Technological Advancements in External Beam Radiation Therapy (EBRT): An Indispensable Tool for Cancer Treatment

References

• Baskar R, Lee KA, Yeo R, Yeoh KW. Cancer and Radiation Therapy: current Advances and Future Directions. Int J Med Sci. 2012;9(3):193–199. doi:10.7150/ijms.3635
   PubMed Web of Science ®Google Scholar
• Orth M, Lauber K, Niyazi M, et al. Current concepts in clinical radiation oncology. Radiat Environ Biophys. 2014;53(1):1–29. doi:10.1007/s00411-013-0497-2
   PubMed Web of Science ®Google Scholar
• Barnett GC, West CML, Dunning AM, et al. Normal tissue reactions to radiotherapy. Nat Rev Cancer. 2009;9(2):134–142. doi:10.1038/nrc2587
   PubMed Web of Science ®Google Scholar
• Prasanna PGS, Stone HB, Wong RS, et al. Normal tissue protection for improving radiotherapy: where are the Gaps? Transl Cancer Res. 2012;1(1). doi:10.21037/372
   PubMed Web of Science ®Google Scholar
• Lee TF, Yang J, Huang EY, Lee CC, Chan MF, Liu A. Technical Advancement of Radiation Therapy. Biomed Res Int. 2014;2014:e797412. doi:10.1155/2014/797412
   PubMed Web of Science ®Google Scholar
• Garibaldi C, Jereczek-Fossa BA, Marvaso G, et al. Recent advances in radiation oncology. Ecancermedicalscience. 2017;11:785. doi:10.3332/ecancer.2017.785
   PubMed Web of Science ®Google Scholar
• Tseng M, Ho F, Leong YH, et al. Emerging radiotherapy technologies and trends in nasopharyngeal cancer. Cancer Commun. 2020;40(9):395–405. doi:10.1002/cac2.12082
   Web of Science ®Google Scholar
• Shirato H, Le QT, Kobashi K, et al. Selection of external beam radiotherapy approaches for precise and accurate cancer treatment. J Radiat Res. 2018;59(Suppl 1):i2–i10. doi:10.1093/jrr/rrx092
   PubMed Web of Science ®Google Scholar
• Tam S, Amit M, Boonsripitayanon M, et al. Adjuvant External Beam Radiotherapy in Locally Advanced Differentiated Thyroid Cancer. JAMA Otolaryngol Head Neck Surg. 2017;143(12):1244–1251. doi:10.1001/jamaoto.2017.2077
   PubMed Web of Science ®Google Scholar
• Mladenov E, Magin S, Soni A, Iliakis G, Double-Strand Break DNA. Repair as Determinant of Cellular Radiosensitivity to Killing and Target in Radiation Therapy. Front Oncol. 2013;3:113. doi:10.3389/fonc.2013.00113
   PubMedGoogle Scholar
• Suman S, Kumar S, Moon BH, et al. Relative Biological Effectiveness of Energetic Heavy Ions for Intestinal Tumorigenesis Shows Male Preponderance and Radiation Type and Energy Dependence in APC1638N/+ Mice. Int J Radiation Oncol. 2016;95(1):131–138. doi:10.1016/j.ijrobp.2015.10.057
   Web of Science ®Google Scholar
• Vignard J, Mirey G, Salles B. Ionizing-radiation induced DNA double-strand breaks: a direct and indirect lighting up. Radiotherapy Oncol. 2013;108(3):362–369. doi:10.1016/j.radonc.2013.06.013
   PubMed Web of Science ®Google Scholar
• Department of Radiation Oncology, University of Health Sciences, Okmeydani Training and Research Hospital, Istanbul, Turkey, Kandemir Gursel O. Recent Technological Advances in Radiotherapy. Eur Arch Med Res. 2018;34(Suppl1):55–60. doi:10.5152/eamr.2018.69775.
