References
- SheppardKKinrossKMSolomonBPearsonRBPhillipsWATargeting PI3 kinase/AKT/mTOR signaling in cancerCrit Rev Oncog2012171699522471665
- De LucaAMaielloMRD’AlessioAPergamenoMNormannoNThe RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approachesExpert Opin Ther Targets201216Suppl 2S17S2722443084
- VanhaesebroeckBStephensLHawkinsPPI3K signalling: the path to discovery and understandingNat Rev Mol Cell Biol201213319520322358332
- EngelmanJATargeting PI3K signalling in cancer: opportunities, challenges and limitationsNat Rev Cancer20099855056219629070
- ManningBDCantleyLCAKT/PKB signaling: navigating downstreamCell29200712971261127417604717
- ShawRJBardeesyNManningBDThe LKB1 tumor suppressor negatively regulates mTOR signalingCancer Cell200461919915261145
- WandziochEEdlingCEPalmerRHCarlssonLHallbergBActivation of the MAP kinase pathway by c-Kit is PI-3 kinase dependent in hematopoietic progenitor/stem cell linesBlood20041041515714996702
- MaLChenZErdjument-BromageHTempstPPandolfiPPPhosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesisCell2005121217919315851026
- SolomonBPearsonRBClass IA phosphatidylinositol 3-kinase signaling in non-small cell lung cancerJ Thorac Oncol20094778779119550242
- LuYWangHMillsGBTargeting PI3K-AKT pathway for cancer therapyRev Clin Exp Hematol20037220522814763163
- VivancoISawyersCLThe phosphatidylinositol 3-Kinase AKT pathway in human cancerNat Rev Cancer20022748950112094235
- MillsGBLuYFangXThe role of genetic abnormalities of PTEN and the phosphatidylinositol 3-kinase pathway in breast and ovarian tumorigenesis, prognosis, and therapySemin Oncol2001285 Suppl 1612514111706404
- GagliardiPAdi BlasioLOrsoF3-phosphoinositide-dependent kinase 1 controls breast tumor growth in a kinase-dependent but Akt-independent mannerNeoplasia201214871973122952425
- KinrossKMMontgomeryKGKleinschmidtMAn activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in miceJ Clin Invest2012122255355722214849
- Stemke-HaleKGonzalez-AnguloAMLluchAAn integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancerCancer Res200868156084609118676830
- ChouMMHouWJohnsonJRegulation of protein kinase C zeta by PI 3-kinase and PDK-1Curr Biol1998819106910779768361
- MizunoHNishidaEThe ERK MAP kinase pathway mediates induction of SGK (serum- and glucocorticoid-inducible kinase) by growth factorsGenes Cells20016326126811260269
- BruhnMAPearsonRBHannanRDSheppardKESecond AKT: the rise of SGK in cancer signallingGrowth Factors201028639440820919962
- TessierMWoodgettJRSerum and glucocorticoid-regulated protein kinases: variations on a themeJ Cell Biochem20069861391140716619268
- LiuMChenLLChanTHSerum and glucocorticoid kinase 3 at 8q13.1 promotes cell proliferation and survival in hepatocellular carcinomaHepatology20125561754176522262416
- VasudevanKMBarbieDADaviesMAAKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancerCancer Cell2009161213219573809
- VanhaesebroeckBGuillermet-GuibertJGrauperaMBilangesBThe emerging mechanisms of isoform-specific PI3K signallingNat Rev Mol Cell Biol201011532934120379207
- FrumanDARegulatory subunits of class IA PI3KCurr Top Microbiol Immunol201034622524420563711
- VogtPKHartJRGymnopoulosMPhosphatidylinositol 3-kinase: the oncoproteinCurr Top Microbiol Immunol20103477910420582532
- JiaSRobertsTMZhaoJJShould individual PI3 kinase isoforms be targeted in cancer?Curr Opin Cell Biol200921219920819200708
- WongKKEngelmanJACantleyLCTargeting the PI3K signaling pathway in cancerCurr Opin Genet Dev2010201879020006486
- SajiMRingelMDThe PI3K-Akt-mTOR pathway in initiation and progression of thyroid tumorsMol Cell Endocrinol20103211202819897009
- ShawRJLKB1 and AMP-activated protein kinase control of mTOR signalling and growthActa Physiol (Oxf)20091961658019245654
- CantleyLCThe phosphoinositide 3-kinase pathwayScience200229655731655165712040186
- MarkmanBDienstmannRTaberneroJTargeting the PI3K/Akt/mTOR pathway – beyond rapalogsOncotarget20101753054321317449
- HuPMargolisBSkolnikEYLammersRUllrichASchlessingerJInteraction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptorsMol Cell Biol19921239819901372091
- McGladeCJEllisCReedijkMSH2 domains of the p85 alpha subunit of phosphatidylinositol 3-kinase regulate binding to growth factor receptorsMol Cell Biol19921239919971372092
