R. Plasticity of type I interferon-mediated responses in cancer therapy: from anti-tumor immunity to resistance. Front Oncol. 2018;8:322. doi:10.3389/fonc.2018.0032230186768
  • Lewis AL, Chaft J, Girotra M, Fischer GW. Immune checkpoint inhibitors: a narrative review of considerations for the anaesthesiologist. Br J Anaesth. 2020;124(3):251–260. doi:10.1016/j.bja.2019.11.03432007241
  • Lusty AJ, Hosier GW, Koti M, et al. Anesthetic technique and oncological outcomes in urology: a clinical practice review. Urol Oncol. 2019;37(12):845–852. doi:10.1016/j.urolonc.2019.08.00431526652
  • Chowdappa R, Tiwari AR, Arjunan R, Althaf S, Kumar RV, Chunduri S. Perioperative mortality in cancer esophagus-a case control study at a high-volume regional cancer center in South India. Indian J Surg Oncol. 2019;10(1):83–90. doi:10.1007/s13193-018-0825-830948879
  • Cata JP, Gutierrez C, Mehran RJ, et al. Preoperative anemia, blood transfusion, and neutrophil-to-lymphocyte ratio in patients with stage I non-small cell lung cancer. Cancer Cell Microenviron. 2016;3(1):e1116.26949721
  • Brown KGM, Solomon MJ, Koh CE. Pelvic exenteration surgery: the evolution of radical surgical techniques for advanced and recurrent pelvic malignancy. Dis Colon Rectum. 2017;60(7):745–754. doi:10.1097/DCR.000000000000083928594725
  • Ma QM, Han GS, Li BW, Li XJ, Jiang T. Effectiveness and safety of the use of antifibrinolytic agents in total-knee arthroplasty: a meta-analysis. Medicine (Baltimore). 2020;99(20):e20214. doi:10.1097/MD.000000000002021432443349
  • Soehle M, Dehne H, Hoeft A, Zenker S. Accuracy of the non-invasive Tcore™ temperature monitoring system to measure body core temperature in abdominal surgery. J Clin Monit Comput. 2019. doi:10.1007/s10877-019-00430-9
  • Laitman BM, Ma Y, Hill B, et al. Mild hypothermia is associated with improved outcomes in patients undergoing microvascular head and neck reconstruction. Am J Otolaryngol. 2019;40(3):418–422. doi:10.1016/j.amjoto.2019.03.01030954327
  • Cajigas I, Mahavadi AK, Shah AH, et al. Analysis of intra-operative variables as predictors of 30-day readmission in patients undergoing glioma surgery at a single center. J Neurooncol. 2019;145(3):509–518. doi:10.1007/s11060-019-03317-631642024
  • Aoki Y, Atsumi K, Kora M, Koh N, Yokoyama J. Sugammadex and amino acid infusion can contribute to safe anesthetic management of variegate porphyria. JA Clin Rep. 2018;4(1):49. doi:10.1186/s40981-018-0187-932026031
  • Du G, Liu Y, Li J, Liu W, Wang Y, Li H. Hypothermic microenvironment plays a key role in tumor immune subversion. Int Immunopharmacol. 2013;17(2):245–253. doi:10.1016/j.intimp.2013.06.01823831011
  • Liang B, Dong T. Effects of propofol on invasion and migration of colon cancer cells and JAK2/STAT3 signaling pathway. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2020;45(3):290–296. doi:10.11817/j.issn.1672-7347.2020.18070432386021
  • Zheng X, Dong L, Zhao S, et al. Propofol affects non-small-cell lung cancer cell biology by regulating the miR-21/PTEN/AKT pathway in vitro and in vivo. Anesth Analg. 2020;Publish Ahead of Print. doi:10.1213/ANE.0000000000004778.
