119
Views
0
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Investigation of the Proteasome 26S Subunit, ATPase Family Genes as Potential Prognostic Biomarkers and Therapeutic Targets for Hepatocellular Carcinoma

ORCID Icon, , , , , , & show all
Pages 95-111 | Received 29 Nov 2023, Accepted 09 Feb 2024, Published online: 14 Feb 2024

References

  • Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209–249. doi:10.3322/caac.21660
  • Toh MR, Wong EYT, Wong SH, et al. Global epidemiology and genetics of hepatocellular carcinoma. Gastroenterology. 2023;164(5):766–782. doi:10.1053/j.gastro.2023.01.033
  • Xu Q, Li Y, Gao X, et al. HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer. Nat Commun. 2020;11(1):3978. doi:10.1038/s41467-020-17818-w
  • Zhen SH, Cheng M, Tao YB, et al. Deep learning for accurate diagnosis of liver tumor based on magnetic resonance imaging and clinical data. Front Oncol. 2020;10:680. doi:10.3389/fonc.2020.00680
  • Xia Y, Tang G, Chen Y, et al. Tumor-targeted delivery of siRNA to silence Sox2 gene expression enhances therapeutic response in hepatocellular carcinoma. Bioact Mater. 2020;6(5):1330–1340. doi:10.1016/j.bioactmat.2020.10.019
  • Davis C, Spaller BL, Matouschek A. Mechanisms of substrate recognition by the 26S proteasome. Curr Opin Struct Biol. 2021;67:161–169. doi:10.1016/j.sbi.2020.10.010
  • Sahu I, Glickman MH. Proteasome in action: substrate degradation by the 26S proteasome. Biochem Soc Trans. 2021;49(2):629–644. doi:10.1042/BST20200382
  • Liu T, Zhang J, Chen H, et al. PSMC2 promotes the progression of gastric cancer via induction of RPS15A/mTOR pathway. Oncogenesis. 2022;11(1):12. doi:10.1038/s41389-022-00386-7
  • Zhu D, Huang J, Liu N, Li W, Yan L. PSMC2/CCND1 axis promotes development of ovarian cancer through regulating cell growth, apoptosis and migration. Cell Death Dis. 2021;12(8):730. doi:10.1038/s41419-021-03981-5
  • Qin J, Wang W, An F, Huang W, Ding J. PSMC2 is up-regulated in pancreatic cancer and promotes cancer cell proliferation and inhibits apoptosis. J Cancer. 2019;10(20):4939–4946. doi:10.7150/jca.27616
  • Wang Y, Zhu M, Li J, et al. Overexpression of PSMC2 promotes the tumorigenesis and development of human breast cancer via regulating plasminogen activator urokinase (PLAU). Cell Death Dis. 2021;12(7):690. doi:10.1038/s41419-021-03960-w
  • Chen Q, Fu L, Hu J, Guo G, Xie A. Silencing of PSMC2 inhibits development and metastasis of prostate cancer through regulating proliferation, apoptosis and migration. Cancer Cell Int. 2021;21(1):235. doi:10.1186/s12935-021-01934-8
  • Zhang JY, Shi KZ, Liao XY, et al. The silence of PSMC6 inhibits cell growth and metastasis in lung adenocarcinoma. Biomed Res Int. 2021;2021:9922185. doi:10.1155/2021/9922185
  • Liu Y, Chen H, Li X, et al. PSMC2 regulates cell cycle progression through the p21/cyclin D1 pathway and predicts a poor prognosis in human hepatocellular carcinoma. Front Oncol. 2021;11:607021. doi:10.3389/fonc.2021.607021
  • Papatheodorou I, Fonseca NA, Keays M, et al. Expression Atlas: gene and protein expression across multiple studies and organisms. Nucleic Acids Res. 2018;46(D1):D246–D251. doi:10.1093/nar/gkx1158
  • Pontén F, Jirström K, Uhlen M. The human protein atlas--a tool for pathology. J Pathol. 2008;216(4):387–393. doi:10.1002/path.2440
