Profile of vismodegib and its potential in the treatment of advanced basal cell carcinoma

References

• ThissenMRNeumannMHSchoutenLJA systematic review of treatment modalities for primary basal cell carcinomasArch Dermatol19991351177118310522664
   PubMed Web of Science ®Google Scholar
• PaverKPoyzerKBurryNDeakinMLetter: The incidence of basal cell carcinoma and their metastases in Australia and New ZealandAustralas J Dermatol197314534753676
   PubMedGoogle Scholar
• CadeSMalignant Disease and its Treatment by RadiumBaltimoreWilliams and Wilkins Company1940
   Google Scholar
• CotranRSMetastasizing basal cell carcinomasCancer1961141036104013695862
   PubMed Web of Science ®Google Scholar
• LakshmipathiTHuntKMMetastasizing basal-cell carcinomaBr J Dermatol1967792672706025574
   PubMed Web of Science ®Google Scholar
• ScanlonEFVolkmerDDOviedoMAKhanedarJDVictorTAMetastatic basal cell carcinomaJ Surg Oncol1980151711807421276
   PubMed Web of Science ®Google Scholar
• WronkowskiZPrzerzuty raka podstawnokomorkowego skory [Metastases in dermal basal cell carcinoma.]Nowotwory1968185155 Polish5669013
   PubMedGoogle Scholar
• WadheraAFazioMBriccaGStantonOMetastatic basal cell carcinoma: a case report and literature review. How accurate is our incidence data?Dermatol Online J200612716962022
   PubMedGoogle Scholar
• von DomarusHStevensPJMetastatic basal cell carcinoma. Report of five cases and review of 170 cases in the literatureJ Am Acad Dermatol198410104310606736323
   PubMed Web of Science ®Google Scholar
• WeissGJKornRLMetastatic basal cell carcinoma in the era of hedgehog signaling pathway inhibitorsCancer20121185310531922511370
   PubMed Web of Science ®Google Scholar
• SnowSNSahlWLoJSMetastatic basal cell carcinoma. Report of five casesCancer1994733283358293396
   PubMed Web of Science ®Google Scholar
• LoJSSnowSNReiznerGTMohsFELarsonPOHruzaGJMetastatic basal cell carcinoma: report of twelve cases with a review of the literatureJ Am Acad Dermatol1991247157191869642
   PubMed Web of Science ®Google Scholar
• BerlinJMWarnerMRBailinPLMetastatic basal cell carcinoma presenting as unilateral axillary lymphadenopathy: report of a case and review of the literatureDermatol Surg2002281082108412460309
   PubMed Web of Science ®Google Scholar
• SitzK VKeppenMJohnsonDFMetastatic basal cell carcinoma in acquired immunodeficiency syndrome-related complexJAMA19872573403433795417
   PubMed Web of Science ®Google Scholar
• WallingH WFoskoS WGeraminejadPAWhitakerDCArpeyCJAggressive basal cell carcinoma: presentation, pathogenesis, and managementCancer Metastasis Rev20042338940215197337
   PubMed Web of Science ®Google Scholar
• MerchantJLHedgehog signalling in gut development, physiology and cancerJ Physiol201259042143222144577
   PubMed Web of Science ®Google Scholar
• TangJYSoPLEpsteinEHJrNovel Hedgehog pathway targets against basal cell carcinomaToxicol Appl Pharmacol200722425726417276471
   PubMed Web of Science ®Google Scholar
• BarakatMTHumkeE WScottM PLearning from Jekyll to control Hyde: Hedgehog signaling in development and cancerTrends Mol Med20101633734820696410
   PubMed Web of Science ®Google Scholar
• InghamP WMcMahonA PHedgehog signaling in animal development: paradigms and principlesGenes Dev2001153059308711731473
   PubMed Web of Science ®Google Scholar
• BhardwajGMurdochBWuDSonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulationNat Immunol2001217218011175816
   PubMed Web of Science ®Google Scholar
• LiuSDontuGMantleIDHedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cellsCancer Res2006666063607116778178
   PubMed Web of Science ®Google Scholar
• JamesAWPangSAskarinamAAdditive effects of sonic hedgehog and Nell-1 signaling in osteogenic versus adipogenic differentiation of human adipose-derived stromal cellsStem Cells Dev2012212170217822264144
   PubMed Web of Science ®Google Scholar
• AhnSJoynerALIn vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehogNature200543789489716208373
   PubMed Web of Science ®Google Scholar
• PaladiniRDSalehJQianCXuGXRubinLLModulation of hair growth with small molecule agonists of the hedgehog signaling pathwayJ Invest Dermatol200512563864616185261
   PubMed Web of Science ®Google Scholar
• MichelottiGAXieGSwiderskaMSmoothened is a master regulator of adult liver repairJ Clin Invest Epub482013
   Web of Science ®Google Scholar
• ZarogoulidisPZarampoukaKHuangHHedgehog signaling pathway: the must, the maybe and the unknownJ Thorac Dis2013519519723585948
   PubMed Web of Science ®Google Scholar
• WangSHyunJYounBJungYHedgehog signaling regulates the repair response in mouse liver damaged by irradiationRadiat Res2013179697523181588