  • Wang H, Jiao H, Jiang Z, Chen R. Propofol inhibits migration and induces apoptosis of pancreatic cancer PANC-1 cells through miR-34a-mediated E-cadherin and LOC285194 signals. Bioengineered. 2020;11(1):510–521. doi:10.1080/21655979.2020.175403832303144
  • Liu F, Qiu F, Fu M, Chen H, Wang H. Propofol reduces epithelial to mesenchymal transition, invasion and migration of gastric cancer cells through the microRNA-195-5p/snail axis. Med Sci Monit. 2020;26:e920981. doi:10.12659/MSM.92390932115570
  • Li M, Qu L, Chen F, Zhu X. Propofol upregulates miR-320a and reduces HMGB1 by downregulating ANRIL to inhibit PTC cell malignant behaviors. Pathol Res Pract. 2020;216(4):152856. doi:10.1016/j.prp.2020.15285632098696
  • Yu X, Shi J, Wang X, Zhang F. Propofol affects the growth and metastasis of pancreatic cancer via ADAM8. Pharmacol Rep. 2020;72(2):418–426. doi:10.1007/s43440-019-00015-y32048249
  • Li F, Chen W. Propofol inhibits cell proliferation, migration, and invasion via mir-410-3p/transforming growth factor-β receptor type 2 (TGFBR2) axis in glioma. Med Sci Monit. 2020;26:e919523.31960827
  • Su Z, Liu HL, Qi B, Liu Y. Effects of propofol on proliferation and apoptosis of cardia cancer cells via MAPK/ERK signaling pathway. Eur Rev Med Pharmacol Sci. 2020;24(1):428–433. doi:10.26355/eurrev_202001_1994231957857
  • Zhang YF, Li CS, Zhou Y, Lu XH. Effects of propofol on colon cancer metastasis through STAT3/HOTAIR axis by activating WIF-1 and suppressing Wnt pathway. Cancer Med. 2020;9(5):1842–1854. doi:10.1002/cam4.284031953926
  • Zhang YF, Li CS, Zhou Y, Lu XH. Propofol facilitates cisplatin sensitivity via lncRNA MALAT1/miR-30e/ATG5 axis through suppressing autophagy in gastric cancer. Life Sci. 2020;244:117280. doi:10.1016/j.lfs.2020.11728031926239
  • Chu CN, Wu KC, Chung WS, et al. Etomidate suppresses invasion and migration of human A549 lung adenocarcinoma cells. Anticancer Res. 2019;39(1):215–223. doi:10.21873/anticanres.1310030591461
  • Chen HT, Zhou J, Fan YL, et al. Anesthetic agent etiomidate induces apoptosis in N2a brain tumor cell line. Mol Med Rep. 2018;18(3):3137–3142. doi:10.3892/mmr.2018.929830066945
  • Hu J, Duan W, Liu Y. Ketamine inhibits aerobic glycolysis in colorectal cancer cells by blocking the NMDA receptor-CaMK II-c-Myc pathway. Clin Exp Pharmacol Physiol. 2020;47(5):848–856. doi:10.1111/1440-1681.1324831889340
  • Duan W, Hu J, Liu Y. Ketamine inhibits colorectal cancer cells malignant potential via blockage of NMDA receptor. Exp Mol Pathol. 2019;107:171–178. doi:10.1016/j.yexmp.2019.02.00430817910
  • Grandhi RK, Lee S, Abd-Elsayed A. Does opioid use cause angiogenesis and metastasis? Pain Med. 2017;18(1):140–151. doi:10.1093/pm/pnw13227346886
  • Zhang J, Yao N, Tian S. Morphine stimulates migration and growth and alleviates the effects of chemo drugs via AMPK-dependent induction of epithelial-mesenchymal transition in esophageal carcinoma cells. Biol Pharm Bull. 2020;43(5):774–781. doi:10.1248/bpb.b19-0077932378556
  • Cui JH, Jiang WW, Liao YJ, Wang QH, Xu M, Li Y. Effects of oxycodone on immune function in patients undergoing radical resection of rectal cancer under general anesthesia. Medicine (Baltimore). 2017;96(31):e7519. doi:10.1097/MD.000000000000751928767570
  • Gaspani L, Bianchi M, Limiroli E, Panerai AE, Sacerdote P. The analgesic drug tramadol prevents the effect of surgery on natural killer cell activity and metastatic colonization in rats. J Neuroimmunol. 2002;129(1–2):18–24. doi:10.1016/S0165-5728(02)00165-012161016
  • Wang HW, Wang LY, Jiang L, Tian SM, Zhong TD, Fang XM. Amide-linked local anesthetics induce apoptosis in human non-small cell lung cancer. J Thorac Dis. 2016;8(10):2748–2757. doi:10.21037/jtd.2016.09.6627867550
