References
- Siegel RL, Miller KD, Jemal A. Cancer statistics. CA Cancer J Clin. 2019;69(1):7–34. doi:10.3322/caac.21551
- Lukacs B, Cornu JN, Aout M, et al. Management of lower urinary tract symptoms related to benign prostatic hyperplasia in real-life practice in France: a comprehensive population study. Eur Urol. 2013;64(3):493–501. doi:10.1016/j.eururo.2013.02.026
- Califf RM. Biomarker definitions and their applications. Exp Biol Med. 2018;243(3):213–221. doi:10.1177/1535370217750088
- Ganepola GA, Nizin J, Rutledge JR, Chang DH. Use of blood-based biomarkers for early diagnosis and surveillance of colorectal cancer. World J Gastrointest Oncol. 2014;6(4):83–97. doi:10.4251/wjgo.v6.i4.83
- Bayci AWL, Baker DA, Somerset AE, et al. Metabolomic identification of diagnostic serum-based biomarkers for advanced stage melanoma. Metabolomics. 2018;14(8):105. doi:10.1007/s11306-018-1398-9
- Yang W, Mu T, Jiang J, et al. Identification of potential biomarkers and metabolic profiling of serum in ovarian cancer patients using UPLC/Q-TOF MS. Cell Physiol Biochem. 2018;51(3):1134–1148. doi:10.1159/000495492
- Yu J, Zhai X, Li X, et al. Identification of MST1 as a potential early detection biomarker for colorectal cancer through a proteomic approach. Sci Rep. 2017;7(1):14265. doi:10.1038/s41598-017-14539-x
- Fan NJ, Chen HM, Song W, et al. Macrophage mannose receptor 1 and S100A9 were identified as serum diagnostic biomarkers for colorectal cancer through a label-free quantitative proteomic analysis. Cancer Biomark. 2016;16(2):235–243. doi:10.3233/CBM-150560
- Michonneau D, Latis E, Curis E, et al. Metabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites. Nat Commun. 2019;10(1):5695. doi:10.1038/s41467-019-13498-3
- Jaurila H, Koivukangas V, Koskela M, et al. (1)H NMR based metabolomics in human sepsis and healthy serum. Metabolites. 2020;10(2):70. doi:10.3390/metabo10020070
- Wojtowicz W, Zabek A, Deja S, et al. Serum and urine (1)H NMR-based metabolomics in the diagnosis of selected thyroid diseases. Sci Rep. 2017;7(1):9108. doi:10.1038/s41598-017-09203-3
- Trilla-Fuertes L, Gamez-Pozo A, Lopez-Camacho E, et al. Computational models applied to metabolomics data hints at the relevance of glutamine metabolism in breast cancer. BMC Cancer. 2020;20(1):307. doi:10.1186/s12885-020-06764-x
- Peng B, Li H, Peng XX. Functional metabolomics: from biomarker discovery to metabolome reprogramming. Protein Cell. 2015;6(9):628–637. doi:10.1007/s13238-015-0185-x
- Denkert C, Bucher E, Hilvo M, et al. Metabolomics of human breast cancer: new approaches for tumor typing and biomarker discovery. Genome Med. 2012;4(4):37. doi:10.1186/gm336
- Kouril K, Kourilova H, Bartram S, Levitt MH, Meier B. Scalable dissolution-dynamic nuclear polarization with rapid transfer of a polarized solid. Nat Commun. 2019;10(1):1733. doi:10.1038/s41467-019-09726-5
- Kehayias P, Jarmola A, Mosavian N, et al. Solution nuclear magnetic resonance spectroscopy on a nanostructured diamond chip. Nat Commun. 2017;8(1):188. doi:10.1038/s41467-017-00266-4