- ZhuGDeckerSJSaltielARDirect analysis of the binding of Srchomology 2 domains of phospholipase C to the activated epidermal growth factor receptorProc Natl Acad Sci U S A19928920955995631384057
- SamuelsYVelculescuVEOncogenic mutations of PIK3CA in human cancersCell Cycle20043101221122415467468
- SamuelsYWangZBardelliAHigh frequency of mutations of the PIK3CA gene in human cancersScience2004304567055415016963
- MarkmanBAtzoriFPerez-GarciaJTaberneroJBaselgaJStatus of PI3K inhibition and biomarker development in cancer therapeuticsAnn Oncol201021468369119713247
- ZhaoJJChengHJiaSThe p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformationProc Natl Acad Sci U S A200610344162961630017060635
- MaoCYangZYHuXFChenQTangJLPIK3CA exon 20 mutations as a potential biomarker for resistance to anti-EGFR monoclonal antibodies in KRAS wild-type metastatic colorectal cancer: a systematic review and meta-analysisAnn Oncol20122361518152522039088
- SamuelsYWaldmanTOncogenic mutations of PIK3CA in human cancersCurr Top Microbiol Immunol2010347214120535651
- PhilpAJCampbellIGLeetCThe phosphatidylinositol 3′-kinase p85alpha gene is an oncogene in human ovarian and colon tumorsCancer Res200161207426742911606375
- IsakoffSJEngelmanJAIrieHYBreast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cellsCancer Res20056523109921100016322248
- SamuelsYDiazLAJrSchmidt-KittlerOMutant PIK3CA promotes cell growth and invasion of human cancer cellsCancer Cell20057656157315950905
- SamuelsYEricsonKOncogenic PI3K and its role in cancerCurr Opin Oncol2006181778216357568
- BaderAGKangSZhaoLVogtPKOncogenic PI3K deregulates transcription and translationNat Rev Cancer200551292192916341083
- ZhaoJJLiuZWangLShinELodaMFRobertsTMThe oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cellsProc Natl Acad Sci U S A200510251184431844816339315
- GymnopoulosMElsligerMAVogtPKRare cancer-specific mutations in PIK3CA show gain of functionProc Natl Acad Sci U S A2007104135569557417376864
- VogtPKGymnopoulosMHartJRPI 3-kinase and cancer: changing accentsCurr Opin Genet Dev2009191121719185485
- ShekarSCWuHFuZMechanism of constitutive phosphoinositide 3-kinase activation by oncogenic mutants of the p85 regulatory subunitJ Biol Chem200528030278502785515932879
- CastellanoEDownwardJRAS interaction with PI3K: more than just another effector pathwayGenes Cancer20112326127421779497
- BackerJMThe regulation and function of Class III PI3Ks: novel roles for Vps34Biochem J2008410111718215151
- YanYBackerJMRegulation of class III (Vps34) PI3KsBiochem Soc Trans200735Pt 223924117371248
- YanYFlinnRJWuHSchnurRSBackerJMhVps15, but not Ca2+/CaM, is required for the activity and regulation of hVps34 in mammalian cellsBiochem J2009417374775518957027
- ThoresenSBPedersenNMLiestolKStenmarkHA phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic trafficExp Cell Res2010316203368337820643123
- NobukuniTJoaquinMRoccioMAmino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinaseProc Natl Acad Sci U S A200510240142381424316176982
- ByfieldMPMurrayJTBackerJMhVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinaseJ Biol Chem200528038330763308216049009
- GulatiPGaspersLDDannSGAmino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34Cell Metab20087545646518460336
- LaplanteMSabatiniDMmTOR signaling in growth control and diseaseCell2012149227429322500797
- KimEGoraksha-HicksPLiLNeufeldTPGuanKLRegulation of TORC1 by Rag GTPases in nutrient responseNat Cell Biol200810893594518604198
- SancakYPetersonTRShaulYDThe Rag GTPases bind raptor and mediate amino acid signaling to mTORC1Science200832058821496150118497260
- FindlayGMYanLProcterJMieuletVLambRFA MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signallingBiochem J20074031132017253963
- KimSKimSFMaagDAmino acid signaling to mTOR mediated by inositol polyphosphate multikinaseCell Metab201113221522121284988
- HannanKMBrandenburgerYJenkinsAmTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBFMol Cell Biol200323238862887714612424
- YangXYangCFarbermanAThe mammalian target of rapamycin-signaling pathway in regulating metabolism and growthJ Anim Sci200886Suppl 14E36E5017998426
- WangXProudCGThe mTOR pathway in the control of protein synthesisPhysiology (Bethesda)20062136236916990457
- JamesMJZomerdijkJCPhosphatidylinositol 3-kinase and mTOR signaling pathways regulate RNA polymerase I transcription in response to IGF-1 and nutrientsJ Biol Chem2004279108911891814688273
