The Chemoprotective Role of Vitamin D in Skin Cancer: A Systematic Review

References

• Mason RS, Reichrath J. Sunlight vitamin D and skin cancer. Anticancer Agents Med Chem. 2013;13(1):83–97. doi:10.2174/187152013804487272
   PubMed Web of Science ®Google Scholar
• Purdue MP, Freeman LE, Anderson WF, et al. Recent trends in incidence of cutaneous melanoma among US Caucasian young adults. J Invest Dermatol. 2008;128:2905–2908. doi:10.1038/jid.2008.159
   PubMed Web of Science ®Google Scholar
• Linos E, Swetter SM, Cockburn MG, et al. Increasing burden of melanoma in the United States. J Invest Dermatol. 2009;129:1666–1674. doi:10.1038/jid.2008.423
   PubMed Web of Science ®Google Scholar
• Memon A, Bannister P, Rogers I, et al. Changing epidemiology and age-specific incidence of cutaneous malignant melanoma in England: an analysis of the national cancer registration data by age, gender and anatomical site, 1981–2018. Lancet Reg Health Eur. 2021;2:100024. doi:10.1016/j.lanepe.2021.100024
   PubMedGoogle Scholar
• Apalla Z, Lallas A, Sotiriou E, et al. Epidemiological trends in skin cancer. Dermatol Pract Concept. 2017;7(2):1–6. doi:10.5826/dpc.0702a01
   PubMedGoogle Scholar
• Giacalone S, Spigariolo CB, Bortoluzzi P, et al. Oral nicotinamide: the role in skin cancer chemoprevention. Dermatol Ther. 2021;34(3):e14892. doi:10.1111/dth.14892
   PubMed Web of Science ®Google Scholar
• Chen JG, Fleischer AB, Smith ED, et al. Cost of nonmelanoma skin cancer treatment in the United States. Dermatol Surg. 2001;27:1035–1038. doi:10.1046/j.1524-4725.2001.01004.x
   PubMed Web of Science ®Google Scholar
• Jeon SM, Shin EA. Exploring vitamin D metabolism and function in cancer. Exp Mol Med. 2018;50(4):1–14. doi:10.1038/s12276-018-0038-9
   Web of Science ®Google Scholar
• Asgari MM, Tang J, Warton ME, et al. Association of prediagnostic serum vitamin D levels with the development of basal cell carcinoma. J Invest Dermatol. 2010;130:1438–1443. doi:10.1038/jid.2009.402
   PubMed Web of Science ®Google Scholar
• Bikle DD. Vitamin D receptor, UVR, and skin cancer: a potential protective mechanism. J Invest Dermatol. 2008;128:2357–2361. doi:10.1038/jid.2008.249
   PubMed Web of Science ®Google Scholar
• Binkley N, Ramamurthy R, Krueger D. Low vitamin D status: definition, prevalence, consequences, and correction. Rheum Dis Clin North Am. 2012;38:45–59. doi:10.1016/j.rdc.2012.03.006
   PubMed Web of Science ®Google Scholar
• Shariev A, Painter N, Reeve VE, et al. PTEN: a novel target for vitamin D in melanoma. J Steroid Biochem Mol Biol. 2022;218:106059. doi:10.1016/j.jsbmb.2022
   PubMed Web of Science ®Google Scholar
• Sutedja EK, Amarassaphira D, Goenawan H, et al. Calcitriol inhibits proliferation and potentially induces apoptosis in B16-F10 cells. Med Sci Monit Basic Res. 2022;28:e935139. doi:10.12659/MSMBR.935139
   PubMed Web of Science ®Google Scholar
• Piotrowska A, Wierzbicka J, Kwiatkowska K, Chodyński M, Kutner A, Żmijewski MA. Antiproliferative activity of side-chain truncated vitamin D analogs (PRI-1203 and PRI-1204) against human malignant melanoma cell lines. Eur J Pharmacol. 2020;881:173170. doi:10.1016/j.ejphar.2020.173170
