Induction of Hepatocellular Carcinoma in Conventional Domestic Swine Using N-Diethylnitrosamine and Phenobarbital

References

• Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–249. doi:10.3322/caac.21660
   PubMed Web of Science ®Google Scholar
• Raza A. Hepatocellular carcinoma review: current treatment, and evidence-based medicine. World J Gastroenterol. 2014;20(15):4115. doi:10.3748/wjg.v20.i15.4115
   PubMed Web of Science ®Google Scholar
• El-Serag HB. Hepatocellular carcinoma. N Engl J Med. 2011;365(12):1118–1127. doi:10.1056/NEJMra1001683
   PubMed Web of Science ®Google Scholar
• Zhang HE, Henderson JM, Gorrell MD. Animal models for hepatocellular carcinoma. Biochim Biophys Acta Mol Basis Dis. 2019;1865(5):993–1002. doi:10.1016/j.bbadis.2018.08.009
   PubMed Web of Science ®Google Scholar
• Tolba R, Kraus T, Liedtke C, Schwarz M, Weiskirchen R. Diethylnitrosamine (DEN)-induced carcinogenic liver injury in mice. Lab Anim. 2015;49(1_suppl):59–69. doi:10.1177/0023677215570086
   PubMedGoogle Scholar
• Ho J, Ware M, Law J, et al. Improved, shorter-latency carcinogen-induced hepatocellular carcinoma model in pigs. Oncology. 2018;95(6):360–369. doi:10.1159/000491092
   PubMed Web of Science ®Google Scholar
• Weisburger JH, Griswold DP, Prejean JD, Casey AE, Wood HB, Weisburger EK. The carcinogenic properties of some of the principal drugs Used in clinical cancer chemotherapy. In: The Ambivalence of Cytostatic Therapy. Berlin, Heidelberg: Springer Berlin Heidelberg; 1975:1–17. doi:10.1007/978-3-642-80940-8_1
   Google Scholar
• Hori T, Yokobori K, Moore R, Negishi M, Sueyoshi T. CAR requires Gadd45β to promote phenobarbital-induced mouse liver tumors in the early stage. Front Oncol. 2023;13. doi:10.3389/fonc.2023.1217847
   Web of Science ®Google Scholar
• Butterworth KT, Williams JP. Animal models for radiotherapy research: all (animal) models are wrong but some are useful. Cancers. 2021;13(6):1319. doi:10.3390/cancers13061319
   PubMed Web of Science ®Google Scholar
• Bekheit M, Bucur PO, Wartenberg M, Vibert E. Computerized tomography–based anatomic description of the porcine liver. J Surg Res. 2017;210:223–230. doi:10.1016/j.jss.2016.11.004
   PubMed Web of Science ®Google Scholar
• Omata M, Cheng AL, Kokudo N, et al. Asia–Pacific clinical practice guidelines on the management of hepatocellular carcinoma: a 2017 update. Hepatol Int. 2017;11(4):317–370. doi:10.1007/s12072-017-9799-9
   PubMed Web of Science ®Google Scholar
• Marrero JA, Kulik LM, Sirlin CB, et al. Diagnosis, staging, and management of hepatocellular carcinoma: 2018 practice guidance by the American Association for the Study of Liver Diseases. Hepatology. 2018;68(2):723–750. doi:10.1002/hep.29913
   PubMed Web of Science ®Google Scholar
• Galle PR, Forner A, Llovet JM, et al. EASL clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol. 2018;69(1):182–236. doi:10.1016/j.jhep.2018.03.019
   PubMed Web of Science ®Google Scholar
• Wang S, Liu Y, Fang D, Shi S. The miniature pig: a useful large animal model for dental and orofacial research. Oral Dis. 2007;13(6):530–537. doi:10.1111/j.1601-0825.2006.01337.x
   PubMed Web of Science ®Google Scholar
• Graw JJ, Berg H. Hepatocarcinogenetic effect of DENA in pigs. Zeitschrift für Krebsforschung und Klinische Onkologie. 1977;89(2):137–143. doi:10.1007/BF00308514
   Google Scholar
• Li X, Zhou X, Guan Y, Wang YXJ, Scutt D, Gong QY. N-Nitrosodiethylamine-induced pig liver hepatocellular carcinoma model: radiological and histopathological Studies. Cardiovasc Intervent Radiol. 2006;29(3):420–428. doi:10.1007/s00270-005-0099-8