   PubMed Web of Science ®Google Scholar
• GailaniMRStahle-BackdahlMLeffellDJThe role of the human homologue of Drosophila patched in sporadic basal cell carcinomasNat Genet19961478818782823
   PubMed Web of Science ®Google Scholar
• HahnHChristiansenJWickingCA mammalian patched homolog is expressed in target tissues of sonic hedgehog and maps to a region associated with developmental abnormalitiesJ Biol Chem199627112125121288647801
   PubMed Web of Science ®Google Scholar
• ZurawelRHAllenCChiappaSAnalysis of Ptch/SMO/SHH pathway genes in medulloblastomaGenes Chromosomes Cancer200027445110564585
   PubMed Web of Science ®Google Scholar
• BarEEChaudhryAFarahMHEberhartCGHedgehog signaling promotes medulloblastoma survival via Bc/IIAm J Pathol200717034735517200206
   PubMed Web of Science ®Google Scholar
• BermanDMKarhadkarSSMaitraAWidespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumoursNature200342584685114520411
   PubMed Web of Science ®Google Scholar
• KarhadkarSSBovaGSAbdallahNHedgehog signalling in prostate regeneration, neoplasia and metastasisNature200443170771215361885
   PubMed Web of Science ®Google Scholar
• FanLPepicelliC VDibbleCCHedgehog signaling promotes prostate xenograft tumor growthEndocrinology20041453961397015132968
   PubMed Web of Science ®Google Scholar
• VorechovskyIBenediktssonK PToftgardRThe patched/hedgehog/ smoothened signalling pathway in human breast cancer: no evidence for H133Y SHH, Ptch and SMO mutationsEur J Cancer19993571171310505029
   PubMed Web of Science ®Google Scholar
• WatkinsDNBermanDMBurkholderSGWangBBeachyPABaylinSBHedgehog signalling within airway epithelial progenitors and in small-cell lung cancerNature200342231331712629553
   PubMed Web of Science ®Google Scholar
• HegdeG VMungerCMEmanuelKTargeting of sonic hedgehog-GLI signaling: a potential strategy to improve therapy for mantle cell lymphomaMol Cancer Ther200871450146018524848
   PubMed Web of Science ®Google Scholar
• HegdeG VPetersonKJEmanuelKHedgehog-induced survival of B-cell chronic lymphocytic leukemia cells in a stromal cell microenvironment: a potential new therapeutic targetMol Cancer Res200861928193619074837
   PubMed Web of Science ®Google Scholar
• DierksCGrbicJZirlikKEssential role of stromally induced hedgehog signaling in B-cell malignanciesNat Med20071394495117632527
   PubMed Web of Science ®Google Scholar
• WarzechaJBonkeLKoehlUThe hedgehog inhibitor cyclopamine induces apoptosis in leukemic cells in vitroLeuk Lymphoma2008492383238619052992
   PubMed Web of Science ®Google Scholar
• KatohYKatohMHedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activationCurr Mol Med2009987388619860666
   PubMed Web of Science ®Google Scholar
• VarnatFDuquetAMalerbaMHuman colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansionEMBO Mol Med2009133835120049737
   PubMed Web of Science ®Google Scholar
• FeldmannGDharaSFendrichVBlockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancersCancer Res2007672187219617332349
   PubMed Web of Science ®Google Scholar
• RasheedZAYangJWangQPrognostic significance of tumorigenic cells with mesenchymal features in pancreatic adenocarcinomaJ Natl Cancer Inst201010234035120164446
   PubMed Web of Science ®Google Scholar
• HuiCCAngersSGli proteins in development and diseaseAnnu Rev Cell Dev Biol20112751353721801010
   PubMed Web of Science ®Google Scholar
• ScalesSJde SauvageFJMechanisms of Hedgehog pathway activation in cancer and implications for therapyTrends Pharmacol Sci20093030331219443052
   PubMed Web of Science ®Google Scholar
• SasakiHNishizakiYHuiCNakafukuMKondohHRegulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signalingDevelopment19991263915392410433919
   PubMed Web of Science ®Google Scholar
• WickingCMcGlinnEThe role of hedgehog signalling in tumorigenesisCancer Lett20011731711578802
   PubMed Web of Science ®Google Scholar
• Ruiz i AltabaATherapeutic inhibition of Hedgehog-GLI signaling in cancer: epithelial, stromal, or stem cell targets?Cancer Cell20081428128318835029
   PubMed Web of Science ®Google Scholar
• Ruiz i AltabaASanchezPDahmaneNGli and hedgehog in cancer: tumours, embryos and stem cellsNat Rev Cancer2002236137212044012
   PubMed Web of Science ®Google Scholar
• YauchRLGouldSEScalesSJA paracrine requirement for hedgehog signalling in cancerNature200845540641018754008
   PubMed Web of Science ®Google Scholar
• JohnsonRLRothmanALXieJHuman homolog of patched, a candidate gene for the basal cell nevus syndromeScience1996272166816718658145
   PubMed Web of Science ®Google Scholar