   Google Scholar
• Chen JLY, Huang YS, Kuo SH, et al. Intensity-modulated radiation therapy achieves better local control compared to three-dimensional conformal radiation therapy for T4-stage nasopharyngeal carcinoma. Oncotarget. 2016;8(8):14068–14077. doi:10.18632/oncotarget.12736
   Google Scholar
• Onal C, Yuce Sari S, Yavas G, et al. Outcome and safety analysis of endometrial cancer patients treated with postoperative 3D-conformal radiotherapy or intensity modulated radiotherapy. Acta Oncol. 2021:1–7. doi:10.1080/0284186X.2021.1926537.
   PubMed Web of Science ®Google Scholar
• Taylor A, Powell MEB. Intensity-modulated radiotherapy—what is it? Cancer Imaging. 2004;4(2):68–73. doi:10.1102/1470-7330.2004.0003
   PubMedGoogle Scholar
• Jones BM, Green S. Modern radiation techniques in early stage breast cancer for the breast radiologist. Clin Imaging. 2021;80:19–25. doi:10.1016/j.clinimag.2021.06.035
   PubMed Web of Science ®Google Scholar
• Guillemin F, Berger L, Lapeyre M, Bellière-Calandry A. [Dosimetric and toxicity comparison of IMRT and 3D-CRT of non-small cell lung cancer]. Cancer Radiother. 2021. doi:10.1016/j.canrad.2021.03.001
   Web of Science ®Google Scholar
• Mansouri K, Rastegari-Pouyani M, Ghanbri-Movahed M, Safarzadeh M, Kiani S, Ghanbari-Movahed Z. Can a metabolism-targeted therapeutic intervention successfully subjugate SARS-COV-2? A scientific rational. Biomed Pharmacother. 2020;131:110694. doi:10.1016/j.biopha.2020.110694
   PubMed Web of Science ®Google Scholar
• Cheung K. Intensity modulated radiotherapy: advantages, limitations and future developments. Biomed Imaging Interv J. 2006;2(1):e19. doi:10.2349/biij.2.1.e19
   PubMedGoogle Scholar
• Shen J, Yang D, Chen M, et al. Hypofractionated Volumetric-Modulated Arc Radiotherapy for Patients With Non-Small-Cell Lung Cancer Not Suitable for Surgery or Conventional Chemoradiotherapy or SBRT. Front Oncol. 2021;11:644852. doi:10.3389/fonc.2021.644852
   PubMed Web of Science ®Google Scholar
• Teoh M, Clark CH, Wood K, Whitaker S, Nisbet A. Volumetric modulated arc therapy: a review of current literature and clinical use in practice. Br J Radiol. 2011;84(1007):967–996. doi:10.1259/bjr/22373346
   PubMed Web of Science ®Google Scholar
• Gupta T, Narayan CA. Image-guided radiation therapy: physician’s perspectives. J Med Phys. 2012;37(4):174–182. doi:10.4103/0971-6203.103602
   PubMedGoogle Scholar
• Chang BK, Timmerman RD. Stereotactic body radiation therapy: a comprehensive review. Am J Clin Oncol. 2007;30(6):637–644. doi:10.1097/COC.0b013e3180ca7cb1
   PubMed Web of Science ®Google Scholar
• Alongi F, Arcangeli S, Filippi AR, Ricardi U, Scorsetti M. Review and uses of stereotactic body radiation therapy for oligometastases. Oncologist. 2012;17(8):1100–1107. doi:10.1634/theoncologist.2012-0092
   PubMed Web of Science ®Google Scholar
• Ge X, Zhu H, Dai W, Sun X. Stereotactic body radiotherapy in the era of radiotherapy with immunotherapy. J Thorac Dis. 2016;8(11):2968–2970. doi:10.21037/jtd.2016.11.16
   PubMed Web of Science ®Google Scholar
• McDonald AM, Dobelbower MC, Yang ES, et al. Prostate Stereotactic Body Radiation Therapy With a Focal Simultaneous Integrated Boost: acute Toxicity and Dosimetry Results From a Prospective Trial. Adv Radiat Oncol. 2018;4(1):90–95. doi:10.1016/j.adro.2018.09.007
   PubMedGoogle Scholar
• Kim YJ, Yoon KJ, Kim YS. Simultaneous integrated boost with stereotactic radiotherapy for dominant intraprostatic lesion of localized prostate cancer: a dosimetric planning study. Sci Rep. 2020;10(1):14713. doi:10.1038/s41598-020-71715-2
   PubMed Web of Science ®Google Scholar
