Baohuoside I via mTOR Apoptotic Signaling to Inhibit Glioma Cell Growth

References

• Korshunov A, Okonechnikov K, Sahm F, et al. Transcriptional profiling of medulloblastoma with extensive nodularity (MBEN) reveals two clinically relevant tumor subsets with VSNL1 as potent prognostic marker. Acta Neuropathol. 2020;139:583–596.31781912
   PubMed Web of Science ®Google Scholar
• Tinkle CL, Simone B, Chiang J, et al. Defining optimal target volumes of conformal radiation therapy for diffuse intrinsic pontine glioma. Int J Radiat Oncol Biol Phys. 2020;106:838–847. doi:10.1016/j.ijrobp.2019.11.02031785339
   PubMed Web of Science ®Google Scholar
• Unsgård G, Lindseth F. 3D ultrasound-guided resection of low-grade gliomas: principles and clinical examples. Neurosurg Focus. 2019;47:E9. doi:10.3171/2019.9.FOCUS19605
   PubMed Web of Science ®Google Scholar
• Liu HW, Lee PM, Bamodu OA, et al. Enhanced Hsa-miR-181d/p-STAT3 and Hsa-miR-181d/p-STAT5A ratios mediate the anticancer effect of garcinol in -addicted glioblastoma. Cancers. 2019;11:1888. doi:10.3390/cancers11121888
   PubMed Web of Science ®Google Scholar
• Yan H, Song J, Jia X, Zhang Z, et al. Hyaluronic acid-modified didecyldimethylammonium bromide/ d-a-tocopheryl polyethylene glycol succinate mixed micelles for delivery of baohuoside I against non-small cell lung cancer: in vitro and in vivo evaluation. Drug Deliv. 2017;24:30–39. doi:10.1080/10717544.2016.122871328155337
   PubMed Web of Science ®Google Scholar
• Yan H-M, Zhang Z, Jia X, Song J. D-α-Tocopheryl polyethylene glycol succinate/Solutol HS 15 mixed micelles for the delivery of baohuoside I against non-small-cell lung cancer: optimization and in vitro, in vivo evaluation. Int J Nanomedicine. 2016;11:4563–4571. doi:10.2147/IJN.S11220427660448
   PubMed Web of Science ®Google Scholar
• Yan H-M, Song J, Zhang Z-H, Jia X-B, et al. Optimization and anticancer activity in vitro and in vivo of baohuoside I incorporated into mixed micelles based on lecithin and Solutol HS 15. Drug Deliv. 2016;23:2911–2918. doi:10.3109/10717544.2015.112036526644047
   PubMed Web of Science ®Google Scholar
• Peng Y-G, Zhang L. Baohuoside-I suppresses cell proliferation and migration by up-regulating miR-144 in melanoma. Pharm Biol. 2018;56:43–50. doi:10.1080/13880209.2017.141839129260980
   PubMed Web of Science ®Google Scholar
• Huang L, Xu W, Yan D, et al. Genetic predisposition to glioma mediated by a MAPKAP1 enhancer variant. Cell Mol Neurobiol. 2020;40:643–652. doi:10.1007/s10571-019-00763-831773361
   PubMed Web of Science ®Google Scholar
• Guo Y, Zhu H, Weng M, Wang C, Sun L. Chemopreventive effect of Betulinic acid via mTOR -Caspases/Bcl2/Bax apoptotic signaling in pancreatic cancer. BMC Complement Med Ther. 2020;20:1–11. doi:10.1186/s12906-020-02976-732020859
   PubMedGoogle Scholar
• Paulus W. GFAP, Ki67 and IDH1: perhaps the golden triad of glioma immunohistochemistry. Acta Neuropathol. 2009;118:603–604. doi:10.1007/s00401-009-0600-619847448
   PubMed Web of Science ®Google Scholar
• Zhang W, Yang Y, Li X, et al. Angelica polysaccharides inhibit the growth and promote the apoptosis of U251 glioma cells in vitro and in vivo. Phytomedicine. 2017;33:21–27. doi:10.1016/j.phymed.2017.06.00728887916
   PubMed Web of Science ®Google Scholar
• Chi G, Xu D, Zhang B, Yang F. Matrine induces apoptosis and autophagy of glioma cell line U251 by regulation of circRNA-104075/BCL-9. Chem Biol Interact. 2019;308:198–205. doi:10.1016/j.cbi.2019.05.03031112718
   PubMed Web of Science ®Google Scholar