- CorradettiMNGuanKLUpstream of the mammalian target of rapamycin: do all roads pass through mTOR?Oncogene200625486347636017041621
- HemmingsBARestucciaDFPI3K-PKB/Akt pathwayCold Spring Harb Perspect Biol201249a01118922952397
- SancakYThoreenCCPetersonTRPRAS40 is an insulinregulated inhibitor of the mTORC1 protein kinaseMol Cell200725690391517386266
- Vander HaarELeeSIBandhakaviSGriffinTJKimDHInsulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40Nat Cell Biol20079331632317277771
- LiangJSlingerlandJMMultiple roles of the PI3K/PKB (Akt) pathway in cell cycle progressionCell Cycle20032433934512851486
- BrunetABonniAZigmondMJAkt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factorCell199996685786810102273
- DattaSRDudekHTaoXAkt phosphorylation of BAD couples survival signals to the cell-intrinsic death machineryCell19979122312419346240
- MayoLDDonnerDBA phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleusProc Natl Acad Sci U S A20019820115981160311504915
- RomashkovaJAMakarovSSNF-kappaB is a target of AKT in anti-apoptotic PDGF signallingNature19994016748869010485711
- ChanJCHannanKMRiddellKAKT promotes rRNA synthesis and cooperates with c-MYC to stimulate ribosome biogenesis in cancerSci Signal20114188ra5621878679
- StaalSPMolecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinomaProc Natl Acad Sci U S A19878414503450373037531
- BellacosaAde FeoDGodwinAKMolecular alterations of the AKT2 oncogene in ovarian and breast carcinomasInt J Cancer19956442802857657393
- HennessyBTSmithDLRamPTLuYMillsGBExploiting the PI3K/AKT pathway for cancer drug discoveryNat Rev Drug Discov2005412988100416341064
- CarptenJDFaberALHornCA transforming mutation in the pleckstrin homology domain of AKT1 in cancerNature2007448715243944417611497
- YuanZQSunMFeldmanRIFrequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancerOncogene200019192324233010822383
- StahlJMSharmaACheungMDeregulated Akt3 activity promotes development of malignant melanomaCancer Res200464197002701015466193
- CristianoBEChanJCHannanKMA specific role for AKT3 in the genesis of ovarian cancer through modulation of G(2)-M phase transitionCancer Res20066624117181172517178867
- Cancer Genome Atlas Research NetworkIntegrated genomic analyses of ovarian carcinomaNature2011474735360961521720365
- WuRHendrix-LucasNKuickRMouse model of human ovarian endometrioid adenocarcinoma based on somatic defects in the Wnt/beta-catenin and PI3K/Pten signaling pathwaysCancer Cell200711432133317418409
- ZhangWHainesBBEffersonCEvidence of mTOR Activation by an AKT-independent mechanism provides support for the combined treatment of PTEN-deficient prostate tumors with mTOR and AKT inhibitorsTransl Oncol20125642242923323157
- XuJWanMHeQSGK3 is associated with estrogen receptor expression in breast cancerBreast Cancer Res Treat2012134253154122576469
- CreightonCJA gene transcription signature of the Akt/mTOR pathway in clinical breast tumorsOncogene200726324648465517213801
- SommerEMDryHCrossDGuichardSDaviesBRAlessiDRElevated SGK1 predicts resistance of breast cancer cells to Akt inhibitorsBiochem J2013452349950823581296
- De MarcoCRinaldoNBruniPMultiple genetic alterations within the PI3K pathway are responsible for AKT activation in patients with ovarian carcinomaPLoS One201382e5536223408974
- LiuDYangXSongyangZIdentification of CISK, a new member of the SGK kinase family that promotes IL-3-dependent survivalCurr Biol200010191233123611050396
- DaiFYuLHeHCloning and mapping of a novel human serum/glucocorticoid regulated kinase-like gene, SGKL, to chromosome 8q12.3-q13.1Genomics1999621959710585774
- WangYZhouDPhungSMasriSSmithDChenSSGK3 is an estrogen-inducible kinase promoting estrogen-mediated survival of breast cancer cellsMol Endocrinol2011251728221084382
- EllsonCDAndrewsSStephensLRHawkinsPTThe PX domain: a new phosphoinositide-binding moduleJ Cell Sci2002115Pt 61099110511884510
- VirbasiusJVSongXPomerleauDPZhanYZhouGWCzechMPActivation of the Akt-related cytokine-independent survival kinase requires interaction of its phox domain with endosomal phosphatidylinositol 3-phosphateProc Natl Acad Sci U S A20019823129081291311606732
- XuJLiuDGillGSongyangZRegulation of cytokine-independent survival kinase (CISK) by the Phox homology domain and phosphoinositidesJ Cell Biol2001154469970511514587
