104
Views
28
CrossRef citations to date
0
Altmetric
Original Research

Nrf2 expression is increased in peripheral blood mononuclear cells derived from mild–moderate ex-smoker COPD patients with persistent oxidative stress

, , , , , , & show all
Pages 1733-1743 | Published online: 28 Jul 2016

References

  • BarnesPJCelliBRSystemic manifestations and comorbidities of COPDEur Respir J20093351165118519407051
  • RennardSIVestboJCOPD: The dangerous underestimate of 15%Lancet200636795181216121916631861
  • RutgersSRPostmaDSten HakenNHOngoing airway inflammation in patients with COPD who do not currently smokeThorax2000551121810607796
  • KirkhamPABarnesPJOxidative stress in COPDChest2013144126627323880677
  • ZuoLHeFSergakisGGInterrelated role of cigarette smoking, oxidative stress, and immune response in COPD and corresponding treatmentsAm J Physiol Lung Cell Mol Physiol20143073L205L21824879054
  • ChoHYKleebergerSRNrf2 protects against airway disordersToxicol Appl Pharmacol20102441435619646463
  • MaQRole of Nrf2 in oxidative stress and toxicityAnnu Rev Pharmacol Toxicol20135340142623294312
  • RangasamyTChoCYThimmulappaRKGenetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in miceJ Clin Invest200411491248125915520857
  • SuzukiMBetsuyakuTItoYDownregulated NF-E2-related factor 2 in pulmonary macrophages of aged smokers and patients with chronic obstructive pulmonary diseaseAm J Respir Cell Mol Biol200839667368218566336
  • KaufmanRJOrchestrating the unfolded protein response in health and diseaseJ Clin Invest2002110101389139812438434
  • RonDWalterPSignal integration in the endoplasmic reticulum unfolded protein responseNat Rev Mol Cell Biol20078751952917565364
  • TagawaYHiramatsuNKasaiAInduction of apoptosis by cigarette smoke via ROS dependent endoplasmic reticulum stress and CCAAT/enhancer-binding protein-homologous protein (CHOP)Free Radic Biol Med200851505918394432
  • KelsenSGDuanXJiRPerezOLiuCMeraliSCigarette smoke induces an unfolded protein response in the human lung: a proteomic approachAm J Respir Cell Mol Biol200838554155018079489
  • MalhotraDThimmulappaRVijNHeightened endoplasmic reticulum stress in the lungs of patients with chronic obstructive pulmonary disease: the role of Nrf2-regulated proteasomal activityAm J Respir Crit Care Med2009180121196120719797762
  • MinTBodasMMazurSVijNCritical role of proteostasis-imbalance in pathogenesis of COPD and severe emphysemaJ Mol Med201189657759321318260
  • BarnesPJShapiroSDPauwelsRAChronic obstructive pulmonary disease: molecular and cellular mechanismsEur Respir J200322467268814582923
  • GarbinUFratta PasiniAStranieriCCigarette smoking blocks the protective expression of Nrf2/ARE pathway in peripheral mono-nuclear cells of young heavy smokers favouring inflammationPLoS One2009412e822520011043
  • MurtaghEHeaneyLGinglesJPrevalence of obstructive lung disease in a general population sample: the NICECOPD studyEur J Epidemiol200520544344516080593
  • FabbriLPauwelsRAHurdSSGlobal strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease: GOLD executive summary updated 2003COPD20041110514116997745
  • de MarcoRAccordiniSAntonicelliLThe Gene-Environment Interactions in Respiratory Diseases (GEIRD) ProjectInt Arch Allergy Immunol2010152325526320150743
  • QuanjerPHTammelingGJCotesJEPedersenOFPeslinRYernaultJCLung volumes and forced ventilator flowsEur Respir J19931654024576915
  • Fratta PasiniAAnselmiMGarbinUEnhanced levels of oxidized low-density lipoprotein prime monocytes to cytokine overproduction via upregulation of CD14 and toll-like receptor 4 in unstable anginaArterioscler Thromb Vasc Biol20072791991199717600225
  • UbbinkJBVermaakWJHBissbortSRapid high performance liquid chromatographic assay for total homocysteine levels in human serumJ Chromatogr19915651–24414461874890
  • MaoJZhangHLuoJNew method for HPLC separation and fluorescence detection of malonaldehyde in normal human plasmaJ Chromatogr B Analyt Technol Biomed Life Sci20068321103108
  • SubbanagounderGNLeitingerDCSchwenkeJWDeterminants of bioactivity of oxidized phospholipids. Specific oxidized fatty acyl groups at the sn-2 positionArterioscler Thromb Vasc Biol200020102248225411031211
  • GriendlingKKSorescuDUshio-FukaiMNAD(P)H oxidase: role in cardiovascular biology and diseaseCirc Res200086549450110720409
