155
Views
1
CrossRef citations to date
0
Altmetric
Review

The roles of beta-adrenergic receptors in tumorigenesis and the possible use of beta-adrenergic blockers for cancer treatment: possible genetic and cell-signaling mechanisms

&
Pages 431-445 | Published online: 18 Dec 2012

References

  • BadinoGRNovelliAGirardiCDi CarloFEvidence for functional beta-adrenoceptor subtypes in CG-5 breast cancer cellPharmacol Res1996334–52552608938018
  • SchullerHMColeBRegulation of cell proliferation by beta-adrenergic receptors in a human lung adenocarcinoma cell lineCarcinogenesis1989109175317552569945
  • ParkPGMerrymanJOrloffMSchullerHMBeta-adrenergic mitogenic signal transduction in peripheral lung adenocarcinoma: implications for individuals with preexisting chronic lung diseaseCancer Res19955516350435087627955
  • ShangZJLiuKLiang deFExpression of beta2-adrenergic receptor in oral squamous cell carcinomaJ Oral Pathol Med200938437137619141064
  • KassahunWTGuenlBUngemachFRJonasSAbrahamGExpression and functional coupling of liver β2 – adrenoceptors in the human hepatocellular carcinomaPharmacology2012895–631332022584966
  • LinXLuoKLvZHuangJBeta-adrenoceptor action on pancreatic cancer cell proliferation and tumor growth in miceHepatogastroenterology20125911458458822353526
  • ZhaoLYangFXuKCommon genetic variants of the β2-adrenergic receptor affect its translational efficiency and are associated with human longevityAging Cell20121161094110123020224
  • ColeSWSoodAKMolecular pathways: beta-adrenergic signaling in cancerClin Cancer Res20121851201120622186256
  • LamkinDMSloanEKPatelAJChronic stress enhances progression of acute lymphoblastic leukemia via β-adrenergic signalingBrain Behav Immun201226463564122306453
  • SchullerHMAl-WadeiHAUllahMFPlummerHK3rdRegulation of pancreatic cancer by neuropsychological stress responses: a novel target for interventionCarcinogenesis201233119119622072614
  • Al-WadeiHAPlummerHK3rdUllahMFUngerBBrodyJRSchullerHMSocial stress promotes and γ-aminobutyric acid inhibits tumor growth in mouse models of non-small cell lung cancerCancer Prev Res (Phila)20125218919621955519
  • LiuXWuWKYuLEpinephrine stimulates esophageal squamous-cell carcinoma cell proliferation via beta-adrenoceptor- dependent transactivation of extracellular signal-regulated kinase/cyclooxygenase-2 pathwayJ Cell Biochem20081051536018452159
  • PalmDLangKNiggemannBThe norepinephrine-driven metastasis development of PC-3 human prostate cancer cells in BALB/c nude mice is inhibited by beta-blockersInt J Cancer2006118112744274916381019
  • Al-WadeiHAAl-WadeiMHSchullerHMCooperative regulation of non-small cell lung carcinoma by nicotinic and beta-adrenergic receptors: a novel target for interventionPLoS One201271e2991522253823
  • HyltanderADanerydPSandströmRKörnerULundholmKBeta-adrenoceptor activity and resting energy metabolism in weight losing cancer patientsEur J Cancer200036333033410708933
  • GambardellaATortorielloRPesceLTagliamonteMRPaolissoGVarricchioMIntralipid infusion combined with propranolol administration has favorable metabolic effects in elderly malnourished cancer patientsMetabolism199948329129710094102
  • GrytliHHFagerlandMWFossåSDTaskénKAHåheimLLUse of β-blockers is associated with prostate cancer-specific survival in prostate cancer patients on androgen deprivation therapyProstate Epub July 20, 2012
  • DiazESKarlanBYLiAJImpact of beta blockers on epithelial ovarian cancer survivalGynecol Oncol2012127237537822819786
  • De GiorgiVGrazziniMGandiniSTreatment with β-blockers and reduced disease progression in patients with thick melanomaArch Intern Med2011171877978121518948
  • TollLJimenezLWalehN{Beta}2-adrenergic receptor agonists inhibit the proliferation of 1321N1 astrocytoma cellsJ Pharmacol Exp Ther2011336252453221071556
  • LongHEffects of propranolol in combination with radiation on apoptosis and survival of gastric cancer cells in vitroRadiat Oncol201059820977754
  • Al-WadeiHAAl-WadeiMHSchullerHMPrevention of pancreatic cancer by the beta-blocker propranololAnticancer Drugs200920647748219387337
  • BarronTIConnollyRMSharpLBennettKVisvanathanKBeta blockers and breast cancer mortality: a population- based studyJ Clin Oncol201129192635264421632503
  • Melhem-BertrandtAChavez-MacgregorMLeiXBeta-blocker use is associated with improved relapse-free survival in patients with triple-negative breast cancerJ Clin Oncol201129192645265221632501
  • PoweDGVossMJZänkerKSBeta-blocker drug therapy reduces secondary cancer formation in breast cancer and improves cancer specific survivalOncotarget20101762863821317458
  • PasquierECiccoliniJCarreMPropranolol potentiates the anti-angiogenic effects and anti-tumor efficacy of chemotherapy agents: implication in breast cancer treatmentOncotarget201121079780922006582
  • CampbellJPKarolakMRMaYStimulation of host bone marrow stromal cells by sympathetic nerves promotes breast cancer bone metastasis in micePLoS Biol2012107e100136322815651
  • NkontchouGAoutMMahmoudiAEffect of long-term propranolol treatment on hepatocellular carcinoma incidence in patients with HCV-associated cirrhosisCancer Prev Res (Phila)2012581007101422525582
  • StanojkovicTPZizakZMihailovic-StanojevicNPetrovicTJuranicZInhibition of proliferation on some neoplastic cell lines-act of carvedilol and captoprilJ Exp Clin Cancer Res200524338739516270525
  • ShanTMaQZhangDβ2-adrenoceptor blocker synergizes with gemcitabine to inhibit the proliferation of pancreatic cancer cells via apoptosis inductionEur J Pharmacol20116651–31721570961
  • MaturoSTseSMKinaneTBHartnickCJInitial experience using propranolol as an adjunctive treatment in children with aggressive recurrent respiratory papillomatosisAnn Otol Rhinol Laryngol20111201172021370676
  • LiaoXCheXZhaoWZhangDBiTWangGThe β-adrenoceptor antagonist, propranolol, induces human gastric cancer cell apoptosis and cell cycle arrest via inhibiting nuclear factor κB signalingOncol Rep20102461669167621042766
  • KozanogluIYandimMKCincinZBOzdoguHCakmakogluBBaranYNew indication for therapeutic potential of an old well-known drug (propranolol) for multiple myelomaJ Cancer Res Clin Oncol2012 Epub Oct19