- KobayashiTDeakMMorriceNCohenPCharacterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinaseBiochem J1999344Pt 118919710548550
- FirestoneGLGiampaoloJRO’KeeffeBAStimulus-dependent regulation of serum and glucocorticoid inducible protein kinase (SGK) transcription, subcellular localization and enzymatic activityCell Physiol Biochem200313111212649597
- Garcia-MartinezJMAlessiDRmTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum-and glucocorticoid-induced protein kinase 1 (SGK1)Biochem J2008416337538518925875
- LuMWangJJonesKTmTOR complex-2 activates ENaC by phosphorylating SGK1J Am Soc Nephrol201021581181820338997
- LyoDXuLFosterDAPhospholipase D stabilizes HDM2 through an mTORC2/SGK1 pathwayBiochem Biophys Res Commun2010396256256520438709
- ParkJLeongMLBusePMaiyarACFirestoneGLHemmingsBASerum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathwayEMBO J199918113024303310357815
- TessierMWoodgettJRRole of the Phox homology domain and phosphorylation in activation of serum and glucocorticoid-regulated kinase-3J Biol Chem200628133239782398916790420
- KobayashiTCohenPActivation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2Biochem J1999339Pt 231932810191262
- Sanchez CanedoCDemeulderBGinionAActivation of the cardiac mTOR/p70(S6K) pathway by leucine requires PDK1 and correlates with PRAS40 phosphorylationAm J Physiol Endocrinol Metab20102984E761E76920051528
- SlagsvoldTMarcheseABrechAStenmarkHCISK attenuates degradation of the chemokine receptor CXCR4 via the ubiquitin ligase AIP4EMBO J200625163738374916888620
- FrodinMAntalTLDummlerBAA phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylationEMBO J200221205396540712374740
- CollinsBJDeakMArthurJSArmitLJAlessiDRIn vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutationEMBO J200322164202421112912918
- BiondiRMKielochACurrieRADeakMAlessiDRThe PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKBEMBO J200120164380439011500365
- XuJLiaoLQinJLiuDSongyangZIdentification of flightless-I as a substrate of the cytokine-independent survival kinase CISKJ Biol Chem200928421143771438519293151
- McCormickJAFengYDawsonKTargeted disruption of the protein kinase SGK3/CISK impairs postnatal hair follicle developmentMol Biol Cell20041594278428815240817
- AlonsoLOkadaHPasolliHASgk3 links growth factor signaling to maintenance of progenitor cells in the hair follicleJ Cell Biol2005170455957016103225
- BiLOkabeIBernardDJWynshaw-BorisANussbaumRLProliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinaseJ Biol Chem199927416109631096810196176
- GrahammerFArtuncFSandulacheDRenal function of gene-targeted mice lacking both SGK1 and SGK3Am J Physiol Regul Integr Comp Physiol20062904R945R95016537821
- MauroTMMcCormickJAWangJAkt2 and SGK3 are both determinants of postnatal hair follicle developmentFASEB J20092393193320219433625
- YaoLJMcCormickJAWangJNovel role for SGK3 in glucose homeostasis revealed in SGK3/Akt2 double-null miceMol Endocrinol201125122106211821980074
- ChoHMuJKimJKInsulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)Science200129255221728173111387480
- BrunetAParkJTranHHuLSHemmingsBAGreenbergMEProtein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)Mol Cell Biol200121395296511154281
- HoKKMyattSSLamEWMany forks in the path: cycling with FoxOOncogene200827162300231118391972
- DaiFYuLHeHHuman serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interactionBiochem Biophys Res Commun200229341191119612054501
- HannanKMSanijEHeinNHannanRDPearsonRBSignaling to the ribosome in cancer – it is more than just mTORC1IUBMB Life2011632798521360636
- EngelmanJALuoJCantleyLCThe evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolismNat Rev Genet20067860661916847462
- FailorKLDesyatnikovYFingerLAFirestoneGLGlucocorticoid-induced degradation of glycogen synthase kinase-3 protein is triggered by serum- and glucocorticoid-induced protein kinase and Akt signaling and controls beta-catenin dynamics and tight junction formation in mammary epithelial tumor cellsMol Endocrinol200721102403241517595317
- GassmannPHaierJSchluterKCXCR4 regulates the early extravasation of metastatic tumor cells in vivoNeoplasia200911765166119568410
- MullerAHomeyBSotoHInvolvement of chemokine receptors in breast cancer metastasisNature20014106824505611242036
- LangFVoelklJTherapeutic potential of serum and glucocorticoid inducible kinase inhibitionExpert Opin Investig Drugs2013226701714