  • Lánczky A, Győrffy B. Web-based survival analysis tool tailored for medical research (KMplot): development and implementation. J Med Internet Res. 2021;23(7):e27633. doi:10.2196/27633
  • Cerami E, Gao J, Dogrusoz U, et al. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2012;2(5):401–404. doi:10.1158/2159-8290.CD-12-0095
  • Modhukur V, Iljasenko T, Metsalu T, et al. MethSurv: a web tool to perform multivariable survival analysis using DNA methylation data. Epigenomics. 2018;10(3):277–288. doi:10.2217/epi-2017-0118
  • Heberle H, Meirelles GV, da Silva FR, Telles GP, Minghim R. InteractiVenn: a web-based tool for the analysis of sets through Venn diagrams. BMC Bioinf. 2015;16(1):169. doi:10.1186/s12859-015-0611-3
  • Sherman BT, Hao M, Qiu J, et al. DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update). Nucleic Acids Res. 2022;50(W1):W216–W221. doi:10.1093/nar/gkac194
  • Donne R, Lujambio A. The liver cancer immune microenvironment: therapeutic implications for hepatocellular carcinoma. Hepatology. 2023;77(5):1773–1796. doi:10.1002/hep.32740
  • Jia H, Tang WJ, Sun L, Wan C, Zhou Y, Shen WZ. Pan-cancer analysis identifies proteasome 26S subunit, ATPase (PSMC) family genes, and related signatures associated with prognosis, immune profile, and therapeutic response in lung adenocarcinoma. Front Genet. 2023;13:1017866. doi:10.3389/fgene.2022.1017866
  • Normann KR, Øystese KAB, Berg JP, et al. Selection and validation of reliable reference genes for RT-qPCR analysis in a large cohort of pituitary adenomas. Mol Cell Endocrinol. 2016;437:183–189. doi:10.1016/j.mce.2016.08.030
  • Kao TJ, Wu CC, Phan NN, et al. Prognoses and genomic analyses of proteasome 26S subunit, ATPase (PSMC) family genes in clinical breast cancer. Aging. 2021;13(14):17970. doi:10.18632/aging.203345
  • Fan Y, Zhang J, Shi J, et al. Genetic cross-talk between oral squamous cell carcinoma and type 2 diabetes: the potential role of immunity. Dis Markers. 2022;2022:6389906. doi:10.1155/2022/6389906
  • Liu B, Hu Y, Wan L, et al. Proteomics analysis of cancer tissues identifies IGF2R as a potential therapeutic target in laryngeal carcinoma. Front Endocrinol. 2022;13:1031210. doi:10.3389/fendo.2022.1031210
  • Hellwinkel OJ, Asong LE, Rogmann JP, et al. Transcription alterations of members of the ubiquitin-proteasome network in prostate carcinoma. Prostate Cancer Prostatic Dis. 2011;14(1):38–45. doi:10.1038/pcan.2010.48
  • Wang Y, Xu J, Fang Y, et al. Comprehensive analysis of a novel signature incorporating lipid metabolism and immune-related genes for assessing prognosis and immune landscape in lung adenocarcinoma. Front Immunol. 2022;13:950001. doi:10.3389/fimmu.2022.950001
  • He Z, Yang X, Huang L, et al. PSMC5 promotes proliferation and metastasis of colorectal cancer by activating epithelial-mesenchymal transition signaling and modulating immune infiltrating cells. Front Cell Dev Biol. 2021;9:657917. doi:10.3389/fcell.2021.657917
  • Mendizabal I, Zeng J, Keller TE, Yi SV. Body-hypomethylated human genes harbor extensive intragenic transcriptional activity and are prone to cancer-associated dysregulation. Nucleic Acids Res. 2017;45(8):4390–4400. doi:10.1093/nar/gkx020