  • RaffegerstSHHoelzlwimmerGKunderSMysliwietzJQuintanilla-MartinezLSchendelDJDiverse hematological malignancies including hodgkin-like lymphomas develop in chimeric MHC class II transgenic micePLoS One2009412e853920046882
  • García-PlataDMozosECarrascoLSolanaRHLA molecule expression in cutaneous squamous cell carcinomas: an immunopathological study and clinical-immunohistopathological correlationsHistol Histopathol1993822192267683937
  • MakniHDaoudJBen SalahHHLA association with nasopharyngeal carcinoma in southern TunisiaMol Biol Rep20103752533253919714482
  • PanzaNDel VecchioLMaioMStrong association between an HLA-DR antigen and thyroid carcinomaTissue Antigens19822021551586814009
  • LindhorstESchumm-DraegerPMBojungaJUsadelKHHerrmannGDifferences in tumor cell proliferation, HLA DR expression and lymphocytic infiltration in various types of thyroid carcinomaExp Clin Endocrinol Diabetes20021101273111835122
  • DonaldsonPTHoSWilliamsRJohnsonPJHLA class II alleles in Chinese patients with hepatocellular carcinomaLiver200121214314811318984
  • LeeHWHahmKBLeeJSJuYSLeeKMLeeKWAssociation of the human leukocyte antigen class II alleles with chronic atrophic gastritis and gastric carcinoma in KoreansJ Dig Dis200910426527119906105
  • AndoTIshikawaTKatoHSynergistic effect of HLA class II loci and cytokine gene polymorphisms on the risk of gastric cancer in Japanese patients with Helicobacter pylori infectionInt J Cancer2009125112595260219544559
  • MichelSLinnebacherMAlcanizJLack of HLA class II antigen expression in microsatellite unstable colorectal carcinomas is caused by mutations in HLA class II regulatory genesInt J Cancer2010127488989820013806
  • Hernández-HernándezDMCerda-FloresRMJuárez-CedilloTHuman leukocyte antigens I and II haplotypes associated with human papillomavirus 16-positive invasive cervical cancer in Mexican womenInt J Gynecol Cancer20091961099110619820376
  • OzdemirEKakehiYMishinaMHigh-resolution HLA-DRB1 and DQB1 genotyping in Japanese patients with testicular germ cell carcinomaBr J Cancer19977610134813529374382
  • ChoiHBRohSYChoiEJAssociation of HLA alleles with non-Hodgkin’s lymphoma in Korean populationInt J Hematol200887220320918301962
  • OzdilliKOguzFSAnakSKekikCCarinMGedikogluGThe frequency of HLA class I and II alleles in Turkish childhood acute leukaemia patientsJ Int Med Res20103851835184421309500
  • NauglerCLiwskiRHLA risk markers for chronic myelogenous leukemia in Eastern CanadaLeuk Lymphoma200950225425919235017
  • Hojjat-FarsangiMJeddi-TehraniMAmirzargarAAHuman leukocyte antigen class II allele association to disease progression in Iranian patients with chronic lymphocytic leukemiaHum Immunol2008691066667418722491
  • LimasCJGoldenbergIFLimasCInfluence of anti-beta-receptor antibodies on cardiac adenylate cyclase in patients with idiopathic dilated cardiomyopathyAm Heart J19901196132213282162138
  • LiQMiloRPanitchHBeverCTJrEffect of propranolol and IFN-beta on the induction of MHC class II expression and cytokine production by IFN-gamma IN THP-1 human monocytic cellsImmunopharmacol Immunotoxicol199820139619543699
  • ShawSMCoppingerTWaywellCThe effect of beta-blockers on the adaptive immune system in chronic heart failureCardiovasc Ther200927318118619689617
  • JohnstonCITissue angiotensin converting enzyme in cardiac and vascular hypertrophy, repair, and remodelingHypertension19942322582688307637
  • DeshayesFNahmiasCAngiotensin receptors: a new role in cancer?Trends Endocrinol Metab200516729329916061390
  • LotfyMEl-KenawyAel-MAbdel-AzizMMEl-KadyITalaatAElevated renin levels in patients with liver cirrhosis and hepatocellular carcinomaAsian Pac J Cancer Prev20101151263126621198274
  • BeyazitYPurnakTSuvakBIncreased ACE in extrahepatic cholangiocarcinoma as a clue for activated RAS in biliary neoplasmsClin Res Hepatol Gastroenterol2011351064464921802387
  • AksuSBeyazitYHaznedarogluICOver-expression of angiotensin-converting enzyme (CD 143) on leukemic blasts as a clue for the activated local bone marrow RAS in AMLLeuk Lymphoma200647589189616753875
  • KocaEHaznedarogluICUnerASayinalpNSaglamAEAngiotensin-converting enzyme expression of the lymphoma-associated macrophages in the lymph nodes of Hodgkin’s diseaseJ Natl Med Assoc20079911124312441246124718020099
  • HuangWYuLFZhongJAngiotensin II type 1 receptor expression in human gastric cancer and induces MMP2 and MMP9 expression in MKN-28 cellsDig Dis Sci200853116316817486447
  • LouisSNWangLChowLAppearance of angiotensin II expression in non-basal epithelial cells is an early feature of malignant change in human prostateCancer Detect Prev200731539139518031950
  • FengYNiLWanHOverexpression of ACE2 produces antitumor effects via inhibition of angiogenesis and tumor cell invasion in vivo and in vitroOncol Rep20112651157116421769437
  • InoKShibataKKajiyamaHAngiotensin II type 1 receptor expression in ovarian cancer and its correlation with tumour angiogenesis and patient survivalBr J Cancer200694455256016434990
  • VolanteMRapaIGandhiMRAS mutations are the predominant molecular alteration in poorly differentiated thyroid carcinomas and bear prognostic impactJ Clin Endocrinol Metab200994124735474119837916
  • Alves CorrêaSARibeiro de NoronhaSMNogueira-de-SouzaNCAssociation between the angiotensin-converting enzyme (insertion/deletion) and angiotensin II type 1 receptor (A1166C) polymorphisms and breast cancer among Brazilian womenJ Renin Angiotensin Aldosterone Syst2009101515819286759
  • González-Zuloeta LaddAMArias VásquezASayed-TabatabaeiFACoeberghJWHofmanAAngiotensin-converting enzyme gene insertion/deletion polymorphism and breast cancer riskCancer Epidemiol Biomarkers Prev20051492143214616172223
  • van der KnaapRSiemesCCoeberghJWvan DuijnCMHofmanAStrickerBHRenin-angiotensin system inhibitors, angiotensin I-converting enzyme gene insertion/deletion polymorphism, and cancer: the Rotterdam StudyCancer2008112474875718181094