   PubMed Web of Science ®Google Scholar
• Mitchell J, Tinkey PT, Avritscher R, et al. Validation of a preclinical model of Diethylnitrosamine-induced hepatic neoplasia in Yucatan miniature pigs. Oncology. 2016;91(2):90–100. doi:10.1159/000446074
   PubMed Web of Science ®Google Scholar
• Mahmoud AM, Zaki AR, Hassan ME, Mostafa-Hedeab G. Commiphora molmol resin attenuates diethylnitrosamine/phenobarbital-induced hepatocarcinogenesis by modulating oxidative stress, inflammation, angiogenesis, and Nrf2/ARE/HO-1 signaling. Chem Biol Interact. 2017;270:41–50. doi:10.1016/j.cbi.2017.04.012
   PubMed Web of Science ®Google Scholar
• Kessler SM, Lebber B, Hoppstädter J, et al. Diethylnitrosamine (DENA) recapitulates the formation of hepatic angiosarcoma in pigs. PLoS One. 2019;14(5):e0214756. doi:10.1371/journal.pone.0214756
   PubMed Web of Science ®Google Scholar
• Zhou J, Sun H, Wang Z, et al. Guidelines for the diagnosis and treatment of hepatocellular carcinoma (2019 edition). Liver Cancer. 2020;9(6):682–720. doi:10.1159/000509424
   PubMed Web of Science ®Google Scholar
• Guglielmi A, Ruzzenente A, Conci S, Valdegamberi A, Iacono C. How much remnant is enough in liver resection? Dig Surg. 2012;29(1):6–17. doi:10.1159/000335713
   PubMed Web of Science ®Google Scholar
• Elguindy NM, Yacout GA, El Azab EF. Amelioration of DENA-induced oxidative stress in rat kidney and brain by the essential oil of Elettaria cardamomum. Beni Suef Univ J Basic Appl Sci. 2018;7(3):299–305. doi:10.1016/j.bjbas.2018.02.005
   Google Scholar
• Vargas-Olvera CY, Sánchez-González DJ, Solano JD, et al. Characterization of N-diethylnitrosamine-initiated and ferric nitrilotriacetate-promoted renal cell carcinoma experimental model and effect of a tamarind seed extract against acute nephrotoxicity and carcinogenesis. Mol Cell Biochem. 2012;369(1–2):105–117. doi:10.1007/s11010-012-1373-0
   PubMed Web of Science ®Google Scholar
• Lee YJ, Lee JM, Lee JS, et al. Hepatocellular carcinoma: diagnostic performance of multidetector CT and MR imaging—a systematic review and meta-analysis. Radiology. 2015;275(1):97–109. doi:10.1148/radiol.14140690
   PubMed Web of Science ®Google Scholar
• Liu X, Jiang H, Chen J, Zhou Y, Huang Z, Song B. Gadoxetic acid disodium-enhanced magnetic resonance imaging outperformed multidetector computed tomography in diagnosing small hepatocellular carcinoma: a meta-analysis. Liver Transpl. 2017;23(12):1505–1518. doi:10.1002/lt.24867
   PubMed Web of Science ®Google Scholar
• Yoo SH, Choi JY, Jang JW, et al. Gd-EOB-DTPA-enhanced MRI is better than MDCT in decision-making of curative treatment for hepatocellular carcinoma. Ann Surg Oncol. 2013;20(9):2893–2900. doi:10.1245/s10434-013-3001-y
   PubMed Web of Science ®Google Scholar
• Ding Y, Chen CZ, Rao SX, Zeng MS. A compared study on Gd+-EOB-DTPA and Gd+-DTPA-enhanced MRI in the detection of hepatocellular carcinoma. Chin J Gen Surg. 2013;28(9):682–685. doi:10.3760/cma.j.issn.1007-631X.2013.09.010
   Google Scholar
• Shafizadeh N, Ferrell LD, Kakar S. Utility and limitations of glypican-3 expression for the diagnosis of hepatocellular carcinoma at both ends of the differentiation spectrum. Mod Pathol. 2008;21:1011–1018. doi:10.1038/modpathol.2008.85
   PubMed Web of Science ®Google Scholar
• Wang T, Zhang K. New blood biomarkers for the diagnosis of AFP-negative hepatocellular carcinoma. Front Oncol. 2020;10:1316. doi:10.3389/fonc.2020.01316
   PubMed Web of Science ®Google Scholar