  • Pollen AA, Bhaduri A, Andrews MG, et al. Establishing cerebral organoids as models of human-specific brain evolution. Cell. 2019;176(4):743–756.e17. doi:10.1016/j.cell.2019.01.017
  • Zucman-Rossi J, Villanueva A, Nault JC, Llovet JM. Genetic landscape and biomarkers of hepatocellular carcinoma. Gastroenterology. 2015;149(5):1226–1239.e4. doi:10.1053/j.gastro.2015.05.061
  • Ullah MA, Islam NN, Moin AT, Park SH, Kim B. Evaluating the prognostic and therapeutic potentials of the Proteasome 26S Subunit, ATPase (PSMC) family of genes in lung adenocarcinoma: a database mining approach. Front Genet. 2022;13:935286. doi:10.3389/fgene.2022.935286
  • Méndez-Matías G, Velázquez-Velázquez C, Castro-Oropeza R, et al. Prevalence of HPV in Mexican patients with head and neck squamous carcinoma and identification of potential prognostic biomarkers. Cancer. 2021;13(22):5602. doi:10.3390/cancers13225602
  • Zheng JF, He S, Zeng Z, Gu X, Cai L, Qi G. PMPCB silencing sensitizes HCC tumor cells to sorafenib therapy. Mol Ther. 2019;27(10):1784–1795. doi:10.1016/j.ymthe.2019.06.014
  • Huang W, Mei J, Liu YJ, et al. An Analysis Regarding the Association Between Proteasome (PSM) and Hepatocellular Carcinoma (HCC). J Hepatocell Carcinoma. 2023;10:497–515. doi:10.2147/JHC.S404396
  • Zhang X, Han S, Zhou H, et al. TIMM50 promotes tumor progression via ERK signaling and predicts poor prognosis of non-small cell lung cancer patients. Mol Carcinog. 2019;58(5):767–776. doi:10.1002/mc.22969
  • Gao SP, Sun HF, Jiang HL, et al. Loss of TIM50 suppresses proliferation and induces apoptosis in breast cancer. Tumour Biol. 2016;37(1):1279–1287. doi:10.1007/s13277-015-3878-0
  • Jiang W, Wang L, Zhang Y, Li H. Circ-ATP5H induces hepatitis B virus replication and expression by regulating miR-138-5p/TNFAIP3 axis. Cancer Manag Res. 2020;12:11031–11040. doi:10.2147/CMAR.S272983
  • Chiao CC, Liu YH, Phan NN, et al. Prognostic and Genomic Analysis of Proteasome 20S Subunit Alpha (PSMA) family members in breast cancer. Diagnostics. 2021;11(12):2220. doi:10.3390/diagnostics11122220
  • Bi J, Liang W, Wang Y, Tian W, Cao S, Liu P. Long noncoding RNA PSMA3 Antisense RNA 1 promotes cell proliferation, migration, and invasion in pancreatic ductal adenocarcinoma via targeting MicroRNA-154-5p to positively modulate karyopherin subunit alpha 4. Pancreas. 2022;51(8):1037–1046. doi:10.1097/MPA.0000000000002136
  • Devalaraja S, Folkert IW. Tumor-derived retinoic acid regulates intratumoral monocyte differentiation to promote immune suppression. Cell. 2020;180(6):1098–1114.e16. doi:10.1016/j.cell.2020.02.042
  • Huo G, Liu W, Zhang S, Chen P. Efficacy of PD-1/PD-L1 plus CTLA-4 inhibitors in solid tumors based on clinical characteristics: a meta-analysis. Immunotherapy. 2023;15(3):189–207. doi:10.2217/imt-2022-0140
  • Lu LG, Zhou ZL, Wang XY, et al. PD-L1 blockade liberates intrinsic antitumourigenic properties of glycolytic macrophages in hepatocellular carcinoma. Gut. 2022;71(12):2551–2560. doi:10.1136/gutjnl-2021-326350
  • Fu Y, Mackowiak B, Feng D, et al. MicroRNA-223 attenuates hepatocarcinogenesis by blocking hypoxia-driven angiogenesis and immunosuppression. Gut. 2023;72(10):1942–1958. doi:10.1136/gutjnl-2022-327924
  • Llovet JM, Castet F, Heikenwalder M, et al. Immunotherapies for hepatocellular carcinoma. Nat Rev Clin Oncol. 2022;19(3):151–172. doi:10.1038/s41571-021-00573-2