The development of AZD7624 for prevention of exacerbations in COPD: a randomized controlled trial

References

• HurstJRVestboJAnzuetoASusceptibility to exacerbation in chronic obstructive pulmonary diseaseN Engl J Med2010363121128113820843247
   PubMed Web of Science ®Google Scholar
• AnzuetoASethiSMartinezFJExacerbations of chronic obstructive pulmonary diseaseProc Am Thorac Soc20074755456417878469
   PubMedGoogle Scholar
• PereraWRHurstJRWilkinsonTMAInflammatory changes, recovery and recurrence at COPD exacerbationEur Respir J200729352753417107990
   PubMed Web of Science ®Google Scholar
• NiewoehnerDEThe impact of severe exacerbations on quality of life and the clinical course of chronic obstructive pulmonary diseaseAm J Med200611910 Suppl 1384516996898
   PubMed Web of Science ®Google Scholar
• VestboJHurdSSAgustíAGGlobal strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary diseaseAm J Respir Crit Care Med2013187434736522878278
   PubMed Web of Science ®Google Scholar
• SethiSMurphyTFInfection in the pathogenesis and course of chronic obstructive pulmonary diseaseN Engl J Med2008359222355236519038881
   PubMed Web of Science ®Google Scholar
• PapiABellettatoCMBraccioniFInfections and airway inflammation in chronic obstructive pulmonary disease severe exacerbationsAm J Respir Crit Care Med2006173101114112116484677
   PubMed Web of Science ®Google Scholar
• GroenewegenKHPostmaDSHopWCJWieldersPLMLSchlösserNJJWoutersEFMIncreased systemic inflammation is a risk factor for COPD exacerbationsChest2008133235035718198263
   PubMed Web of Science ®Google Scholar
• ThomsenMIngebrigtsenTSMarottJLInflammatory biomarkers and exacerbations in chronic obstructive pulmonary diseaseJAMA2013309222353236123757083
   PubMed Web of Science ®Google Scholar
• CelliBRBarnesPJExacerbations of chronic obstructive pulmonary diseaseEur Respir J20072961224123817540785
   PubMed Web of Science ®Google Scholar
• ErnstPSaadNSuissaSInhaled corticosteroids in COPD: the clinical evidenceEur Respir J201545252553725537556
   PubMed Web of Science ®Google Scholar
• MartinezFJCalverleyPMAGoehringU-MBroseMFabbriLMRabeKFEffect of roflumilast on exacerbations in patients with severe chronic obstructive pulmonary disease uncontrolled by combination therapy (REACT): a multicentre randomised controlled trialLancet2015385997185786625684586
   PubMed Web of Science ®Google Scholar
• SaklatvalaJThe p38 MAP kinase pathway as a therapeutic target in inflammatory diseaseCurr Opin Pharmacol20044437237715251131
   PubMed Web of Science ®Google Scholar
• ChungKFp38 Mitogen-activated protein kinase pathways in asthma and COPDChest201113961470147921652557
   PubMed Web of Science ®Google Scholar
• RendaTBaraldoSPelaiaGIncreased activation of p38 MAPK in COPDEur Respir J2008311626917959643
   PubMed Web of Science ®Google Scholar
• MacNeeWAllanRJJonesIDe SalvoMCTanLFEfficacy and safety of the oral p38 inhibitor PH-797804 in chronic obstructive pulmonary disease: a randomised clinical trialThorax201368873874523539534
   PubMed Web of Science ®Google Scholar
• WatzHBarnacleHHartleyBFChanREfficacy and safety of the p38 MAPK inhibitor losmapimod for patients with chronic obstructive pulmonary disease: a randomised, double-blind, placebo-controlled trialLancet Respir Med201421637224461903
   PubMed Web of Science ®Google Scholar
• FiskMGajendragadkarPRMäki-PetäjäKMWilkinsonIBCheriyanJTherapeutic potential of p38 MAP kinase inhibition in the management of cardiovascular diseaseAm J Cardiovasc Drugs201414315516524504769
   PubMed Web of Science ®Google Scholar
• From the Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD)2017 Available from: http://goldcopd.org
   Google Scholar
• PizzichiniEPizzichiniMMEfthimiadisAIndices of airway inflammation in induced sputum: reproducibility and validity of cell and fluid-phase measurementsAm J Respir Crit Care Med199615423083178756799
   PubMed Web of Science ®Google Scholar
