262
Views
6
CrossRef citations to date
0
Altmetric
Original Research

KLF16 Downregulates the Expression of Tumor Suppressor Gene TGFBR3 to Promote Bladder Cancer Proliferation and Migration

, , ORCID Icon &
Pages 465-477 | Published online: 09 Feb 2022

References

  • Antoni S, Ferlay J, Soerjomataram I, Znaor A, Jemal A, Bray F. Bladder cancer incidence and mortality: a global overview and recent trends. Eur Urol. 2017;71(1):96–108. doi:10.1016/j.eururo.2016.06.010
  • Kamat A, Hahn N, Efstathiou J, et al. Bladder cancer. Lancet. 2016;388(10061):2796–2810. doi:10.1016/S0140-6736(16)30512-8
  • Siegel R, Miller K, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69(1):7–34. doi:10.3322/caac.21551
  • Chen W, Zheng R, Baade P, et al. Cancer statistics in China, 2015. CA Cancer J Clin. 2016;66(2):115–132. doi:10.3322/caac.21338
  • Ashrafizadeh M, Hushmandi K, Hashemi M, et al. Role of microRNA/epithelial-to-mesenchymal transition axis in the metastasis of bladder cancer. Biomolecules. 2020;10(8):8. doi:10.3390/biom10081159
  • Mirzaei S, Gholami MH, Mahabady MK, et al. Pre-clinical investigation of STAT3 pathway in bladder cancer: paving the way for clinical translation. Biomed Pharmacother. 2021;133:111077.
  • Ashrafizadeh M, Yaribeygi H, Sahebkar A. Therapeutic effects of curcumin against bladder cancer: a review of possible molecular pathways. Anticancer Agents Med Chem. 2020;20(6):667–677. doi:10.2174/1871520620666200203143803
  • Mirzaei S, Paskeh MDA, Hashemi F, et al. Long non-coding RNAs as new players in bladder cancer: lessons from pre-clinical and clinical studies. Life Sci. 2021;288:119948. doi:10.1016/j.lfs.2021.119948
  • Ashrafizadeh M, Zarrabi A, Samarghandian S, Najafi M. PTEN: what we know of the function and regulation of this onco-suppressor factor in bladder cancer? Eur J Pharmacol. 2020;881:173226. doi:10.1016/j.ejphar.2020.173226
  • Zhu B, Liu Q, Han Q, Zeng B, Chen J, Xiao Q. Downregulation of Krüppel‑like factor 1 inhibits the metastasis and invasion of cervical cancer cells. Mol Med Rep. 2018;18(4):3932–3940.
  • Wang R, Xu J, Xu J, et al. MiR-326/Sp1/KLF3: a novel regulatory axis in lung cancer progression. Cell Prolif. 2019;52(2):e12551. doi:10.1111/cpr.12551
  • Ma P, Sun C, Wang Y, et al. KLF16 promotes proliferation in gastric cancer cells via regulating p21 and CDK4. Am J Transl Res. 2017;9(6):3027–3036.
  • Chen X, Li S, Ke Y, et al. KLF16 suppresses human glioma cell proliferation and tumourigenicity by targeting TFAM. Artif Cells Nanomed Biotechnol. 2018;46(sup1):608–615. doi:10.1080/21691401.2018.1431654
  • Liang K, Liu T, Chu N, et al. KLF8 is required for bladder cancer cell proliferation and migration. Biotechnol Appl Biochem. 2015;62(5):628–633. doi:10.1002/bab.1310
  • Ohnishi S, Ohnami S, Laub F, et al. Downregulation and growth inhibitory effect of epithelial-type Krüppel-like transcription factor KLF4, but not KLF5, in bladder cancer. Biochem Biophys Res Commun. 2003;308(2):251–256. doi:10.1016/S0006-291X(03)01356-1
  • Yang H, Li G, Cheng B, Jiang R. ZFAS1 functions as an oncogenic long non-coding RNA in bladder cancer. Biosci Rep. 2018;38(3):3. doi:10.1042/BSR20180475
  • He Q, Yan D, Dong W, et al. circRNA circFUT8 upregulates Krüpple-like factor 10 to inhibit the metastasis of bladder cancer via sponging miR-570-3p. Mol Ther Oncolytics. 2020;16:172–187. doi:10.1016/j.omto.2019.12.014
  • Chandrashekar DS, Bashel B, Balasubramanya SAH, et al. UALCAN: a portal for facilitating tumor subgroup gene expression and survival analyses. Neoplasia. 2017;19(8):649–658. doi:10.1016/j.neo.2017.05.002
  • Chen X, Wang P, Wang S, Li J, Ou T, Zeng X. CIZ1 knockdown suppresses the proliferation of bladder cancer cells by inducing apoptosis. Gene. 2019;719:143946. doi:10.1016/j.gene.2019.143946
  • Kim C, He P, Bialkowska A, Yang V. SP and KLF transcription factors in digestive physiology and diseases. Gastroenterology. 2017;152(8):1845–1875. doi:10.1053/j.gastro.2017.03.035
  • Kaczynski J, Cook T, Urrutia R. Sp1- and Krüppel-like transcription factors. Genome Biol. 2003;4(2):206. doi:10.1186/gb-2003-4-2-206
  • Zhang J, Yu W, Wang X, Hu B, Wu D, Shi G. KLF16 affects the MYC signature and tumor growth in prostate cancer. Onco Targets Ther. 2020;13:1303–1310. doi:10.2147/OTT.S233495
  • Zhang J, Yan X, Wu S, Liu Q, Ma J. KLF16 overexpression deleteriously affects the proliferation and migration of retinoblastoma by transcriptionally repressing BCL2L15. Biochem Biophys Res Commun. 2020;529(4):977–983. doi:10.1016/j.bbrc.2020.06.027
  • Bang S, Li J, Zhang M, et al. The clinical relevance and function of Krüppel-like factor 16 in breast cancer. Cancer Manag Res. 2020;12:6373–6383. doi:10.2147/CMAR.S256490
  • Fang W, Kuo Y, Chang J, et al. The tumor suppressor TGFBR3 blocks lymph node metastasis in head and neck cancer. Cancers. 2020;12(6):1375. doi:10.3390/cancers12061375
  • Huang JJ, Corona AL, Dunn BP, Cai EM, Prakken JN, Blobe GC. Increased type III TGF-β receptor shedding decreases tumorigenesis through induction of epithelial-to-mesenchymal transition. Oncogene. 2019;38(18):3402–3414. doi:10.1038/s41388-018-0672-7
  • Nishida J, Miyazono K, Ehata S. Decreased TGFBR3/betaglycan expression enhances the metastatic abilities of renal cell carcinoma cells through TGF-β-dependent and -independent mechanisms. Oncogene. 2018;37(16):2197–2212. doi:10.1038/s41388-017-0084-0
  • Li D, Liu K, Li Z, Wang J, Wang X. miR-19a and miR-424 target TGFBR3 to promote epithelial-to-mesenchymal transition and migration of tongue squamous cell carcinoma cells. Cell Adh Migr. 2018;12(3):236–246. doi:10.1080/19336918.2017.1365992
  • Zhang S, Sun W, Wu J, Gu Y, Wei W. Decreased expression of the type III TGF-β receptor enhances metastasis and invasion in hepatocellullar carcinoma progression. Oncol Rep. 2016;35(4):2373–2381. doi:10.3892/or.2016.4615