  • WangXWangSLinYWAngiotensin-converting enzyme insertion/deletion polymorphism and the risk of prostate cancer in the Han population of ChinaMed Oncol20122931964197121874567
  • FengYWanHLiuJThe angiotensin-converting enzyme 2 in tumor growth and tumor-associated angiogenesis in non-small cell lung cancerOncol Rep201023494194820204277
  • ZhouLZhangRYaoWWangJQianADecreased expression of angiotensin-converting enzyme 2 in pancreatic ductal adenocarcinoma is associated with tumor progressionTohoku J Exp Med2009217212313119212105
  • ZhouLZhangRZhangLYaoWLiJYuanYAngiotensin-converting enzyme 2 acts as a potential molecular target for pancreatic cancer therapyCancer Lett20113071182521481527
  • KinoshitaJFushidaSHaradaSLocal angiotensin II-generation in human gastric cancer: correlation with tumor progression through the activation of ERK1/2, NF-kappaB and survivinInt J Oncol20093461573158219424575
  • DuNFengJHuLJAngiotensin II receptor type 1 blockers suppress the cell proliferation effects of angiotensin II in breast cancer cells by inhibiting AT1R signalingOncol Rep20122761893190322426690
  • WilopSvon HobeSCrysandtMEsserAOsiekaRJostEImpact of angiotensin I converting enzyme inhibitors and angiotensin II type 1 receptor blockers on survival in patients with advanced non-small-cell lung cancer undergoing first-line platinum-based chemotherapyJ Cancer Res Clin Oncol2009135101429143519399518
  • NakaiYIsayamaHIjichiHInhibition of renin-angiotensin system affects prognosis of advanced pancreatic cancer receiving gemcitabineBr J Cancer2010103111644164820978506
  • KeizmanDHuangPEisenbergerMAAngiotensin system inhibitors and outcome of sunitinib treatment in patients with metastatic renal cell carcinoma: a retrospective examinationEur J Cancer201147131955196121600760
  • MingMWuJLachanceSDelalandreACarrièreSChanJSBeta-adrenergic receptors and angiotensinogen gene expression in mouse hepatoma cells in vitroHypertension19952511051097843740
  • NakamaruMJacksonEKInagamiTBeta-adrenoceptor-mediated release of angiotensin II from mesenteric arteriesAm J Physiol19862501 Pt 2H144H1483002196
  • RichardsEMHermannKSumnersCRaizadaMKPhillipsMIRelease of immunoreactive angiotensin II from neuronal cultures: adrenergic influencesAm J Physiol19892573 Pt 1C588C5952571298
  • TangSSStevensonLDzauVJEndothelial renin-angiotensin pathway. Adrenergic regulation of angiotensin secretionCirc Res19906611031082153059
  • TaddeiSFavillaSDurantiPSimoniniNSalvettiAVascular renin-angiotensin system and neurotransmission in hypertensive personsHypertension19911832662771653766
  • Vilas-BoasWWRibeiro-OliveiraAJrRibeiro RdaCEffect of propranolol on the splanchnic and peripheral renin angiotensin system in cirrhotic patientsWorld J Gastroenterol200814446824683019058308
  • SaijonmaaONymanTFyhrquistFCarvedilol inhibits basal and stimulated ACE production in human endothelial cellsJ Cardiovasc Pharmacol200443561662115071347
  • Cohen SolalAJondeauGBeauvaisFBerdeauxABeneficial effects of carvedilol on angiotensin-converting enzyme activity and renin plasma levels in patients with chronic heart failureEur J Heart Fail20046446346615182772
  • ItinteangTBraschHDTanSTDayDJExpression of components of the renin-angiotensin system in proliferating infantile haemangioma may account for the propranolol-induced accelerated involutionJ Plast Reconstr Aesthet Surg201164675976520870476
  • Léauté-LabrèzeCDumas de la RoqueEHubicheTBoraleviFThamboJBTaïebAPropranolol for severe hemangiomas of infancyN Engl J Med2008358242649265118550886
  • SansVde la RoqueEDBergeJPropranolol for severe infantile hemangiomas: follow-up reportPediatrics20091243e423e43119706583
  • ShuklaSMacLennanGTFuPNuclear factor-kappaB/p65 (Rel A) is constitutively activated in human prostate adenocarcinoma and correlates with disease progressionNeoplasia20046439040015256061
  • FurukawaKUwagawaTHarukiKNuclear factor κB activity correlates with the progression and prognosis of pancreatic cancer in a mouse modelSurg Today2012 Epub Aug15
  • OzbekEAliskanTOtunctemurAComparison of tumor grade and stage with nuclear factor kappa b and p38 mitogene activated protein kinase expressions in renal cell cancerArch Ital Urol Androl2012842536022908772
  • SpirinaLVYunusovaNVKondakovaIVAssociation of growth factors, HIF-1 and NF-κB expression with proteasomes in endometrial cancerMol Biol Rep20123998655866222711307
  • SpillerSELogsdonNJDeckardLASontheimerHInhibition of nuclear factor kappa-B signaling reduces growth in medulloblastoma in vivoBMC Cancer20111113621492457
  • YuYLiuHJinMThe joint association of REST and NFKB1 polymorphisms on the risk of colorectal cancerAnn Hum Genet201276426927622530801
  • LinCWHsiehYSHsinCHEffects of NFKB1 and NFKBIA gene polymorphisms on susceptibility to environmental factors and the clinicopathologic development of oral cancerPLoS One201274e3507822509384
  • SongSChenDLuJNFκB1 and NFκBIA polymorphisms are associated with increased risk for sporadic colorectal cancer in a southern Chinese populationPLoS One201166e2172621738780
  • WangXLuPXuLUpdated meta-analysis of NFkappaB1-94 ins/Delattg promoter polymorphism and cancer risk based on 19 case-control studiesAsian Pac J Cancer Prev201112102479248422320942
  • FanYYuWYePWangHWangZNFKB1 insertion/deletion promoter polymorphism increases the risk of advanced ovarian cancer in a Chinese populationDNA Cell Biol201130424124521138333
  • ZhouBQieMWangYRelationship between NFKB1-94 insertion/deletion ATTG polymorphism and susceptibility of cervical squamous cell carcinoma riskAnn Oncol201021350651119892748
  • WangSZhangMZengZIκBα polymorphisms were associated with increased risk of gastric cancer in a southern Chinese population: a case-control studyLife Sci20118817–1879279721376060
  • LiYShiJYangBFKetamine-induced ventricular structural, sympathetic and electrophysiological remodelling: pathological consequences and protective effects of metoprololBr J Pharmacol201216561748175621883145
  • YangSPHoLJLinYLCarvedilol, a new antioxidative beta-blocker, blocks in vitro human peripheral blood T cell activation by downregulating NF-kappaB activityCardiovasc Res200359377678714499879