• Chua GWY, Chua KLM. Which patients benefit most from stereotactic body radiotherapy or surgery in medically operable non‐small cell lung cancer? An in‐depth look at patient characteristics on both sides of the debate. Thoracic Cancer. 2019;10(10):1857. doi:10.1111/1759-7714.13160
   PubMed Web of Science ®Google Scholar
• Musielak M, Suchorska WM, Fundowicz M, Milecki P, Malicki J. Future Perspectives of Proton Therapy in Minimizing the Toxicity of Breast Cancer Radiotherapy. J Pers Med. 2021;11(5):410. doi:10.3390/jpm11050410
   PubMed Web of Science ®Google Scholar
• Flatten V, Baumann KS, Weber U, Engenhart-Cabillic R, Zink K. Quantification of the dependencies of the Bragg peak degradation due to lung tissue in proton therapy on a CT-based lung tumor phantom. Phys Med Biol. 2019;64(15):155005. doi:10.1088/1361-6560/ab2611
   PubMed Web of Science ®Google Scholar
• Athar BS, Bednarz B, Seco J, Hancox C, Paganetti H. Comparison of out-of-field photon doses in 6 MV IMRT and neutron doses in proton therapy for adult and pediatric patients. Phys Med Biol. 2010;55(10):2879–2891. doi:10.1088/0031-9155/55/10/006
   PubMed Web of Science ®Google Scholar
• Demizu Y, Mizumoto M, Onoe T, et al. Proton beam therapy for bone sarcomas of the skull base and spine: a retrospective nationwide multicenter study in Japan. Cancer Sci. 2017;108(5):972–977. doi:10.1111/cas.13192
   PubMed Web of Science ®Google Scholar
• Jiang GL. Particle therapy for cancers: a new weapon in radiation therapy. Front Med. 2012;6(2):165–172. doi:10.1007/s11684-012-0196-4
   PubMedGoogle Scholar
• Kinashi Y, Yokomizo N, Takahashi S, Double-strand Breaks DNA. Induced byFractionated Neutron Beam Irradiation for Boron Neutron Capture Therapy. Anticancer Res. 2017;37(4):1681–1685. doi:10.21873/anticanres.11499
   PubMed Web of Science ®Google Scholar
• Malouff TD, Mahajan A, Krishnan S, Beltran C, Seneviratne DS, Trifiletti DM. Carbon Ion Therapy: a Modern Review of an Emerging Technology. Front Oncol. 2020;1:10.
   Google Scholar
• Farr JB, Flanz JB, Gerbershagen A, Moyers MF. New horizons in particle therapy systems. Med Phys. 2018;45(11):e953–e983. doi:10.1002/mp.13193
   PubMed Web of Science ®Google Scholar
• Dell’Oro M, Short M, Wilson P, Bezak E. Clinical Limitations of Photon, Proton and Carbon Ion Therapy for Pancreatic Cancer. Cancers. 2020;12(1):163. doi:10.3390/cancers12010163
   PubMed Web of Science ®Google Scholar
• Mang TS. Lasers and light sources for PDT: past, present and future. Photodiagnosis Photodyn Ther. 2004;1(1):43–48. doi:10.1016/S1572-1000(04)00012-2
   PubMed Web of Science ®Google Scholar
• Wilson BC. Photodynamic therapy for cancer: principles. Can J Gastroenterol. 2002;16(6):393–396. doi:10.1155/2002/743109
   PubMed Web of Science ®Google Scholar
• Ormond AB, Freeman HS. Dye Sensitizers for Photodynamic Therapy. Materials. 2013;6(3):817–840. doi:10.3390/ma6030817
   PubMed Web of Science ®Google Scholar
• Marcus KJ, Haas-Kogan D. 8 - Pediatric Radiation Oncology. In: Orkin SH, Fisher DE, Look AT, Lux SE, Ginsburg D, Nathan DG, editors. Oncology of Infancy and Childhood. 2009:241–255. doi:10.1016/B978-1-4160-3431-5.00008-X
   Google Scholar
• Capella MAM, Capella LS. A light in multidrug resistance: photodynamic treatment of multidrug-resistant tumors. J Biomed Sci. 2003;10(4):361–366. doi:10.1007/BF02256427
   PubMed Web of Science ®Google Scholar
• Gupta S, Dwarakanath BS, Chaudhury NK, Mishra AK, Muralidhar K, Jain V. In vitro and in vivo targeted delivery of photosensitizers to the tumor cells for enhanced photodynamic effects. J Cancer Res Ther. 2011;7(3):314–324. doi:10.4103/0973-1482.87035
   PubMed Web of Science ®Google Scholar
• Papineni RV, Krishnan S, Pulickel A, Sahin O. Abstract 3057: development of radiation-triggered phosphor platform for localized activation in combinatory cancer treatment. Cancer Res. 2021;81(13 Supplement):3057.