   PubMed Web of Science ®Google Scholar
• Piotrowska A, Wierzbicka J, Rybarczyk A, Tuckey RC, Slominski AT, Żmijewski MA. Vitamin D and its low calcemic analogs modulate the anticancer properties of cisplatin and dacarbazine in the human melanoma A375 cell line. Int J Oncol. 2019;54(4):1481–1495. doi:10.3892/ijo.2019.4725
   PubMed Web of Science ®Google Scholar
• Podgorska E, Drzal A, Matuszak Z, et al. Calcitriol and calcidiol can sensitize melanoma cells to low⁻LET proton beam irradiation. Int J Mol Sci. 2018;19(8):2236. doi:10.3390/ijms19082236
   PubMed Web of Science ®Google Scholar
• Skobowiat C, Oak AS, Kim TK, et al. Noncalcemic 20-hydroxyvitamin D3 inhibits human melanoma growth in in vitro and in vivo models. Oncotarget. 2017;8(6):9823–9834. doi:10.18632/oncotarget.14193
   PubMedGoogle Scholar
• Spath L, Ulivieri A, Lavra L, et al. Antiproliferative effects of 1α-OH-vitD3 in malignant melanoma: potential therapeutic implications. Sci Rep. 2017;7:40370. doi:10.1038/srep40370
   PubMed Web of Science ®Google Scholar
• Piotrowska A, Wierzbicka J, Nadkarni S, Brown G, Kutner A, Żmijewski MA. Antiproliferative activity of double point modified analogs of 1,25-Dihydroxyvitamin D2 against human malignant melanoma cell lines. Int J Mol Sci. 2016;17(1):76. doi:10.3390/ijms17010076
   PubMed Web of Science ®Google Scholar
• Wasiewicz T, Szyszka P, Cichorek M, et al. Antitumor effects of vitamin D analogs on hamster and mouse melanoma cell lines in relation to melanin pigmentation. Int J Mol Sci. 2015;16(4):6645–6667. doi:10.3390/ijms16046645
   PubMed Web of Science ®Google Scholar
• Slominski AT, Janjetovic Z, Kim TK, et al. Novel vitamin D hydroxyderivatives inhibit melanoma growth and show differential effects on normal melanocytes. Anticancer Res. 2012;32(9):3733–3742. doi:10.1016/j.mce.2012.04.001
   PubMed Web of Science ®Google Scholar
• Makarova A, Wang G, Dolorito JA, Kc S, Libove E, Epstein EH. Vitamin D3 produced by skin exposure to UVR inhibits murine basal cell carcinoma carcinogenesis. J Invest Dermatol. 2017;137(12):2613–2619. doi:10.1016/j.jid.2017.05.037
   PubMed Web of Science ®Google Scholar
• Kim JS, Jung M, Yoo J, et al. Protective effect of topical vitamin D3 against photocarcinogenesis in a murine model. Ann Dermatol. 2016;28(3):304–313. doi:10.5021/ad.2016.28.3.304
   PubMed Web of Science ®Google Scholar
• Pommergaard HC, Burcharth J, Rosenberg J, Raskov H. Topical combination of diclofenac, calcipotriol, and difluoromethylornithine has beneficial effects comparable to 5-fluorouracil for the treatment of non-melanoma skin cancer in mice. J Chemother. 2014;26(2):105–110. doi:10.1179/1973947813Y.0000000117
   PubMed Web of Science ®Google Scholar
• Pommergaard HC, Burcharth J, Rosenberg J, Raskov H. Combination chemoprevention with diclofenac, calcipotriol and difluoromethylornithine inhibits development of non-melanoma skin cancer in mice. Anticancer Res. 2013;33(8):3033–3039.
