Development and Validation of a Novel Diagnostic Nomogram Model Using Serum Oxidative Stress Markers and AURKA for Prediction of Nasopharyngeal Carcinoma

References

• Chen YP, Chan ATC, Le QT, Blanchard P, Sun Y, Ma J. Nasopharyngeal carcinoma. Lancet. 2019;394(10192):64–80. doi:10.1016/S0140-6736(19)30956-0
   PubMed Web of Science ®Google Scholar
• Zhou X, Cao SM, Cai YL, et al. A comprehensive risk score for effective risk stratification and screening of nasopharyngeal carcinoma. Nat Commun. 2021;12(1):5189. doi:10.1038/s41467-021-25402-z
   PubMed Web of Science ®Google Scholar
• Bansal A, Simon MC. Glutathione metabolism in cancer progression and treatment resistance. J Cell Biol. 2018;217(7):2291–2298. doi:10.1083/jcb.201804161
   PubMed Web of Science ®Google Scholar
• Mazzuferi G, Bacchetti T, Islam MO, Ferretti G. High density lipoproteins and oxidative stress in breast cancer. Lipids Health Dis. 2021;20(1):143. doi:10.1186/s12944-021-01562-1
   PubMed Web of Science ®Google Scholar
• Braga-Neto MB, Costa DVS, Queiroz DMM, et al. Increased oxidative stress in gastric cancer patients and their first-degree relatives: a prospective study from Northeastern Brazil. Oxid Med Cell Longev. 2021;2021:6657434. doi:10.1155/2021/6657434
   PubMed Web of Science ®Google Scholar
• Wu Z, Huang H, Han Q, et al. SENP7 senses oxidative stress to sustain metabolic fitness and antitumor functions of CD8+ T cells. J Clin Invest. 2022;132(7). doi:10.1172/JCI155224
   Web of Science ®Google Scholar
• Wigner P, Szymanska B, Bijak M, et al. Oxidative stress parameters as biomarkers of bladder cancer development and progression. Sci Rep. 2021;11(1):15134. doi:10.1038/s41598-021-94729-w
   PubMed Web of Science ®Google Scholar
• Bilgin E, Atli G, Duman BB, Okten AI. Evaluation of oxidative stress biomarkers in brain metastatic and non-metastatic lung cancer patients with different cell types. Anticancer Agents Med Chem. 2021;21(15):2032–2040. doi:10.2174/1871520621666210211163055
   PubMed Web of Science ®Google Scholar
• Niu B, Liao K, Zhou Y, et al. Application of glutathione depletion in cancer therapy: enhanced ROS-based therapy, ferroptosis, and chemotherapy. Biomaterials. 2021;277:121110. doi:10.1016/j.biomaterials.2021.121110
   PubMed Web of Science ®Google Scholar
• Pakfetrat A, Dalirsani Z, Hashemy SI, et al. Evaluation of serum levels of oxidized and reduced glutathione and total antioxidant capacity in patients with head and neck squamous cell carcinoma. J Cancer Res Ther. 2018;14(2):428–431. doi:10.4103/0973-1482.189229
   PubMed Web of Science ®Google Scholar
• Xue N, Zhou R, Deng M, et al. High serum superoxide dismutase activity improves radiation-related quality of life in patients with esophageal squamous cell carcinoma. Clinics. 2021;76:e2226. doi:10.6061/clinics/2021/e2226
   PubMed Web of Science ®Google Scholar
• Perluigi M, Coccia R, Butterfield DA. 4-Hydroxy-2-nonenal, a reactive product of lipid peroxidation, and neurodegenerative diseases: a toxic combination illuminated by redox proteomics studies. Antioxid Redox Signal. 2012;17(11):1590–1609. doi:10.1089/ars.2011.4406
   PubMed Web of Science ®Google Scholar
• Wang YK, Chiang WC, Kuo FC, et al. Levels of malondialdehyde in the gastric juice: its association with Helicobacter pylori infection and stomach diseases. Helicobacter. 2018;23(2):e12460. doi:10.1111/hel.12460