- Yang B, Liao GQ, Wen XF, et al. Nuclear magnetic resonance spectroscopy as a new approach for improvement of early diagnosis and risk stratification of prostate cancer. J Zhejiang Univ Sci B. 2017;18(11):921–933. doi:10.1631/jzus.B1600441
- Ahmed N, Kidane B, Wang L, et al. Non-invasive exploration of metabolic profile of lung cancer with magnetic resonance spectroscopy and mass spectrometry. Contemp Clin Trials Commun. 2019;16:100445. doi:10.1016/j.conctc.2019.100445
- Deja S, Porebska I, Kowal A, et al. Metabolomics provide new insights on lung cancer staging and discrimination from chronic obstructive pulmonary disease. J Pharm Biomed Anal. 2014;100:369–380. doi:10.1016/j.jpba.2014.08.020
- Sant’Anna-Silva ACB, Santos GC, Campos SPC, Oliveira Gomes AM, Perez-Valencia JA, Rumjanek FD. Metabolic profile of oral squamous carcinoma cell lines relies on a higher demand of lipid metabolism in metastatic cells. Front Oncol. 2018;8:13. doi:10.3389/fonc.2018.00013
- Gupta A, Gupta S, Mahdi AA. (1)H NMR-derived serum metabolomics of leukoplakia and squamous cell carcinoma. Clin Chim Acta. 2015;441:47–55. doi:10.1016/j.cca.2014.12.003
- Wang H, Zhang H, Deng P, et al. Tissue metabolic profiling of human gastric cancer assessed by (1)H NMR. BMC Cancer. 2016;16(1):371. doi:10.1186/s12885-016-2356-4
- Chan AW, Mercier P, Schiller D, et al. (1)H-NMR urinary metabolomic profiling for diagnosis of gastric cancer. Br J cancer. 2016;114(1):59–62. doi:10.1038/bjc.2015.414
- Carrola J, Rocha CM, Barros AS, et al. Metabolic signatures of lung cancer in biofluids: NMR-based metabonomics of urine. J Proteome Res. 2011;10(1):221–230. doi:10.1021/pr100899x
- Li Y, Wang C, Li D, et al. 1H-NMR-based metabolic profiling of a colorectal cancer CT-26 lung metastasis model in mice. Oncol Rep. 2017;38:3044–3054.
- Farshidfar F, Weljie AM, Kopciuk K, et al. Serum metabolomic profile as a means to distinguish stage of colorectal cancer. Genome Med. 2012;4(5):42. doi:10.1186/gm341
- Zhang Y, Du Y, Song Z, et al. Profiling of serum metabolites in advanced colon cancer using liquid chromatography-mass spectrometry. Oncol Lett. 2020;19(6):4002–4010. doi:10.3892/ol.2020.11510
- Lu J, Tan M, Cai Q. The Warburg effect in tumor progression: mitochondrial oxidative metabolism as an anti-metastasis mechanism. Cancer Lett. 2015;356(2):156–164. doi:10.1016/j.canlet.2014.04.001
- Beckers A, Organe S, Timmermans L, et al. Chemical inhibition of acetyl-CoA carboxylase induces growth arrest and cytotoxicity selectively in cancer cells. Cancer Res. 2007;67(17):8180–8187. doi:10.1158/0008-5472.CAN-07-0389
- Yang J, Ren B, Yang G, et al. The enhancement of glycolysis regulates pancreatic cancer metastasis. Cell Mol Life Sci. 2020;77(2):305–321. doi:10.1007/s00018-019-03278-z
- Hirschhaeuser F, Sattler UG, Mueller-Klieser W. Lactate: a metabolic key player in cancer. Cancer Res. 2011;71(22):6921–6925. doi:10.1158/0008-5472.CAN-11-1457
- Goetze K, Walenta S, Ksiazkiewicz M, Kunz-Schughart LA, Mueller-Klieser W. Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release. Int J Oncol. 2011;39(2):453–463. doi:10.3892/ijo.2011.1055
- Halestrap AP. The monocarboxylate transporter family–Structure and functional characterization. IUBMB Life. 2012;64:1–9. doi:10.1002/iub.573