• QuanjerPHStanojevicSColeTJMulti-ethnic reference values for spirometry for the 3–95-yr age range: the global lung function 2012 equationsEur Respir J20124061324134322743675
   PubMed Web of Science ®Google Scholar
• JenkinsCRCelliBAndersonJASeasonality and determinants of moderate and severe COPD exacerbations in the TORCH studyEur Respir J2012391384521737561
   PubMed Web of Science ®Google Scholar
• AhrensRCTeresiMEHanSHDonnellDVanden BurgtJALuxCRAsthma stability after oral prednisone: a clinical model for comparing inhaled steroid potencyAm J Respir Crit Care Med200116471138114511673199
   PubMed Web of Science ®Google Scholar
• CalverleyPMBoonsawatWCsekeZZhongNPetersonSOlssonHMaintenance therapy with budesonide and formoterol in chronic obstructive pulmonary diseaseEur Respir J200322691291914680078
   PubMed Web of Science ®Google Scholar
• BurgePSCalverleyPMJonesPWSpencerSAndersonJAMaslenTKRandomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: the ISOLDE trialBMJ200032072451297130310807619
   PubMed Web of Science ®Google Scholar
• DransfieldMTBourbeauJJonesPWOnce-daily inhaled fluticasone furoate and vilanterol versus vilanterol only for prevention of exacerbations of COPD: two replicate double-blind, parallel-group, randomised controlled trialsLancet Respir Med20131321022324429127
   PubMed Web of Science ®Google Scholar
• ErikssonGCalverleyPMJenkinsCRThe effect of COPD severity and study duration on exacerbation outcome in randomized controlled trialsInt J Chron Obstruct Pulmon Dis2017121457146828553098
   PubMed Web of Science ®Google Scholar
• HopeHRAndersonGDBurnetteBLAnti-inflammatory properties of a novel N-phenyl pyridinone inhibitor of p38 mitogen-activated protein kinase: preclinical-to-clinical translationJ Pharmacol Exp Ther2009331388289519720877
   PubMed Web of Science ®Google Scholar
• AstonNMBamboroughPBucktonJBp38α mitogen-activated protein kinase inhibitors: optimization of a series of biphenylamides to give a molecule suitable for clinical progressionJ Med Chem200952206257626919772287
   PubMed Web of Science ®Google Scholar
• Marks-KonczalikJCostaMRobertsonJMcKieEYangSPascoeSA post-hoc subgroup analysis of data from a six month clinical trial comparing the efficacy and safety of losmapimod in moderate-severe COPD patients with ≤2% and >2% blood eosinophilsRespir Med2015109786086926033641
   PubMed Web of Science ®Google Scholar
• AulRArmstrongJDuvoixAInhaled LPS challenges in smokers: a study of pulmonary and systemic effectsBr J Clin Pharmacol20127461023103222469312
   PubMed Web of Science ®Google Scholar
• KorsgrenMLindenMEntwistleNInhalation of LPS induces inflammatory airway responses mimicking characteristics of chronic obstructive pulmonary diseaseClin Physiol Funct Imaging2012321717922152082
   PubMed Web of Science ®Google Scholar
• MichelODentenerMCataldoDEvaluation of oral corticosteroids and phosphodiesterase-4 inhibitor on the acute inflammation induced by inhaled lipopolysaccharide in humanPulm Pharmacol Ther200720667668317045826
   PubMed Web of Science ®Google Scholar
• RennardSICalverleyPMGoehringUMBredenbrokerDMartinezFJReduction of exacerbations by the PDE4 inhibitor roflumilast – the importance of defining different subsets of patients with COPDRespir Res2011121821272339
   PubMed Web of Science ®Google Scholar
• RennardSIDaleDCDonohueJFCXCR2 Antagonist MK-7123. A phase 2 proof-of-concept trial for chronic obstructive pulmonary diseaseAm J Respir Crit Care Med201519191001101125695403
   PubMed Web of Science ®Google Scholar
• PavordIDLettisSLocantoreNBlood eosinophils and inhaled corticosteroid/long-acting β-2 agonist efficacy in COPDThorax201671211812526585525
   PubMed Web of Science ®Google Scholar
• ReganEAHokansonJEMurphyJRGenetic Epidemiology of COPD (COPDGene) study designCOPD201071324320214461
   PubMedGoogle Scholar
• MedDRA [webpage on the Internet]Medical Dictionary for Regulartory Activities; 2014: version 17.0 Available from: https://www.meddra.org/how-to-use/support-documentation/englishAccessed February 1, 2018
   Google Scholar