   PubMed Web of Science ®Google Scholar
• Johansson H, Spadola G, Tosti G, et al. Vitamin D supplementation and disease-free survival in stage II melanoma: a randomized placebo controlled trial. Nutrients. 2021;13(6):1931. doi:10.3390/nu13061931
   PubMed Web of Science ®Google Scholar
• Passarelli MN, Karagas MR, Mott LA, Rees JR, Barry EL, Baron JA. Risk of keratinocyte carcinomas with vitamin D and calcium supplementation: a secondary analysis of a randomized clinical trial. Am J Clin Nutr. 2020;112(6):1532–1539. doi:10.1093/ajcn/nqaa267
   PubMed Web of Science ®Google Scholar
• Ince B, Yildirim MEC, Dadaci M. Assessing the effect of vitamin D replacement on basal cell carcinoma occurrence and recurrence rates in patients with vitamin D deficiency. Horm Cancer. 2019;10(4–6):145–149. doi:10.1007/s12672-019-00365-2
   PubMed Web of Science ®Google Scholar
• Rosenberg AR, Tabacchi M, Ngo KH, et al. Skin cancer precursor immunotherapy for squamous cell carcinoma prevention. JCI Insight. 2019;4(6):e125476. doi:10.1172/jci.insight.125476
   PubMed Web of Science ®Google Scholar
• Brinkhuizen T, Frencken KJ, Nelemans PJ, et al. The effect of topical diclofenac 3% and calcitriol 3 μg/g on superficial basal cell carcinoma (sBCC) and nodular basal cell carcinoma (nBCC): a Phase II, randomized controlled trial. J Am Acad Dermatol. 2016;75(1):126–134. doi:10.1016/j.jaad.2016.01.050
   PubMed Web of Science ®Google Scholar
• Caini S, Boniol M, Tosti G, et al. Vitamin D and melanoma and non-melanoma skin cancer risk and prognosis: a comprehensive review and meta-analysis. Eur J Cancer. 2014;50:2649–2658. doi:10.1016/j.ejca.2014.06.024
   PubMed Web of Science ®Google Scholar
• Lim A, Shayan R, Varigos G. High serum vitamin D level correlates with better prognostic indicators in primary melanoma: a pilot study. Australas J Dermatol. 2018;59(3):182–187. doi:10.1111/ajd.12648
   PubMed Web of Science ®Google Scholar
• Wyatt C, Lucas RM, Hurst C, Kimlin MG. Vitamin D deficiency at melanoma diagnosis is associated with higher Breslow thickness. PLoS One. 2015;10(5). doi:10.1371/journal.pone.0126394
   Web of Science ®Google Scholar
• Bagatini MD, Bertolin K, Bridi A, et al. 1α, 25-Dihydroxyvitamin D3 alters ectonucleotidase expression and activity in human cutaneous melanoma cells. J Cell Biochem. 2019;120(6):9992–10000. doi:10.1002/jcb.28281
   PubMed Web of Science ®Google Scholar
• Pawlowska E, Wysokinski D, Blasiak J. Nucleotide excision repair and vitamin D—relevance for skin cancer therapy. Int J Mol Sci. 2016;17(4):1‐21. doi:10.3390/ijms17040372
   PubMed Web of Science ®Google Scholar
• Dzhandzhugazyan KN, Kirkin AF, Thor Straten P, Zeuthen J. Ecto‐ATP diphosphohydrolase/CD39 is overexpressed in differentiated human melanomas. FEBS Lett. 1998;430:227‐230. doi:10.1016/S0014-5793(98)00603-6
   PubMed Web of Science ®Google Scholar
• Nanzer AM, Chambers ES, Ryanna K, et al. Enhanced production of IL‐17A in patients with severe asthma is inhibited by 1α,25‐dihydroxyvitamin D3 in a glucocorticoid‐independent fashion. J Allergy Clin Immunol. 2013;132(2):297‐304.e3. doi:10.1016/j.jaci.2013.03.037
   PubMed Web of Science ®Google Scholar
• Su M, Mei Y, Sinha S. Role of the crosstalk between autophagy and apoptosis in cancer. J Oncol. 2013;2013:102735. doi:10.1155/2013/102735
   PubMedGoogle Scholar
• Su Z, Yang Z, Xu Y, Chen Y, Yu Q. Apoptosis, autophagy, necroptosis, and cancer metastasis. Mol Cancer. 2015;14(1):48. doi:10.1186/s12943-015-0321-5
   PubMed Web of Science ®Google Scholar
• Gunadi JW, Welliangan AS, Soetadji RS, Jasaputra DK, Lesmana R. The role of autophagy modulated by exercise in cancer cachexia. Life. 2021;11:781. doi:10.3390/life11080781
   PubMedGoogle Scholar
• Wu S, Sun J. Vitamin D, vitamin D receptor, and macroautophagy in inflammation and infection. Discov Med. 2011;11(59):325–335.
   PubMed Web of Science ®Google Scholar
• Abdel-Mohsen MA, El-Braky AA, Ghazal AAE, Shamseya MM. Autophagy, apoptosis, vitamin D, and vitamin D receptor in hepatocellular carcinoma associated with hepatitis C virus. Medicine. 2018;97(12):e0172. doi:10.1097/MD.0000000000010172
   PubMed Web of Science ®Google Scholar
• Tavera-Mendoza L, Wang TT, Lallemant B, et al. Convergence of vitamin D and retinoic acid signaling at a common hormone response element. EMBO Rep. 2006;7(2):180–185. doi:10.1038/sj.embor.7400594
   PubMed Web of Science ®Google Scholar