- Payen VL, Mina E, Van Hee VF, Porporato PE, Sonveaux P. Monocarboxylate transporters in cancer. Mol Metab. 2020;33:48–66. doi:10.1016/j.molmet.2019.07.006
- Martins SF, Amorim R, Viana-Pereira M, et al. Significance of glycolytic metabolism-related protein expression in colorectal cancer, lymph node and hepatic metastasis. BMC Cancer. 2016;16(1):535. doi:10.1186/s12885-016-2566-9
- Tasdogan A, Faubert B, Ramesh V, et al. Metabolic heterogeneity confers differences in melanoma metastatic potential. Nature. 2020;577(7788):115–120. doi:10.1038/s41586-019-1847-2
- Zheng H, Ji J, Zhao L, et al. Prediction and diagnosis of renal cell carcinoma using nuclear magnetic resonance-based serum metabolomics and self-organizing maps. Oncotarget. 2016;7(37):59189–59198. doi:10.18632/oncotarget.10830
- Luo X, Liu J, Wang H, Lu H. Metabolomics identified new biomarkers for the precise diagnosis of pancreatic cancer and associated tissue metastasis. Pharmacol Res. 2020;156:104805. doi:10.1016/j.phrs.2020.104805
- Mashimo T, Pichumani K, Vemireddy V, et al. Acetate is a bioenergetic substrate for human glioblastoma and brain metastases. Cell. 2014;159(1603–1614):1603–1614. doi:10.1016/j.cell.2014.11.025
- Sullivan WJ, Christofk HR. The metabolic milieu of metastases. Cell. 2015;160(3):363–364. doi:10.1016/j.cell.2015.01.023
- Bacci M, Lorito N, Ippolito L, et al. Reprogramming of amino acid transporters to support aspartate and glutamate dependency sustains endocrine resistance in breast cancer. Cell Rep. 2019;28(1):104–118 e108. doi:10.1016/j.celrep.2019.06.010
- Xiang L, Mou J, Shao B, et al. Glutaminase 1 expression in colorectal cancer cells is induced by hypoxia and required for tumor growth, invasion, and metastatic colonization. Cell Death Dis. 2019;10(2):40. doi:10.1038/s41419-018-1291-5
- Lange F, Wesslau K, Porath K, et al. AMPA receptor antagonist perampanel affects glioblastoma cell growth and glutamate release in vitro. PLoS One. 2019;14(2):e0211644. doi:10.1371/journal.pone.0211644
- Sun J, Nagel R, Zaal EA, et al. SLC 1A3 contributes to L-asparaginase resistance in solid tumors. EMBO J. 2019;38(21):e102147. doi:10.15252/embj.2019102147
- Paget S. The distribution of secondary growths in cancer of the breast. 1889. Cancer Metastasis Rev. 1989;8(2):98–101.
- Harmon C, Robinson MW, Hand F, et al. Lactate-mediated acidification of tumor microenvironment induces apoptosis of liver-resident NK cells in colorectal liver metastasis. Cancer Immunol Res. 2019;7(2):335–346. doi:10.1158/2326-6066.CIR-18-0481
- Takeuchi H, Tanaka M, Tanaka A, Tsunemi A, Yamamoto H. Predominance of M2-polarized macrophages in bladder cancer affects angiogenesis, tumor grade and invasiveness. Oncol Lett. 2016;11(5):3403–3408. doi:10.3892/ol.2016.4392
- Mehla K, Singh PK. Metabolic regulation of macrophage polarization in cancer. Trends Cancer. 2019;5:822–834. doi:10.1016/j.trecan.2019.10.007
- Liu N, Luo J, Kuang D, et al. Lactate inhibits ATP6V0d2 expression in tumor-associated macrophages to promote HIF-2alpha-mediated tumor progression. J Clin Invest. 2019;129(2):631–646. doi:10.1172/JCI123027