  • ZhangDMaQYHuHTZhangMβ2-adrenergic antagonists suppress pancreatic cancer cell invasion by inhibiting CREB, NFκB and AP-1Cancer Biol Ther2010101192920424515
  • MasutaniMNakagamaHSugimuraTPoly(ADP-ribose) and carcinogenesisGenes Chromosomes Cancer200338433934814566854
  • TongWMYangYGCaoWHPoly(ADP-ribose) polymerase-1 plays a role in suppressing mammary tumourigenesis in miceOncogene200726263857386717160013
  • TongWMCortesUHandeMPSynergistic role of Ku80 and poly(ADP-ribose) polymerase in suppressing chromosomal aberrations and liver cancer formationCancer Res200262236990699612460917
  • PrasadSCThravesPJBhatiaKGSmulsonMEDritschiloAEnhanced poly(adenosine diphosphate ribose) polymerase activity and gene expression in Ewing’s sarcoma cellsCancer Res199050138432104538
  • TomodaTKurashigeTMorikiTYamamotoHFujimotoSTaniguchiTEnhanced expression of poly(ADP-ribose) synthetase gene in malignant lymphomaAm J Hematol19913742232271907096
  • NoshoKYamamotoHMikamiMOverexpression of poly(ADP-ribose) polymerase-1 (PARP-1) in the early stage of colorectal carcinogenesisEur J Cancer200642142374238116809031
  • Quiles-PerezRMuñoz-GámezJARuiz-ExtremeraAInhibition of poly adenosine diphosphate-ribose polymerase decreases hepatocellular carcinoma growth by modulation of tumor-related gene expressionHepatology201051125526620034026
  • RojoFGarcía-ParraJZazoSNuclear PARP-1 protein overexpression is associated with poor overall survival in early breast cancerAnn Oncol20122351156116421908496
  • BartonVNDonsonAMKleinschmidt-DeMastersBKGoreLLiuAKForemanNKPARP1 expression in pediatric central nervous system tumorsPediatr Blood Cancer20095371227123019533660
  • BarnettJCBeanSMNakayamaJMKondohEMurphySKBerchuckAHigh poly(adenosine diphosphate-ribose) polymerase expression and poor survival in advanced-stage serous ovarian cancerObstet Gynecol20101151495420027033
  • GonçalvesAFinettiPSabatierRPoly(ADP-ribose) polymerase-1 mRNA expression in human breast cancer: a meta-analysisBreast Cancer Res Treat2011127127328121069454
  • ZhangQLiYLiXPARP-1 Val762Ala polymorphism, CagA+ H. pylori infection and risk for gastric cancer in Han Chinese populationMol Biol Rep20093661461146718716896
  • LockettKLHallMCXuJThe ADPRT V762A genetic variant contributes to prostate cancer susceptibility and deficient enzyme functionCancer Res200464176344634815342424
  • HaoBWangHZhouKIdentification of genetic variants in base excision repair pathway and their associations with risk of esophageal squamous cell carcinomaCancer Res200464124378438415205355
  • ZhangJJinXFangSThe functional polymorphism in the matrix metalloproteinase-7 promoter increases susceptibility to esophageal squamous cell carcinoma, gastric cardiac adenocarcinoma and non-small cell lung carcinomaCarcinogenesis200526101748175315930031
  • JinXMKimHNLeeIKParkKSKimHJPARP-1 Val762Ala polymorphism is associated with reduced risk of non-Hodgkin lymphoma in Korean malesBMC Med Genet2010113820196871
  • WangXGWangZQTongWMShenYPARP1 Val762Ala polymorphism reduces enzymatic activityBiochem Biophys Res Commun2007354112212617214964
  • YuHMaHYinMWeiQAssociation between PARP-1 V762A polymorphism and cancer susceptibility: a meta-analysisGenet Epidemiol2011361566522127734
  • OláhGFinnertyCCSbranaEIncreased poly(ADP-ribosyl)ation in skeletal muscle tissue of pediatric patients with severe burn injury: prevention by propranolol treatmentShock2011361182321368715
  • MikamiMGoubaevaFSongJHLeeHTYangJbeta-Adrenoceptor blockers protect against staurosporine-induced apoptosis in SH-SY5Y neuroblastoma cellsEur J Pharmacol20085891–3142118534571
  • UstaEMustafiMStraubAZiemerGThe nonselective beta-blocker carvedilol suppresses apoptosis in human cardiac tissue: a pilot studyHeart Surg Forum2010134E218E22220719722
  • HabonTSzabadosEKesmarkyGThe effect of carvedilol on enhanced ADP-ribosylation and red blood cell membrane damage caused by free radicalsCardiovasc Res200152115316011557244
  • StrosznajderRPJeskoHDziewulskaJEffect of carvedilol on neuronal survival and poly(ADP-ribose) polymerase activity in hippocampus after transient forebrain ischemiaActa Neurobiol Exp (Wars)200565213714315960297
  • OsborneNNWoodJPMetipranolol blunts nitric oxide-induced lipid peroxidation and death of retinal photoreceptors: a comparison with other anti-glaucoma drugsInvest Ophthalmol Vis Sci200445103787379515452090
  • PartykaRGonciarzMJałowieckiPKokocińskaDByrczekTVEGF and metalloproteinase 2 (MMP 2) expression in gastric cancer tissueMed Sci Monit2012184BR130BR13422460086
  • ZaravinosAVolanisDLambrouGIDelakasDSpandidosDARole of the angiogenic components, VEGFA, FGF2, OPN and RHOC, in urothelial cell carcinoma of the urinary bladderOncol Rep20122841159116622895562
  • ZhouZHCuiXNXingHGYanRHYaoDKWangLXChanges and Prognostic Value of Serum Vascular Endothelial Growth Factor in Patients with Differentiated Thyroid CancerMed Princ Pract Epub August 8, 2012
  • GrayRTO’DonnellMEMcGuiganJASpenceGMQuantification of tumour and circulating vascular endothelial growth factor (VEGF) in patients with oesophagogastric cancer: a long-term follow-up studyBr J Biomed Sci2012692717522872931
  • Villarejo-CamposPPadilla-ValverdeDMartinRMSerum VEGF and VEGF-C values before surgery and after postoperative treatment in gastric cancerClin Transl Oncol Epub July 24, 2012
  • LammliJFanMRosenthalHGExpression of Vascular Endothelial Growth Factor correlates with the advance of clinical osteosarcomaInt Orthop201236112307231322855059
  • YenCJLinYJYenCSHepatitis B virus X protein upregulates mTOR signaling through IKKβ to increase cell proliferation and VEGF production in hepatocellular carcinomaPLoS One201277e4193122848663
  • Arias-PulidoHChaherNGongYQuallsCVargasJRoyceMTumor stromal vascular endothelial growth factor A is predictive of poor outcome in inflammatory breast cancerBMC Cancer20121229822813402
  • BandieraEFranceschiniRSpecchiaCPrognostic significance of vascular endothelial growth factor serum determination in women with ovarian cancerISRN Obstet Gynecol2012201224575622792477