  • ScanlonPDConnettJEWallerLASmoking cessation and lung function in mild-to moderate chronic obstructive pulmonary disease. The lung health studyAm J Respir Crit Care Med20001612 Pt 138139010673175
  • RahmanIMacNeeWRole of transcription factors in inflammatory lung diseasesThorax19985376016129797762
  • GovenDBouttenALecon-MalasVAltered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysemaThorax2008631091692418559366
  • MalhotraDThimmulappaRNavas-AcienADecline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1Am J Respir Crit Care Med2008178659260418556627
  • BhattacharyaSTyagiSSrisumaSPeripheral blood gene expression profiles in COPD subjectsJ Clin Bioinforma2011111221884629
  • PoliskaSCsankyESzantoAChronic obstructive pulmonary disease-specific gene expression signatures of alveolar macrophages as well as peripheral blood monocytes overlap and correlate with lung functionRespiration201181649951021430361
  • ChoHYJedlickaAEReddySPRole of NRF2 in protection against hyperoxic lung injury in miceAm J Respir Cell Mol Biol200226217518211804867
  • SinghALingGSuhasiniANNrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungsFree Radic Biol Med200946337638619027064
  • BouttenAGovenDBoczkowskiJBonayMOxidative stress targets in pulmonary emphysema: focus on the Nrf2 pathwayExpert Opin Ther Targets201014332934620148719
  • MaestrelliPPáskaCSaettaMDecreased haeme oxygenase-1 and increased inducible nitric oxide synthase in the lung of severe COPD patientsEur Respir J200321697197612797490
  • KorfeiMRuppertCMahavadiPEpithelial endoplasmic reticulum stress and apoptosis in sporadic idiopathic pulmonary fibrosisAm J Respir Crit Care Med2008178883884618635891
  • YamadaKAsaiKNagayasuFImpaired nuclear factor erythroid 2-related factor 2 expression increases apoptosis of airway epithelial cells in patients with chronic obstructive pulmonary disease due to cigarette smokingBMC Pulm Med20161612726861788
  • MozziniCFratta PasiniAGarbinUIncreased endoplasmic reticulum stress and Nrf2 repression in peripheral blood mononuclear cells of patients with stable coronary artery diseaseFree Radic Biol Med20146817818524373961
  • HuangCWangJJMaJHJinCYuQZhangSXActivation of the UPR protects against cigarette smoke-induced RPE apoptosis through up-regulation of Nrf2J Biol Chem201529095367538025568320
  • LeeSHurEGRyooIGJungKAKwakJKwakMKInvolvement of the Nrf2-proteasome pathway in the endoplasmic reticulum stress response in pancreatic beta-cellsToxicol Appl Pharmacol2012264343143822959925
  • PoppekDGruneTProteasomal defense of oxidative protein modificationsAntioxid Redox Signal200681–217318416487051
  • LouhelainenNRytiläPHaahtelaTKinnulaVLDjukanovićRPersistence of oxidant and protease burden in the airways after smoking cessationBMC Pulm Med200992519473482
  • WofniakAGóreckiDSzpindaMMila-KierzenkowskaCWoźniakBOxidant-antioxidant balance in the blood of patients with chronic obstructive pulmonary disease after smoking cessationOxid Med Cell Longev2013201389707524089631
  • PapaiahgariSKleebergerSRChoHYKalvakolanuDVReddySPNADPH oxidase and ERK signaling regulates hyperoxia-induced Nrf2-ARE transcriptional response in pulmonary epithelial cellsJ Biol Chem200427940423024231215292179
  • LiJMMullenAMYunSEssential role of the NADPH oxidase subunit p47(phox) in endothelial cell superoxide production in response to phorbol ester and tumor necrosis factor-alphaCirc Res200290214315011834706
  • Fratta PasiniAAlbieroAStranieriCSerum oxidative stress-induced repression of Nrf2 and GSH depletion: a mechanism potentially involved in endothelial dysfunction of young smokersPLoS One201271e3029122272327
  • WillemseeBWMten HackenNHRutgersBEffect of 1-year smoking cessation on airway inflammation in COPD and asymptomatic smokersEur Respir J200526583584516264044
  • LapperreTSPostmaDSGosmanMMRelation between duration of smoking cessation and bronchial inflammation in COPDThorax200661211512116055612
  • SussanTERangasamyTBlakeDJTargeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in miceProc Natl Acad Sci U S A2009106125025519104057
  • GaoBDoanAHybertsonBMThe clinical potential of influencing Nrf2 signaling in degenerative and immunological disordersClin Pharmacol20146193424520207