  • Retsky M, Rogers R, Demicheli R, et al. NSAID analgesic ketorolac used perioperatively may suppress early breast cancer relapse: particular relevance to triple negative subgroup. Breast Cancer Res Treat. 2012;134(2):881–888. doi:10.1007/s10549-012-2094-522622810
  • Chen Y, Wang Q, Li Z, et al. Naproxen platinum(iv) hybrids inhibiting cycloxygenases and matrix metalloproteinases and causing DNA damage: synthesis and biological evaluation as antitumor agents in vitro and in vivo. Dalton Trans. 2020;49(16):5192–5204. doi:10.1039/D0DT00424C32236281
  • Zhang W, Sheng B, Chen S, et al. Sevoflurane enhances proliferation, metastatic potential of cervical cancer cells via the histone deacetylase 6 modulation in vitro. Anesthesiology. 2020;132(6):1469–1481. doi:10.1097/ALN.000000000000312932412720
  • Han XC, Zhang YJ, Dong X, Xing QZ, Li KH, Zhang L. Sevoflurane modulates the cancer stem cell-like properties and mitochondrial membrane potential of glioma via Ca(2+)-dependent CaMKII/JNK cascade. Life Sci. 2020;253:117675. doi:10.1016/j.lfs.2020.11767532360621
  • Kang K, Wang Y. Sevoflurane inhibits proliferation and invasion of human ovarian cancer cells by regulating JNK and p38 MAPK signaling pathway. Drug Des Devel Ther. 2019;13:4451–4460. doi:10.2147/DDDT.S223581
  • Li R, Huang Y, Lin J. Distinct effects of general anesthetics on lung metastasis mediated by IL-6/JAK/STAT3 pathway in mouse models. Nat Commun. 2020;11(1):642. doi:10.1038/s41467-019-14065-632005799
  • Zhang C, Wang B, Wang X, Sheng X, Cui Y. Sevoflurane inhibits the progression of ovarian cancer through down-regulating stanniocalcin 1 (STC1). Cancer Cell Int. 2019;19:339. doi:10.1186/s12935-019-1062-031889892
  • Xue F, Xu Y, Song Y, Zhang W, Li R, Zhu X. The effects of sevoflurane on the progression and cisplatinum sensitivity of cervical cancer cells. Drug Des Devel Ther. 2019;13:3919–3928. doi:10.2147/DDDT.S219788
  • Chen M, Zhou L, Liao Z, et al. Sevoflurane inhibited osteosarcoma cell proliferation and invasion via targeting miR-203/WNT2B/Wnt/β-catenin axis. Cancer Manag Res. 2019;11:9505–9515. doi:10.2147/CMAR.S22591131814757
  • Hu J, Jiao H, Li Q, Li Q. Anesthetic effects of isoflurane and the molecular mechanism underlying isoflurane‑inhibited aggressiveness of hepatic carcinoma. Mol Med Rep. 2018;18(1):184–192. doi:10.3892/mmr.2018.894529749446
  • Elias KM, Kang S, Liu X, Horowitz NS, Berkowitz RS, Frendl G. Anesthetic selection and disease-free survival following optimal primary cytoreductive surgery for stage III epithelial ovarian cancer. Ann Surg Oncol. 2015;22(4):1341–1348. doi:10.1245/s10434-014-4112-925287437
  • Hurmath FK, Mittal M, Ramaswamy P, Umamaheswara Rao GS, Dalavaikodihalli Nanjaiah N. Sevoflurane and thiopental preconditioning attenuates the migration and activity of MMP-2 in U87MG glioma cells. Neurochem Int. 2016;94:32–38. doi:10.1016/j.neuint.2016.02.00326875426
  • Bundscherer AC, Ullrich V, Malsy M, et al. Effects of volatile anesthetics on proliferation and viability of SW480 colon cancer cells in vitro. Anticancer Res. 2019;39(11):6049–6055. doi:10.21873/anticanres.1381131704831
  • Cata JP, Keerty V, Keerty D, et al. A retrospective analysis of the effect of intraoperative opioid dose on cancer recurrence after non-small cell lung cancer resection. Cancer Med. 2014;3(4):900–908. doi:10.1002/cam4.23624692226
  • Zhu J, Han S. Lidocaine inhibits cervical cancer cell proliferation and induces cell apoptosis by modulating the lncRNA-MEG3/miR-421/BTG1 pathway. Am J Transl Res. 2019;11(9):5404–5416.31632519
  • Wall TP, Crowley PD, Sherwin A, Foley AG, Buggy DJ. Effects of lidocaine and src inhibition on metastasis in a murine model of breast cancer surgery. Cancers (Basel). 2019;11(10):1414. doi:10.3390/cancers11101414