  • LiYLiangJLiuXCorrelation of polymorphisms of the vascular endothelial growth factor gene and the risk of lung cancer in an ethnic Han group of North ChinaExp Ther Med20123467367622969949
  • SupicGJovicNZeljicKKozomaraRMagicZAssociation of VEGF-A genetic polymorphisms with cancer risk and survival in advanced-stage oral squamous cell carcinoma patientsOral Oncol201248111171117722818823
  • ZhaoZBaCWangWWangXXueRWuXVascular endothelial growth factor (VEGF) gene polymorphisms and colorectal cancer: a meta-analysis of epidemiologic studiesGenet Test Mol Biomarkers201216121390139423005896
  • HuKZhangYWangRLiGLiGZhangDCurrent evidence on VEGF+405G/C polymorphism and malignancy susceptibility: a meta-analysis involving 30 studiesTwin Res Hum Genet201215449650222853925
  • PengLZhanPZhouYPrognostic significance of vascular endothelial growth factor immunohistochemical expression in gastric cancer: a meta-analysisMol Biol Rep201239109473948422729879
  • ZangJLiCZhaoLNPrognostic value of vascular endothelial growth factor in patients with head and neck cancer: A meta-analysisHead Neck Epub September 18, 2012
  • LutgendorfSKColeSCostanzoEStress-related mediators stimulate vascular endothelial growth factor secretion by two ovarian cancer cell linesClin Cancer Res20039124514452114555525
  • YangEVSoodAKChenMNorepinephrine up-regulates the expression of vascular endothelial growth factor, matrix metalloproteinase (MMP)-2, and MMP-9 in nasopharyngeal carcinoma tumor cellsCancer Res20066621103571036417079456
  • HajighasemiFHajighasemiSEffect of propranolol on angiogenic factors in human hematopoietic cell lines in vitroIran Biomed J200913422322819946348
  • WongHPHoJWKooMWEffects of adrenaline in human colon adenocarcinoma HT-29 cellsLife Sci20118825–261108111221565206
  • KamataTRoles of Nox1 and other Nox isoforms in cancer developmentCancer Sci200910081382138819493276
  • BlockKGorinYNewDDThe NADPH oxidase subunit p22phox inhibits the function of the tumor suppressor protein tuberinAm J Pathol201017652447245520304964
  • YamauraMMitsushitaJFurutaSNADPH oxidase 4 contributes to transformation phenotype of melanoma cells by regulating G2-M cell cycle progressionCancer Res20096962647265419276355
  • MaraldiTPrataCVieceli Dalla SegaFNAD(P)H oxidase isoform Nox2 plays a prosurvival role in human leukaemia cellsFree Radic Res200943111111112119707918
  • HongJResnickMBeharJAcid-induced p16 hypermethylation contributes to development of esophageal adenocarcinoma via activation of NADPH oxidase NOX5-SAm J Physiol Gastrointest Liver Physiol20102993G697G70620576920
  • LuCLQiuJLHuangPZNADPH oxidase DUOX1 and DUOX2 but not NOX4 are independent predictors in hepatocellular carcinoma after hepatectomyTumour Biol20113261173118221915726
  • KimJKoyanagiTMochly-RosenDPKCδ activation mediates angiogenesis via NADPH oxidase activity in PC-3 prostate cancer cellsProstate201171994695421541971
  • WangRDashwoodWMNianHNADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)Int J Cancer2011128112581259020715105
  • HsiehCHShyuWCChiangCYKuoJWShenWCLiuRSNADPH oxidase subunit 4-mediated reactive oxygen species contribute to cycling hypoxia-promoted tumor progression in glioblastoma multiformePLoS One201169e2394521935366
  • YinLKosugiMKufeDInhibition of the MUC1-C oncoprotein induces multiple myeloma cell death by down-regulating TIGAR expression and depleting NADPHBlood2012119381081622117045
  • NaoeTTakeyamaKYokozawaTAnalysis of genetic polymorphism in NQO1, GST-M1, GST-T1, and CYP3A4 in 469 Japanese patients with therapy-related leukemia/myelodysplastic syndrome and de novo acute myeloid leukemiaClin Cancer Res20006104091409511051261
  • FernLPallisMIan CarterGSeedhouseCRussellNByrneJClonal haemopoiesis may occur after conventional chemotherapy and is associated with accelerated telomere shortening and defects in the NQO1 pathway; possible mechanisms leading to an increased risk of t-AML/MDSBr J Haematol20041261637115198733
  • HamajimaNMatsuoKIwataHNAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism and the risk of eight cancers for JapaneseInt J Clin Oncol20027210310812018106
  • ChanECLamSYFuKHKwongYLPolymorphisms of the GSTM1, GSTP1, MPO, XRCC1, and NQO1 genes in Chinese patients with non-small cell lung cancers: relationship with aberrant promoter methylation of the CDKN2A and RARB genesCancer Genet Cytogenet20051621102016157195
  • LanQZhengTShenMGenetic polymorphisms in the oxidative stress pathway and susceptibility to non-Hodgkin lymphomaHum Genet2007121216116817149600
  • HoffmannMSchirmerMATzvetkovMVGerman Study Group for High-Grade Non-Hodgkin LymphomaA functional polymorphism in the NAD(P)H oxidase subunit CYBA is related to gene expression, enzyme activity, and outcome in non-Hodgkin lymphomaCancer Res20107062328233820215507
  • GraOAGlotovASKozhekbaevaZHMakarovaOVNasedkinaTVGenetic polymorphism in GST, NAT2, and MTRR and susceptibility to childhood acute leukemiaMol Biol (Mosk)2008422214225 Russian18610829
  • SeiboldPHeinRSchmezerPPolymorphisms in oxidative stress-related genes and postmenopausal breast cancer riskInt J Cancer201112961467147621792883
  • MalikMASharmaKLZargarSAMittalBAssociation of matrix metalloproteinase-7 (-181A>G) polymorphism with risk of esophageal squamous cell carcinoma in Kashmir ValleySaudi J Gastroenterol201117530130621912055
  • SorrentinoSADoerriesCManesCNebivolol exerts beneficial effects on endothelial function, early endothelial progenitor cells, myocardial neovascularization, and left ventricular dysfunction early after myocardial infarction beyond conventional β1-blockadeJ Am Coll Cardiol201157560161121272752
  • ManriqueCLastraGHabibiJNebivolol improves insulin sensitivity in the TGR(Ren2)27 ratMetabolism201160121757176621640361
  • Whaley-ConnellAHabibiJJohnsonMNebivolol reduces proteinuria and renal NADPH oxidase-generated reactive oxygen species in the transgenic Ren2 ratAm J Nephrol200930435436019609077
  • ZhouXMaLHabibiJNebivolol improves diastolic dysfunction and myocardial remodeling through reductions in oxidative stress in the Zucker obese ratHypertension201055488088820176997