   PubMed Web of Science ®Google Scholar
• Zińczuk J, Maciejczyk M, Zaręba K, et al. Antioxidant barrier, redox status, and oxidative damage to biomolecules in patients with colorectal cancer. can malondialdehyde and catalase be markers of colorectal cancer advancement? Biomolecules. 2019;9(10):637. doi:10.3390/biom9100637
   PubMed Web of Science ®Google Scholar
• Dillioglugil MO, Mekık H, Muezzinoglu B, Ozkan TA, Demir CG, Dillioglugil O. Blood and tissue nitric oxide and malondialdehyde are prognostic indicators of localized prostate cancer. Int Urol Nephrol. 2012;44(6):1691–1696. doi:10.1007/s11255-012-0221-1
   PubMed Web of Science ®Google Scholar
• Kaynar H, Meral M, Turhan H, Keles M, Celik G, Akcay F. Glutathione peroxidase, glutathione-S-transferase, catalase, xanthine oxidase, Cu-Zn superoxide dismutase activities, total glutathione, nitric oxide, and malondialdehyde levels in erythrocytes of patients with small cell and non-small cell lung cancer. Cancer Lett. 2005;227(2):133–139. doi:10.1016/j.canlet.2004.12.005
   PubMed Web of Science ®Google Scholar
• Gargouri B, Lassoued S, Ben Mansour R, et al. High levels of autoantibodies against catalase and superoxide dismutase in nasopharyngeal carcinoma. South Med J. 2009;102(12):1222–1226. doi:10.1097/SMJ.0b013e3181bb85b5
   PubMed Web of Science ®Google Scholar
• Gargouri B, Lassoued S, Ayadi W, et al. Lipid peroxidation and antioxidant system in the tumor and in the blood of patients with nasopharyngeal carcinoma. Biol Trace Elem Res. 2009;132(1–3):27–34. doi:10.1007/s12011-009-8384-z
   PubMed Web of Science ®Google Scholar
• Bozan N, Demir H, Gursoy T, et al. Alterations in oxidative stress markers in laryngeal carcinoma patients. J Chin Med Assoc. 2018;81(9):811–815. doi:10.1016/j.jcma.2018.02.004
   PubMed Web of Science ®Google Scholar
• Dawei H, Honggang D, Qian W. AURKA contributes to the progression of oral squamous cell carcinoma (OSCC) through modulating epithelial-to-mesenchymal transition (EMT) and apoptosis via the regulation of ROS. Biochem Biophys Res Commun. 2018;507(1–4):83–90. doi:10.1016/j.bbrc.2018.10.170
   PubMed Web of Science ®Google Scholar
• Mehra R, Serebriiskii IG, Burtness B, Astsaturov I, Golemis EA. Aurora kinases in head and neck cancer. Lancet Oncol. 2013;14(10):e425–e435. doi:10.1016/S1470-2045(13)70128-1
   PubMed Web of Science ®Google Scholar
• Huang C, Chen L, Zhang Y, et al. Predicting AURKA as a novel therapeutic target for NPC: a comprehensive analysis based on bioinformatics and validation. Front Genet. 2022;13:926546. doi:10.3389/fgene.2022.926546
   PubMed Web of Science ®Google Scholar
• Du R, Huang C, Liu K, Li X, Dong Z. Targeting AURKA in Cancer: molecular mechanisms and opportunities for Cancer therapy. Mol Cancer. 2021;20(1):15. doi:10.1186/s12943-020-01305-3
   PubMed Web of Science ®Google Scholar
• Katsha A, Soutto M, Sehdev V, et al. Aurora kinase A promotes inflammation and tumorigenesis in mice and human gastric neoplasia. Gastroenterology. 2013;145(6):1312–1322 e1311–1318. doi:10.1053/j.gastro.2013.08.050
   Web of Science ®Google Scholar
• Skorska KB, Placzkowska S, Prescha A, et al. Serum total SOD activity and SOD1/2 concentrations in predicting all-cause mortality in lung cancer patients. Pharmaceuticals. 2021;14(11):1067. doi:10.3390/ph14111067