• UndenABZaphiropoulosPGBruceKToftqardRStahle-BackdahlMHuman patched (Ptch) mRNA is overexpressed consistently in tumor cells of both familial and sporadic basal cell carcinomaCancer Res199757233623409192803
   PubMed Web of Science ®Google Scholar
• DahmaneNLeeJRobinsPHellerPRuiz i AltabaAActivation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumoursNature19973898768819349822
   PubMed Web of Science ®Google Scholar
• AszterbaumMRothmanAJohnsonRLIdentification of mutations in the human PATCHED gene in sporadic basal cell carcinomas and in patients with the basal cell nevus syndromeJ Invest Dermatol19981108858889620294
   PubMed Web of Science ®Google Scholar
• ReifenbergerJWolterMWeberRGMissense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous systemCancer Res199858179818039581815
   PubMed Web of Science ®Google Scholar
• EpsteinEHBasal cell carcinomas: attack of the hedgehogNat Rev Cancer2008874375418813320
   PubMed Web of Science ®Google Scholar
• ReifenbergerJWolterMKnobbeCBSomatic mutations in the Ptch, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomasBr J Dermatol2005152435115656799
   PubMed Web of Science ®Google Scholar
• RobargeKDBruntonSACastanedoGMGDC-0449-a potent inhibitor of the hedgehog pathwayBioorg Med Chem Lett2009195576558119716296
   PubMed Web of Science ®Google Scholar
• GrahamRALumBLCheetiSPharmacokinetics of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with locally advanced or metastatic solid tumors: the role of alpha-1-acid glycoprotein bindingClin Cancer Res2011172512252021300760
   PubMed Web of Science ®Google Scholar
• GiannettiAMWongHDijkgraafGJIdentification, characterization, and implications of species-dependent plasma protein binding for the oral Hedgehog pathway inhibitor vismodegib (GDC-0449)J Med Chem2011542592260121438527
   PubMed Web of Science ®Google Scholar
• GrahamRALumBLMorrisonGA single dose mass balance study of the Hedgehog pathway inhibitor vismodegib (GDC-0449) in humans using accelerator mass spectrometryDrug Metab Dispos2011391460146721602311
   PubMed Web of Science ®Google Scholar
• WongHChenJZChouBPreclinical assessment of the absorption, distribution, metabolism and excretion of GDC-0449 (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl) benzamide), an orally bioavailable systemic Hedgehog signalling pathway inhibitorXenobiotica20093985086119845436
   PubMed Web of Science ®Google Scholar
• YueQChenYHMulderTAbsorption, distribution, metabolism, and excretion of [14C]GDC-0449 (vismodegib), an orally active hedgehog pathway inhibitor, in rats and dogs: a unique metabolic pathway via pyridine ring openingDrug Metab Dispos20113995296521363998
   PubMed Web of Science ®Google Scholar
• LoRussoPMJimenoADyGPharmacokinetic dose-scheduling study of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with locally advanced or metastatic solid tumorsClin Cancer Res2011175774578221753154
   PubMed Web of Science ®Google Scholar
• LoRussoPMRudinCMReddyJCPhase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumorsClin Cancer Res2011172502251121300762
   PubMed Web of Science ®Google Scholar
• KeatingGMVismodegib: in locally advanced or metastatic basal cell carcinomaDrugs2012721535154122788238
   PubMed Web of Science ®Google Scholar
• AasiSSilkissRTangJYNew onset of keratoacanthomas after vismodegib treatment for locally advanced Basal cell carcinomas: a report of 2 casesJAMA Dermatol201314924224323426496
   PubMed Web of Science ®Google Scholar
• AxelsonMLiuKJiangXUS Food and drug administration approval: vismodegib for recurrent, locally advanced, or metastatic Basal cell carcinomaClin Cancer Res2013192289229323515405
   PubMed Web of Science ®Google Scholar
• YauchRLDijkgraafGJAlickeBSmoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastomaScience200932657257419726788
   PubMed Web of Science ®Google Scholar
• DijkgraafGJAlickeBWeinmannLSmall molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistanceCancer Res20117143544421123452
   PubMed Web of Science ®Google Scholar
• TherassePArbuckSGEisenhauerEAWandersJKaplanRSRubinsteinLNew guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of CanadaJ Natl Cancer Inst2000922051610655437
   PubMed Web of Science ®Google Scholar
• SekulicAMigdenMROroAEEfficacy and safety of vismodegib in advanced basal-cell carcinomaN Engl J Med20123662171217922670903
   PubMed Web of Science ®Google Scholar
• TangJ YMackay-WigganJMAszterbaumMInhibiting the hedgehog pathway in patients with the basal-cell nevus syndromeN Engl J Med20123662180218822670904
   PubMed Web of Science ®Google Scholar
• ChangALOroAEInitial assessment of tumor regrowth after vismodegib in advanced Basal cell carcinomaArch Dermatol20121481324132522910979
   PubMedGoogle Scholar