  • ArozalWWatanabeKVeeraveeduPTProtective effect of carvedilol on daunorubicin-induced cardiotoxicity and nephrotoxicity in ratsToxicology20102741–3182620452391
  • MollnauHSchulzEDaiberANebivolol prevents vascular NOS III uncoupling in experimental hyperlipidemia and inhibits NADPH oxidase activity in inflammatory cellsArterioscler Thromb Vasc Biol200323461562112692005
  • KobayashiNMitaSYoshidaKCeliprolol activates eNOS through the PI3K-Akt pathway and inhibits VCAM-1 Via NF-kappaB induced by oxidative stressHypertension20034251004101314557279
  • GaramszegiNGaramszegiSPScullySPMatrix metalloproteinase-1 contribution to sarcoma cell invasionJ Cell Mol Med20121661331134121801306
  • DongWLiHZhangYMatrix metalloproteinase 2 promotes cell growth and invasion in colorectal cancerActa Biochim Biophys Sin (Shanghai)2011431184084821968416
  • PengWJZhangJQWangBXPanHFLuMMWangJPrognostic value of matrix metalloproteinase 9 expression in patients with non-small cell lung cancerClin Chim Acta201241313–141121112622465234
  • QiuJShaoSYangGShenZZhangYAssociation of Toll like receptor 9 expression with lymph node metastasis in human breast cancerNeoplasma201158325125521391743
  • ZhangWYangHCWangQClinical value of combined detection of serum matrix metalloproteinase-9, heparanase, and cathepsin for determining ovarian cancer invasion and metastasisAnticancer Res201131103423342821965756
  • YanWZhangWSunLIdentification of MMP-9 specific microRNA expression profile as potential targets of anti-invasion therapy in glioblastoma multiformeBrain Res2011141110811521831363
  • XiaZLiuWLiSExpression of matrix metalloproteinase-9, type IV collagen and vascular endothelial growth factor in adamantinous craniopharyngiomaNeurochem Res201136122346235121814723
  • FengSCenJHuangYMatrix metalloproteinase-2 and -9 secreted by leukemic cells increase the permeability of blood-brain barrier by disrupting tight junction proteinsPLoS One201168e2059921857898
  • ParsonsSLWatsonSACollinsHMGriffinNRClarkePASteeleRJGelatinase (MMP-2 and -9) expression in gastrointestinal malignancyBr J Cancer19987811149515029836483
  • AltaşMBayrakOFAyanEThe effect of polymorphisms in the promoter region of the MMP-1 gene on the occurrence and invasiveness of hypophyseal adenomaActa Neurochir (Wien)201015291611161720437278
  • TeeYTLiuYFChangJTSingle-nucleotide polymorphisms and haplotypes of membrane type 1-matrix metalloproteinase in susceptibility and clinical significance of squamous cell neoplasia of uterine cervix in Taiwan womenReprod Sci201219993293822527983
  • SrivastavaPLoneTAKapoorRMittalRDAssociation of promoter polymorphisms in MMP2 and TIMP2 with prostate cancer susceptibility in North IndiaArch Med Res201243211712422374248
  • ZhaoXWangXWuWMatrix metalloproteinase-2 polymorphisms and clinical outcome of Chinese patients with nonsmall cell lung cancer treated with first-line, platinum-based chemotherapyCancer2012118143587359822072145
  • DzikiLPrzybyłowskaKMajsterekITrzcińskiRMikMSygutAA/G polymorphism of the MMP-7 gene promoter region in colorectal cancerPol Przegl Chir2011831162262622246095
  • ChaudharyAKPandyaSMehrotraRSinghMSinghMRole of functional polymorphism of matrix metalloproteinase-2 (-1306 C/T and -168 G/T) and MMP-9 (-1562 C/T) promoter in oral submucous fibrosis and head and neck squamous cell carcinoma in an Indian populationBiomarkers201116757758621958210
  • WieczorekEReszkaEGromadzinskaJWasowiczWGenetic polymorphism of matrix metalloproteinases in breast cancerNeoplasma201259323724722296495
  • ZhangLYRenKWMeta-analysis of MMP2 -1306T allele as a protective factor in digestive cancerArch Med Res201142323924321722821
  • ZhangLFMiYYCaoQUpdate analysis of studies on the MMP-9 -1562 C>T polymorphism and cancer riskMol Biol Rep20123943435344121717058
  • LiuDGuoHLiYXuXYangKBaiYAssociation between polymorphisms in the promoter regions of matrix metalloproteinases (MMPs) and risk of cancer metastasis: a meta-analysisPLoS One201272e3125122348060
  • LiuDDuanWGuoHXuXBaiYMeta-analysis of associations between polymorphisms in the promoter regions of matrix metalloproteinases and the risk of colorectal cancerInt J Colorectal Dis20112691099110521538057
  • AnnabiBLachambreMPPlouffeKMoumdjianRBéliveauRPropranolol adrenergic blockade inhibits human brain endothelial cells tubulogenesis and matrix metalloproteinase-9 secretionPharmacol Res200960543844519467330
  • LirussiFO’BrienMWendremaireMSAR150640, a selective beta3-adrenoceptor agonist, prevents human myometrial remodelling and activation of matrix metalloproteinase in an in vitro model of chorioamnionitisBr J Pharmacol201015961354136620136828
  • GuoKMaQWangLNorepinephrine-induced invasion by pancreatic cancer cells is inhibited by propranololOncol Rep200922482583019724861
  • HipskindRABilbeGMAP kinase signaling cascades and gene expression in osteoblastsFront Biosci19983d804d8169682034
  • WangSNLeeKTTsaiCJChenYJYehYTPhosphorylated p38 and JNK MAPK proteins in hepatocellular carcinomaEur J Clin Invest. 20122012421212951301
  • BangYJKwonJHKangSHKimJWYangYCIncreased MAPK activity and MKP-1 overexpression in human gastric adenocarcinomaBiochem Biophys Res Commun1998250143479735328
  • HoriMInagawaSShimazakiJItabashiMHoriMOverexpression of mitogen-activated protein kinase superfamily proteins unrelated to Ras and AF-1 of estrogen receptor alpha mutation in advanced stage human breast cancerPathol Res Pract20001961281782611156322
  • SullivanRJFlahertyKMAP kinase signaling and inhibition in melanomaOncogene2012 Epub September3
  • Al-AzayzihAGaoFGocASomanathPRTGFβ1 induces apoptosis in invasive prostate cancer and bladder cancer cells via Akt-independent, p38 MAPK and JNK/SAPK-mediated activation of caspasesBiochem Biophys Res Commun2012427116517022989755
  • SlatteryMLLundgreenAWolffRKMAPKinase genes and colon and rectal cancerCarcinogenesis201233122398240823027623