   Web of Science ®Google Scholar
• NIH/NCI 399 - Combinatory Treatment Utilizing Radiation to Locally Activate Systemically Delivered Therapeutics | NCI: SBIR & STTR. Available from: https://sbir.cancer.gov/funding/contracts/399. Accessed July 9, 2021.
   Google Scholar
• Deng W, Chen W, Clement S, et al. Controlled gene and drug release from a liposomal delivery platform triggered by X-ray radiation. Nat Commun. 2018;9(1):2713. doi:10.1038/s41467-018-05118-3
   PubMed Web of Science ®Google Scholar
• Ma N, Xu H, An L, Li J, Sun Z, Zhang X. Radiation-sensitive diselenide block co-polymer micellar aggregates: toward the combination of radiotherapy and chemotherapy. Langmuir. 2011;27(10):5874–5878. doi:10.1021/la2009682
   PubMed Web of Science ®Google Scholar
• Liu H, Laan AC, Plomp J, et al. Ionizing Radiation-Induced Release from Poly(ε-caprolactone-b-ethylene glycol) Micelles. ACS Appl Polym Mater. 2021;3(2):968–975. doi:10.1021/acsapm.0c01258
   Web of Science ®Google Scholar
• Papineni R, Adhikary A. Abstract 482: multiple chemical action cancer therapeutics. Cancer Res. 2020;80(16 Supplement):482.
   Google Scholar
• Verma A, Adhikary A, Woloschak G, Dwarakanath BS, Papineni RVL. A combinatorial approach of a polypharmacological adjuvant 2-deoxy-D-glucose with low dose radiation therapy to quell the cytokine storm in COVID-19 management. Int J Radiat Biol. 2020;96(11):1323–1328. doi:10.1080/09553002.2020.1818865
   PubMed Web of Science ®Google Scholar
• Papineni RV, Adhikary A, Tandon R, Mitra D. Abstract 713: inhibition of pseudo SARS-CoV-2 binding activity of a anti-cancer polypharmacological agent analogs. Cancer Res. 2021;81(13Supplement):713. doi:10.1158/1538-7445.AM2021-713
   PubMedGoogle Scholar
• Glide-Hurst CK, Lee P, Yock AD, et al. Adaptive Radiation Therapy (ART) Strategies and Technical Considerations: a State of the ART Review From NRG Oncology. Int J Radiat Oncol Biol Phys. 2021;109(4):1054–1075. doi:10.1016/j.ijrobp.2020.10.021
   PubMed Web of Science ®Google Scholar
• van Timmeren JE, Cester D, Tanadini-Lang S, Alkadhi H, Baessler B. Radiomics in medical imaging—“how-to” guide and critical reflection. Insights Imaging. 2020;11(1):91. doi:10.1186/s13244-020-00887-2
   PubMed Web of Science ®Google Scholar
• Wilson JD, Hammond EM, Higgins GS, Petersson K. Ultra-High Dose Rate (FLASH) Radiotherapy: Silver Bullet or Fool’s Gold?. Front Oncol. 2020;9:1563. doi:10.3389/fonc.2019.01563
   Web of Science ®Google Scholar