• Modrek AS, Bayin NS, Placantonakis DG. Brain stem cells as the cell of origin in glioma. World J Stem Cells. 2014;6:43–52. doi:10.4252/wjsc.v6.i1.4324567787
   PubMedGoogle Scholar
• Lin L, Wang G, Ming J, et al. Analysis of expression and prognostic significance of vimentin and the response to temozolomide in glioma patients. Tumour Biol. 2016;37:15333–15339. doi:10.1007/s13277-016-5462-727704357
   PubMedGoogle Scholar
• Ming J, Sun B, Li Z, et al. Aspirin inhibits the SHH/GLI1 signaling pathway and sensitizes malignant glioma cells to temozolomide therapy. Aging. 2017;9:1233–1247. doi:10.18632/aging.10122428446712
   PubMedGoogle Scholar
• Li L, Wu P, Wang Z, et al. NoncoRNA: a database of experimentally supported non-coding RNAs and drug targets in cancer. J Hematol Oncol. 2020;13:15. doi:10.1186/s13045-020-00849-732111231
   PubMed Web of Science ®Google Scholar
• Chen R, Smith-Cohn M, Cohen AL, Colman H. Glioma subclassifications and their clinical significance. Neurotherapeutics. 2017;14:284–297. doi:10.1007/s13311-017-0519-x28281173
   PubMed Web of Science ®Google Scholar
• Faje AT, Nachtigall L, Wexler D, Miller KK, Klibanski A, Makimura H. Central diabetes insipidus: a previously unreported side effect of temozolomide. J Clin Endocrinol Metab. 2013;98:3926–3931. doi:10.1210/jc.2013-243523928668
   PubMed Web of Science ®Google Scholar
• Elmore S. Apoptosis: a review of programmed cell death. Toxicol Pathol. 2007;35:495–516. doi:10.1080/0192623070132033717562483
   PubMed Web of Science ®Google Scholar
• Ouyang L, Shi Z, Zhao S. Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis. Cell Prolif. 2012;45:487–498. doi:10.1111/j.1365-2184.2012.00845.x23030059
   PubMed Web of Science ®Google Scholar
• Wu K-J, Huang J-M, Zhong H-J. A natural product-like JAK2/STAT3 inhibitor induces apoptosis of malignant melanoma cells. PLoS One. 2017;12:e0177123. doi:10.1371/journal.pone.017712328570563
   PubMed Web of Science ®Google Scholar
• Li JL, Liu XL, Guo SF, et al. Long noncoding RNA UCA1 regulates proliferation and apoptosis in multiple myeloma by targeting miR-331-3p/IL6R axis for the activation of JAK2/STAT3 pathway. Eur Rev Med Pharmacol Sci. 2019;23:9238–9250.31773675
   PubMed Web of Science ®Google Scholar
• Wang Y, Hu Z, Liu Z, et al. MTOR inhibition attenuates DNA damage and apoptosis through autophagy-mediated suppression of CREB1. Autophagy. 2013;9:2069–2086. doi:10.4161/auto.2644724189100
   PubMed Web of Science ®Google Scholar
• Liu H, Dai C, Fan Y, et al. From autophagy to mitophagy: the roles of P62 in neurodegenerative diseases. J Bioenerg Biomembr. 2017;49:413–422. doi:10.1007/s10863-017-9727-728975445
   PubMed Web of Science ®Google Scholar
• Tian S, Jin S, Wu Y, et al. High-throughput screening of functional deubiquitinating enzymes in autophagy. Autophagy. 2020;1–12.
   PubMed Web of Science ®Google Scholar
• Li W, Liu J. Overexpression of the zinc-α2-glycoprotein accelerates apoptosis and inhibits growth via the mTOR/PTEN signaling pathway in gastric carcinoma cells. Life Sci. 2020;240:117117. doi:10.1016/j.lfs.2019.11711731790689
   PubMed Web of Science ®Google Scholar
• Liu W, Wang X, Liu Z, et al. SGK1 inhibition induces autophagy-dependent apoptosis via the mTOR-Foxo3a pathway. Br J Cancer. 2017;117:1139–1153. doi:10.1038/bjc.2017.29329017179
   PubMed Web of Science ®Google Scholar
• Xi Y, Jiang T, Yu J, et al. Preliminary studies on the anti-osteoporosis activity of Baohuoside I. Biomed Pharmacother. 2019;115:108850. doi:10.1016/j.biopha.2019.10885031004988
   PubMed Web of Science ®Google Scholar