  • GröschlBBettstetterMGiedlCExpression of the MAP kinase phosphatase DUSP4 is associated with microsatellite instability in colorectal cancer (CRC) and causes increased cell proliferationInt J Cancer Epub September 11, 2012
  • HuangXYWangHCYuanZHuangJZhengQNorepinephrine stimulates pancreatic cancer cell proliferation, migration and invasion via β-adrenergic receptor-dependent activation of P38/MAPK pathwayHepatogastroenterology20125911588989322020907
  • ChimHArmijoBSMillerEGliniakCSerretMAGosainAKPropranolol induces regression of hemangioma cells through HIF-1α-mediated inhibition of VEGF-AAnn Surg2012256114615622580939
  • JabbourHNMilneSAWilliamsARAndersonRABoddySCExpression of COX-2 and PGE synthase and synthesis of PGE(2)in endometrial adenocarcinoma: a possible autocrine/paracrine regulation of neoplastic cell function via EP2/EP4 receptorsBr J Cancer20018571023103111592775
  • KunduNYangQDorseyRFultonAMIncreased cyclooxygenase-2 (cox-2) expression and activity in a murine model of metastatic breast cancerInt J Cancer200193568168611477578
  • GatalicaZLillebergSLKoulMSCOX-2 gene polymorphisms and protein expression in renomedullary interstitial cell tumorsHum Pathol200839101495150418619641
  • OkawaTYoshinagaKUetakeHCyclooxygenase-2 overexpression is related to polypoid growth and K-ras gene mutation in T1 colorectal carcinomasDis Colon Rectum200447111915192115622585
  • LeungWKToKFNgYPAssociation between cyclo- oxygenase-2 overexpression and missense p53 mutations in gastric cancerBr J Cancer200184333533911161397
  • SalesKJKatzAADavisMCyclooxygenase-2 expression and prostaglandin E(2) synthesis are up-regulated in carcinomas of the cervix: a possible autocrine/paracrine regulation of neoplastic cell function via EP2/EP4 receptorsJ Clin Endocrinol Metab20018652243224911344234
  • BrosensLAIacobuzio-DonahueCAKellerJJIncreased cyclooxygenase-2 expression in duodenal compared with colonic tissues in familial adenomatous polyposis and relationship to the -765G -> C COX-2 polymorphismClin Cancer Res200511114090409615930344
  • MarkosyanNChenEPNdongVNDeletion of cyclooxygenase 2 in mouse mammary epithelial cells delays breast cancer onset through augmentation of type 1 immune responses in tumorsCarcinogenesis201132101441144921771729
  • SantanderSCebriánCEsquiviasPCyclooxygenase inhibitors decrease the growth and induce regression of human esophageal adenocarcinoma xenografts in nude miceInt J Oncol201240252753421971589
  • RozicJGChakrabortyCLalaPKCyclooxygenase inhibitors retard murine mammary tumor progression by reducing tumor cell migration, invasiveness and angiogenesisInt J Cancer200193449750611477553
  • KangSKimYBKimMHPolymorphism in the nuclear factor kappa-B binding promoter region of cyclooxygenase-2 is associated with an increased risk of bladder cancerCancer Lett20052171111615596291
  • SakodaLCGaoYTChenBEProstaglandin-endoperoxide synthase 2 (PTGS2) gene polymorphisms and risk of biliary tract cancer and gallstones: a population-based study in Shanghai, ChinaCarcinogenesis20062761251125616361272
  • ParkJMChoiJEChaeMHRelationship between cyclooxygenase 8473T>C polymorphism and the risk of lung cancer: a case-control studyBMC Cancer200667016542464
  • LiraMGMazzolaSTessariGAssociation of functional gene variants in the regulatory regions of COX-2 gene (PTGS2) with nonmelanoma skin cancer after organ transplantationBr J Dermatol20071571495717578436
  • UpadhyayRJainMKumarSGhoshalUCMittalBFunctional polymorphisms of cyclooxygenase-2 (COX-2) gene and risk for esophageal squmaous cell carcinomaMutat Res20096631–2525919428370
  • Ben NasrHChahedKBouaouinaNChouchaneLPTGS2 (COX-2) -765 G > C functional promoter polymorphism and its association with risk and lymph node metastasis in nasopharyngeal carcinomaMol Biol Rep200936119320017968676
  • ZhaoDXuDZhangXInteraction of cyclooxygenase-2 variants and smoking in pancreatic cancer: a possible role of nucleophosminGastroenterology200913651659166819422084
  • LurieGTerryKLWilkensLRPooled analysis of the association of PTGS2 rs5275 polymorphism and NSAID use with invasive ovarian carcinoma riskCancer Causes Control201021101731174120559705
  • AbrahamJEHarringtonPDriverKECommon polymorphisms in the prostaglandin pathway genes and their association with breast cancer susceptibility and survivalClin Cancer Res20091562181219119276290
  • LiYHeWLiuTZhangQA new cyclo-oxygenase-2 gene variant in the Han Chinese population is associated with an increased risk of gastric carcinomaMol Diagn Ther201014635135521275453
  • ZhengJChenSJiangLYouYWuDZhouYFunctional genetic variations of cyclooxygenase-2 and susceptibility to acute myeloid leukemia in a Chinese populationEur J Haematol201187648649321848701
  • AmirianESIttmannMMScheurerMEAssociations between arachidonic acid metabolism gene polymorphisms and prostate cancer riskProstate201171131382138921308720
  • PetersWHLackoMTe MorscheRHVoogdACOude OphuisMBManniJJCOX-2 polymorphisms and the risk for head and neck cancer in white patientsHead Neck200931793894319280666
  • GongZBostickRMXieDGenetic polymorphisms in the cyclooxygenase-1 and cyclooxygenase-2 genes and risk of colorectal adenomaInt J Colorectal Dis200924664765419205707
  • AkkızHBayramSBekarAAkgöllüEÜlgerYFunctional polymorphisms of cyclooxygenase-2 gene and risk for hepatocellular carcinomaMol Cell Biochem20113471–220120821042835
  • DongJDaiJZhangMHuZShenHPotentially functional COX-2-1195G>A polymorphism increases the risk of digestive system cancers: a meta-analysisJ Gastroenterol Hepatol20102561042105020594217
  • ZhuWWeiBBShanXLiuP-765G>C and 8473T>C polymorphisms of COX-2 and cancer risk: a meta-analysis based on 33 case-control studiesMol Biol Rep201037127728819669667
  • ShrubsoleMJCaiQWenWUrinary prostaglandin E2 metabolite and risk for colorectal adenomaCancer Prev Res (Phila)20125233634222166248
  • HogendorfPDurczyńskiAKumorAStrzelczykJProstaglandin E2 (PGE2) in portal blood in patients with pancreatic tumor – a single institution seriesJ Invest Surg201225181322272632
  • RasmusonAKockAFuskevågOMAutocrine prostaglandin E2 signaling promotes tumor cell survival and proliferation in childhood neuroblastomaPLoS One201271e2933122276108