   Web of Science ®Google Scholar
• Strycharz-Dudziak M, Foltyn S, Dworzanski J, et al. Glutathione Peroxidase (GPx) and Superoxide Dismutase (SOD) in oropharyngeal cancer associated with EBV and HPV coinfection. Viruses. 2020;12(9):1008. doi:10.3390/v12091008
   PubMed Web of Science ®Google Scholar
• Liu Q, Ding X, Xu X, et al. Tumor-targeted hyaluronic acid-based oxidative stress nanoamplifier with ROS generation and GSH depletion for antitumor therapy. Int J Biol Macromol. 2022;207:771–783. doi:10.1016/j.ijbiomac.2022.03.139
   PubMed Web of Science ®Google Scholar
• Verlaet AAJ, Breynaert A, Ceulemans B, et al. Oxidative stress and immune aberrancies in attention-deficit/hyperactivity disorder (ADHD): a case-control comparison. Eur Child Adolesc Psychiatry. 2019;28(5):719–729. doi:10.1007/s00787-018-1239-4
   PubMed Web of Science ®Google Scholar
• Wu Q, Shang Y, Shen T, Liu F, Zhang W. Biochanin A protects SH-SY5Y cells against isoflurane-induced neurotoxicity by suppressing oxidative stress and apoptosis. Neurotoxicology. 2021;86:10–18. doi:10.1016/j.neuro.2021.06.007
   PubMed Web of Science ®Google Scholar
• Forman HJ, Zhang H. Targeting oxidative stress in disease: promise and limitations of antioxidant therapy. Nat Rev Drug Discov. 2021;20(9):689–709. doi:10.1038/s41573-021-00233-1
   PubMed Web of Science ®Google Scholar
• Wu J, Ning P, Gao R, et al. Programmable ROS-mediated cancer therapy via magneto-inductions. Adv Sci. 2020;7(12):1902933. doi:10.1002/advs.201902933
   Web of Science ®Google Scholar
• Gomaa A, Peng D, Chen Z, et al. Epigenetic regulation of AURKA by miR-4715-3p in upper gastrointestinal cancers. Sci Rep. 2019;9(1):16970. doi:10.1038/s41598-019-53174-6
   PubMedGoogle Scholar
• Xie Y, Zhu S, Zhong M, et al. Inhibition of Aurora Kinase A induces necroptosis in pancreatic carcinoma. Gastroenterology. 2017;153(5):1429–1443 e1425. doi:10.1053/j.gastro.2017.07.036
   PubMed Web of Science ®Google Scholar
• Wang-Bishop L, Chen Z, Gomaa A, et al. Inhibition of AURKA reduces proliferation and survival of gastrointestinal cancer cells with activated KRAS by preventing activation of RPS6KB1. Gastroenterology. 2019;156(3):662–675 e667. doi:10.1053/j.gastro.2018.10.030
   PubMed Web of Science ®Google Scholar
• Peng F, Xu J, Cui B, et al. Oncogenic AURKA-enhanced N(6)-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells. Cell Res. 2021;31(3):345–361. doi:10.1038/s41422-020-00397-2
   PubMed Web of Science ®Google Scholar
• Sun H, Wang H, Wang X, et al. Aurora-A/SOX8/FOXK1 signaling axis promotes chemoresistance via suppression of cell senescence and induction of glucose metabolism in ovarian cancer organoids and cells. Theranostics. 2020;10(15):6928–6945. doi:10.7150/thno.43811
   PubMed Web of Science ®Google Scholar
• Wang GF, Dong Q, Bai Y, et al. Oxidative stress induces mitotic arrest by inhibiting Aurora A-involved mitotic spindle formation. Free Radic Biol Med. 2017;103:177–187. doi:10.1016/j.freeradbiomed.2016.12.031
   PubMed Web of Science ®Google Scholar
• Huang Y, Pepe MS. Assessing risk prediction models in case-control studies using semiparametric and nonparametric methods. Stat Med. 2010;29(13):1391–1410. doi:10.1002/sim.3876
   PubMed Web of Science ®Google Scholar