  • Sun H, Sun Y. Lidocaine inhibits proliferation and metastasis of lung cancer cell via regulation of miR-539/EGFR axis. Artif Cells Nanomed Biotechnol. 2019;47(1):2866–2874. doi:10.1080/21691401.2019.163680731299862
  • Dong Q, Mao Z. The local anaesthetic lignocaine exhibits potent antilung cancer cell activity by inhibiting the phosphoinositide 3-kinases/mammalian target of rapamycin/mammalian target of rapamycin pathway. Pharmacology. 2019;104(3–4):139–146. doi:10.1159/00050074331203272
  • Xia W, Wang L, Yu D, Mu X, Zhou X. Lidocaine inhibits the progression of retinoblastoma in vitro and in vivo by modulating the miR‑520a‑3p/EGFR axis. Mol Med Rep. 2019;20(2):1333–1342. doi:10.3892/mmr.2019.1036331173241
  • Ye L, Zhang Y, Chen YJ, Liu Q. Anti-tumor effects of lidocaine on human gastric cancer cells in vitro. Bratisl Lek Listy. 2019;120(3):212–217. doi:10.4149/BLL_2019_03631023040
  • Xing W, Chen DT, Pan JH, et al. Lidocaine induces apoptosis and suppresses tumor growth in human hepatocellular carcinoma cells in vitro and in a xenograft model in vivo. Anesthesiology. 2017;126(5):868–881. doi:10.1097/ALN.000000000000152828121635
  • Zhu Q, Zhu G, Xu W, Dan J, Xia R, Liu W. Bupivacaine inhibits angiogenesis through oxidative stress-dependent inhibition of Akt/mTOR and activation of AMPK. Fundam Clin Pharmacol. 2020. doi:10.1111/fcp.12554
  • Zhang H, Lin J, Hu T, Ren Z, Wang W, He Q. Effect of miR-132 on bupivacaine-induced neurotoxicity in human neuroblastoma cell line. J Pharmacol Sci. 2019;139(3):186–192. doi:10.1016/j.jphs.2019.01.01430850243
  • Xuan W, Zhao H, Hankin J, Chen L, Yao S, Ma D. Local anesthetic bupivacaine induced ovarian and prostate cancer apoptotic cell death and underlying mechanisms in vitro. Sci Rep. 2016;6:26277. doi:10.1038/srep2627727195613
  • Li YC, Wang Y, Li DD, Zhang Y, Zhao TC, Li CF. Procaine is a specific DNA methylation inhibitor with anti-tumor effect for human gastric cancer. J Cell Biochem. 2018;119(2):2440–2449. doi:10.1002/jcb.2640728926119
  • Li C, Gao S, Li X, Ma L, Ma L. Procaine inhibits the proliferation and migration of colon cancer cells through inactivation of the ERK/MAPK/FAK pathways by regulation of RhoA. Oncol Res. 2018;26(2):209–217. doi:10.3727/096504017X1494458587362228492141
  • Ying B, Huang H, Li H, Song M, Wu S, Ying H. Procaine inhibits proliferation and migration and promotes cell apoptosis in osteosarcoma cells by upregulation of microRNA-133b. Oncol Res. 2017;25(9):1463–1470. doi:10.3727/096504017X1487851829107728251881
  • Ma Y, Ren Z, Ma S, et al. Morphine enhances renal cell carcinoma aggressiveness through promotes survivin level. Ren Fail. 2017;39(1):258–264. doi:10.1080/0886022X.2016.125632227866460
  • Li T, Chen L, Zhao H, et al. Both Bupivacaine and Levobupivacaine inhibit colon cancer cell growth but not melanoma cells in vitro. J Anesth. 2019;33(1):17–25. doi:10.1007/s00540-018-2577-630426213
  • Malsy M, Graf B, Bundscherer A. The effects of analgesics and local anesthetics on gene transcription mediated by NFATc2 and Sp1 in pancreatic carcinoma. Anticancer Res. 2019;39(9):4721–4728. doi:10.21873/anticanres.1365431519571
  • Wang HL, Yan HD, Liu YY, et al. Intraoperative intravenous lidocaine exerts a protective effect on cell-mediated immunity in patients undergoing radical hysterectomy. Mol Med Rep. 2015;12(5):7039–7044. doi:10.3892/mmr.2015.423526299324
  • Piegeler T, Votta-Velis EG, Liu G, et al. Antimetastatic potential of amide-linked local anesthetics: inhibition of lung adenocarcinoma cell migration and inflammatory Src signaling independent of sodium channel blockade. Anesthesiology. 2012;117(3):548–559. doi:10.1097/ALN.0b013e318266197722846676
  • Li R, Xiao C, Liu H, Huang Y, Dilger JP, Lin J. Effects of local anesthetics on breast cancer cell viability and migration. BMC Cancer. 2018;18(1):666. doi:10.1186/s12885-018-4576-229914426