  • HanSRomanJSuppression of prostaglandin E2 receptor subtype EP2 by PPARgamma ligands inhibits human lung carcinoma cell growthBiochem Biophys Res Commun200431441093109914751245
  • GlasnerAAvrahamRRosenneEImproving survival rates in two models of spontaneous postoperative metastasis in mice by combined administration of a beta-adrenergic antagonist and a cyclooxygenase-2 inhibitorJ Immunol201018452449245720124103
  • BenishMBartalIGoldfarbYPerioperative use of beta-blockers and COX-2 inhibitors may improve immune competence and reduce the risk of tumor metastasisAnn Surg Oncol20081572042205218398660
  • GuptaSCHeviaDPatchvaSParkBKohWAggarwalBBUpsides and downsides of reactive oxygen species for cancer: the roles of reactive oxygen species in tumorigenesis, prevention, and therapyAntioxid Redox Signal201216111295132222117137
  • MarraMSordelliIMLombardiALambertiMTarantinoLMolecular targets and oxidative stress biomarkers in hepatocellular carcinoma: an overviewJ Transl Med2011917121985599
  • ZhangQMaYChengYFLiWJZhangZChenSYInvolvement of reactive oxygen species in 2-methoxyestradiol-induced apoptosis in human neuroblastoma cellsCancer Lett2011313220121021978530
  • WangHCChoudharySReactive oxygen species-mediated therapeutic control of bladder cancerNat Rev Urol201181160861621971316
  • RogalskaAGajekASzwedMJóŸwiakZMarczakAThe role of reactive oxygen species in WP 631-induced death of human ovarian cancer cells: a comparison with the effect of doxorubicinToxicol in Vitro20112581712172021896327
  • Gupta-EleraGGarrettARRobisonRAO’NeillKLThe role of oxidative stress in prostate cancerEur J Cancer Prev201221215516221857523
  • HongCCAmbrosoneCBAhnJGenetic variability in iron-related oxidative stress pathways (Nrf2, NQ01, NOS3, and HO-1), iron intake, and risk of postmenopausal breast cancerCancer Epidemiol Biomarkers Prev20071691784179417726138
  • WoodsonKTangreaJALehmanTAManganese superoxide dismutase (MnSOD) polymorphism, alpha-tocopherol supplementation and prostate cancer risk in the alpha-tocopherol, beta-carotene cancer prevention study (Finland)Cancer Causes Control200314651351812948282
  • WangSWangFShiXAssociation between manganese superoxide dismutase (MnSOD) Val-9Ala polymorphism and cancer risk – A meta-analysisEur J Cancer200945162874288119467856
  • MaoCQiuLXZhanPMnSOD Val16Ala polymorphism and prostate cancer susceptibility: a meta-analysis involving 8,962 subjectsJ Cancer Res Clin Oncol2010136797597920012093
  • MaXChenCXiongHNo association between SOD2 Val16Ala polymorphism and breast cancer susceptibility: a meta-analysis based on 9,710 cases and 11,041 controlsBreast Cancer Res Treat2010122250951420052533
  • LarsonBEStockwellDWBoasSAndrewsTWellmanGCCardiac reactive oxygen species after traumatic brain injuryJ Surg Res20121732e738122172132
  • MaLGulRHabibiJNebivolol improves diastolic dysfunction and myocardial remodeling through reductions in oxidative stress in the transgenic (mRen2) ratAm J Physiol Heart Circ Physiol201230211H2341H235122447938
  • Le PennecSMirebeau-PrunierDBoutet-BouzamondoNNitric oxide and calcium participate in the fine regulation of mitochondrial biogenesis in follicular thyroid carcinoma cellsJ Biol Chem201128620182291823921454643
  • BentzBGChandraRHainesGK3rdRobinsonAMShahPRadosevichJANitric oxide and apoptosis during human head and neck squamous cell carcinoma developmentAm J Otolaryngol200223141111791242
  • SiripinDFucharoenSTanyongDINitric oxide and caspase 3 mediated cytokine induced apoptosis in acute leukemiaAsian Pac J Allergy Immunol201129110211121560495
  • SaleemWSuzukiYMobarakiAYoshidaYNodaSReduction of nitric oxide level enhances the radiosensitivity of hypoxic non-small cell lung cancerCancer Sci2011102122150215621899660
  • GulerEBaspinarOCekmenMKilincMBalatANitric oxide: a new biomarker of Doxorubicin toxicity in children?Pediatr Hematol Oncol201128539540221699469
  • ChinMPDeenWMPrediction of nitric oxide concentrations in melanomasNitric Oxide201023431932620854923
  • EllieELoiseauHLafondFArsautJDemotes-MainardJDifferential expression of inducible nitric oxide synthase mRNA in human brain tumoursNeuroreport1995712942968742473
  • ZhangWHeXJMaYYInducible nitric oxide synthase expression correlates with angiogenesis, lymphangiogenesis, and poor prognosis in gastric cancer patientsHum Pathol20114291275128221333324
  • GlynnSABoersmaBJDorseyTHIncreased NOS2 predicts poor survival in estrogen receptor-negative breast cancer patientsJ Clin Invest2010120113843385420978357
  • CardnellRJMikkelsenRBNitric oxide synthase inhibition enhances the antitumor effect of radiation in the treatment of squamous carcinoma xenograftsPLoS One201165e2014721647438
  • RykCSteineckGWiklundNPNybergTde VerdierPJThe (CCTTT)n microsatellite polymorphism in the nitric oxide synthase 2 gene may influence bladder cancer pathogenesisJ Urol201018452150215720850837
  • ShenCHWangYHWangWCInducible nitric oxide synthase promoter polymorphism, cigarette smoking, and urothelial carcinoma riskUrology20076951001100617482959
  • KaiseMMiwaJSuzukiNInducible nitric oxide synthase gene promoter polymorphism is associated with increased gastric mRNA expression of inducible nitric oxide synthase and increased risk of gastric carcinomaEur J Gastroenterol Hepatol200719213914517272999
  • ArıkanSCacinaCGulerEÇulcuSTunaGYaylım-EraltanIThe effects of NOS3 Glu298Asp variant on colorectal cancer risk and progression in Turkish populationMol Biol Rep20123933245324921706163
  • HanXZhengTLanQGenetic polymorphisms in nitric oxide synthase genes modify the relationship between vegetable and fruit intake and risk of non-Hodgkin lymphomaCancer Epidemiol Biomarkers Prev20091851429143819423521
  • HaoYMontielRHuangYEndothelial nitric oxide synthase (eNOS) 894 G>T polymorphism is associated with breast cancer risk: a meta-analysisBreast Cancer Res Treat2010124380981320428939
  • DaiYHouFBuckmillerLDecreased eNOS protein expression in involuting and propranolol-treated hemangiomasArch Otolaryngol Head Neck Surg2012138217718222351865